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US20130252843 |
METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS
Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern... |
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US20120122711 |
SCREENING OF BIOPOLYMERS
Described herein are inventive compositions and methods relating to sampling of biopolymers and, in particular, to fractional sampling of biopolymers. In one aspect, embodiments are generally... |
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US20140213483 |
LABELED DEVICE
A microarray is disclosed comprising a reaction zone and a labeling zone, wherein the at least one labeling zone contains a marker, such as an alphanumerical code, a binary code, a barcode, a 2D... |
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US20150141296 |
METHODS FOR PERFORMING PATTERNED CHEMISTRY
Provided are methods for performing patterned chemistry and arrays prepared thereby. |
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US20120245057 |
WHOLE PROTEOME TILING MICROARRAYS
The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100%... |
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US20140342947 |
Compositions and methods for entrapping protein on a surface
The present invention provides a formulation to link protein to a solid support that comprises one or more proteins, Oligo-dT and one or more non-volatile, water-soluble protein solvents, solutes... |
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US20130029858 |
Method of Drug Screening through Quantitative Detection by Atomic Force Microscopy and Effective Protein Chips Development through Method Thereof
A method for drug screening is provided. An atomic force microscopy (AFM) is used to obtain quantitative difference. At least one receptor is immobilized on a probe of the AFM and at least one... |
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US20150065389 |
MULTI-WELL MICROPATTERNING BY ABLATION
The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen... |
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US20140235510 |
MICROFLUIDIC INTERFACE FOR HIGHLY PARALLEL ADDRESSING OF SENSING ARRAYS
Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or... |
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US20120122737 |
METHODS FOR SELECTING AND AMPLIFYING POLYNUCLEOTIDES
The invention provides methods for controlling the density of different molecular species on the surface of a solid support. A first mixture of different molecular species is attached to a solid... |
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US20150005202 |
MACROMOLECULE DELIVERY TO NANOWELLS
Provided herein is technology relating to depositing and/or placing a macromolecule at a desired site for an assay and particularly, but not exclusively, to methods and systems for transporting a... |
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US20120258892 |
Methods, Compositions, and Kits for Making Targeted Nucleic Acid Libraries
The present invention provides a method and a kit for selecting and enriching target sequences specific for a genomic region of interest or a subset of a transcriptome using a target-capturing... |
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US20130324439 |
Elastic Modulus-modified MicroEnvironment microArrays (eMEArrays) and Uses Thereof
A combinatorial elastic modulus-modified microenvironment microarray (eMEArray) platform and methods for cell-based functional screening of interactions with combinatorial microenvironments. The... |
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US20150159204 |
Single Molecule Arrays for Genetic and Chemical Analysis
Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the... |
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US20150087555 |
METHOD FOR IMMOBILIZING BIOLOGIC MOLECULES ON SOLID SURFACES
The invention provides a method for immobilization of biological molecules such as nucleic acids, peptides and proteins onto the surface of a glass or plastic solid support. |
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US20150174547 |
TRANSFECTION SYSTEMS, METHODS AND MEDIA
Systems, methods and media for transfection are provided. In an example embodiment, a method of printing layered arrays of spots onto a substrate includes printing a first array of spots onto the... |
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US20110152123 |
CELLULAR SCREENING SUBSTRATUM AND MANUFACTURING PROCESS FOR IT, AND METHOD AND APPARATUS FOR CELLULAR SCREENING WITH IT
The present invention provides cellular screening substrata which can be formed in simple processing steps. The cellular screening substrata can be formed which are characterized in that plural... |
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US20150024974 |
MULTIANALYTE MOLECULAR ANALYSIS USING APPLICATION-SPECIFIC RANDOM PARTICLE ARRAYS
The present invention provides a method for the generation of novel libraries of encoded magnetic particles from sub-libraries of by the generation of novel sub-libraries of magnetic nanoparticles... |
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US20110118150 |
METHOD FOR MAKING BIOCHIPS
A method for immobilizing biological polymers such as DNA or proteins, on a solid support, by ionocovalent bond, for making biochips, and the resulting chips obtained by the method. Also, a kit... |
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US20150203809 |
CELL CULTURE
The disclosure relates to the fabrication of a three dimensional [3-D] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for... |
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US20110257046 |
Emulsion PCR And Amplicon Capture
Compositions and methods of use are disclosed for clonally amplifying target polynucleotide sequences in solution and attaching the amplicons to a surface by activation of a masked binding moiety. |
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US20080058225 |
Artificial receptors, building blocks, and methods
The present invention relates to artificial receptors and arrays or microarrays of artificial receptors or candidate artificial receptors. Each member of the array includes a plurality of building... |
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US20100304982 |
SCAFFOLDED NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their... |
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US20120040872 |
PREPARING CARBOHYDRATE MICROARRAYS AND CONJUGATED NANOPARTICLES
The present invention is directed to carbohydrate microarray and conjugated nanoparticles methods of making the same. |
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US20140018260 |
ARRAYS AND METHODS FOR GUIDED CELL PATTERNING
Guided cell patterning arrays for single cell patterning are disclosed. The arrays include a plurality of cell adhesion sites that are individually isolated on an inert surface. Each cell adhesion... |
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US20150038373 |
DE NOVO SYNTHESIZED GENE LIBRARIES
De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are... |
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US20120142551 |
Methods for Genotyping Selected Polymorphism
Methods for genotyping polymorphisms using a locus specific primer that is complementary to a region near a selected polymorphism are described. Methods for synthesizing pools of locus specific... |
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US20120172259 |
USING POPULATIONS OF BEADS FOR THE FABRICATION OF ARRAYS ON SURFACES
The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes... |
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US20140296111 |
Protein-Immobilizing Solid Phase, Polynucleotide-Immobilizing Solid Phase, and Nucleic Acid Recovery Method
A protein-immobilizing solid phase is a protein-immobilizing solid phase comprising an mRNA-nucleic acid linker-protein complex, obtained by linking the mRNA and the protein encoded by that mRNA... |
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US20140256561 |
SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface... |
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US20120245049 |
System and Method for Pixelated Fluid Assay
A method of performing a fluid-material assay employing a device including at least one active pixel having a sensor with an assay site functionalized for selected fluid-assay material. The method... |
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US20140274771 |
METHODS FOR MAKING MICROARRAYS AND THEIR USES
The present invention provides microarrays that can be analysed by more than one technique using a non-covalent ligand attachment strategy to solid supports such as indium tin oxide (ITO) covered... |
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US20130267433 |
Carbohydrate Chip for Detection of Pathogen Vibrio Cholerae and Method of Preparing the Same
The present invention related to a saccharide-based cholera toxin detection sensor for detection of Vibrio cholerae and its use. More specifically, the present invention relates to a carbohydrate... |
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US20130096034 |
MICROFABRICATION METHODS FOR THE OPTIMAL PATTERNING OF SUBSTRATES
A method of fabricating a microarray including the steps of: (a) contacting a substrate having wells with a reagent reactive with said substrate to produce a surface modification within said wells... |
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US20140308303 |
METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND
The disclosure relates to the field of candidate drug testing and drug development. A method is provided for providing a compound composed of at least one molecule attached via at least two... |
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US20150141269 |
HYBRIDIZATION-BASED REPLICATION OF NUCLEIC ACID MOLECULES
The present invention provides methods for replication of nucleic acid molecules distributed on a surface or within a layer by transferring them to a target surface covered with oligonucleotides,... |
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US20130190202 |
DEVICES AND PROCESSES FOR ANALYSING INDIVIDUAL CELLS
A device for individually analysing cells of interest, comprising (a) a channel for receiving the contents of a cell of interest, wherein the channel has an input end and an output end, and (b) a... |
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US20130237430 |
PROTEIN OR PEPTIDE PRINTING METHOD, PROTEIN ARRAY OR PEPTIDE ARRAY AND FUNCTIONAL PROTEIN OR FUNCTIONAL PEPTIDE IDENTIFICATION METHOD
The present invention relates to a protein or peptide printing method, comprising (a) a step for preparing nucleic acids and a cell-free protein synthesis system in an engraved plate composed of... |
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US20140235505 |
RNA ARRAY COMPOSITIONS AND METHODS
Described herein are RNA arrays, and compositions and methods for generating RNA arrays, particularly high density RNA arrays. The disclosed methods for generating RNA arrays utilize template DNA... |
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US20140349891 |
Preparation of Templates for Nucleic Acid Sequencing
The invention relates to methods of generating templates for a nucleic acid sequencing reaction which comprise: providing at least one double-stranded nucleic acid molecule, wherein both strands... |
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US20050032084 |
Method of attaching a biopolymer to a solid support
The present invention relates, in general, to a method of attaching a biopolymer to a solid support and, in particular, to a method of attaching a nucleic acid to a glass surface, and to reagents... |
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US20150065356 |
METHODS OF BEAD MANIPULATION AND FORMING BEAD ARRAYS
According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash... |
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US20150099656 |
Multiplex Immuno Screening Assay
The present invention provides kits and assay methods for the early detection of pathogens, precise identification of the etiologic agent, and improved disease surveillance. More specifically, the... |
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US20090081638 |
Immobilisation of Antigenic Carbohydrates to Support Detection of Pathogenic Microorganisms
The invention relates to the field of chemistry and diagnosis, more in particular to diagnosis of current and/or past and/or symptomless infections or of a history of exposure to, a... |
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US20110130307 |
Microanalysis Chip Adhesive Sheet, Microanalysis Chip, And Manufacturing Method Thereof
Disclosed is a microanalysis chip adhesive sheet with an adhesive surface, which can be inexpensively but easily bonded to a substrate at a relatively low temperature, with which fabrication of... |
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US20090163380 |
ANALYTE FOCUSING BIOCHIPS FOR AFFINITY MASS SPECTROMETRY
A novel affinity capture surface, as well as methods of using and making the affinity capture surface and sample presentation devices or biochips comprising the affinity capture surface, are... |
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US20140287945 |
SURFACE OXIDATION FOR SEQUESTERING BIOMOLECULES AND RELATED METHODS
Solid supports comprising polymers covalently bound to a solid substrate are provided. The polymers find utility in any number of applications including immobilizing analyte molecules to solid... |
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US20110046013 |
METHOD TO GENERATE BIOMOLECULAR MICRO- AND NANO-PATTERNS BY PARTICLE PRINTING LITHOGRAPHY
Methods for preparing useful patterns of biomolecules on solid supports employ particle printing lithography techniques whereby suspensions of different bioconjugates are loaded onto portions of a... |
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US20140256594 |
DNA PHOTOLITHOGRAPHY WITH CINNAMATE CROSSLINKERS
The present invention relates generally to cinnamate crosslinkers. Specifically, the present invention relates to gels, biochips, and functionalized surfaces useful as probes, in assays, in gels,... |
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US20080312100 |
Hybridization Method as Well as Hybridization Microarray and Hybridization Kit
A method of simply and reliably hybridizing a sample biopolymer using a glass coverslip and a closed vessel by hybridizing the sample biopolymer and a probe biopolymer with each other in a state... |