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US20130102082 PROTEIN CONCENTRATION ASSAY METHOD ANALYSIS TOOL AND ANALYZER  
Provided is a protein concentration assay method that uses a protein indicating reagent and that enables highly accurate assay. The protein concentration assay method includes: optically analyzing...
US20130090550 METHODS OF IDENTIFYING PATIENTS WITH OVARIAN EPITHELIAL NEOPLASMS BASED ON HIGH-RESOLUTION MASS SPECTROMETRY  
Methods for identifying patients with ovarian neoplasms are provided herein comprising performing an assay step of detecting a metabolite in a serum sample of a patient where the metabolite is...
US20110021370 SALIVARY PROTEIN BIOMARKERS FOR HUMAN ORAL CANCER  
The present invention relates to the identification of novel oral cancer and periodontal disease biomarkers. Further, the present invention provides novel methods of diagnosing and for providing a...
US20130295679 PREDICTION OF A SMALL-FOR-GESTATIONAL AGE (SGA) INFANT  
A method of predicting a SGA infant in a patient at a pre-symptomatic gestational stage is described. The method comprises a step of assaying a biological sample from the patient for an abundance...
US20140162891 METHODS AND MATERIALS FOR DETECTION, DIAGNOSIS AND MANAGEMENT OF OVARIAN CANCER  
The subject invention concerns methods using a panel of proteins to detect, diagnose, and monitor therapy during treatment of ovarian cancer in a female patient. The proteins were identified using...
US20140141415 NUCLEIC ACID ENCODING A SELF-ASSEMBLING SPLIT-FLUORESCENT PROTEIN SYSTEM  
The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with...
US20150099664 PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR AUTOIMMUNE AND ALLOIMMUNE DISEASES  
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the...
US20140322203 FORMULATIONS WITH REDUCED OXIDATION  
The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and...
US20140314778 FORMULATIONS WITH REDUCED OXIDATION  
The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and...
US20110190243 DIAGNOSIS AND TREATMENT OF BACK PAIN  
The present invention relates to methods of diagnosing and/or treating lower back pain (LBP). In one embodiment, the invention relates to a system for diagnosis of a form of lower back pain in an...
US20110076778 SOLUBILIZATION OF PROTEINS IN REVERSE MICELLES BY EXTRACTION FROM A SOLID SUPPORT  
A general method for solubilizing proteins by direct extraction of an immobilized protein into a reverse micelle solution is disclosed. The reverse micelle protein solutions are amenable to...
US20120040906 PROTEIN TARGETS IN DISEASE  
MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte...
US20110112037 CRYSTAL STRUCTURE  
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...
US20100304419 METHOD FOR DETERMINING THE PROGNOSIS OF GASTRIC CANCER  
The 14-3-3β protein is used herein as a tumor marker for prognosis in gastric cancer. The method comprises steps of providing a biological sample, qualifying the 14-3-3β protein level in the...
US20150210751 Method and Composition for Crystallizing G Protein-Coupled Receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20100311099 USE OF HE4 FOR ASSESSMENT OF BREAST CANCERS  
The disclosure relates to use of the HE4 marker to assess breast cancer in a patient. The disclosure also relates to using HE4 and other tumors markers for diagnosis, grading and staging of breast...
US20110086796 METHODS FOR PREDICTING THE DEVELOPMENT AND RESOLUTION OF ACUTE RESPIRATORY DISTRESS SYNDROME  
The subject invention features methods for predicting whether a subject at risk of developing Acute Respiratory Distress Syndrome (ARDS) will develop ARDS by determining the amount of elafin...
US20110033941 RISK ANALYSIS IN PATIENTS WITH AND WITHOUT METABOLIC SYNDROME  
The present invention relates to a method for identifying a subject being susceptible to a metabolic syndrome related therapy based on determining the amounts of adiponectin, retinol binding...
US20110039276 IDENTIFYING ORGAN DAMAGE  
The present invention provides methods for identifying whether or not a patient has, or is at risk of developing drug induced organ damage and methods of treating patients having drug induced...
US20150126402 Method for Quantifying Proteins and Isoforms Thereof  
A method for quantifying metallothionein protein isomers is described herein. Such metallothionein isomer protein quantification is useful for detecting and monitoring disease. As illustrated...
US20110008258 METHODS RELATING TO BREATHING DISORDERS  
Methods for treating breathing disorders by inhibition of the induced PGE2 pathway in a mammalian subject, methods for assessing apnea, hypoxic ischemic encephalopathy or perinatal asphyxia by...
US20110045501 ST2-BASED DENGUE FEVER DIAGNOSTIC  
A cytokine receptor family member (ST2), which has membrane bound as well as soluble bound forms, is elevated in patients during acute phase of dengue fever. Moreover, secondary cases of dengue...
US20120172356 SERUM BIOMARKERS FOR CHAGAS DISEASE  
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying Chagas disease status in a patient. In particular, the biomarkers of this invention...
US20130210665 METHOD AND KIT FOR THE DIAGNOSIS AND/OR PROGNOSIS OF TOLERANCE IN LIVER TRANSPLANTATION  
The invention refers to a method and kit for the in vitro diagnosis and/or prognosis of the tolerant state of a patient to be submitted to liver transplantation, which comprises assessing the...
US20120245216 COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROPATHIC PAIN  
The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the...
US20110111512 QUANTITATION OF INSULIN-LIKE GROWTH FACTOR-I AND INSULIN-LIKE GROWTH FACTOR-II WITH HIGH-RESOLUTION MASS SPECTROMETRY  
Methods are provided for determining the amount of an IGF-I and/or IGF-II protein in a sample using high resolution/high accuracy mass spectrometry. The methods generally comprise enriching an...
US20110027314 Influenza Vaccines Containing Hemagglutinin and Matrix Proteins  
An immunogenic composition comprising influenza virus haemagglutinin and matrix proteins. These may be from influenza viruses grown in cell culture rather than eggs. The matrix protein may be a...
US20110183904 METHODS AND COMPOSITIONS FOR ALTERING BEHAVIOR ASSOCIATED WITH AUTISM SPECTRUM DISORDER  
The present invention discloses methods for the diagnosis and treatment of autism. The diagnostic tools provided use analysis of levels of G-protein expression, oxytocin, and vasopressin....
US20110137131 RISK FACTORS AND PREDICTION OF MYOCARDIAL INFARCTION  
Biomarkers and methods are disclosed for diagnosing the risk of a myocardial infarction in an individual by measuring the levels of a set of biomarkers in a sample from an individual. A risk score...
US20150051096 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS  
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20140031327 NON-SURGICAL METHOD OF TREATMENT FOR CATARACT  
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of...
US20120171190 METHODS FOR DIAGNOSING CHRONIC DIARRHEA THROUGH PROTEIN SECRETION ANALYSIS  
Methods for diagnosing chronic diarrhea and other gastrointestinal conditions. In the methods, a sample of gastrointestinal secretions is obtained from a control group; or a group who has been...
US20110033942 PREDICTING RENAL FAILURE IN DIABETES PATIENTS BASED ON PLACENTAL GROWTH FACTOR AND SOLUBLE FLT-1  
Disclosed is a method for predicting the risk of developing renal failure or mortality for a subject suffering from diabetes mellitus. More specifically, a method is disclosed for predicting the...
US20140087407 Methods of Measuring Protein and/or Fat Digestibility and Uses Thereof  
The present invention provides methods for continuous measurement of protein and/or triglyceride digestibility during a meal. Stable isotope of 15N-spirulina protein and 2H5-phenylalanine was...
US20130203101 METHOD AND SYSTEM FOR PURIFYING AND QUANTITATING PROTEINS USING HEME FUSION TAGS  
A method is provided for purifying a protein comprising the steps of providing a heme tag with an open coordination site and tagging the recombinant protein of interest with the heme tag. A resin...
US20110165146 METHODS OF DIAGNOSING ALZHEIMER'S DISEASE  
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the...
US20110159514 BIOMARKER FOR OSTEOARTHRITIS AND/OR OTHER AGEING-RELATED DISEASES, AND USE THEREOF  
The invention relates to the identification of a biomarker whose abundance in biological sample is changed in subjects with osteoarthritis and/or other ageing-related diseases. The biomarker has...
US20110136690 METHODS FOR IDENTIFYING AND MONITORING DRUG SIDE EFFECTS  
The present invention relates generally to methods for identifying drug side effects by detecting perturbations in organ-specific molecular blood fingerprints. The invention further relates to...
US20120003744 DIAGNOSTIC METHODS  
The present invention provides a method for identifying a biomarker for diagnosis of lymphoma in a canine subject. The method comprises the following steps: (i) providing serum samples from canine...
US20150198612 Isotopic Labelling of Proteins  
The present invention provides methods for enhancing the synthesis of isotope labelled native proteins in specific biological pathways for the purpose of protein quantification and qualification....
US20140093896 Point-Of-Care, Medical Condition Screening Kit  
A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a...
US20110177612 Human G Protein-Coupled Receptors and Modulators Thereof for the Treatment of Metabolic-Related Disorders  
The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In preferred embodiments, the GPCR is human. In other...
US20110236912 SYSTEMS AND METHODS FOR CHARACTERIZING LUPUS ERYTHEMATOSUS  
The present invention provides systems and methods for characterizing biological markers in the urine of systemic lupus erythematosus (SLE) subjects. In particular, the present invention relates...
US20110281364 METHOD AND MARKER FOR DIAGNOSING DIABETES MELLITUS  
A process for the diagnosis of diabetes mellitus comprising the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide...
US20110008812 METHODS AND SUBSTANCES FOR THE DIAGNOSIS AND THERAPY OF SEPSIS AND SEPSIS-LIKE SYSTEMIC INFECTIONS  
Uses of recombinant procalcitonin 3-116 in the diagnosis and therapy of septic diseases and the measurement of prohormones other than procalcitonin, and of dipeptidyl peptidase IV, as biomarkers...
US20110172153 SCREENING METHODS USING G-PROTEIN COUPLED RECEPTORS AND RELATED COMPOSITIONS  
The present invention provides screening methods for GPCRs based on the discovery that the affinity of a receptor agonist for a GPCR (such as the parathyroid hormone receptor) when not bound to a...
US20110104724 BIOMARKERS OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE  
A method for quantifying a neurodegenerative disorder in a patient that includes obtaining a fluid sample from the subject; measuring a protein biomarker complex in said fluid sample and...
US20110183421 COMPOSITION AND METHOD FOR CONVERTING A NON-PATHOGENIC PRION PROTEIN INTO A PATHOGENIC CONFORMATION AND USES THEREOF  
Described herein is a composition for converting a non-pathogenic prion protein (“PrPN”) into a prion protein in a pathogenic conformation (“PrPPath”) comprising a lipid and a polyanion. Also...
US20130252843 METHOD OF MAKING AND USING FLUORESCENT-TAGGED NANOPARTICLES AND MICROARRAYS  
Disclosed embodiments concern differentiating and classifying one or more targets using a perhalophenylazide-derived nanoparticle probe, or multiple such probes. Particular embodiments concern...
US20140273251 COLLOIDAL COOMASSIE STAIN  
Colloidal formulation for staining proteins and methods of their use are provided.