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US20140186494 Pregastric Esterase and Derivatives Thereof  
The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in...
US20110311679 PREGASTRIC ESTERASE AND DERIVATIVES THEREOF  
The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in...
US20130115239 PROSTATE CANCER DNA VACCINE  
The present invention concerns an (adjuvant) treatment or prevention option for the treatment and prevention of prostate cancer. In particular, it pertains to the provision of recombinant,...
US20150166985 METHODS FOR CORRECTING VON WILLEBRAND FACTOR POINT MUTATIONS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a...
US20120114776 METHODS FOR PREPARING PROBIOTIC NANOPARTICLES  
Various embodiments of the present invention are directed toward a method for preparing probiotic nanoparticles from natural sources, comprising performing a biological preparation phase such as...
US20110081374 RECOMBINANT AVIAN PARAMYXOVIRUS VACCINE AND METHOD FOR MAKING AND USING THEREOF  
The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods...
US20150166983 METHODS FOR CORRECTING PRESENILIN POINT MUTATIONS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a...
US20150166982 METHODS FOR CORRECTING PI3K POINT MUTATIONS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a...
US20150031077 CONVERSION SYSTEMS FOR BIOMASS  
The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with...
US20140364489 Pharmaceutical Composition Producing antioxidant, antimicrobal, antitoxic protein - human lactoferrin, production process and therapeutic method.  
The pharmaceutical composition producing the antioxidant, antimicrobal, antitoxic protein—human lactoferrin in which the therapeutic effect is achieved as a result of the antioxidant,...
US20140073006 METHODS USING A PROGRESSIVE CAVITY PUMP BIOREACTOR  
Methods of using a progressive cavity pump as a bioreactor are disclosed. Methods of isolating a biological product, such as pancreatic islet cells, using the bioreactor are also disclosed.
US20110104693 QUANTITATIVE NUCLEASE PROTECTION SEQUENCING (qNPS)  
The present invention provides a new approach, quantitative Nuclease Protection Sequencing (qNPS™), for addressing several challenges that face sequencing and which provides improvements for...
US20110142843 FETAL POLYPEPTIDES FROM HUMAN LIVER  
Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are...
US20150166984 METHODS FOR CORRECTING ALPHA-ANTITRYPSIN POINT MUTATIONS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a...
US20110142879 INFECTIOUS CLONES  
Methods of preparing a DNA comprising sequences derived from the genomic RNA (gRNA) of a coronavirus are provided, comprising cloning under the expression of a promoter a coronavirus interfering...
US20150045537 EXTRACELLULAR RELEASE OF LIPIDS BY PHOTOSYNTHETIC CELLS  
The invention relates to methods for harvesting macromolecules such as lipids and proteins by culturing in growth medium a photo synthetic cyanobacteria that secretes vesicles into the growth...
US20110277046 HYDROLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
US20110070609 Production of Foreign Nucleic Acids and Polypeptides in Sprout Systems  
The present invention provides systems and methods for producing a nucleic acid or protein in transgenic sprouted seedlings or sprouted seedlings engineered to transiently express a nucleic acid...
US20110039916 Helper Virus-Free Herpesvirus Amplicon Particles and Uses Thereof  
The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases...
US20140371088 MULTIPLEXABLE TAG-BASED REPORTER SYSTEM  
The present invention relates to compositions and methods for the detection and quantification of individual target molecules in biomolecular samples. In particular, the invention relates to...
US20090317873 Design, synthesis and assembly of synthetic nucleic acids  
Methods of synthesizing oligonucleotides with high coupling efficiency (>99.5%) are provided. Methods for purification of synthetic oligonucleotides are also provided. Instrumentation...
US20120100179 USE OF MICRORNAS TO CONTROL VIRUS HELPER NUCLEIC ACIDS  
Provided herein are helper nucleic acids comprising at least one microRNA target sequence of an endogenous, cellular microRNA and a nucleic acid encoding a viral protein, wherein the microRNA...
US20110129461 Mat II Beta Subunit RNAi and Therapeutic Methods Using Same  
The presently disclosed subject matter generally relates to methods and compositions for modulating MAT II activity. More particularly, the presently disclosed subject matter relates to methods...
US20100298419 ANTIBIOTIC-FREE PLASMID  
The present invention provides a method of maintaining a gram negative bacterium plasmid without the use of antibiotic selection pressure. Further, the invention relates to the drugless plasmids...
US20110119777 USE OF AAV REPLICATION MACHINERY FOR IMPROVED PROTEIN PRODUCTION  
The present invention provides a method for enhanced production of a gene product of interest in a cell, using the AAV replication machinery. The present invention further relates to a cell for...
US20120270271 Toxin-Immunity System  
The present invention provides host cells whose survivability can be conditionally controlled, and vectors that can be used for preparing such host cells and for selectable cloning.
US20140109260 In vivo Assembly of Transcription Units  
Methods of providing gene suppression DNA in a eukaryotic organism comprising introducing a first DNA segment and at least one second DNA segment into the genome of the organism. One of the DNA...
US20110262966 DNA REPLICON SYSTEM FOR HIGH-LEVEL RAPID PRODUCTION OF VACCINES AND MONOCLONAL ANTIBODY THERAPEUTICS IN PLANTS  
Plant viral vectors have great potential in rapid production of proteins, but no simple. Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes,...
US20120301499 Packaging of Immunostimulatory Substances into Virus-Like Particles: Method of Preparation and Use  
The invention relates to the finding that virus like particles (VLPs) can be loaded with immunostimulatory substances, in particular with DNA oligonucleotides containing non-methylated C and G...
US20140234908 USE OF NON-SUBTYPE B GAG PROTEINS FOR LENTIVIRAL PACKAGING  
The invention encompasses a lentiviral packaging vector comprising a non-subtype B gag-pol sequence, particularly a subtype D gag-pol sequence. The invention further encompasses methods for making...
US20140212928 METHODS AND COMPOSITIONS FOR TARGETED SINGLE-STRANDED CLEAVAGE AND TARGETED INTEGRATION  
Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
US20140193856 CONTROL OF GENE EXPRESSION  
The present invention relates generally to a method of modifying gene expression and to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic...
US20120142049 Recombinant Gene Expression  
Genes are expressed by culturing cells comprising a host chromosome comprising an integrated artificial chromosome comprising recombinant genes, under conditions whereby each recombinant gene is...
US20130266988 METHOD FOR GENE AMPLIFICATION  
The present invention provides a double-stranded DNA constructed specifically for high speed gene amplification, a method for gene amplification and a method for synthesizing protein. The gene...
US20150166981 METHODS FOR NUCLEIC ACID EDITING  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the...
US20150176002 Human Lambda Light Chain Mice  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20130323790 HUMAN LAMBDA LIGHT CHAIN MICE  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20120070861 Human Lambda Light Chain Mice  
Genetically modified mice are provided that express human λ variable (hVλ) sequences, including mice that express hVλ sequences from an endogenous mouse λ light chain locus, mice that express hVλ...
US20150184213 ENGINEERING DNA ASSEMBLY IN VIVO AND METHODS OF MAKING AND USING THE REVERSE TRANSCRIPTASE TECHNOLOGY  
Cells that can synthesize oligonucleotides in vivo to produce a nucleic acid nanostructure are described. Methods for producing oligonucleotide nanostructures for use in regulating gene expression...
US20150225728 CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE  
The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific...
US20110045468 Polynucleotides for the identification and quantification of group a streptococcus nucleic acids  
The present invention provides polynucleotides that can specifically hybridize to Group A Streptococcus (GAS) nucleic acids from all genotypes. These polynucleotides can be used in...
US20120183512 TCTEX-1 REGULATORY SEQUENCE AS STEM CELL MARKER  
The disclosure relates to an isolated regulatory sequence for Tctex-1 that is transcriptionally active in adult neural progenitor and stem cells, including Type 1, Type 2 and Type 3 progenitors,...
US20120192301 METHODS AND COMPOSITIONS FOR GENE CORRECTION  
Disclosed herein are methods and compositions for correction and/or mutation of genes associated with Parkinson's Disease as well as clones and animals derived therefrom.
US20120040406 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY  
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
US20120040405 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY  
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
US20090275087 ASYMMETRIC ADAPTER LIBRARY CONSTRUCTION  
The present invention provides methods and compositions for asymmetrically tagging a nucleic acid fragment using asymmetric adapters.
US20120156728 CLONAL AMPLIFICATION OF NUCLEIC ACID ON SOLID SURFACE WITH TEMPLATE WALKING  
Novel methods of generating a localized population of immobilized clonal amplicons on a support are provided.
US20110135607 VIRAL NUCLEIC ACID FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS  
This invention relates to a non-coding RNA (ncRNA) sequence from Human cytomegalovirus (HCMV) (termed “TRL4”) that specifically protects neuronal cells from cell death and may therefore be useful...
US20130122549 RECOMBINANT PHAGE AND METHODS  
This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage genome is engineered to comprise a...
US20120079613 Homeobox Transcription Factor BSX and Uses Thereof for Treating Diseases, in Particular Obesity  
The present invention relates to the human homeobox transcription factor Bsx protein, nucleic acids encoding for said protein, vectors and cells comprising the nucleic acids, antibodies directed...

Matches 1 - 50 out of 437 1 2 3 4 5 6 7 8 9 >