Match Document Document Title
US20130224798 Methods of Making Hemagglutinin Proteins  
Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a...
US20110086059 NON-HEMOLYTIC CLYA FOR EXCRETION OF PROTEINS  
The disclosure below provides a protein export system utilizing non-hemolytic variants of HlyE family member proteins for efficiently producing recombinant protein from a host cell. In a preferred...
US20150133379 COSMETIC COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING FUSION PROTEIN  
The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a...
US20120315671 EXPRESSION MEDIA FOR PROTEINS IN YEAST SYSTEM  
The subject invention provides advantageous new media formulations, methods for their production, methods for cultivating cells using the media as well as compositions thereof and their use for...
US20140255361 ESTROGEN-RECEPTOR BASED LIGAND SYSTEM FOR REGULATING PROTEIN STABILITY  
Disclosed herein are systems, methods and compositions for rapidly and reversibly destabilizing a target protein in vitro or in vivo, in the presence or absence of a cell-permeable, synthetic...
US20150210751 Method and Composition for Crystallizing G Protein-Coupled Receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20140194595 Method and Composition for Crystallizing G Protein-Coupled Receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20110009603 Method and composition for crystallizing G protein-coupled receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20110027267 Fusion Proteins of Mannose Binding Lectins for Treatment of Disease  
Fusion proteins having sequences that target specific moieties such as carbohydrates, lipids, and/or proteins that are associated with certain cell types and/or pathogens; and a sequence that...
US20140179612 Transferrin-Tumstatin Fusion Protein and Methods For Producing and Using the Same  
The present invention provides recombinant proteins comprising transferrin that is linked to tumstatin or other antiangiogenic protein and methods for producing and using the same. The present...
US20100303849 Lipidated Vaccine against Dengue Virus Infection  
Disclosed are immunogenic composition, fusion proteins, and related methods for inducing immune response to dengue virus infection.
US20140249295 LIGHT-INDUCIBLE SYSTEM FOR REGULATING PROTEIN STABILITY  
Disclosed herein are a light-inducible system and method for rapidly and reversibly modulating protein stability and function. This system and method employs conditionally stable protein domains...
US20120184714 COST-EFFECTIVE METHOD FOR EXPRESSION AND PURIFICATION OF RECOMBINANT PROTEINS IN PLANTS  
Downstream purification of recombinant proteins from plant-based samples is performed by elastin-like polypeptides (ELP)-intein fusion expression and purification through inverse phase transition...
US20140235823 FUSION PROTEIN CONTAINING A SINGLE-STRANDED DNA BINDING PROTEIN AND METHODS FOR EXPRESSION AND PURIFICATION OF THE SAME  
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification...
US20110237777 FUSION PROTEIN CONTAINING A SINGLE-STRANDED DNA BINDING PROTEIN AND METHODS FOR EXPRESSION AND PURIFICATION OF THE SAME  
The present invention provides an expression vector comprising a promoter and a polynucleotide sequence encoding a fusion protein. The present invention further provides a method for purification...
US20110294983 SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS  
The present invention relates to single-chain proteins of the formula HRS1-L1-HRS2-L2-HRS3, wherein HRS1, HRS2 and HRS3 are heptad repeat sequences and L1 and L2 are structurally flexible linker...
US20130324701 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20120301921 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20110281302 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20120196803 FUSION PROTEINS FOR DELIVERY OF GDNF AND BDNF TO THE CENTRAL NERVOUS SYSTEM  
The present invention relates to a compound that includes a peptide vector, such as angiopep-2 which acts as a carrier across the blood-brain barrier, linked to glial-derived neurotrophic factor...
US20120219992 METHOD AND COMPOSITION FOR CRYSTALLIZING A FAMILY C GPCR  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled...
US20150030593 COMPOSITIONS OF PENETRATION-ENHANCED TARGETING PROTEINS AND METHODS OF USE  
The disclosure relates to penetration-enhanced targeted proteins and their uses for therapeutics delivery.
US20130203101 METHOD AND SYSTEM FOR PURIFYING AND QUANTITATING PROTEINS USING HEME FUSION TAGS  
A method is provided for purifying a protein comprising the steps of providing a heme tag with an open coordination site and tagging the recombinant protein of interest with the heme tag. A resin...
US20130203959 NONNATURAL COLLAGEN-LIKE PROTEIN AND USE THEREOF  
This present invention relates to compositions comprising biological active proteins fused with extended recombinant gelatin-like protein (GLK), nucleic acids encoding the compositions and vectors...
US20140112896 METHODS AND COMPOSITIONS FOR THE PROVISION OF PROTEINS DEFICIENT IN LYSOSOMAL STORAGE DISEASES  
Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for the...
US20120065106 Methods and Compositions for Enhanced Protein Expression and Purification  
Methods for enhancing expression levels, secretion, and purification of heterologous fusion proteins in a host cell are disclosed.
US20140315804 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF  
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral...
US20110033891 MUSSEL BIOADHESIVE  
The present invention relates to a bioadhesive derived from mussel. In particular, it relates to a novel Mytilus galloprovincialis foot protein type 5 (MGFP-5) and a recombinant protein that is a...
US20130326727 Modified Protein Body Tags and Production Methods Thereof  
The present invention belongs to genetic engineering technical field and discloses modified protein body tags, a system for evaluating the efficacy of the modified polypeptides, and methods for...
US20130034877 METHOD FOR INCREASING THERMAL STABILITY AND RETAINING ACTIVITY OF A PROTEIN  
The present invention provides a method and a system for increasing thermal stability of a starch binding protein (SBP)-tagged recombinant protein. The present invention also provides a method for...
US20110151514 Vectors, Methods, Systems and Kits for Protein Purification  
Disclosed herein are autocleaved peptide linkers for producing purified proteins. The autocleaved peptide linkers are inserted between a chitin binding protein (CBP) and a target protein to form a...
US20100305040 PRODUCTION OF SOLUBLE RECOMBINANT PROTEIN BY PI VALUE CONTROL OF N-TERMINAL  
The present invention relates to a method for improving secretion efficiency of a recombinant foreign protein using a polypeptide fragment containing N-region of a signal sequence (directional...
US20140090104 INSECTICIDAL PROTEINS  
Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at least corn rootworm are provided. By...
US20140371426 METHOD FOR PRODUCING APOLIPOPROTEIN IN PLANTS  
The present invention provides, in one aspect, a method for producing Apolipoprotein in a plant comprising incubating or growing a plant comprising a nucleic acid construct comprising, consisting...
US20130345399 METHOD OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES  
This invention relates to methods of expressing eukaryotic proteins in prokaryotic hosts, particularly eukaryotic proteins that require formation of disulfide bridges for biological activity....
US20110183377 METHODS, SYSTEMS AND REAGENTS FOR IMPROVED IMMUNODETECTION  
The instant invention provides methods, systems and reagents for immunodetection involving novel epitope tags and antibodies which recognize these new epitope tags as well as the antibodies which...
US20120244577 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS  
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at...
US20150166613 FUSION PROTEINS AND COMBINATION VACCINES COMPRISING HAEMOPHILUS INFLUENZAE PROTEIN E AND PILIN A  
The present invention relates to compositions comprising Haemophilus influenzae Protein E and Pilin A. More particularly, the present application relates to fusion proteins and immunogenic...
US20130203116 EXPRESSION AND PURIFICATION OF FUSION PROTEIN WITH MULTIPLE MBP TAGS  
The present invention provides a new method for recombinantly expressing a protein of interest, such as the human BR-CA2 protein, BLM protein, CtIP protein, or EXOI protein, by expressing the...
US20130052660 METHOD FOR DETECTING PROTEIN-PROTEIN INTERACTIONS IN CELLS  
The present invention relates to a method for detecting protein-protein interactions in living cells, and more particularly, to a method for providing cells comprising a first construct and a...
US20120269844 VACCINES FOR THE TREATMENT OF NEOPLASIAS FROM VIRAL CAPSIDS OF BIRNAVIRUS CONTAINING ANTIGENS OF THE HUMAN PAPILLOMAVIRUS  
The invention relates to therapeutic vaccines for the treatment of neoplasias caused by the human papillomavirus (HPV). In particular, the vaccines of the present invention are formed by chimeric...
US20110033893 IMPROVED METHODS FOR PROTEIN PRODUCTION  
Methods for low cell-density bacterial protein expression that can achieve levels of up to 180 mg/l using a simple and low cost strategy. Full codon optimization is unnecessary to improve...
US20130156801 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20130004530 VACCINE COMPOSITION  
Neisserial immunogenic compositions and vaccines, their manufacture and methods for the use of such compositions in medicine are provided herein.
US20140220631 Rapid Screening Method of Translational Fusion Partners for Producing Recombinant Proteins and Translational Fusion Partners Screened Therefrom  
Disclosed are a method for rapid screening of suitable translational fusion partners (TFPs) capable of inducing expression or secretory production of non-producible proteins, which are difficult...
US20140322257 FUSION PROTEINS REPRESENTING DIFFERENT NS: PROPOSAL FOR A VACCINE AGAINST ALLERGY TO MITES  
The present invention refers to recombinant DNA molecules codifying fused peptides from different allergens from Blomia tropicalis and Dermatophagoides pteronyssinus having potential usefulness in...
US20130252282 OPTICAL CONTROL OF PROTEIN ACTIVITY AND LOCALIZATION BY FUSION TO PHOTOCHROMIC PROTEIN DOMAINS  
Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent...
US20120231505 Gene Expression Technique  
The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding...
US20140099667 BACTERIORHODOPSIN FUSION MEMBRANE PROTEIN EXPRESSION SYSTEM  
An expression vector is disclosed, which comprises: a) a polynucleotide sequence encoding a bacteriorhodopsin or a mutant bacteriorhodopsin; b) a multiple cloning site; c) a T7 promoter, d) a...
US20120178647 ENGINEERING OF ZINC FINGER ARRAYS BY CONTEXT-DEPENDENT ASSEMBLY  
A method of designing a multi-zinc-finger polypeptide predicted to bind to a sequence of interest that has at least three subsites includes the steps of: a) providing a nucleotide sequence of...