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US20100015144 |
Methods for dosing an activin-actriia antagonist and monitoring of treated patients
In certain aspects, the present invention provides methods for dosing a patient with an activin-ActRIIa antagonist and methods for managing patients treated with an activin-ActRIIa anatagonist. In... |
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US20150132747 |
Treatment of Neurodegeneration and Neuroinflammation
Methods of treating a subject having a condition characterized by at least one of neurodegeneration and neuroinflammation are provided. Methods of reducing astrogliosis in a subject having a... |
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US20120237449 |
METHODS FOR TREATING NEURAL CELL SWELLING
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different... |
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US20110243956 |
METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY
Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity... |
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US20110200991 |
AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE
A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively... |
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US20100331251 |
POLYPEPTIDES HOMOLOGOUS TO VEGF AND BMP1
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor... |
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US20100317540 |
METHODS FOR PRODUCING MEMBERS OF SPECIFIC BINDING PAIRS
A member of a specific binding pair (sbp) is identified by expressing DNA encoding a genetically diverse population of such sbp members in recombinant host cells in which the sbp members are... |
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US20100227418 |
METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY
A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and... |
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US20100209346 |
AMYLOID BETA(1-42) OLIGOMERS, DERIVATIVES THEREOF AND ANTIBODIES THERETO, METHODS OF PREPARATION THEREOF AND USE THEREOF
The invention relates to neuromodulatory oligomers of the amyloid β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high... |
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US20090233807 |
ASSAYS THAT USE THE T1R1 RECEPTOR POLYPEPTIDES TO SCREEN FOR T1R1-ASSOCIATED TASTE MODULATORS
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in... |
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US20090226947 |
NON-INVASIVE ENZYME SCREEN FOR TISSUE REMODELLING-ASSOCIATED CONDITIONS
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are... |
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US20090041718 |
Methods of Modulating Cytokine Activity; Related Reagents
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering... |
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US20090035217 |
Truncated Fragments of Alpha-Synuclein in Lewy Body Disease
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of... |
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US20080299594 |
Proteomic analysis of biological fluids
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin,... |
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US20080057590 |
Markers associated with arteriovascular events and methods of use thereof
Disclosed are methods of identifying subjects with arteriovascular disease, subjects at risk for developing arteriovascular disease, methods of differentially diagnosing diseases associated with... |
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US20050186559 |
Abeta42 lowering agents
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an Aβ42 lowering agent to a mammal under conditions in which levels of... |
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US20120129150 |
PARTICLES EMBEDDED IN A POROUS SUBSTRATE FOR REMOVING TARGET ANALYTE FROM A SAMPLE
The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality... |
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US20110165146 |
METHODS OF DIAGNOSING ALZHEIMER'S DISEASE
Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the... |
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US20110129477 |
NOGO Receptor Homologs
The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The... |
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US20110070659 |
SAMPLE PRESENTATION DEVICE
The present invention relates to sample presentation devices useful in performing analytical measurements. These devices have been configured to enable various aspects of liquid handling such as:... |
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US20110052692 |
NOVEL HYDROGELS AND USES THEREOF
The present invention provides novel hydrogels and methods of making and using such hydrogels. The present invention provides hydrogels that may be formed by the self-assembly of peptides in... |
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US20100291100 |
Compositions And Methods For Screening And Using Compounds Antagonizing Spore-Surface Interactions
The present invention provides genes encoding novel microbial proteins (i.e., for example, exosporium genes and proteins) that mediate the attachment of microbial spores to surfaces. Specific... |
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US20100075342 |
Biomarker for ovarian cancer CTAP3-related proteins
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a... |
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US20090234202 |
METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE DETECTION OF MOLECULES
The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or... |
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US20080274907 |
FLUOROGENIC PH SENSITIVE DYES AND THEIR METHOD OF USE
A new class of pH sensitive fluorescent dyes and assays relating thereto are described. The dyes and assays are particularly suited for biological applications including phagocytosis and... |
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US20080058360 |
Soluble CD40L (CD 154) as a prognostic marker of atherosclerotic diseases
This invention involves the new use of a diagnostic test to determine the risk of atherosclerotic diseases such as myocardial infarction and stroke, particularly among individuals with no signs or... |
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US20060003385 |
Mass intensity profiling system and uses thereof
The present invention is directed to computer automated methods and systems for identifying and characterizing biomolecules in a biological sample. Mass spectrometry measurements are obtained on... |
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US20050196823 |
Methods and apparatus for gel-free qualitative and quantitative proteome analysis, and uses therefore
Methods and apparatus for qualitative and quantitative proteome analysis are provided. The methods and apparatus allow for the isolation of a subset of peptides out of complex mixtures of... |
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US20110218116 |
BIOMARKERS OF OSTEOARTHRITIS
Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject,... |
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US20100313283 |
USES OF GDNF AND GDNF RECEPTOR
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are... |
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US20100081160 |
Method for Diagnosing Multiple Sclerosis
Disclosed is a method for diagnosing multiple sclerosis and more particularly to a method for diagnosing multiple sclerosis by measuring levels of antibodies to glycans in a biological sample. |
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US20090075307 |
METHODS FOR IDENTIFYING PATIENTS WITH AN INCREASED LIKELIHOOD OF HAVING OVARIAN CANCER AND COMPOSITIONS THEREFOR
Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of... |
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US20090062133 |
Expression analysis of FKBP54 in the diagnosis and treatment of prostate cancer
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating prostate cancer. FKBP markers are provided, wherein changes in the levels of... |
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US20080213910 |
METHOD FOR BLOCKING NON-SPECIFIC PROTEIN BINDING ON A FUNCTIONALIZED SURFACE
A method of blocking non-specific protein binding on surfaces, such as protein-coated biosensor surfaces. |
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US20080107668 |
CYTOTOXIC T-LYMPHOCYTE-INDUCING IMMUNOGENS FOR PREVENTION, TREATMENT, AND DIAGNOSIS OF CANCER
The present invention relates to compositions and methods for the prevention, treatment, and diagnosis of cancer, especially carcinomas, such as breast carcinoma. The invention discloses peptides,... |
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US20080015194 |
METHODS AND COMPOSITIONS OF TARGETED DRUG DEVELOPMENT
The present invention is directed to methods for developing one or more drugs for one or more targeted therapies and compositions derived therefrom. In accordance with one aspect of the present... |
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US20080004186 |
Systematic evaluation of sequence and activity relationships using site evaluation libraries for engineering multiple properties
The present invention provides methods for protein engineering. Specifically, the invention provides methods utilizing site evaluation libraries to design libraries that optimize two or more... |
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US20060275910 |
Misfolded protein sensor method in body fluids
A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal... |
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US20060240562 |
CLEAVABLE SURFACTANTS AND METHODS OF USE THEREOF
Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins. |
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US20060134677 |
Methods for drug discovery, disease treatment, and diagnosis using metabolomics
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources,... |
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US20160033511 |
METHODS AND COMPOSITIONS FOR DETECTING PANCREATIC CANCER
The present invention relates to non-invasive methods for the diagnosis and prognosis of pancreatic cancer. In some embodiments, such methods and compositions relate to particular pancreatic... |
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US20150323545 |
SELECTED REACTION MONITORING ASSAYS
Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays. |
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US20130108549 |
PEPTIDE PROBES FOR DIAGNOSTICS AND THERAPEUTICS
Disclosed are agents and methods that may be used to diagnose and treat a variety of diseases associated with conformationally-altered proteins. The agents and methods may be used to identify and... |
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US20120164628 |
AFFINITY CAPTURE OF CIRCULATING BIOMARKERS
Methods, devices and systems for capturing biomarkers are provided. In particular, methods, compositions, and systems that utilize affinity capture devices comprising a processing chamber,... |
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US20110118140 |
METHODS FOR IDENTIFICATION, AND COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inhibiting extra-cellular matrix degradation, including joint degenerative inhibiting and/or... |
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US20110065136 |
Methods and Devices for Detecting Glomerulonephritis and Associated Disorders
Methods and devices for diagnosing, monitoring, or determining glomerulonephritis or an associated disorder in a mammal are described. In particular, methods and devices for diagnosing,... |
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US20110064747 |
METHODS FOR TREATMENT OF A SARCOMA USING AN EPIMETABOLIC SHIFTER (COENZYME Q10)
Methods and formulations for treating a sarcoma in humans using an epimetabolic shifter, such as Coenzyme Q10, a building block of CoQ10, a derivative of CoQ10, an analog of CoQ10, a metabolite of... |
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US20100190843 |
Tubulin Isotype Screening in Cancer Therapy Using Halichondrin B Analogs
Chemotherapeutic agents that interfere with microtubule assembly or disassembly in the cell are potent inhibitors of cell replication. Examples of such agents include halichondrin B analogs. It... |
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US20100098627 |
PROTEINS
The present invention provides methods and compositions for treatment, prevention, diagnosis and monitoring of colorectal cancer, kidney cancer, lung cancer and/or pancreatic cancer in particular... |
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US20100075894 |
REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES
Endoplasmic reticulum stress has been found to be associated with obesity. Therefore, agents that reduce or prevent ER stress may be used to treat diseases associated with obesity including... |