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US20140051101 Luciferase Reporter System for Roots and Methods of Using the Same  
The present invention relates to a systems and methods of using expression of one or two luminescent proteins in a plant root cell to visualize plant root structure as well as to determine how...
US20120135435 Methods for Identifying Factors That Control the Folding of Amyloid Proteins of Diverse Origin  
The present invention provides a yeast cell based system for determining factors that control the folding of amyloid proteins of diverse origins. Further the present invention provides methods of...
US20120214677 LUCIFERASE BIOSENSOR  
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
US20140234852 HUMAN KERATINOCYTES PTCH1 CELL LINE  
A cellular model is described for targeting dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular...
US20130337461 METHOD FOR DIAGNOSIS, MONITORING THE EFFICACY OF A THERAPY AND FOR DEVELOPMENT OF TREATMENT FOR MULTIPLE SCLEROSIS  
The present invention relates to a method for diagnosis and/or prognosis of multiple sclerosis or to monitor the efficacy of a therapy and/or to screen for a treatment for multiple sclerosis...
US20120311744 Marked Cannabis For Indicating Medical Marijuana  
The invention involves transforming Cannabis with a transgene(s) or chemical(s) expressing biological, chemical, luminescent, and fluorescent markers from the UV, visible, near, mid, and far...
US20120165265 Calcium Signaling Modulators Involving STIM and ORAI Proteins  
The present invention provides compositions and methods for investigating the structural basis of the activation process of CRAC channels, which are essential for T-lymphocyte activation and...
US20140162289 IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS  
Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.
US20120115723 Ballast Water Treatment System  
A composition for treating waters, e.g. ballast water or injection water for oil recovery, to kill in-situ aquatic invasive species comprises at least one biocide capable of killing both animal...
US20120252818 HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME  
The present subject matter relates to a compound represented by the general formula (I) or (I′) or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one...
US20140170239 METHODS FOR SCREENING INHIBITORS OF TUMOR ASSOCIATED PROTEIN AGGREGATION  
The disclosure relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt...
US20150167051 METHODS AND SYSTEMS FOR MONITORING BIOFILM GROWTH  
Systems and methods for monitoring biofilm growth are provided. A method comprises supporting at least one coupon in a water reservoir, wherein the water reservoir feeds water into a tower...
US20150010932 METHODS FOR ASSAYING PROTEIN-PROTEIN INTERACTIONS  
Provided herein is an assay for interrogating transient and dynamic protein-protein interactions and for screening and characterizing agents as agonists or antagonists of protein-protein...
US20130244899 DETECTING INFECTION IN REDUCED PRESSURE WOUND TREATMENT  
Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site....
US20140378536 TRANSCRIPTIONAL REPRESSION LEADING TO PARKINSON'S DISEASE  
Parkinson's disease is caused by the preferential loss of substantia nigra dopamine neurons. A Parkin Interacting Substrate, PARIS (ZNF746) is identified. The levels of PARIS are regulated by the...
US20140296292 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR  
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments...
US20150258151 GUT BARRIER DYSFUNCTION TREATMENT AND PREVENTION  
Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with gut barrier dysfunction in a subject comprising administering to the subject bacterium that...
US20130071866 METHOD FOR TESTING THE SEVERTIY OF AN ILLNESS  
An object of the present invention is directed to a method for assaying the severity of an illness in real time and is to provide a testing method capable of assessing the severity of an illness...
US20140087402 Synthetic luciferase gene and protein  
A codon optimized and stabilized luciferase gene and a novel recombinant DNA characterized by incorporating this new gene coding for a novel luciferase into a vector DNA for improved activities in...
US20130273554 BIOLUMINESCENT PACKAGING  
Some embodiments provided herein relate to bioluminescent packaging, methods of making, and methods of sensing the state of a material, in some embodiments, light emitted by a bioluminescent...
US20110191873 Methods of Protein Destabilization and Uses Thereof  
This invention is directed towards methods of destabilizing proteins in living cells, and their use for the development of novel assays. In one embodiment, the invention comprises the use of...
US20120065101 METHODS FOR REGULATING NEURAL DIFFERENTIATION  
Methods of producing populations of predominantly astrocytes, neurons or oligodendrocytes are provided. In addition, methods of treating mammals having astroglial tumors, oligodendrocyte tumors,...
US20110287439 CLASTOGENICITY TESTING  
The present invention relates to improved methods for detecting agents that cause or potentiate DNA damage and to genetically transformed cells that may be usefully employed in such methods.
US20110275101 METHOD FOR USING DIVISION ARRESTED CELLS IN SCREENING ASSAYS  
Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal...
US20140030740 Rapid Bioluminescence Detection System  
An assay is provided for detecting the activity of a reporter kinase comprising (i) adding said reporter kinase to an assay mixture wherein said reporter kinase is contacted with bioluminescent...
US20140093894 COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H  
The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox...
US20130130289 COMPOUNDS AND METHODS FOR ASSAYING REDOX STATE OF METABOLICALLY ACTIVE CELLS AND METHODS FOR MEASURING NAD(P)/NAD(P)H  
The present invention provides compounds and methods for assaying redox state of metabolically active cells and methods for assaying enzyme activity and/or metabolite level by coupling to redox...
US20130040326 FIREFLY LUCIFERASE  
According to one embodiment, the present invention relates to luciferase derived from Malaysian Luciola firefly, the luciferase having a maximum luminescent wavelength of 580 nm at pH 8, or the...
US20120028837 RAPID SCREEN FOR REPRODUCTIVE TOXICANTS  
Disclosed herein are methods to assess the biological safety of an agent. The method involves contacting one or more test agents to a culture of C. elegans and analyzing the culture for meiotic...
US20110111392 INTEGRATED ENHANCED CHEMILUMINESCENCE BIOSENSORS  
A method and apparatus for determining the concentration of an analyte in a sample is provided. This method involves combining enhanced chemiluminescence with microchip capillary electrophoresis...
US20110189655 REAGENTS AND KITS FOR DETECTION OF INFLUENZA VIRUS AND THE LIKE  
The present invention relates to reagents and methods for influenza virus detection. These reagents and methods disclosed in the present invention enable simple, rapid, specific and sensitive...
US20110306521 SEPARATION OF PYROPHOSPHATE RELEASE AND PYROPHOSPHATE DETECTION  
The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed...
US20120034635 METHOD FOR AMPLIFYING ADENOSINE TRIPHOSPHATE AND METHOD AND REAGENT FOR DETECTING THE CONCENTRATION OF MICROORGANISMS  
A method for amplifying adenosine triphosphate is provided, including mixing adenosine triphosphate sulfurylase, adenosine 5′ phosphosulfate, adenylate kinase, uridine triphosphate, acetate...
US20150017663 IDENTIFICATION OF ANTITUMOR COMPOUNDS USING PLACENTA  
Provided herein are methods of evaluating potential antitumor compounds, and thereby identifying antitumor compounds, using placenta or a portion thereof and tumor cells, and compositions for...
US20120164124 PHAGE-ASSOCIATED LYTIC ENZYMES FOR TREATMENT OF BACILLUS ANTHRACIS AND RELATED CONDITIONS  
The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The...
US20150241448 LANTHIONINE SYNTHETASE COMPONENT C-LIKE PROTEINS AS MOLECULAR TARGETS FOR PREVENTING AND TREATING DISEASES AND DISORDERS  
The present invention relates to the field of medical treatments for diseases and disorders. More specifically, the present invention relates to the use of the lanthionine synthetase component...
US20140273037 COMPOSITIONS AND METHODS DIRECTED TO CRISPR/CAS GENOMIC ENGINEERING SYSTEMS  
The invention relates to engineered CRISPR/Cas9 systems for genomic modification in mammalian cells. The present specification describes the design and testing of a polynucleotide encoding the...
US20110003300 RAPID STERILITY MICROASSAY  
The present invention relates to a method for detecting a viable microorganism in a pharmaceutical composition comprising the steps of providing a filterable pharmaceutical composition; filtering...
US20090326416 DETECTING INFECTION IN REDUCED PRESSURE WOUND TREATMENT  
Provided is a method of detecting infection in a wound caused by an infecting organism at a wound site. Also provided is a system for detecting an infection in a wound at a wound site....
US20110065116 Method for Detecting ATP  
Methods are provided for detection of concentrations of less than 3.4 picomolar of adenosine triphosphate (ATP) using recombinant luciferase in the luciferin-luciferase reaction. Aspects include a...
US20130095509 ENGINEERED LIGHT-EMITTING REPORTER GENES  
Compositions and methods are provided for enhanced expression of light emitting reporters. Such reporters are used in methods for monitoring cultures for production of target compounds.
US20110144043 Stat modulators  
The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for...
US20110065128 Methods for Assessing CDK5 Activation and Function  
As described herein, signaling events occurring in neurons or at neuronal synapses have been identified that involve Cdk5 and various other molecules which bind to, are activated by, and/or...
US20130017250 Methods For High Density Lipoprotein Cholesterol Regulation  
It was discovered that insulin binding to insulin receptors signals the upregulation of expression of the liver enzyme deiodinase 1 (Dio1), which in turn activates the ApoA-1 promoter, thereby...
US20110301095 METHODS AND COMPOSITIONS FOR ASSESSING AND TREATING METASTASIS, METASTATIC CANCER, AND POTENTIAL FOR METASTASIS  
Disclosed are methods, compounds, and compositions for detection, diagnosis, prognosis, monitoring, treatment, monitoring treatment, and selecting treatment of cancer and metastasis, and for...
US20120252042 Artificial Feces  
A composition to simulate feces. A method of using artificial feces to evaluate the efficacy of a cleaning product and/or cleaning procedure. A method of demonstrating the cleaning efficiency of a...
US20150126438 Novel ChREBP Isoforms and Methods Using the Same  
The invention provides diagnostic and prognostic methods and methods of evaluating treatment protocols for disorders such as obesity, diabetes, metabolic syndrome, cancer and vascular disease by...
US20130078658 METHOD OF QUANTIFYING RECOVERY RATE OF EXOSOME  
A recombinant exosome comprising a fusion protein of a membrane protein and light-emitting protein, and a method of determining an exosome recovery rate by using the recombinant exosome are...
US20150104787 Non-Replicative Transduction Particles and Transduction Particle-Based Reporter Systems  
Methods and systems are provided for packaging reporter nucleic acid molecules into non-replicative transduction particles for use as reporter molecules. The non-replicative transduction particles...
US20140212895 Cancer Analysis System  
The invention provides for detecting target subpopulations of cells that have high proliferative and renewal properties in animals, including circulating tumor cells, cancer stem cells,...

Matches 1 - 50 out of 424 1 2 3 4 5 6 7 8 9 >