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US20150259734 LARGE-SCALE BIOMOLECULAR ANALYSIS WITH SSEQUENCE TAGS  
The invention is directed to sequence-based profiling of populations of nucleic acids by multiplex amplification and attachment of one or more sequence tags to target nucleic acids anchor copies...
US20150045237 METHOD FOR IDENTIFICATION OF THE SEQUENCE OF POLY(A)+RNA THAT PHYSICALLY INTERACTS WITH PROTEIN  
The invention relates to an in vitro method for identifying the sequence of one or more poly(A)+RNA molecules that physically interacts with protein. The present invention provides a method to...
US20120264620 METHODS FOR DIAGNOSIS AND TREATMENT OF ENDOMETRIAL CANCER  
The present invention discloses methods of using endothelial membrane protein 2 (EMP2) as a biomarker for stratification of endometrial premalignancy, diagnosing, staging and imaging of...
US20140303009 Compositions, Methods, and Kits for Identifying Candidate Molecules from Encoded Chemical Libraries  
The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence compositions, a method for identifying a...
US20130210645 PERSONALIZED TUMOR BIOMARKERS  
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE),...
US20110082046 METHOD AND DEVICE FOR THE MANIPULATION OF MICROCARRIERS FOR AN IDENTIFICATION PURPOSE  
The present invention relates to a method for the manipulation for an identification purpose of a microcarrier comprising the steps of: (a) an identification purpose step of the microcarrier; and...
US20150133319 COMPOSITIONS AND KITS FOR MOLECULAR COUNTING  
Methods, kits and systems are disclosed for analyzing one or more molecules in a sample. Analyzing the one or more molecules may comprise quantitation of the one or more molecules. Individual...
US20150184238 DNA SEQUENCING  
Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to methods, compositions, systems, and kits for sequencing a nucleic acid using a...
US20120245041 BASE-BY-BASE MUTATION SCREENING  
Aspects of the present invention are drawn to screening assays for isolating polynucleotides having a sequence variation or mutation. Embodiments of the screening assays include generating a...
US20130123118 Metal Nanoparticle Structures For Enhancing Fluorescence-Based Arrays  
Provided, among other things, is a multiplex assay comprising: conducting a fluorescence-developing assay on microtabs having at least one surface that shows plasmonic enhancement, wherein a...
US20130059741 BINDING ASSAYS FOR MARKERS  
This invention provides compositions and methods for assaying the presence of a target analyte in a sample using a solid support. Embodiments of the present invention provide a solid support...
US20120071329 METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES  
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
US20150167092 FRET-BASED ANALYTES DETECTION AND RELATED METHODS AND SYSTEMS  
FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at...
US20150038346 MONITORING IMMUNE RESPONSIVENESS TO CANCER VACCINATION  
The invention is direct to a method for determining a cancer patient's immune responsiveness to anti-cancer vaccination. In one aspect, for each of a plurality of vaccinations, pairs of clonotype...
US20150240302 Methods and Compositions for Tagging and Identifying Polynucleotides  
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the...
US20130065770 Methods and Compositions for Tagging and Identifying Polynucleotides  
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the...
US20120238456 RATIONAL LIBRARY  
The invention relates to a method to generate rational libraries comprising genetic elements which are involved in transcriptional and/or translational regulation of a gene and devised to increase...
US20140128271 ASSAY METHOD USING ENCODED PARTICLE-BASED PLATFORM  
Provided is an assay method using an encoded particle-based platform. In the assay method, first, a plurality of encoded particles having codes distinguishable from one another according to kinds...
US20120277107 Methods and Compositions for Tagging and Identifying Polynucleotides  
The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the...
US20140100120 METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF  
Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any...
US20140141982 Methods for sorting nucleic acids and multiplexed preparative in vitro cloning  
Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid molecules having the desired predetermined...
US20130281308 Methods for sorting nucleic acids and preparative in vitro cloning  
Methods and compositions relate to the sorting and cloning of high fidelity nucleic acids using high throughput sequencing. Specifically, nucleic acid molecules having the desired predetermined...
US20120329660 METHODS AND COMPOSITIONS FOR SORTING AND/OR DETERMINING ORGANISMS  
This invention is directed to methods and compositions for sorting and/or determining microscopic organisms or cells. The methods and compositions are directed to the use of molecular probes to...
US20150126379 LONG INSERT-BASED WHOLE GENOME SEQUENCING  
The present invention is directed to a method of detecting a genomic rearrangement in a nucleic acid sample with Long Insert Whole Genome Sequencing (LI-WGS). The method may include obtaining a...
US20110118125 NEONATAL SALIVARY GENOMICS  
The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or...
US20150259736 LINKING SEQUENCE READS USING PAIRED CODE TAGS  
Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target...
US20150126380 METHOD FOR ANALYZING MATERNAL DNA IN LARGE PLANT POPULATIONS  
The present invention relates to a non-destructive method for analyzing maternal DNA of a seed. In this method the DNA may be dislodged from the seed coat surface and may be used to collect...
US20140323321 DETECTION OF HEAD AND NECK CANCER USING HYPERMETHYLATED GENE DETECTION  
Methods and kits for detection of a cell proliferative disorder, such as head and neck cancer are provided utilizing analysis of the methylation state of targeted genes or regulatory regions of...
US20150031559 Increased Confidence of Allele Calls with Molecular Counting  
Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original...
US20120071331 INCREASING CONFIDENCE OF ALLELE CALLS WITH MOLECULAR COUNTING  
Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original...
US20150133318 ENZYMATIC METHOD TO ENRICH FOR CAPPED RNA, KITS FOR PERFORMING SAME, AND COMPOSITIONS DERIVED THEREFROM  
The instant invention is based, at least in part, on the identification of novel methods for the enzymatic enrichment of capped RNAs. The invention provides, e.g., methods for enrichment of capped...
US20130116130 Digital Counting of Individual Molecules by Stochastic Attachment of Diverse Label-Tags  
Compositions, methods and kits are disclosed for high-sensitivity counting of individual molecules by stochastic labeling of a identical molecules in mixtures of molecules by attachment of a...
US20150152474 BIOMARKER COMPOSITIONS AND METHODS  
Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate...
US20140121118 METHODS, SYSTEMS AND COMPOSITIONS REGARDING MULTIPLEX CONSTRUCTION PROTEIN AMINO-ACID SUBSTITUTIONS AND IDENTIFICATION OF SEQUENCE-ACTIVITY RELATIONSHIPS, TO PROVIDE GENE REPLACEMENT SUCH AS WITH TAGGED MUTANT GENES, SUCH AS VIA EFFICIENT HOMOLOGOUS RECOMBINATION  
A method is provided to construct libraries of nucleic acids that comprise a plurality of mutations, each of which may be identified with particularity, such as following a selection or screening.
US20150141270 SINGLE-STRANDED NUCLEIC ACID APTAMERS SPECIFICALLY BINDING TO KLEBSIELLA PNEUMONIAE AND METHOD FOR DETECTING K. PNEUMONIA USING THE SAME  
Provided is a single-stranded nucleic acid aptamer specifically binding to Klebsiella pneumoniae, and a method for detecting Klebsiella pneumoniae by using the same. The aptamer of the present...
US20130338014 Calibration Standards For Digital Histocytometry  
An analytical reference for digital histochemistry is constituted of an on-slide standard used to calibrate biomarker expression in biopsy material and tissue sections. The standard consists of...
US20150225789 HAPLOTYING OF HLA LOCI WITH ULTRA-DEEP SHOTGUN SEQUENCING  
Methods are provided to determine the entire genomic region of a particular HLA locus including both intron and exons. The resultant consensus sequences provides linkage information between...
US20130190192 Methods And Systems For Long Distance Tagging, Tracking, And Locating Using Wavelength Upconversion  
Methods and systems for plasmonically enhanced bionanoantennas for tagging, tracking, and locating targets of interest at long distances in both day and nighttime conditions. The nanoantennas are...
US20150087535 MEASUREMENT OF NUCLEIC ACID VARIANTS USING HIGHLY-MULTIPLEXED ERROR-SUPPRESSED DEEP SEQUENCING  
Methods and compositions are disclosed for measuring low-abundance DNA variants from a complex mixture of DNA molecules. Embodiments of the methods allow for extremely sensitive detection and can...
US20120178635 COMPOSITIONS AND METHODS FOR IDENTIFYING AND DETECTING SITES OF TRANSLOCATION AND DNA FUSION JUNCTIONS  
The present invention provides a powerful technique based on ultra high-throughput sequencing that finds structural aberrations of chromosomes and defines breakpoints. It is disclosed herein that,...
US20130274117 High-Throughput Single Cell Barcoding  
Methods and compositions for high-throughput, single cell analyses are provided. The methods and compositions can be used for analysis of genomes and transcriptomes, as well as antibody discovery,...
US20150099648 SOYBEAN TRANSFORMATION METHOD  
The present disclosure relates in part to a method for identifying a soybean germline transformant from a population of soybean transformants by incorporating a selection agent within rooting...
US20150065359 Culture Based Screening Assay and Methods of Use Thereof to Identify Agents Which Modulate Tumor Development, Invasion and Differentiation  
A 3D organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.
US20140315730 SCALABLE CHARACTERIZATION OF NUCLEIC ACIDS BY PARALLEL SEQUENCING  
A method for detecting the presence or absence of a target polynucleotide in a sample is described.
US20150080234 Cell Patterning  
The present disclosure provides technologies for achieving cell patterning, as well as patterned cell arrays achieved with such technologies. Provided apparatus and methods are useful in a variety...
US20150072875 IDENTIFICATION OF NUCLEIC ACIDS  
This disclosure relates to methods for identifying target nucleic acids in a sample by detecting an amplified sequence corresponding to the target using a detectable probe and by monitoring its...
US20110118148 NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES  
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds...
US20120289414 METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION  
The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction.
US20150087534 METHODS OF NUCLEIC ACID SEQUENCING  
Provided herein is a method of using transposition to improve methods of sequencing RNA molecules. Provided herein is a method of tagging nucleic acid duplexes, such as DNA:RNA duplexes or DNA:DNA...
US20150148241 METHOD FOR GENOME SEQUENCING  
The present invention relates to a high throughput method for the identification and detection of molecular markers wherein restriction fragments are generated and suitable adaptors comprising...