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US20140155295 CAPSULE ARRAY DEVICES AND METHODS OF USE  
This disclosure provides microwell capsule array devices. The microwell capsule array devices are generally capable of performing one or more sample preparation operations. Such sample preparation...
US20130059296 Compositions and Methods For High Fidelity Assembly of Nucleic Acids  
Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end...
US20110224087 SIMULTANEOUS DETERMINATION OF ANEUPLOIDY AND FETAL FRACTION  
The invention provides compositions and methods for simultaneously determining the presence or absence of fetal aneuploidy and the relative amount of fetal nucleic acids in a sample obtained form...
US20170114404 TM-ENHANCED BLOCKING OLIGONUCLEOTIDES AND BAITS FOR IMPROVED TARGET ENRICHMENT AND REDUCED OFF-TARGET SELECTION  
The invention is directed to modified oligonucleotide compositions and methods for selectively reducing unwanted nucleic acid contaminants and enriching for desired nucleic acid targets from...
US20160201117 ULTRA SENSITIVE METHOD FOR IN SITU DETECTION OF NUCLEIC ACIDS  
Disclosed is a method for in situ detection of one or more target nucleic acids based on a combination of RNAscope® method and a general ISH signal amplification method. This new method produces...
US20160195516 Methods of Detecting Signatures of Disease or Conditions in Bodily Fluids  
Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having...
US20160194717 Methods of Detecting Diseases or Conditions Using Phagocytic Cells  
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to...
US20160145693 METHODS FOR THE DIAGNOSIS OF ONCOLOGICAL DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS  
Methods and formulations for diagnosing onocological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
US20160130656 METHODS FOR EVALUATING LUNG CANCER STATUS  
The disclosure in some aspects provides methods of determining the likelihood that a subject has lung cancer based on the expression of informative-genes. In other aspects, the disclosure provides...
US20160068916 TEST KITS  
This invention relates to prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for colorectal cancer. Specifically, this invention...
US20160011189 ARRAYS, SUBSTRATES, DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES  
Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and...
US20150203900 Methods of Diagnosing Infectious Disease Pathogens and Their Drug Sensitivity  
The specification relates generally to methods of detecting, diagnosing, and/or identifying pathogens, e.g., infectious disease pathogens and determining their drug sensitivity and appropriate...
US20150159204 Single Molecule Arrays for Genetic and Chemical Analysis  
Random arrays of single molecules are provided for carrying out large scale analyses, particularly of biomolecules, such as genomic DNA, cDNAs, proteins, and the like. In one aspect, arrays of the...
US20150018249 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection...
US20140315757 DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS  
The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligation detection...
US20140235506 POLYNUCLEOTIDE BARCODE GENERATION  
The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including...
US20140105918 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
US20130225447 siRNA Targeting Apolipoprotein B (APOB)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20130203814 Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of ADHD are provided.
US20130172197 HIGH THROUGHPUT NUCLEIC ACID SEQUENCING BY EXPANSION  
Nucleic acid sequencing methods and related products are disclosed. Methods for sequencing a target nucleic acid comprise providing a daughter strand produced by a template-directed synthesis, the...
US20130096014 MULTIPLEX AMPLIFICATION OF POLYNUCLEOTIDES  
The present invention provides methods, reagents and kits for carrying out a variety of assays suitable for analyzing polynucleotides or samples that include an amplification step performed in a...
US20130085079 Cardiovascular Risk Event Prediction and Uses Thereof  
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of a caradiovascular (CV) Event within 5 years. In one aspect, the disclosure...
US20130059760 siRNA Targeting Fructose-1, 6-bisphosphatase 1 (FBP1)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20130023446 siRNA Targeting Beta Secretase (BACE)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20130013214 METHOD AND APPARATUS FOR CORRELATING LEVELS OF BIOMARKER PRODUCTS WITH DISEASE  
In one aspect the invention is a method of testing for one or more colorectal pathologies or one or more subtypes of colorectal pathology (in one embodiment colorectal cancer) in a test individual...
US20120316082 NUCLEIC ACID DETECTION AND QUANTIFICATION BY POST-HYBRIDIZATION LABELING AND UNIVERSAL ENCODING  
The present invention provides, among other things, methods and compositions for detecting and quantifying target nucleic acids via post-hybridization labeling.
US20120283311 siRNA Targeting Glucagon Receptor (GCCR)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20120270751 siRNA Targeting Diacylglycerol O-Acyltransferase Homolog 2 (DGAT2)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20120258888 siRNA Targeting Proto-oncogene MET  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20120252873 siRNA Targeting Interleukin-1 Receptor-associated Kinase 4 (IRAK4)  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20120238475 Methods of Amplifying and Sequencing Nucleic Acids  
An apparatus and method for performing rapid DNA sequencing, such as genomic sequencing, is provided herein. The method includes the steps of preparing a sample DNA for genomic sequencing,...
US20120220495 ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF  
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological...
US20120184602 METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE  
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
US20120135892 siRNA targeting spleen tyrosine kinase  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rationale design, one can maximize the generation of an effective gene...
US20120053088 MICROFLUIDIC TEST MODULE FOR BIOCHEMICAL PROCESSING AND ANALYSIS  
A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical...
US20120028842 GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH POSITIVE CONTROL CHAMBERS INCORPORATING PROBES THAT HYBRIDIZE FOR ANY AMPLICON  
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequence, and, an array of probes each having a nucleic acid...
US20120015850 siRNA targeting Superoxide  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20110319297 siRNA targeting gremlin  
Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene...
US20110312611 TEST MODULE WITH TRANSITION METAL-LIGAND COMPLEX FLUOROPHORE  
A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and,...
US20110312610 TEST MODULE WITH LONG FLUORESCENCE LIFETIME PROBES  
A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and,...
US20110312609 TEST MODULE FOR ORIENTATION-INDEPENDENT OPERATION  
A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for...
US20110312608 TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER AND LOW-VOLUME REAGENT RESERVOIR  
A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, a reagent reservoir containing a reagent for addition to the...
US20110312606 LOC DEVICE WITH DIGITAL MEMORY  
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with...
US20110312605 LOC DEVICE WITH INTEGRAL CONTROLLER  
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with...
US20110312604 LOC HAVING ON-CHIP ELECTRONICS FOR USE IN A TEST MODULE TO CONTROL MODULE COMMUNICATIONS  
A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a...
US20110312603 TEST MODULE WITH LOC HAVING ON-CHIP ELECTRONICS FOR MODULE CONTROL  
A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, a supporting substrate, and,...
US20110312601 LOC DEVICE WITH DIGITAL MEMORY FOR SECURE STORAGE OF DATA  
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for...
US20110312596 MICROFLUIDIC DEVICE WITH SURFACE TENSION VALVE AT REAGENT RESERVOIR OUTLET  
A microfluidic device for processing a fluid sample, the microfluidic device having a reservoir for containing a reagent, and, a surface tension valve having an aperture configured to pin a...
US20110312595 MICROFLUIDIC DEVICE WITH MIXING SECTION  
A microfluidic device having a sample inlet for receiving a sample of biological material having nucleic acid sequences, a polymerase chain reaction (PCR) section for amplifying the nucleic acid...
US20110312593 MICROFLUIDIC DEVICE WITH INCUBATOR HAVING TWO-DIMENSIONAL CONTROL OF INPUT HEAT FLUX  
A microfluidic device having an inlet for receiving a fluid, an incubation section having a microchannel configured to have a plurality of mutually parallel, adjacent channel sections, and a...