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US20130005590 SYNTHETIC BIOLOGY TOOLS  
Methods for design of genetic circuits are provided.
US20110118131 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS  
The present disclosure relates to methods and materials for mutagenesis, including for the generation of novel or improved proteins and libraries or arrays of mutant proteins or nucleic acids...
US20120165226 PHAGE DISPLAY  
The transformation yield of electroporation is increased by using higher DNA concentrations and DNA affinity purification. Fusion proteins of a viral coat protein variant and a heterologous...
US20110124515 Methods and Systems for Pre-Conceptual Prediction of Progeny Attributes  
Methods and systems for assessing the probabilities of the expression of one or more traits in progeny are described.
US20120165228 EVOLVING NEW MOLECULAR FUNCTION  
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for...
US20150133319 COMPOSITIONS AND KITS FOR MOLECULAR COUNTING  
Methods, kits and systems are disclosed for analyzing one or more molecules in a sample. Analyzing the one or more molecules may comprise quantitation of the one or more molecules. Individual...
US20120208706 OPTIMIZATION OF MULTIGENE ANALYSIS OF TUMOR SAMPLES  
A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample;(b) contacting the library with a bait set to provide selected...
US20110166868 METHOD FOR PROVIDING GENOMIC CLONES  
Subscription-based systems and methods where a provider provides one or more customers, identified as subscribers or non-subscribers, with research products and services (e.g., for industries...
US20110045081 MAGNETIC, PARAMAGNETIC AND/OR SUPERPARAMAGNETIC NANOPARTICLES  
The present invention relates to nanoparticles having a mean diameter of <500 nm and comprising, at their surface, a selected material. The nanoparticles are taken up by cells under physiological...
US20110201506 Methods of Primer Extension Using Porous Particle Supports  
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their...
US20110065610 Synthetic Polypeptide Libraries and Methods for Generating Naturally Diversified Polypeptide Variants  
The invention provides compositions and methods for generating libraries of DNA sequences encoding homologous polypeptides, and uses of the libraries to identify naturally diversified polypeptide...
US20140315755 Genome-wide Antisense Oligonucleotide and RNAi  
The present invention relates to the generation and construction of libraries for genome-wide antisense oligonucleotide and siRNA.
US20110039735 PROBE DESIGN FOR OLIGONUCLEOTIDE FLUORESCENCE IN SITU HYBRIDIZATION (FISH)  
A method and a system for selecting a set of FISH probe oligonucleotide sequences from a plurality of overlapping tiled candidate FISH probe oligonucleotide sequences are provided. A composition...
US20110039308 AMYLASES AND GLUCOAMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
In one aspect, the invention is directed to polypeptides having an amylase and/or glucoamylase activity, polynucleotides encoding the polypeptides, and methods for making and using these...
US20140073581 Hybrid Cyclic Libraries and Screens Thereof  
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the...
US20110071046 MATRIX SCREENING METHOD  
The invention concerns a method which can be used to screen two or more repertoires of molecules against one another and/or to create combinatorial repertoires by combining two or more...
US20110015091 ASSAY MODULES HAVING ASSAY REAGENTS AND METHODS OF MAKING AND USING SAME  
We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays....
US20140030761 METHOD OF CLONING NUCLEIC ACID  
The present disclosure provides methods for producing expression constructs comprising linking a plurality of unlinked nucleic acids, including nucleic acid encoding a marker protein.
US20120157324 METHYLATION BIOMARKERS AND METHODS OF USE  
Disclosed are methods and compositions of assessing one or more statuses of a subject. Also disclosed are methods and compositions of identifying status biomarkers associated with a status of a...
US20150018253 Methods and Compositions for Selective Labeling of Different Biotinylated Targets within Multicolor or Multilabel Assays  
Disclosed are compositions and methods for the labeling of two or more targets with different labels. Specifically, disclosed are compositions for biotin and the protection of biotin within...
US20110020292 Use of Stem Cells to Reduce Leukocyte Extravasation  
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using...
US20130274118 COMBINATORIAL PROBE LIBRARIES  
Provided herein is a set of reagents comprising: a plurality of at least three probe libraries, wherein each library of the plurality comprises one or more probe sets that are each specific for a...
US20110312543 Expression Vectors Based on Modified Ribosomal Protein Promoters and Uses Thereof in Post-Transcriptional Assessment  
The present invention relates to expression vector comprising (a) a promoter region comprising a non-inducible constitutively active ribosomal protein gene promoter, (b) an operably linked...
US20110105346 Universal fingerprinting chips and uses thereof  
The present invention discloses a designing strategy for constructing a set of probes useful for analyzing all or most prokaryotic and eukaryotic genomes. A set of capture probes with optimal...
US20120208724 LINKING SEQUENCE READS USING PAIRED CODE TAGS  
Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target...
US20120208705 LINKING SEQUENCE READS USING PAIRED CODE TAGS  
Artificial transposon sequences having code tags and target nucleic acids containing such sequences. Methods for making artificial transposons and for using their properties to analyze target...
US20120115753 Method for Drug Screening For Agents for the Treatment of Hepatitis C Virus Infection  
The present invention describes an improved method of screening of anti HCV agents that may have an efficacy for treatment of hepatitis C virus. The invention includes cryogenic hepatocyte bank,...
US20130172206 GENOME-WIDE DETECTION OF GENOMIC REARRANGEMENTS AND USE OF GENOMIC REARRANGEMENTS TO DIAGNOSE GENETIC DISEASE  
The disclosure relates to the genome-wide identification of “rearrangement hotspots”. The disclosure also relates to a microarray chip system for use in detecting genomic rearrangements and a...
US20130096019 Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses  
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that...
US20100240538 Programmable iterated elongation: a method for manufacturing synthetic genes and combinatorial dna and protein libraries  
A method for manufacturing synthetic genes and combinatorial DNA and protein libraries, termed here Divide and Conquer-DNA synthesis (D&C-DNA synthesis) method. The method can be used in a...
US20110172110 TRACERS AND ASSEMBLY FOR LABELING CHEMICAL OR BIOLOGICAL MOLECULES METHODS AND KITS USING THE SAME  
An improved process to create an arbitrarily large number of distinguishable particles allows more flexibility in experimental design and related efficiencies of scale. Novel enhanced tracers, for...
US20140309136 REAL-TIME MULTIPLEX DETECTION OF THREE BACTERIAL SPECIES RESPONSIBLE FOR SEXUALLY TRANSMITTED DISEASES  
The invention relates to the detection of three different bacterial species which are responsible for sexually-transmitted diseases, i.e., Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG)...
US20130196879 ASSAY SYSTEM  
The invention provides a method of forming a plurality of re-constitutable doses of at least one drug in a plurality of wells, the method including the steps of (i) placing a known amount of said...
US20130281322 PROCESS OF FABRICATING TISSUE ARRAY  
In a process of fabricating a tissue array, a tissue block is sliced to obtain sheet-form pieces of tissue, and each of the sheet-form pieces is closely rolled around a guide member to form a...
US20110098197 Method for Specific Covalent Coupling of Antibody Using a Photoactivable Protein G Variant  
The present invention relates to a protein G variant comprising a mutated Fc binding domain, which is prepared by substituting cysteine for specific residues of the Fc-binding domain of protein G,...
US20120071354 NORMALIZED NUCLEIC ACID LIBRARIES AND METHODS OF PRODUCTION THEREOF  
The present invention relates generally to methods for producing normalized nucleic acid libraries in which each member of the library can be isolated with approximately equivalent probability. In...
US20110077163 Reverse Transfection Of Cell Arrays For Structural And Functional Analyses Of Proteins  
The present invention relates to articles and methods for determining the function of genes, gene products, and nucleic acid products. The present invention also relates to identifying ligands and...
US20150094238 Reagent Bead Inserter  
A system for inserting reagent or macrobeads into bores of a sample plate is disclosed comprising an insertion device arranged to retain one or more reagent or macrobeads by means of a vacuum...
US20140378330 Multi-primer Assay for Mycoplasma Detection  
Disclosed is a multi-primer amplification assay, method and kits for detecting Mycoplasma species and closely related species utilizing a plurality of oligonucleotide primers in contact with a...
US20150211048 Microfluidic Devices, Solid Supports for Reagents and Related Methods  
A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid...
US20130333070 SMALL INTERFERING RNAS WITH TARGET-SPECIFIC SEED SEQUENCES  
Disclosed are methods for design and synthesis of siRNA libraries, siRNA libraries produced thereby, siRNA molecules, and uses thereof.
US20130059759 REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN  
The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other...
US20110257039 REVERSE TRANSCRIPTION PRIMERS AND METHODS OF DESIGN  
The present invention provides novel algorithms for designing oligonucleotides that do not substantially hybridize to a small group of unwanted transcripts, while hybridizing to most other...
US20140221250 Rationally Designed, Synthetic Antibody Libraries and Uses Therefor  
The present invention overcomes the inadequacies inherent in the known methods for generating libraries of antibody-encoding polynucleotides by specifically designing the libraries with directed...
US20110152116 NANOASSAYS  
The present invention provides assays of nanometer-level dimension.
US20110319274 Identification of Compounds Modifying a Cellular Response  
The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of...
US20120101000 HIGH COMPLEXITY MAMMALIAN DISPLAY LIBRARY AND METHODS OF SCREENING  
Provided herein are methods of isolating a polynucleotide encoding a polypeptide such as an antibody with a desired property by way of mammalian display library screening and methods of generating...
US20110274623 Stabilized Fibronectin Domain Compositions, Methods and Uses  
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that...
US20150105298 MULTI-OLIGOMER IN SITU HYBRIDIZATION PROBES  
The disclosure relates to in situ hybridization probes for the detection of target nucleic acid sequences within a sample and methods of making and using the same. The in situ hybridization probes...
US20110118148 NUCLEAR MAGNETIC RESONANCE ASSEMBLY OF CHEMICAL ENTITIES USING ADVANCED ANTENNA PROBES  
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds...

Matches 1 - 50 out of 286 1 2 3 4 5 6 >