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US20100015144 Methods for dosing an activin-actriia antagonist and monitoring of treated patients  
In certain aspects, the present invention provides methods for dosing a patient with an activin-ActRIIa antagonist and methods for managing patients treated with an activin-ActRIIa anatagonist. In...
US20150132747 Treatment of Neurodegeneration and Neuroinflammation  
Methods of treating a subject having a condition characterized by at least one of neurodegeneration and neuroinflammation are provided. Methods of reducing astrogliosis in a subject having a...
US20120237449 METHODS FOR TREATING NEURAL CELL SWELLING  
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different...
US20110243956 METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY  
Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity...
US20110200991 AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE  
A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively...
US20100331251 POLYPEPTIDES HOMOLOGOUS TO VEGF AND BMP1  
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor...
US20100317540 METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS  
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are...
US20100227418 METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY  
A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and...
US20100209346 AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF  
The invention relates to neuromodulatory oligomers of the amyloid β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high...
US20090233807 ASSAYS THAT USE THE T1R1 RECEPTOR POLYPEPTIDES TO SCREEN FOR T1R1-ASSOCIATED TASTE MODULATORS  
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
US20090226947 NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS  
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are...
US20090041718 Methods of Modulating Cytokine Activity; Related Reagents  
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering...
US20090035217 Truncated Fragments of Alpha-Synuclein in Lewy Body Disease  
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of...
US20080299594 Proteomic analysis of biological fluids  
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin,...
US20080057590 Markers associated with arteriovascular events and methods of use thereof  
Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with...
US20050186559 Abeta42 lowering agents  
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of...
US20120129150 PARTICLES EMBEDDED IN A POROUS SUBSTRATE FOR REMOVING TARGET ANALYTE FROM A SAMPLE  
The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality...
US20110165146 METHODS OF DIAGNOSING ALZHEIMER'S DISEASE  
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the...
US20110129477 NOGO Receptor Homologs  
The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The...
US20110070659 SAMPLE PRESENTATION DEVICE  
The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as:...
US20110052692 NOVEL HYDROGELS AND USES THEREOF  
The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in...
US20100291100 Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions  
The present invention provides genes encoding novel microbial proteins (i.e., for example, exosporium genes and proteins) that mediate the attachment of microbial spores to surfaces. Specific...
US20100075342 Biomarker for ovarian cancer CTAP3-related proteins  
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a...
US20090234202 METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE DETECTION OF MOLECULES  
The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or...
US20080274907 FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE  
A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and...
US20080058360 Soluble CD40L (CD 154) as a prognostic marker of atherosclerotic diseases  
This invention involves the new use of a diagnostic test to determine the risk of atherosclerotic diseases such as myocardial infarction and stroke, particularly among individuals with no signs or...
US20060003385 Mass intensity profiling system and uses thereof  
The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on...
US20050196823 Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore  
Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of...
US20110218116 BIOMARKERS OF OSTEOARTHRITIS  
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject,...
US20100313283 USES OF GDNF AND GDNF RECEPTOR  
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are...
US20100081160 Method for Diagnosing Multiple Sclerosis  
Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample.
US20090075307 METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR  
Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of...
US20090062133 Expression analysis of FKBP54 in the diagnosis and treatment of prostate cancer  
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of...
US20080213910 METHOD FOR BLOCKING NON-SPECIFIC PROTEIN BINDING ON A FUNCTIONALIZED SURFACE  
A method of blocking non-specific protein binding on surfaces, such as protein-coated biosensor surfaces.
US20080107668 CYTOTOXIC T-LYMPHOCYTE-INDUCING IMMUNOGENS FOR PREVENTION, TREATMENT, AND DIAGNOSIS OF CANCER  
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as breast carcinoma. The invention discloses peptides,...
US20080015194 METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT  
The present invention is directed to methods for developing one or more drugs for one or more targeted therapies and compositions derived therefrom. In accordance with one aspect of the present...
US20080004186 Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties  
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more...
US20060275910 Misfolded protein sensor method in body fluids  
A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal...
US20060240562 CLEAVABLE SURFACTANTS AND METHODS OF USE THEREOF  
Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
US20060134677 Methods for drug discovery, disease treatment, and diagnosis using metabolomics  
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources,...
US20160033511 METHODS AND COMPOSITIONS FOR DETECTING PANCREATIC CANCER  
The present invention relates to non-invasive methods for the diagnosis and prognosis of pancreatic cancer. In some embodiments, such methods and compositions relate to particular pancreatic...
US20150323545 SELECTED REACTION MONITORING ASSAYS  
Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays.
US20130108549 PEPTIDE PROBES FOR DIAGNOSTICS AND THERAPEUTICS  
Disclosed are agents and methods that may be used to diagnose and treat a variety of diseases associated with conformationally-altered proteins. The agents and methods may be used to identify and...
US20120164628 AFFINITY CAPTURE OF CIRCULATING BIOMARKERS  
Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber,...
US20110118140 METHODS FOR IDENTIFICATION, AND COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES  
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or...
US20110065136 Methods and Devices for Detecting Glomerulonephritis and Associated Disorders  
Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing,...
US20110064747 METHODS FOR TREATMENT OF A SARCOMA USING AN EPIMETABOLIC SHIFTER (COENZYME Q10)  
Methods and formulations for treating a sarcoma in humans using an epimetabolic shifter, such as Coenzyme Q10, a building block of CoQ10, a derivative of CoQ10, an analog of CoQ10, a metabolite of...
US20100190843 Tubulin Isotype Screening in Cancer Therapy Using Halichondrin B Analogs  
Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It...
US20100098627 PROTEINS  
The present invention provides methods and compositions for treatment, prevention, diagnosis and monitoring of colorectal cancer, kidney cancer, lung cancer and/or pancreatic cancer in particular...
US20100075894 REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES  
Endoplasmic reticulum stress has been found to be associated with obesity. Therefore, agents that reduce or prevent ER stress may be used to treat diseases associated with obesity including...