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US20100331192 |
SURFACE DISPLAY OF RECOMBINANT PROTEINS IN LOWER EUKARYOTES
Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening... |
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US20110183855 |
SOMATIC HYPERMUTATION SYSTEMS
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility... |
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US20100304462 |
Synthetic Binding Proteins
Methods and compositions are provided for creating a binding protein that recognizes a rationally chosen recognition sequence in which a first amino acid has been substituted for a second amino... |
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US20130116125 |
NOVEL METHODS OF PROTEIN EVOLUTION
The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from,... |
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US20110306503 |
TEMPLATE-DEPENDENT NUCLEIC ACID POLYMERIZATION USING OLIGONUCLEOTIDE TRIPHOSPHATES BUILDING BLOCKS
A novel use of a template-dependent polymerase. The novel use is effected by employing the template-dependent polymerase for incorporating at least one oligonucleotide triphosphate onto a nascent... |
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US20120172236 |
Selection and Enrichment of Proteins Using In Vitro Compartmentalization
Compositions and methods are provided for selection and enrichment of a target gene from a library of polynucleotide sequences such as might be formed from a genome or by random mutagenesis of a... |
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US20150240231 |
ISOLATING TRAFFIC-ENHANCING MUTANTS OF DRUG DELIVERY PROTEIN
The invention relates to methods for isolating traffic-enhancing mutants of drug delivery proteins. In one embodiment, the invention provides a carrier for delivering a therapeutic agent to an... |
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US20140302999 |
METHOD FOR DETERMINATION OF PHARMACOLOGICAL PROPERTIES OF RECOMBINANT PROTEINS
The present invention is directed to a method for obtaining an in vitro pharmacological model of a recombinant protein drug in a given host. A plurality of biomolecules are selected which are... |
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US20150133308 |
METHOD FOR IMPROVING REPEBODY CONTAINING REPEAT MODULES
The present invention relates to a method for improving a repebody protein comprising repeat modules and a nucleotide library encoding a repebody protein library for improving the repebody... |
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US20110201506 |
Methods of Primer Extension Using Porous Particle Supports
The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their... |
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US20120295793 |
METHODS OF GENERATING MODIFIED POLYNUCLEOTIDE LIBRARIES AND METHODS OF USING THE SAME FOR DIRECTED PROTEIN EVOLUTION
The invention provides for methods of generating modified polynucleotide libraries by inserting and/or deleting at least three nucleotide residues in polynucleotide sequences. Theses methods may... |
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US20140109249 |
SCREENING METHODS
The present invention relates to methods for the screening, identification and/or application of microorganisms of use in imparting beneficial properties to plants. |
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US20120258865 |
MIRAC PROTEINS
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly... |
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US20140243209 |
METHOD FOR DETECTING PROTEIN THAT INTERACTS WITH TARGET SUBSTANCE
The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives. This method is a... |
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US20130029850 |
Competitive Differential Screening
The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the... |
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US20150203838 |
Methods for Generating Pools of Variants of a DNA Template
The invention provides methods for generating pools of variants of DNA templates, and methods of using pools of variants to identify sequences involved in conferring sensitivity or resistance to... |
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US20120015820 |
METHODS AND COMPOSITIONS FOR POLYPEPTIDE ENGINEERING
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods... |
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US20110053781 |
METHODS AND COMPOSITIONS FOR POLYPEPTIDE ENGINEERING
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods... |
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US20140100120 |
METHODS OF X-APTAMER GENERATION AND COMPOSITIONS THEREOF
Provided herein are methods for a novel bead-based next-generation “X-aptamer” selection scheme that extends aptamer technology to include X-modified bases, thus resulting in X-aptamers, at any... |
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US20150110836 |
EPITOPE FOCUSING BY VARIABLE EFFECTIVE ANTIGEN SURFACE CONCENTRATION
The present disclosure provides compositions and methods for the generation of an antibody or immunogenic composition, such as a vaccine, through epitope focusing by variable effective antigen... |
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US20120028812 |
METHOD FOR PRODUCING SECOND-GENERATION LIBRARY
The present invention relates to a method for generating a second-generation library. In a first step, a library of encoded molecules associated with an identifier nucleic acid comprising codons... |
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US20140200145 |
METHOD OF METABOLIC EVOLUTION
The invention relates to a method for metabolic evolution of a variant of a natural small aromatic molecule product of a metabolic pathway, by somatic in vivo assembly and recombination of said... |
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US20120220010 |
PHOTOSYNTHETIC HYDROGEN PRODUCTION FROM THE GREEN ALGA CHLAMYDOMONAS REINHARDII
The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced... |
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US20150247843 |
METHOD OF DETECTING TARGET SUBSTANCE
Provided are a method of detecting a target substance and the like using a probe with a simple design for target substance detection. The method of detecting a target substance of the present... |
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US20110098184 |
Competitve differntial screeing
The invention is drawn to a novel method useful for screening. In particular, the present invention provides methods for competitive differential screening. In some preferred embodiments, the... |
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US20120252681 |
EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of... |
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US20110190140 |
EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of... |
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US20130178368 |
IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into... |
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US20120015819 |
MIXTURE OF AT LEAST TWO FUSION PROTEINS, THE PRODUCTION THEREOF AND THE USE OF THE SAME
The present invention concerns a protein mixture comprising at least a first fusion protein comprising a protein or protein fragment, and an interaction domain and a protein translocation... |
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US20140323315 |
POLYSPECIFICITY REAGENTS, METHODS FOR THEIR PREPARATION AND USE
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and... |
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US20130090246 |
METHOD OF GENERATING GENE MOSAICS
The invention relates to a method for generating a gene mosaic by somatic in vivo recombination, comprising: e) in a single step procedure (vii) transforming a cell with at least one gene A having... |
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US20150133307 |
AUTOMATED SCREENING OF ENZYME VARIANTS
Disclosed are methods for identifying bio-molecules with desired properties (or which are most suitable for a round of directed evolution) from complex bio-molecule libraries or sets of such... |
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US20150031549 |
Cellular High Throughput Encapsulation for Screening or Selection
The invention relates to a method for selecting a sequence set from a library of expressed nucleic acid sequences, wherein cells are provided, each cell comprises an expressed nucleic acid... |
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US20140357497 |
DESIGNING PADLOCK PROBES FOR TARGETED GENOMIC SEQUENCING
Methods, systems, and computer programs for designing probes or primers for nucleic acid sequencing, generating libraries of nucleic acid sequences, and mapping genomic sequences are provided herein, |
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US20130137582 |
QUANTITATIVE PCR-BASED METHOD TO PREDICT THE EFFICIENCY OF TARGET ENRICHMENT FOR NEXT-GENERATION SEQUENCING USING REPETITIVE DNA ELEMENTS (LINES/SINES) AS NEGATIVE CONTROLS
A method for determining an efficiency of target enrichment from a DNA library, includes: adding a negative control sequence and a positive control sequence to the DNA library, or picking a... |
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US20120178917 |
RNA APTAMERS AND METHODS FOR IDENTIFYING THE SAME
RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA... |
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US20130059732 |
AAV CAPSID PROTEINS FOR NUCLEIC ACID TRANSFER
Recombinant adeno-associated viral (AAV) capsid proteins are provided. Methods for generating the recombinant adeno-associated viral capsid proteins and a library from which the capsids are... |
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US20130116417 |
Methods for the Development of Vaccines Based on Oligosaccharide-Oligonucleotide Conjugates
Described herein are oligosaccharide-oligonucleotide conjugates useful as vaccines against one or more human or veterinary therapeutic indications, and methods of synthesizing and identifying... |
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US20140094373 |
HIGHLY MULTIPLEX PCR METHODS AND COMPOSITIONS
The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such... |
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US20120046175 |
METHODS AND SYSTEMS FOR SOLUTION BASED SEQUENCE ENRICHMENT
The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention... |
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US20100204450 |
Preparation Method for a Protein With New Function Through Simultaneous Incorporation of Functional Elements
Disclosed is a method for preparing a protein having a new function. The method comprises (A) a functional element-designing step of designing functional elements required for a new function... |
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US20150119254 |
NUCLEIC ACID FRAGMENT BINDING TO TARGET PROTEIN
An object of the present invention is to develop and provide a method for efficiently producing a nucleic acid aptamer, particularly, a DNA aptamer, having higher specificity and binding activity... |
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US20140256557 |
METHOD OF GENERATING AN OPTIMIZED, DIVERSE POPULATION OF VARIANTS
The disclosure relates to a method of generating a diverse set of variants to screen improved and novel properties within the variant population, a system for creating the diverse set of variants,... |
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US20140056959 |
NUCLEIC ACID APTAMERS
The present invention relates to optimized aptamers and methods of using these aptamers. |
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US20150104433 |
TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS
The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences... |
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US20130164271 |
TAILORED RECOMBINASE FOR RECOMBINING ASYMMETRIC TARGET SITES IN A PLURALITY OF RETROVIRUS STRAINS
The present invention relates to a method for preparing an expression vector encoding a tailored recombinase, which tailored recombinase is capable of recombining asymmetric target sequences... |
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US20120264616 |
LENTIVIRAL-BASED VECTOR AND ITS USE IN DIRECTED EVOLUTION OF GENOMIC REGIONS, GENES AND POLYNUCLEOTIDES
The present invention concerns a method of directing evolution of a target polynucleotide of interest for obtaining variants of this target polynucleotide, as well as a method to generate genetic... |
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US20140121115 |
CUSTOM-MADE MEGANUCLEASE AND USE THEREOF
New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal,... |
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US20130045871 |
ENGINEERING CORRECTLY FOLDED ANTIBODIES USING INNER MEMBRANE DISPLAY OF TWIN-ARGININE TRANSLOCATION INTERMEDIATES
The present invention provides systems, vectors and methods for isolation of enhanced ligand-binding proteins from combinatorial libraries displayed on the inner membrane of a host cell. |
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US20140213460 |
RNA-YY1 Interactions
Methods relating to obtaining libraries of YY1-binding long non-coding RNAs, libraries obtained thereby, and methods of use thereof. |