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US20140357521 TOOLS AND METHODS FOR EXPRESSION OF MEMBRANE PROTEINS  
The disclosure relates cells or cellular systems that express both a membrane protein and a binding domain directed to the membrane protein. Also, methods are provided that use such cells or...
US20120005782 CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM  
The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system...
US20120164140 HEMOJUVELIN FUSION PROTEINS AND USES THEREOF  
The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also...
US20140221621 SINGLE-CHAIN MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS  
Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the...
US20120315671 EXPRESSION MEDIA FOR PROTEINS IN YEAST SYSTEM  
The subject invention provides advantageous new media formulations, methods for their production, methods for cultivating cells using the media as well as compositions thereof and their use for...
US20150183866 METHODS TO CONTROL PROTEIN HETEROGENEITY  
The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins...
US20150183865 METHODS TO CONTROL PROTEIN HETEROGENEITY  
The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins...
US20140314745 METHODS TO CONTROL PROTEIN HETEROGENEITY  
The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins...
US20140235476 MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS FOR IDENTIFYING VARIANTS OF SAME  
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., DVD-Fab or DVD-Ig molecules) and the use of these libraries for the screening of multivalent...
US20130129727 METHODS AND SYSTEMS FOR INCREASING PROTEIN STABILITY  
Methods and systems for increasing stability of a target polypeptide in a serum are described. The methods and systems utilize a fusion protein comprising a single-domain antibody against a serum...
US20130115208 HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM  
The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other...
US20120028301 SOMATIC HYPERMUTATION SYSTEMS  
The present application relates to somatic hypermutation (SHM) systems and synthetic genes. Synthetic genes can be designed using computer-based approaches to increase or decrease susceptibility...
US20150050693 METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS  
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the...
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20140178389 IL-1 BINDING PROTEINS  
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of...
US20110014656 SOLUBLE IL-17RA/RC FUSION PROTEINS AND RELATED METHODS  
Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and...
US20130074201 CANCER-SPECIFIC GENETIC REARRANGEMENTS  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating cancer characterized by the expression of...
US20130065276 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20150152129 Synthetic Oligosaccharides for P. Aeruginosa Vaccine  
The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide...
US20140127743 METHODS FOR PRODUCING RECOMBINANT PROTEINS  
Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
US20150253342 PRODEFENSIN-A6 ASSAY METHOD FOR THE IN VITRO DIAGNOSIS OF COLORECTAL CANCER  
The present invention relates to a method for the in vitro diagnosis of colorectal cancer by determining the presence of the Prodefensin-A6 tumour marker in a biological sample taken from a...
US20140044739 CDIM Binding Proteins And Uses Thereof  
The present disclosure relates to Cell Death Inducing Molecule (“CDIM”) binding proteins and pharmaceutical compositions thereof. Particularly, the disclosure provides CDIM binding proteins that...
US20140357565 METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20120028900 METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20110039302 Method of Producing Factor VIII Proteins by Recombinant Methods  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20150175952 STIRRER SYSTEM  
The present invention concerns a stirrer system for animal cell culture consisting of a combination of at least one radially-conveying stirrer element and at least one axially-conveying stirrer...
US20140271458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-1 and/or IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-1β and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20130236458 DUAL SPECIFIC BINDING PROTEINS DIRECTED AGAINST IL-13 AND/OR IL-17  
Engineered multivalent and multispecific binding proteins that bind IL-13 and/or IL-17 are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20130295084 BINDING PROTEINS HAVING TETHERED LIGHT CHAINS  
The present invention relates to binding proteins having tethered light chains and methods of making and using them.
US20120288895 Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V  
Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
US20110159540 Methods for Chemically Synthesizing Immunoglobulin Chimeric Proteins  
The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.
US20130052685 PREVENTION AND TREATMENT OF COMPLEMENT-ASSOCIATED EYE CONDITIONS  
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by...
US20130164786 FUCOSYLATION-DEFICIENT CELLS  
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
US20100304436 Fucosylation-Deficient Cells  
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
US20150183849 COMPOSITIONS AND METHODS FOR INCREASING SERUM HALF-LIFE  
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or...
US20110171218 COMPOSITIONS AND METHODS FOR INCREASING SERUM HALF-LIFE  
Provided herein are glycovariant Fc fusion proteins having increased serum half lives. Also provided are methods for increasing the serum half life of an Fc fusion protein by introducing one or...
US20140154743 METHODS AND MATERIALS FOR ENHANCING FUNCTIONAL PROTEIN EXPRESSION IN BACTERIA  
Novel materials and methods useful for expressing heterologous proteins in prokaryotic cells are provided, including prokaryotic cells expressing FkpA and/or Skp.
US20140219913 Dual Specific Binding Proteins Having a Receptor Sequence  
Engineered multispecific binding proteins that bind at least one ligand for a receptor are provided, along with methods of making and uses in the prevention, diagnosis, and/or treatment of disease.
US20140255996 Method for Secretory Production of Protein  
A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by...
US20140271632 METHODS FOR MODULATING PROTEIN GLYCOSYLATION PROFILES OF RECOMBINANT PROTEIN THERAPEUTICS USING MONOSACCHARIDES AND OLIGOSACCHARIDES  
The present invention relates to the field of protein production, and in particular to methods and compositions for modulating glycosylation of proteins expressed in host cells.
US20140271641 THROMBOSPONDIN-1 POLYPEPTIDES AND METHODS OF USING SAME  
The invention features thrombospondin-1 (TSP-1) polypeptides (e.g., 3TSR-Fc fusion proteins), nucleic acid molecules encoding the TSP-1 polypeptides, and compositions thereof. The invention also...
US20120017336 TRANSGENIC ALOE PLANTS FOR PRODUCTION OF PROTEINS AND RELATED METHODS  
The present inventions provide transgenic aloe plants and recombinant constructs for transforming aloe plants, aspects of which, may be applied to other monocots. The recombinant constructs may...
US20140273094 METHODS OF ENHANCING PROTEIN QUALITY AND QUANTITY BY YEAST FED-BATCH FERMENTATION  
The present invention describes a method for producing an antibody in Pichia pastoris, such as by fed-batch fermentation. The method may include a strategy of increasing the ethanol concentration...
US20130195864 FGFR-FC FUSION PROTEIN AND USE THEREOF  
The present invention belongs to the field of biotechnology and relates to the treatment of diseases, especially the treatment of FGF overexpression-related diseases. Particularly, the present...
US20140309405 METHOD OF PRODUCING HETEROGENEOUS PROTEIN  
The present invention provides a method capable of producing a natural or recombinant protein in high yield. The present invention relates to a method of producing a polypeptide, comprising...
US20120244577 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS  
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at...
US20150031081 METHODS AND MATERIALS FOR REDUCING DEGRADATION OF RECOMBINANT PROTEINS  
Described herein are methods and materials for reducing degradation of recombinant proteins in fungal cells such as Yarrowia.
US20140072560 CORRECTLY FOLDED ETANERCEPT IN HIGH PURITY AND EXCELLENT YIELD  
A mixed mode chromatography method for separating correctly folded from incorrectly folded conformations of a given protein is provided. The method is highly effective in separating correctly...
US20110142843 FETAL POLYPEPTIDES FROM HUMAN LIVER  
Novel fetal genes (fls353 and fls485) have been successfully isolated from human fetal liver-derived cDNAs. These genes were specifically expressed in tissues including fetal tissues which are...
US20130034551 Wnt Antagonists and Methods of Treatment and Screening  
The present invention relates to compositions comprising Wnt antagonists and methods of treating Wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the...