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US20120204276 METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS  
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement...
US20120040906 PROTEIN TARGETS IN DISEASE  
MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte...
US20100311662 Treatment of Acute Coronary Syndrome with an Exendin  
The invention relates to methods for treating a patient suffering from acute coronary syndrome, but who is not suffering from a Q-wave myocardial infarction, comprising administration of a...
US20110152171 HISTAMINE BINDING PROTEIN  
The invention relates to histamine binding proteins. The invention also relates to the use of such histamine binding proteins in the treatment and prevention of diseases.
US20120213738 Cardiac Repair By Reprogramming of Cardiac Fibroblasts Into Cardiomyocytes  
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo....
US20140378376 Dosage Regime for Apolipoprotein Formulations  
An apolipoprotein formulation is provided at a fixed dosage that is efficacious in the prophylactic and/or therapeutic treatment of diseases or conditions including, but not limited to...
US20060142193 Selective inhibition of rock1 in cardiac therapy  
The present invention is directed to the treatment and/or prevention of disease as it relates to Rho kinase. In specific embodiments, disease is treated and/or prevented through the administration...
US20110256130 METHODS OF TREATING INFLAMMATORY DISORDERS  
Disclosed herein, in certain embodiments, are methods and compositions for treating inflammatory disorders. In some embodiments, the methods comprise co-administering synergistic combinations of...
US20150119333 METHODS OF INHIBITING ADVERSE CARDIAC EVENTS AND TREATING ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE USING GALECTIN-3 BINDING PROTEIN (GAL-3BP, BTBD17B, MAC-2 BINDING PROTEIN)  
The invention provides Galectin-3 binding protein (Gal-3BP, BTBD17B) polypeptide sequences and compositions that include Gal-3BP polypeptide sequences, and methods of using Gal-3BP polypeptide...
US20120121590 METHODS OF INHIBITING ADVERSE CARDIAC EVENTS AND TREATING ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE USING GALECTIN-3 BINDING PROTEIN (GAL-3BP, BTBD17B, MAC-2 BINDING PROTEIN)  
The invention provides Galectin-3 binding protein (Gal-3BP, BTBD17B) polypeptide sequences and compositions that include Gal-3BP polypeptide sequences, and methods of using Gal-3BP polypeptide...
US20130035282 METABOLIC AND CARDIOPROTECTION BY THE MYOKINE FOLLISTATIN-LIKE 1 POLYPEPTIDE  
Described herein are methods and compositions related to the discovery that the Follistatin-like 1 protein (Fstl-1) has metabolic and cardioprotective effects in vivo. Fstl-1 and portions and...
US20110091543 ORAL DELIVERY OF MODIFIED TRANSFERRIN FUSION PROTEINS  
Pharmaceutical compositions containing modified fusion proteins of transferrin and therapeutic proteins or peptides with increased serum half-life or increased serum stability are disclosed....
US20110021433 METHODS FOR TREATING OR PREVENTING HEART FAILURE  
The invention provides methods for inhibiting cell death or inflammation in a mammal brought about by diseases or conditions such as heart failure, wherein the method comprises administering to a...
US20130011335 Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and SRC  
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation...
US20120270793 METHODS OF TREATING A PATIENT RECEIVING A CARDIAC STENT IMPLANT  
Methods of treating a patient receiving a cardiac stent implant including the steps of: (i) monitoring the circulating level of Tn I or CK-MB in the patient; and (ii) administering SERP-I to the...
US20110190730 METHODS OF INDUCING PLURIPOTENCY INVOLVING OCT4 PROTEIN  
The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell...
US20150080311 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a...
US20120058946 COMPOUND AND METHOD FOR TREATING MYOTONIC DYSTROPHY  
An antisense compound for use in treating myotonic dystrophy DM1 or DM2, a method of enhancing antisense targeting to heart and quadricep muscles, and a method for treating DM1 or DM2 in a...
US20140068794 R2R1/2 In Diagnosis and Therapy  
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered...
US20110293725 CHIMERIC THERAPEUTICS, COMPOSITIONS, AND METHODS FOR USING SAME  
Chimeric therapeutics are disclosed that include a modified viral core protein and a nucleic acid bound to the modified viral core protein. The nucleic acid may be substantially homologous to a...
US20110124568 USE OF HEAT-SHOCK PROTEIN 27 FOR CARDIOVASCULAR DISEASE PREVENTION AND TREATMENT  
A method of reducing cholesterol in a subject is provided. The method may be used to decrease serum cholesterol and/or arterial wall cholesterol. The method comprises administering a...
US20120077750 USE OF A GROWTH-STIMULATING PROTEIN  
This invention relates to the inhibition of a newly discovered growth-stimulating protein in an individual. Further, the invention relates to a method for preventing or treating a cancer, or...
US20140011737 COMPOSITIONS AND METHODS FOR REGULATING METABOLISM  
The present invention features compositions and methods for treating and preventing a metabolic syndrome featuring the collagen triple helix repeat containing-1 (Cthrc1) protein.
US20140271672 GENETIC POLYMORPHISMS ASSOCIATED WITH MYOCARDIAL INFARCTION, METHODS OF DETECTION AND USES THEREOF  
The present invention is based on the discovery of genetic polymorphisms that are associated with myocardial infarction. In particular, the present invention relates to nucleic acid molecules...
US20130102521 COMPOSITIONS FOR OXYGEN TRANSPORT COMPRISING A HIGH OXYGEN AFFINITY MODIFIED HEMOGLOBIN  
The present invention relates to blood products, and more particularly to compositions comprising a modified oxygenated hemoglobin having a high affinity for oxygen and methods for making such...
US20110135665 METHODS FOR TREATING REPERFUSION INJURIES  
The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.
US20110190729 METHODS OF INDUCING PLURIPOTENCY INVOLVING SOX2 PROTEIN  
The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell...
US20110318318 ANTI-APOPTOTIC FUSION PROTEINS  
The present invention relates to a fusion protein comprising a protein transduction domain capable of introducing the fusion protein into a mammalian cell and an anti-apoptotic protein comprising...
US20140274891 METHOD OF GENERATING AN INDEX SCORE FOR MBL DEFICIENCY TO PREDICT CARDIODIABETES RISK  
This application relates to methods of predicting susceptibility or likelihood of a clinically-relevant mannose-binding lectin (MBL)-deficient subject to develop a cardiovascular disease and/or...
US20140056925 Methods of Reducing Myocardial Injury Following Myocardial Infarction  
The present invention discloses methods of reducing injury resulting from cardiovascular disease, such as myocardial infarction, and/or promoting myocardial repair. The methods include...
US20120122789 Methods of Reducing Myocardial Injury Following Myocardial Infarction  
The present invention discloses methods of reducing injury resulting from cardiovascular disease, such as myocardial infarction, and/or promoting myocardial repair. The methods include...
US20110033469 LEUKOTRIENE B4 BINDING SOLUBLE LIPOCALIN RECEPTOR FROM IXODES RICINUS  
Leukotriene B4 binding polypeptide is obtained from Ixodes ricinus, the polynucleotide and related polypeptides may be used as research reagents and materials for the development of treatments and...
US20110002893 DIAGNOSIS AND TREATMENT OF CONGENITAL HEART DEFECTS USING NELL1  
The present invention provides diagnostic methods for detecting congenital heart defects, or increased risk thereof, based on the Nell1 gene, RNA and protein. The methods include obtaining a...
US20130309211 Wnt1 for Treatment of Cardiovascular Disorders and Injuries  
The present invention relates to the discovery of the role of Wnt1 in multiple cardiovascular processes, including cardiac repair, angiogenesis, and stimulation of endothelial progenitor cells....
US20120208762 Methods of Diagnosing Diastolic Dysfunction  
Diagnostic methods relating to a cardiac ventricular dysfunction are provided. In some embodiments, the diagnostic method is a method of diagnosing diastolic dysfunction in the absence of systolic...
US20140045758 Methods for Treating and Preventing Cardiac Dysfunction in Septic Shock  
Cardiac dysfunction during sepsis is due, at least in part, to cardiac energy deficiency. It has been discovered that lipopolysaccharide (LPS)-mediated cardiac dysfunction is prevented or treated...
US20110091527 COMPOSITIONS AND METHODS FOR REDUCING SCAR FORMATION IN WOUND HEALING  
The invention pertains to a method of reducing scar formation during wound healing by administering a phosphatidylserine-binding compound, in particular an annexin, to a subject in need thereof....
US20110059885 TREATMENT OF DISEASES AND CONDITIONS MEDIATED BY EICOSANOIDS  
The method of the invention relates to an OmCI polypeptide or a polynucleotide encoding an OmCI polypeptide for the treatment of a disease or condition mediated by a leukotriene or hydroxyeicosanoid.
US20130150303 GLYCOSAMINOGLYCAN-ANTAGONISING MCP-1 MUTANTS AND METHODS OF USING SAME  
Novel mutants of human monocyte chemoattractant protein 1 (MCP-1) with increased glycosaminoglycan (GAG) binding affinity and knocked-out or reduced GPCR activity compared to wild type MCP-1, and...
US20140107019 ENGINEERED POLYPEPTIDES HAVING ENHANCED DURATION OF ACTION  
Compounds are provided having inter alia good duration of action, high potency and/or convenient dosing regimens including oral administration. The compounds are engineered polypeptides which...
US20110293524 METHODS AND COMPOSITIONS FOR THE REGULATION OF LECTIN COMPLEMENT PATHWAY (LCP)-ASSOCIATED COMPLEMENT ACTIVATION IN HYPERGLYCEMIC MYOCARDIAL DAMAGE  
The present invention relates to methods and compositions for regulating lectin complement pathway (LCP)-associated complement activation. In particular, the invention relates to methods and...
US20110059089 Protein Markers for Cardiovascular Events  
The present invention relates to a method for predicting the risk of a subject developing a cardiovascular event comprising detecting at least one biomarker in (a sample of) the cardiovascular...
US20110123521 METHODS FOR MODULATING EXPRESSION OF RBP4  
Methods are provided for modulating RBP4 by administering a RBP4-specific modulator. Also provided are methods for treating cardiovascular and metabolic disorders in a subject or delaying or...
US20150056161 REGENERATION OF ENDOGENOUS MYOCARDIAL TISSUE  
This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a...
US20120329718 COMPOSITIONS AND METHODS FOR TREATING ATRIAL FIBRILLATION  
The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor...
US20130324462 Method of Reducing The Effects of Chemotherapy Using Flagellin Related Polypeptides  
The use of flagellin and flagellin related polypeptides for reducing cancer treatment side effects in mammals is described.
US20110243923 ORGANIC COMPOUNDS  
The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7, 25-dihydroxycholesterol) (“7,25DHC”) and/or...
US20110071086 COMPOSITIONS FOR TISSUE REPAIR/REGENERATION  
The invention provides compositions and methods for cardiac repair and/or regeneration of tissues such as myocardium.
US20110218143 COMPOSITIONS AND METHODS FOR TISSUE REPAIR  
The invention generally provides compositions and methods for the repair or regeneration of a tissue or organ in need thereof.
US20110105399 PREVENTION AND TREATMENT OF INFLAMMATION AND ORGAN INJURY AFTER ISCHEMIA/REPERFUSION USING MFG-E8  
Provided are methods for preventing and treating inflammation and organ injury after ischemia/reperfusion, and methods for treating lung injury, comprising administering a milk fat globule...