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US20140155295 |
CAPSULE ARRAY DEVICES AND METHODS OF USE
This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation... |
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US20130059296 |
Compositions and Methods For High Fidelity Assembly of Nucleic Acids
Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end... |
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US20110224087 |
SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION
The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form... |
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US20170114404 |
TM-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION
The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from... |
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US20160201117 |
ULTRA SENSITIVE METHOD FOR IN SITU DETECTION OF NUCLEIC ACIDS
Disclosed is a method for in situ detection of one or more target nucleic acids based on a combination of RNAscope® method and a general ISH signal amplification method. This new method produces... |
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US20160195516 |
Methods of Detecting Signatures of Disease or Conditions in Bodily Fluids
Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having... |
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US20160194717 |
Methods of Detecting Diseases or Conditions Using Phagocytic Cells
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to... |
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US20160145693 |
METHODS FOR THE DIAGNOSIS OF ONCOLOGICAL DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS
Methods and formulations for diagnosing onocological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described. |
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US20160130656 |
METHODS FOR EVALUATING LUNG CANCER STATUS
The disclosure in some aspects provides methods of determining the likelihood that a subject has lung cancer based on the expression of informative-genes. In other aspects, the disclosure provides... |
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US20160068916 |
TEST KITS
This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention... |
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US20160011189 |
ARRAYS, SUBSTRATES, DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES
Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and... |
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US20150203900 |
Methods of Diagnosing Infectious Disease Pathogens and Their Drug Sensitivity
The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate... |
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US20150159204 |
Single Molecule Arrays for Genetic and Chemical Analysis
Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the... |
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US20150018249 |
DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection... |
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US20140315757 |
DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection... |
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US20140235506 |
POLYNUCLEOTIDE BARCODE GENERATION
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including... |
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US20140105918 |
METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS
The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample.... |
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US20130225447 |
siRNA Targeting Apolipoprotein B (APOB)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20130203814 |
Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same
Compositions and methods for the detection and treatment of ADHD are provided. |
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US20130172197 |
HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION
Nucleic acid sequencing methods and related products are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the... |
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US20130096014 |
MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES
The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a... |
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US20130085079 |
Cardiovascular Risk Event Prediction and Uses Thereof
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (CV) Event within 5 years. In one aspect, the disclosure... |
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US20130059760 |
siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20130023446 |
siRNA Targeting Beta Secretase (BACE)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20130013214 |
METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE
In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual... |
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US20120316082 |
NUCLEIC ACID DETECTION AND QUANTIFICATION BY POST-HYBRIDIZATION LABELING AND UNIVERSAL ENCODING
The present invention provides, among other things, methods and compositions for detecting and quantifying target nucleic acids via post-hybridization labeling. |
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US20120283311 |
siRNA Targeting Glucagon Receptor (GCCR)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20120270751 |
siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20120258888 |
siRNA Targeting Proto-oncogene MET
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20120252873 |
siRNA Targeting Interleukin-1 Receptor-associated Kinase 4 (IRAK4)
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20120238475 |
Methods of Amplifying and Sequencing Nucleic Acids
An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing,... |
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US20120220495 |
ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological... |
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US20120184602 |
METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction... |
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US20120135892 |
siRNA targeting spleen tyrosine kinase
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene... |
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US20120053088 |
MICROFLUIDIC TEST MODULE FOR BIOCHEMICAL PROCESSING AND ANALYSIS
A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical... |
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US20120028842 |
GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH POSITIVE CONTROL CHAMBERS INCORPORATING PROBES THAT HYBRIDIZE FOR ANY AMPLICON
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, and, an array of probes each having a nucleic acid... |
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US20120015850 |
siRNA targeting Superoxide
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20110319297 |
siRNA targeting gremlin
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene... |
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US20110312611 |
TEST MODULE WITH TRANSITION METAL-LIGAND COMPLEX FLUOROPHORE
A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and,... |
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US20110312610 |
TEST MODULE WITH LONG FLUORESCENCE LIFETIME PROBES
A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and,... |
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US20110312609 |
TEST MODULE FOR ORIENTATION-INDEPENDENT OPERATION
A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for... |
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US20110312608 |
TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER AND LOW-VOLUME REAGENT RESERVOIR
A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, a reagent reservoir containing a reagent for addition to the... |
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US20110312606 |
LOC DEVICE WITH DIGITAL MEMORY
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with... |
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US20110312605 |
LOC DEVICE WITH INTEGRAL CONTROLLER
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with... |
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US20110312604 |
LOC HAVING ON-CHIP ELECTRONICS FOR USE IN A TEST MODULE TO CONTROL MODULE COMMUNICATIONS
A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a... |
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US20110312603 |
TEST MODULE WITH LOC HAVING ON-CHIP ELECTRONICS FOR MODULE CONTROL
A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a supporting substrate, and,... |
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US20110312601 |
LOC DEVICE WITH DIGITAL MEMORY FOR SECURE STORAGE OF DATA
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for... |
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US20110312596 |
MICROFLUIDIC DEVICE WITH SURFACE TENSION VALVE AT REAGENT RESERVOIR OUTLET
A microfluidic device for processing a fluid sample, the microfluidic device having a reservoir for containing a reagent, and, a surface tension valve having an aperture configured to pin a... |
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US20110312595 |
MICROFLUIDIC DEVICE WITH MIXING SECTION
A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid... |
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US20110312593 |
MICROFLUIDIC DEVICE WITH INCUBATOR HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX
A microfluidic device having an inlet for receiving a fluid, an incubation section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a... |