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US20140205648 |
METHODS FOR THE IN SITU TREATMENT OF BONE CANCER
The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning... |
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US20110142904 |
Methods for the In Situ Treatment of Bone Cancer
The present invention relates to methods for in situ treatment of malignant cells from a cancer associated with bone. In one method, the treatment is for a primary cancer and entails positioning... |
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US20110166107 |
METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF
Methods of and kits for determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) involve associating particular proteins and... |
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US20110098252 |
Treatment of Spinal Mechanical Pain
The invention is directed to a method of treating chronic spinal mechanical pain by intravenous administration to a subject in need of chronic spinal mechanical pain relief of an effective amount... |
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US20110286937 |
SYNTHETIC GLYCOLIPID-CONTAINING LIPOSOME
The present invention provides a glycolipid-containing liposome. In such a glycolipid-containing liposome, the glycolipid includes a plant ceramide portion and a sugar chain portion. The present... |
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US20150182552 |
COMPOSITION AND METHOD TO ALLEVIATE JOINT PAIN USING PHOSPHOLIPIDS AND ASTAXANTHIN
A dietary supplement composition and associated method of use has the composition formulated in a therapeutic amount to treat and alleviate symptoms of joint pain in a person having joint pain.... |
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US20120076770 |
Modulation of autophagy and and serotonin for treatment of multiple myeloma related diseases
THE INVENTION RELATES TO compounds, proteins and methods of treatment therewith. Aspects of embodiments of the invention further relates to compounds and methods of treatment for bone, bone... |
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US20120322767 |
FORMULATIONS OF BISPHOSPHONATES AND VITAMIN D SUIUTABLE FOR INTERMITTENT INTRAMUSCULAR AND SUBCUTANEOUS ADMINISTRATION
Compositions for pharmaceutical use are described, comprising bisphosphonates and vitamin D in high concentration, destined to the intramuscular and subcutaneous intermittent administration for... |
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US20150005261 |
METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS
The invention provides methods for treating fibrosis, as well as methods for modulating mitochondrial peroxide production in a cell, and methods for modulating the import of Rac1 into the... |
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US20110224128 |
METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY
The invention features methods, compositions, and kits useful for the treatment of muscular dystrophy, e.g., Duchenne muscular dystrophy, in a patient. |
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US20120035138 |
Bisphosphonate Formulation
A bisphosphonate is formulated with an agent to reduce surface tension and/or reduce foaming in the stomach, leading to reduced reflux and oesophageal irritation in use and increased patient... |
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US20120093914 |
IMPLANTABLE LIPOSOME EMBEDDED MATRIX COMPOSITION, USES THEREOF, AND POLYCAPROLACTONE PARTICLES AS SCAFFOLDS FOR TISSUE REGENERATION
In various embodiments, the present invention describes materials and methods for the local reprogramming of cells in a location where the treatment is applied. The invention can be used to... |
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US20140274953 |
EX VIVO HUMAN MULTIPLE MYELOMA CANCER NICHE AND ITS USE AS A MODEL FOR PERSONALIZED TREATMENT OF MULTIPLE MYELOMA
The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue... |
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US20100317622 |
Producing Method of Phospholipids Including Long-Chain Polyunsaturated Fatty Acids as Constituents, and Use of Such Phospholipids
The present invention provides a method of efficiently and stably producing LCPUFA-PL. Specifically, the invention provides a method for producing phospholipids that contain LCPUFA as a... |
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US20130315981 |
METHOD FOR INDUCING FAT LOSS IN MAMMALS
The present invention is a method of increasing lipolysis in an adipose tissue of a mammal comprising delivering to macrophages at the adipose tissue of the mammal an effective amount of an agent... |
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US20120028926 |
Phosphate Management with Small Molecules
This invention relates to methods and small molecules having a phosphate group that can be used to inhibit phosphate transport and to treat or prevent diseases that are related to disorders in the... |
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US20150030541 |
NANOPARTICLE PEG MODIFICATION WITH H-PHOSPHONATES
The present invention provides phosphonate conjugates and methods of preparing the phosphonate conjugates so as to allow, for example, improved methods and compounds for modifying the surface of a... |
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US20140080775 |
MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant... |
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US20110251144 |
MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant... |
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US20120064088 |
METHODS OF TREATING ANEURYSM
The present invention is directed to a method for treating aneurysms in vascular tissue. The method includes administering a bisphosphonate compound to a subject in an amount which is effective... |
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US20110236365 |
METHOD FOR PROTECTING AND TREATING AT LEAST ONE MUSCARINIC RECEPTOR FROM DYSFUNCTION RESULTING FROM FREE RADICAL DAMAGE
Methods and compositions for enhancing cellular function through protection of a tissue components such receptors, proteins, lipids, nucleic acids, carbohydrates, hormones, vitamins, and... |
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US20130244962 |
CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the... |
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US20110178044 |
TRANSDERMAL ADMINISTRATION OF HYDROPHILIC DRUGS USING PERMEATION ENHANCER COMPOSITION
Methods, formulations, and drug delivery systems are provided for enhancing the flux of a transdermally administered hydrophilic drug using a basic permeation enhancer composition. The enhancer... |
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US20140296166 |
BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING AND\OR REDUCING CARDIAC DYSFUNCTION
The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a... |
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US20150231269 |
DELIVERY OF THERAPEUTIC COMPOUNDS WITH IRON OXIDE NANOPARTICLES
The present invention relates to the field of drug delivery, in particular the delivery of unmodified cargo molecules (such as doxorubicin and Taxol®) using iron oxide nanoparticles as therapeutic... |
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US20110237552 |
Composite Material Consisting of a Collagen Matrix Mineralised with Silicate and Calcium Phosphate Phases, Method for the Production and Use Thereof
The invention relates to novel composite materials based on a collagen matrix mineralised with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an... |
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US20140271825 |
PHARMACEUTICAL FORMULATIONS OF CHELATING AGENTS AS A METAL REMOVAL TREATMENT SYSTEM
The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating... |
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US20140039454 |
METHODS OF TREATING SUBCHONDRAL BONE TO PREVENT THE PROGRESSION OF OSTEOARTHRITIS IN JOINTS
Methods of therapeutically treating osteoarthritis in a joint are disclosed. These methods aim to prevent the progression of osteoarthritis of a joint by treating the subchondral bone to heal, or... |
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US20140072571 |
OSTEOPOROSIS ASSOCIATED MARKERS AND METHODS OF USE
Disclosed are methods of identifying subjects with osteoporosis or osteopenia, subjects at risk for developing osteoporosis, osteopenia, and bone fractures, methods of evaluating the effectiveness... |
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US20130116215 |
COMBINATION THERAPIES FOR TREATING NEUROLOGICAL DISORDERS
The invention features novel pharmaceutical combinations useful for the treatment of neurological diseases, specifically neurodegenerative diseases. The novel pharmaceutical combinations of the... |
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US20110262528 |
PHARMACEUTICAL COMPOSITION FOR THE PREVENTION AND TREATMENT OF BONE TISSUE RESORPTION OF VARIOUS ETIOLOGY
The invention relates to medicine and pharmacology, and represents a pharmaceutical composition for the treatment of bone resorption of various etiology comprising, as the biologically active... |
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US20130035314 |
METHODS AND KITS FOR DETECTING RISK FACTORS FOR DEVELOPMENT OF JAW OSTEONECROSIS AND METHODS OF TREATMENT THEREOF
Methods of and kits for determining the pharmacogenetic, pharmacokinetic and cellular basis of bisphosphonate-induced osteonecrosis of the jaw (BONJ) involve associating particular proteins and... |
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US20150139909 |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OSTEOARTHRITIS
The present invention relates to the field of osteoarthritis. More specifically, the present invention provides compositions and methods useful for treating or preventing osteoarthritis. In one... |
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US20140045794 |
Phosphonate Compounds
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis... |
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US20130045950 |
Phosphonate Compounds
The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis... |
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US20150141339 |
TREATMENT OF OSTEOPOROSIS
According to the invention there is provided a compound of formula (I): wherein R1, R2, R3 and n have meanings given in the description, or a pharmaceutically acceptable solvate, salt or prodrug... |
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US20120288485 |
USE OF JASMONE FOR MODULATING MELATONIN PRODUCTION AND CALCIFICATION OF THE PINEAL GLAND
A formulation, composition or combination of substances comprising jasmonate for modulating melatonin production and/or calcification of a pineal gland and/or modulation and/or treatment of... |
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US20140234210 |
METAL BISPHOSPHONATE NANOPARTICLES FOR ANTI-CANCER THERAPY AND IMAGING AND FOR TREATING BONE DISORDERS
Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate... |
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US20100305056 |
CYSTEINE PROTEASE INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASE
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions. Inhibition or decreasing function of these proteases can be useful in the... |
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US20130090371 |
METHODS AND COMPOSITIONS FOR INHIBITION OF BETA2-ADRENERGIC RECEPTOR DEGRADATION
The present invention generally relates to compositions and kits comprising a β2-AR agonist and a modulator of a β2-AR regulator gene, where the modulator of the β2-AR regulator gene inhibits the... |
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US20130096091 |
COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS, AND MANUFACTURING METHOD THEREFOR
The present invention relates to a composition for preventing or treating osteoporosis which comprises an ibandronic acid, or a pharmaceutically acceptable salt thereof, or a hydrate thereof, and... |
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US20110052703 |
BETA-CASEIN ASSEMBLIES FOR MUCOSAL DELIVERY OF THERAPEUTIC BIOACTIVE AGENTS
Nanoparticulate assemblies of isolated beta-casein, are useful for encapsulation of bioactive therapeutic substances, particularly therapeutic agents with poor bioavailability. These nano-sized... |
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US20110014265 |
Implant Improving Local Bone Formation
A bone implant comprises an active agent on at least a portion thereof. The active agent is locally deliverable to bone proximate the implant in at least a two-phased release scheme. A first phase... |
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US20080293677 |
Use of Alternating Amine and Non-Amine Bisphosphonate Combinations For Treating Osteoporosis
A method of treating osteoporosis in a human in need thereof by administering alternating amine and non-amine bisphosphonates in a defined dosing schedule. The invention demonstrates an effective... |
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US20110311602 |
TRANSDERMAL VENOUS ACCESS LOCKING SOLUTIONS
Microbial growth inhibiting solutions and methods of employing the microbial growth inhibiting solutions in flushing and coating medical devices are disclosed. In alternative embodiments, the... |
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US20140220128 |
Solid Dosage Form
A solid dosage form comprises coated particles of bisphosphonate or a pharmaceutically acceptable analogue or derivative thereof. |
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US20080167271 |
PHARMACEUTICAL COMPOSITIONS COMPRISING A BISPHOSPHONATE COMPOUND
The present invention relates to pharmaceutical compositions comprising a bisphosphonate compound. |
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US20130195856 |
METHODS OF ALTERING BONE GROWTH BY ADMINISTRATION OF SOST OR WISE ANTAGONIST OR AGONIST
The present invention provides a method of promoting local bone growth by administering a therapeutic amount of a Sost antagonist to a mammalian patient in need thereof. Preferably, the Sost... |
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US20100222875 |
METHOD FOR FORMING A POROUS STENT COATING
Methods for forming porous stent coatings are disclosed. |
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US20110112053 |
PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS
Disclosed herein are compositions and methods for decreasing vascular permeability in a blood vessel and treating or preventing conditions associated with defects or injuries of vascular... |