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US20110105360 PAPER-BASED CELLULAR ARRAYS  
Three-dimensional cellular arrays, methods of making three-dimensional cellular arrays, and methods of identifying agents using the arrays are disclosed.
US20130005608 YEAST SCREENS FOR TREATMENT OF HUMAN DISEASE  
Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are...
US20150133341 Intra-Operative Cancer Diagnosis Based on a Hyperpolarized Marker  
The present invention is concerned with an in vitro method of diagnosing cancer in a tissue sample, wherein said tissue sample is obtained from a patient undergoing cancer surgery. The method...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20130324438 METAGENE EXPRESSION SIGNATURE FOR PROGNOSIS OF BREAST CANCER PATIENTS  
Described are gene expression signatures able to distinguish individuals having or suspected to have breast cancer with good clinical prognosis from individuals with poor clinical prognosis, based...
US20150079038 SELECTIVE RECOVERY  
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US20140296106 METHODS FOR SCREENING SUBSTANCES CAPABLE OF MODULATING THE REPLICATION OF AN INFLUENZA VIRUS  
The present invention relates to methods for screening substances capable of modulating the replication of an influenza virus. More particularly, the present invention relates to methods for...
US20150038350 Method for Determining Condition of Oral Cavity and Analytical Tool, Apparatus, and Program Used for the Method  
Means of determining the condition of the oral cavity in a subject is provided. The condition of the oral cavity in the subject is determined by using an analytical tool comprising the following...
US20140205620 ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES WITH CONTROL OF CELL-TO-CELL VIRUS TRANSMISSION FOR ENHANCED SAFETY OF LIVE VIRUS VACCINES  
Highly antigenic yet safe vaccines against diseases caused by Paramyxoviridae viruses such as respiratory syncytial virus (RSV) are provided. The vaccines comprise attenuated Paramyxoviridae...
US20140142000 MICROFLUIDIC ARRAY PLATFORM FOR SIMULTANEOUS CELL CULTURE UNDER OXYGEN TENSIONS  
The present invention relates to a microfluidic array platform comprising a substrate and two layers between which one membrane is sandwiched, wherein a plurality of cell culture wells are...
US20120316321 METHODS FOR IDENTIFYING MARKERS FOR EARLY-STAGE HUMAN CANCER, CANCER PROGRESSION AND RECURRENCE  
A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing...
US20110319286 SYSTEM FOR SCREENING AGONISTS/ANTAGONISTS OF CELLULAR SIGNALING PATHWAYS  
The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also...
US20120171225 Diagnostic Method for Predicting the Risk of Cancer Recurrence Based on Histone Macroh2A Isoforms  
The present invention relates to a method for diagnosing the risk of cancer recurrence in a mammalian patient, comprising detecting the expression of macroH2A1.1 and/or macroH2A2 in a biological...
US20110110899 Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells  
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
US20140128287 SYSTEMS FOR INDUCTION OF GENE EXPRESSION AND PROTEIN DEPLETION IN YEAST  
A system allows for rapid and specific induction of individual genes in eukaryotic cells using a chimeric transcriptional activator that is responsive to hormone inducer. Upon addition of the...
US20140336142 Method For Treatment Of Macular Degeneration By Modulating P2Y12 or P2X7 Receptors  
Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal...
US20120264708 Method For Treatment Of Macular Degeneration By Modulating P2Y12 or P2X7 Receptors  
Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal...
US20150087552 METHODS FOR SCREENING VOLTAGE-GATED PROTEINS  
In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a...
US20150113680 ISOLATED NOVEL NUCLEIC ACID AND PROTEIN MOLECULES FROM CORN AND METHODS OF USING THOSE MOLECULES TO GENERATE TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS  
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing DNA for expression of the proteins that are useful for...
US20150031562 BIOMARKERS FOR MULTIPLE SCLEROSIS AND METHODS OF USE THEREOF  
Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing...
US20150030572 IDENTIFICATION OF MOLECULAR PATHWAYS AND METHODS OF USE THEREOF FOR TREATING RETINAL NEURODEGENERATION AND OTHER NEURODEGENERATIVE DISORDERS  
Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
US20130137599 LIPID MULTILAYER MICROARRAYS AND THEIR USE FOR CELL CULTURE SCREENING  
Provided is a device having one or more lipid multilayer arrays of lipid multilayer structures on a substrate. Each lipid multilayer structure encapsulates an encapsulated material that may be...
US20150232953 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20150225702 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF  
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells, when administered via...
US20120225085 DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE  
Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion...
US20120066783 AAV CAPSID LIBRARY AND AAV CAPSID PROTEINS  
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating a library of recombinant adeno-associated viral capsid proteins are also provided.
US20150174130 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS  
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting...
US20140356388 Vaccine - Screening Method  
The present invention provides screening methods which may be regarded as in vitro or ex vivo methods of interrogating the immune system to understand what viral antigens are “seen” and responded...
US20140163075 MODULATION OF THE UBIQUITIN-PROTEASOME SYSTEM (UPS)  
The invention relates to the field of 26S proteasome inhibition, activation and modulation and to identify compounds which activate 26S proteasome in live cells and a method of treating autoimmune...
US20110230369 METHOD FOR SCREENING COMPOUNDS FOR THEIR ABILITY TO INCREASE RIGIDITY OF RED BLOOD CELLS INFECTED BY A PROTOZOAN PARASITE OF THE GENUS PLASMODIUM, METHOD FOR FILTERING RED BLOOD CELLS, AND APPLICATION THEREOF  
The invention relates to a method for screening compounds for their ability to increase rigidity of red blood cells (RBCs) infected by a protozoan parasite of the genus Plasmodium and in...
US20130036519 Compositions and Methods for the Control of Root Lesion Nematode  
The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus Pratylenchus (root lesion nematodes). The present...
US20150246067 ANTIVIRAL TREATMENT OF LYMPHOMA AND CANCER  
The present invention provides compositions and methods to treat lymphoma and cancer. In particular, the present invention provides treatment of lymphoma and cancer using anti-HERV-K(HML-2)...
US20120165265 Calcium Signaling Modulators Involving STIM and ORAI Proteins  
The present invention provides compositions and methods for investigating the structural basis of the activation process of CRAC channels, which are essential for T-lymphocyte activation and...
US20130324440 METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS  
The present application relates to a system for designing promoters for selective expression of genes. Thereby identified transcription regulatory elements are selected according to a specific...
US20130137601 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20130137600 LAMINAR LIBRARY SCREEN  
Described is a method of screening libraries of variant proteins produced in plant leaves using a plant viral vector to identify a gene of interest comprising, inoculating leaves with a library of...
US20120302450 Bacterial Metastructure and Methods of Use  
The present invention provides a method of determining bacterial metastructure by integrating multiple genome-scale information yielded by high-throughput technologies. The metastructure...
US20130203814 Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of ADHD are provided.
US20110092569 Administration of Exogenous mi/siRNA  
Certain genes controlled by endogenous miRNA are actually upregulated upon the transfection of exogenous mi/siRNA. Based on this, methods of determining whether administration of mi/siRNA will...
US20130197056 NOVEL BIOMARKERS AND TARGETS FOR OVARIAN CARCINOMA  
Novel biomarkers and targets associated with ovarian cancer, particularly clear-cell carcinoma, endometrioid carcinoma, and uterine carcinoma, are disclosed. Mutations in genes encoding proteins...
US20130345144 Use of ID4 for Diagnosis and Treatment of Cancer  
Methods for diagnosis and treatment of cancer using ID4 are disclosed. Specifically, epigenetic inactivation of ID4 in colorectal carcinomas and breast correlates with poor differentiation and...
US20120149668 GLUCOCORTICOID RECEPTOR ALLELES AND USES THEREOF  
Provided here in are, inter alia, methods of determining whether a patient is resistant or sensitive to glucocorticoid therapy.
US20130197106 METHODS OF IDENTIFYING A CANDIDATE COMPOUND  
The invention relates to methods identifying compounds for the treatment of cell proliferation-related disorders, e.g., proliferative disorders such as cancer.
US20150037257 COMPOSITIONS AND METHODS FOR HIGH-THROUGHPUT SCREENING IN SKIN FIBROBLASTS WITH AN ALPHA-SYNUCLEIN TRIPLICATION  
Human-derived fibroblast cells with copy number variation for alpha-synuclein, and methods of use thereof, are provided. For example, compositions and methods for high through-put screening of...
US20150133340 METHOD OF DETERMINING TERATOGENIC RISK  
The present invention relates to a method of determining the risk of drug induced teratogenicity using pluripotent stem cells.
US20130315931 CXCR4 as a Susceptibility Locus in Juvenile Idiopathic Arthritis (JIA) and Methods of Use Thereof for the Treatment and Diagnosis of the Same  
Compositions and methods useful for the diagnosis and treatment of juvenile idiopathic arthritis are disclosed.
US20110152112 DIAGNOSIS AND TREATMENT OF REVERSE CHOLESTEROL TRANSPORT DEFICIENCY-RELATED DISEASES  
The present invention provides compositions and methods to assess the state of a reverse cholesterol transport (RCT). In one aspect of the invention provides methods, compositions and kits for...
US20150233928 METHODS AND KITS FOR PREDICTING THE SENSITIVITY OF A SUBJECT TO CHEMOTHERAPY  
The present invention relates to a method of predicting or monitoring the sensitivity of a subject having a tumor to a chemotherapy, to a method of selecting an appropriate chemotherapeutic...
US20140234271 COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS  
We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells...
US20140296223 METHOD FOR REGULATING SKIN PIGMENTATION  
This invention relates to a method for regulating skin pigmentation of a subject, comprising the step of administering the agent for inhibiting the expression or activation of Microphthalmia...