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US20120028879 |
HIGHLY SENSITIVE DETECTION METHOD FOR HIGHLY VIRULENT ORAL CAVITY BACTERIA
Provided is a method that involves the detection of protein antigen (PA) and/or collagen-binding protein (CBP) of oral cavity bacteria in a sample, and in which oral cavity bacteria that... |
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US20130084581 |
Method of Identifying Transmembrane Protein-Interacting Compounds
A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins... |
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US20100331192 |
SURFACE DISPLAY OF RECOMBINANT PROTEINS IN LOWER EUKARYOTES
Methods for display of recombinant proteins or protein libraries on the surface of lower eukaryotes such as yeast and filamentous fungi are described. The methods are useful for screening... |
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US20110165597 |
METHOD FOR THE SCREENING OF CONSERVED SECRETED PROTEINS
Conserved polypeptides from protozoan parasitic species which are secreted through the endoplasmic reticulum/Golgi dependent secretory pathway, their identification and their use. |
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US20110065661 |
PHARMACOPERONES FOR CORRECTING DISEASE STATES INVOLVING PROTEIN MISFOLDING
This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are... |
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US20110160081 |
FUNCTIONAL COMPLEMENTATION ASSAY FOR DEFINED GPCR OLIGOMERS
The present invention is directed to, inter alia, a biological reagent that includes a complex having a first GPCR and a second GPCR linked to a G-protein, the linkage between the second GPCR and... |
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US20140106378 |
METHODS FOR DIAGNOSIS AND PROGNOSIS OF EPITHELIAL CANCERS
The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial... |
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US20110195431 |
HUMAN ORPHAN G PROTEIN-COUPLED RECEPTORS
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors. |
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US20140302523 |
Small-Molecule Hydrophobic Tagging of Fusion Proteins and Induced Degradation of Same
The present invention includes compounds that are useful in perturbing or disrupting the function of a transmembrane or intracellular protein, whereby binding of a compound to the transmembrane or... |
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US20120270230 |
MUTANT G-PROTEIN COUPLED RECEPTORS AND METHODS FOR SELECTING THEM
The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein... |
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US20130078644 |
Post-Translational Modifications Identified by Elemental Analysis
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate... |
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US20140147856 |
Intestinal Permeability Assay for Neurodegenerative Diseases
A method of identifying a subject at risk of developing or having a neurodegenerative disorder is provided. The method includes obtaining a biological sample from the subject and assaying a level... |
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US20100333239 |
METHODS USING ACYL-COA BINDING PROTEINS TO ENHANCE LOW-TEMPERATURE TOLERANCE IN GENETICALLY MODIFIED PLANTS
ACBP6 can be used to enhance low temperature tolerance in genetically modified plants. An acbp6 T-DNA insertional mutant that lacked ACBP6 mRNA and protein, displayed increased sensitivity to... |
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US20140113309 |
METHOD AND APPARATUS FOR ANALYZING PROTEIN-PROTEIN INTERACTION ON SINGLE-MOLECULE LEVEL WITHIN THE CELLULAR ENVIRONMENT
A method of analyzing protein-protein interactions includes binding the first proteins to the substrate where the first proteins are tagged with the first markers which bind specifically to the... |
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US20140221241 |
Mass Dots: Nanoparticle Isotope Tags
Compositions and methods are provided for the use of nanoparticles, which may be referred to herein as mass dots, as mass tags for probes such as antibodies, aptamers, nucleic acids, etc. in... |
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US20140068794 |
R2R1/2 In Diagnosis and Therapy
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered... |
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US20120276558 |
KITS FOR MULTIPARAMETRIC PHOSPHO ANALYSIS
As disclosed herein, the present invention provides for kits and a composition for diagnosis, prognosis, drug discovery, drug development, and patient stratification. The kits can comprise a... |
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US20140221325 |
GLOMERULONEPHRITIS BIOMARKERS
The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment... |
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US20110165144 |
METHODS FOR TREATING RHEUMATOID ARTHRITIS
Provided are methods of treating rheumatoid arthritis by inhibiting Neuromedin U signalling. |
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US20130011409 |
Compositions, Kits, and Methods for the Diagnosis, Prognosis, Monitoring, Treatment and Modulation of Post-Transplant Lymphoproliferative Disorders and Hypoxia Associated Angiogenesis Disorders Using Galectin-1
The present invention is based, in part, on the discovery that galectin-1 (Gal1) plays a role in viral-associated PTLD, e.g., EBV-associated PTLD and hypoxia associated angiogenesis disorders.... |
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US20150064713 |
METHODS, KITS AND MEANS FOR DETERMINING INTRACELLULAR INTERACTIONS
Methods, kits and systems for determining whether a reaction occurs between a chimeric transmembrane receptor and an intracellular interaction partner thereof within a cell. |
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US20120159664 |
Transgenic Plants With Enhanced Agronomic Traits
This invention provides recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. Also provided by this invention is... |
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US20110182881 |
SIGNATURE AND DETERMINANTS ASSOCIATED WITH METASTASIS AND METHODS OF USE THEREOF
The present invention provides methods of detecting cancer using biomarkers. |
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US20110104261 |
REMOTE DETECTION OF SUBSTANCE DELIVERY TO CELLS
The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability... |
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US20120227134 |
Plants with Increased Yield
A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or... |
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US20110053139 |
Detection of bioagents using a shear horizontal surface acoustic wave biosensor
Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge... |
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US20110112177 |
Human G-Protein Coupled Receptor (HETGQ23)
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were... |
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US20110028383 |
Activated Forms Of Notch And Methods Based Thereon
The present invention is directed to methods for detecting or measuring Notch activation by observing or measuring the appearance of Notch on the cell surface or by observing or measuring Notch... |
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US20130172205 |
MARKERS OF ACUTE KIDNEY FAILURE
The present invention relates to the method of determining the risk of acute kidney injury comprising determining the amount of a marker selected from VCAN, NRP1, CCL2, CCL19, COL3A1, GZMM or any... |
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US20100279318 |
METHOD OF IDENTIFYING TRANSMEMBRANE PROTEIN-INTERACTING COMPOUNDS
A method for screening compounds for their ability to interact with transmembrane proteins is provided. Also provided is a method for determining whether proteins such as transmembrane proteins... |
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US20130316366 |
EXPRESSION OF SECRETED AND CELL-SURFACE POLYPEPTIDES
Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide... |
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US20120164666 |
Glycoprotein Vesicles and Their Methods of Use
Provided are methods of collecting, detecting and altering cells and molecular entities using glycoprotein micelles and vesicles. Glycoprotein vesicles comprising a glycoprotein micelle, at least... |
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US20100173788 |
BIOMARKERS FOR BREAST CANCER
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention... |
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US20120003628 |
Methods for Diagnosing Pervasive Development Disorders, Dysautonomia and Other Neurological Conditions
Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death... |
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US20110165087 |
TARGETED DELIVERY OF IMAGING PROBES FOR IN VIVO CELLULAR IMAGING
The present invention relates to nitroxide imaging probes that are isotopically modified or unmodified. Such nitroxide imaging probes may be included in liposomes that encapsulate self-quenching... |
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US20110010780 |
KCNN3 AS DIAGNOSTIC AND THERAPEUTIC TARGET FOR NEURODEGENERATIVE DISEASES
The present invention discloses a dysregulation of the KCNN3 gene and the protein products thereof in Alzheimer's disease patients and individuals being at risk of developing Alzheimer's disease.... |
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US20130035258 |
LUMINESCENT TETRAPODS DOTS AND VARIOUS APPLICATIONS
A tetrapod article and its uses are disclosed whereby such tetrapod article comprises an apex base nanomaterial and X leg base nanomaterial protruding from the apex, wherein X is an integer. In an... |
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US20120184485 |
USES OF CYSTATIN
The present invention relates to uses of cystatins derived from nematodes and to a method of screening using such cystatin. The present invention also relates to methods of treatment and/or... |
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US20110003306 |
IDENTIFICATION OF ANTIBIOTIC RESISTANCE USING LABELLED ANTIBIOTICS
Subject of the present invention is a method for detection of an antibiotic resistance in a micro-organism comprising the steps of exposing suspected micro-organism to a labelled (fluorescent)... |
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US20130095490 |
COMPOSITION FOR DIAGNOSIS OF LUNG CANCER AND DIAGNOSIS KIT OF LUNG CANCER
Disclosed is as a biomarker useful in early diagnosis of lung cancer, at least one protein selected from the group including Quescin-sulfhydryl oxidase 1, Fibrillin-1, Isoform A of Lamin-A/C,... |
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US20150010903 |
Real Time Diagnostic Assays Using an Evanescence Biosensor
The present invention relates to a method for the detection of a substance in an aqueous, physiological or chemical liquid using the evanescence field method, and to a diagnostic device for... |
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US20130052657 |
MEASUREMENT METHOD FOR PHYSIOLOGICALLY ACTIVE SUBSTANCE OF BIOLOGICAL ORIGIN, AND REAGENT KIT FOR MEASUREMENT
Disclosed is a technique which simplifies the adjustment of a reagent which makes the proteins contained in limulus amoebocyte lysate (LAL) attach to the surface of microparticles dispersed in a... |
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US20130330278 |
MULTICOLORED pH-ACTIVATABLE FLUORESCENCE NANOPLATFORM
The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not... |
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US20140057948 |
VIF AS A TARGET FOR HIV INHIBITION
The present invention relates, e.g., to a method for inhibiting infectivity of a lentivirus (e.g., a lentivirus which expresses a Viral infectivity factor (Vif) protein), such as, e.g., SIV, SHIV... |
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US20130040850 |
SEROLOGY ASSAYS
The invention provides methods and kits for measuring the ability of a test sample to inhibit the binding of a receptor expressed by a pathogen to a host cell ligand of the pathogen. |
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US20100183578 |
NITROPROTEIN BIOMARKERS FOR COPD
Specific nitroprotein biomarkers may be used as prognostic and diagnostic tools for COPD. Identification of certain specific nitroprotein biomarkers allows the development of targeted therapies... |
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US20110177085 |
Bitter Taste Receptors
The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or... |
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US20120115130 |
METHOD FOR DETECTING TARGET CELL
A target cell detection method includes performing a test measurement on a dispersion to obtain a measurement result 1, the test measurement being an optical or electromagnetic measurement, and... |
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US20150132775 |
METHOD AND DEVICE FOR DETERMINING CONCENTRATION, CROSSTALK AND DISPLACEMENT FLUORESCENCE CROSS CORRELATION SPECTROSCOPY
The present invention provides a FCCS method for determining the concentration and/or the diffusion coefficient of at least a first labeled species, a second labeled species and/or a complex... |
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US20110236884 |
MICROBUBBLES FOR AFFINITY SEPARATION
The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule.... |