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US20130005590 SYNTHETIC BIOLOGY TOOLS  
Methods for design of genetic circuits are provided.
US20150080237 PIPELINE FOR RATIONAL DESIGN AND INTERPRETATION OF BIOMARKER PANELS  
A new pipeline for the rational design and interpretation of biomarker panels is provided. The pipeline includes: generating the maximally informative marker set from biomarker databases;...
US20130303387 METHODS AND APPARATUS FOR PREDICTING PROTEIN STRUCTURE  
The present invention relates to a method for predicting three-dimensional structure of a protein from its sequence. Three-dimensional structure may be determined by: (a) generating a multiple...
US20150079066 MEANS AND METHODS FOR GENERATING IMPROVED PROTEINS  
The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to...
US20110150775 GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS  
The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods...
US20100304983 METHOD FOR PROTEIN STRUCTURE DETERMINATION, GENE IDENTIFICATION, MUTATIONAL ANALYSIS, AND PROTEIN DESIGN  
An efficient computational method and system for predicting the folding regions and associated secondary and tertiary structures of a protein is disclosed. Methods and systems for sorting amino...
US20150252409 SYSTEMS GENETICS NETWORK REGULATORS AS DRUG TARGETS  
The present invention provides for methods, processes and platforms to validate systems genetics networks to define their genetic regulators and to optimize translational applicability to humans...
US20140121121 SYSTEM AND METHOD FOR DETERMINING INDIVIDUALIZED MEDICAL INTERVENTION FOR A DISEASE STATE  
A system and method for determining individualized medical intervention for a particular disease state, and especially for cancers, that includes the molecular profiling of a biological sample...
US20110301048 DIAGNOSIS AND PROGNOSIS OF BREAST CANCER PATIENTS  
The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to...
US20120295796 System and Method of Predicting Chemical Interaction and Functionality of Molecules  
A system and method of identifying a target molecule that bind to the bioactive site of a protein or protein complex is described. The system and method includes the steps of calculating the...
US20110160071 Novel Proteins and Methods for Designing the Same  
Aspects of the invention relate to variant proteins and methods for designing and using the same. In some embodiments, the invention relates to methods for determining a functional variant of a...
US20110098238 ELUCIDATING LIGAND-BINDING INFORMATION BASED ON PROTEIN TEMPLATES  
A method, computer-readable medium, and system for identifying compounds from chemical libraries that can be used for the therapeutic treatment of a disease or used as lead compounds in a drug...
US20120322671 METHODS AND SYSTEMS FOR PRE-CONCEPTUAL PREDICTION OF PROGENY ATTRIBUTES  
Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
US20110124515 Methods and Systems for Pre-Conceptual Prediction of Progeny Attributes  
Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
US20150051090 METHODS FOR IN SILICO SCREENING  
In one aspect, the invention relates to a method for identifying a small molecule which binds an evolved three dimensional topological feature on a target protein. In certain embodiments, the...
US20150154345 REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER  
Methods of “reprogramming” epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset...
US20130116125 NOVEL METHODS OF PROTEIN EVOLUTION  
The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from,...
US20140221222 MOLECULAR PROFILING OF TUMORS  
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as...
US20140221221 MOLECULAR PROFILING OF TUMORS  
Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as...
US20110245092 DIAGNOSING AND MONITORING DEPRESSION DISORDERS BASED ON MULTIPLE SERUM BIOMARKER PANELS  
Materials and Methods related to developing a unipolar depression (MDD) disease score in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to...
US20110136675 IDENTIFICATION AND CHARACTERIZATION OF PROTEINS USING NEW DATABASE SEARCH MODES  
A method of selecting a set of candidate polypeptides for a sample polypeptide that includes a first refining of a collection of candidate polypeptides from differences in mass of fragments of the...
US20140303011 HIGH RESOLUTION CHARACTERIZATION OF BIOLOGICAL MATRICES  
The invention provides for a method for distinguishing spore preparation procedures using spore molecular signatures, the method comprising harvesting spores from a sample; extracting molecules...
US20140296085 METHOD OF PREDICTING BREAST CANCER PROGNOSIS  
The present invention relates to biomarkers associated with breast cancer prognosis. These biomarkers include coding transcripts and their expression products, as well as non-coding transcripts,...
US20120220469 TOXICITY TYPING USING LIVER STEM CELLS  
This invention provides methods and systems for identifying and typing toxicity of chemical compositions, as well as for screening new compositions for toxicity. The invention involves detecting...
US20140162887 METHODS OF USING GENE EXPRESSION SIGNATURES TO SELECT A METHOD OF TREATMENT, PREDICT PROGNOSIS, SURVIVAL, AND/OR PREDICT RESPONSE TO TREATMENT  
Methods and compositions for determining and/or predicting a response to a therapy, prognosis of a cancer subject or survival of a cancer and kits for performing the same are described herein.
US20140171332 SYSTEM FOR THE EFFICIENT DISCOVERY OF NEW THERAPEUTIC DRUGS  
The invention provides for carrying out 3-dimensional similarity searching by comparing a probe molecule to each member of a 3-dimensional database. The probe molecule is overlapped with each...
US20140274751 CHEMICAL IDENTIFICATION USING A CHROMATOGRAPHY RETENTION INDEX  
Provided herein is technology relating to identifying unknown compounds and particularly, but not exclusively, to methods and systems for identifying unknown compounds by gas chromatography-mass...
US20110160070 COPD BIOMARKER SIGNATURES  
The present invention relates to methods of detecting differentially expressed protein expression indicative of COPD in a test sample. The detection of circulating levels of proteins within an...
US20110039714 Probes, Systems, and Methods for Drug Discovery  
Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes...
US20140351962 GENETIC TEST FOR LIVER COPPER ACCUMULATION IN DOGS  
The present invention provides a method of testing a dog to determine the susceptibility of the dog to liver copper accumulation, comprising detecting in a sample the presence or absence in the...
US20110124657 METHOD FOR SCREENING OF 5HT7 RECEPTOR LIGANDS BASED ON A NEW PHARMACOPHORE MODEL AND A DESCRIPTOR'S PROFILE FILTER  
The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor; to a method for identifying them as 5-HT7 ligands, especially as agonists, by using a...
US20130252831 METHOD OF DIAGNOSING EARLY STAGE NON-SMALL CELL LUNG CANCER  
A “malignancy-risk” (MR) gene signature score was developed with abundant proliferative genes using principal component analysis. This MR gene signature was shown to be a predictive and prognostic...
US20120040847 Personal Diabetic Carbohydrate Counting Procedure System and Method  
A program interface for diabetic users to streamline the process of carbohydrate counting of meals. The present invention helps diabetic patients keep track of their blood glucose levels and help...
US20120046344 TREATMENT OF LIPID TRANSPORT AND METABOLISM GENE RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO A LIPID TRANSPORT AND METABOLISM GENE  
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Lipid transport and metabolism gene, in particular, by targeting natural antisense...
US20150023949 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDER  
Methods for treatment and diagnosis of pervasive developmental disorders in humans are described.
US20140364434 Biomarkers for Prediction of Response to PARP Inhibition in Breast Cancer  
Methods and systems for identifying a cancer patient suitable for treatment with a PARP inhibitor. A 6-gene, 7-gene and 8-gene predictor panels of genes that are predictive of patient resistance...
US20150259741 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF MULTIPLE SCLEROSIS  
Disclosed herein are methods and compositions for diagnosing multiple sclerosis (“MS”) in a subject or the risk of MS in a subject. More particularly, methods and compositions for the use of...
US20120108791 Rotamer Libraries and Methods of Use Thereof  
Rotamer libraries and methods of use thereof are provided.
US20150247133 METHODS AND TOOLS FOR IDENTIFICATION OF RSK/MSK KINASE INHIBITORS  
The present invention concerns 3D-crystals of complexes of ribosomal S6 kinase (RSK) and mitogen- and stress-activated protein kinase (MSK) proteins and their ligands, as well as methods for...
US20150254397 Method of Validating mRNA Splciing Mutations in Complete Transcriptomes  
A method is described for the automatic validation of DNA sequencing variants that alter mRNA splicing from nucleic acids isolated from a patient or tissue sample. Evidence the a predicted...
US20110269633 INFLAMMATORY BIOMARKERS FOR MONITORING DEPRESSIVE DISORDERS  
Materials and Methods related to developing a unipolar depression (MDD) disease score in a subject using a multi-parameter system to measure a plurality of parameters, and an algorithm to...
US20140274750 SEQUENCE ASSEMBLY USING OPTICAL MAPS  
The invention generally relates to sequence assembly and particularly to ordering the alignment of contigs to reference maps. The invention provides systems and methods for assembling contigs by...
US20130324426 Method to improve protein production  
Method to create in silico protein mutants with improved expression level in an expression host compared to an original protein. The mutants retain unaltered or minimally altered function and...
US20140179807 MODULE-LEVEL ANALYSIS OF PERIPHERAL BLOOD LEUKOCYTE TRANSCRIPTIONAL PROFILES  
The present invention includes an apparatus, system and method for the development and use of transcriptional modules by obtaining individual gene expression levels from cells obtained from one or...
US20150057166 METHOD FOR ANALYZING THE THREE DIMENSIONAL STRUCTURE OF A GPCR  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled...
US20150252366 IDENTIFICATION AND USE OF TARGET GENES FOR CONTROL OF PLANT PARASITIC NEMATODES  
The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological functions, and their use. The invention...
US20150065362 DYNAMIC METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER  
Disclosed herein are computer-based systems, media and methods of generating dynamic classifiers and uses thereof. The dynamic classifiers may be generated from a subset of cases and/or a subset...
US20120004289 ANNEXIN A11 AND ASSOCIATED GENES AS BIOMARKERS FOR CANCER  
The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at...
US20150089684 Transgenic plants with enhanced agronomic traits  
This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention...
US20140303228 Biomarkers for Amyotrophic Lateral Sclerosis and Methods Using the Same  
The disclosure provides biomarkers of amyotrophic lateral sclerosis (ALS). The disclosure also provides various methods of using the biomarkers, including methods for diagnosis of ALS, methods of...