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US20130281667 USES OF SPATIAL CONFIGURATION TO MODULATE PROTEIN FUNCTION  
This invention provides a set of methods for modulating protein spatial configuration. First, select the amino-acid codon for encoding the target protein according to host codon usage. Second,...
US20110070195 USES OF SPATIAL CONFIGURATION TO MODULATE PROTEIN FUNCTION  
This invention provides a set of methods for modulating protein spatial configuration. First, select the amino-acid codon for encoding the target protein according to host codon usage. Second,...
US20120064573 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES  
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the...
US20140220631 Rapid Screening Method of Translational Fusion Partners for Producing Recombinant Proteins and Translational Fusion Partners Screened Therefrom  
Disclosed are a method for rapid screening of suitable translational fusion partners (TFPs) capable of inducing expression or secretory production of non-producible proteins, which are difficult...
US20120231505 Gene Expression Technique  
The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising: (a) providing a host cell comprising a first recombinant gene encoding...
US20110135596 FUSION PROTEIN COMPRISING UBIQUITIN OR UBIQUITIN-LIKE PROTEIN, MEMBRANE TRANSLOCATION SEQUENCE AND BIOLOGICALLY ACTIVE MOLECULE AND USE THEREOF  
A transmembrane fusion protein including ubiquitin or a ubiquitin-like protein, a membrane translocation sequence linked to the C-terminus of the ubiquitin or ubiquitin-like protein, and a...
US20110306753 Method for Increasing Protein Expression in Cells  
The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or...
US20150147780 METHOD FOR HARVESTING ORGANIC COMPOUNDS FROM GENETICALLY MODIFIED ORGANISMS  
Disclosed herein are embodiments for a novel method of producing an organic compound, including harvesting at least one organic compound from an organism or cell line genetically engineered with a...
US20110217784 METHOD FOR PRODUCING SOLUBLE RECOMBINANT INTERFERON PROTEIN WITHOUT DENATURING  
The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to extraction of soluble, active recombinant protein from an insoluble fraction...
US20120231503 Gene Expression Technique  
The present disclosure relates to a method for producing heterologous protein including: (c) providing a host cell comprising a 2 μm-family plasmid, the plasmid comprising a gene encoding a...
US20110288269 Design of Spacers To Increase The Expression of Recombinant Fusion Proteins  
The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin...
US20130273606 SECRETION YIELD OF A PROTEIN OF INTEREST BY IN VIVO PROTEOLYTIC PROCESSING OF A MULTIMERIC PRECURSOR  
The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The...
US20150191511 Genetically Modified Organisms to Produce Organic Compounds  
Disclosed herein are embodiments for a genetically modified organism or cell line; a composition containing the same; and a method of harvesting at least one organic compound from an organism or...
US20140087392 GLYCOSYL TRANSFERASE FROM CHINESE HAMSTER AND RELATED METHODS  
A glycosyl transferase from Chinese hamster and related methods are described.
US20140370546 Protease Deficient Filamentous Fungal Cells and Methods of Use Thereof  
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
US20110159539 METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM  
A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in...
US20150184135 CHINESE HAMSTER OVARY CELL LINES  
We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in...
US20110177555 CHINESE HAMSTER OVARY CELL LINES  
We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in...
US20120082644 CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS  
The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an...
US20110091936 PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA  
The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies,...
US20150105537 CODON OPTIMIZED SEQUENCE FOR AN ANTIVIRAL PROTEIN  
A codon optimized nucleic acid sequence for Interferon Alpha-2a is provided which can be used for expression of Interferon Alpha-2a in E. Coli.
US20110053221 RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS  
The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic...
US20140106403 DRAIN DOWN AND RE-FEED OF MICROCARRIER BIOREACTOR  
The invention provides a method of increasing product yield per culture in a population of product-secreting cells bound to a scaffold, for example, a microcarrier, at least partially immersed in...
US20150259431 COMPOSITIONS AND METHODS FOR IMPROVING PRODUCTION OF RECOMBINANT POLYPEPTIDES  
The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors...
US20150037842 MODIFIED BACTERIAL CELL  
The disclosure relates to a Gram negative bacterial cell that is transformed with a nucleic acid molecule that encodes a Gram positive twin-arginine translocase and including methods for the...
US20130197068 RNA Containing Modified Nucleosides and Methods of Use Thereof  
This invention provides RNA, oligoribonucleotide, and polyribonucleotide molecules comprising pseudouridine or a modified nucleoside, gene therapy vectors comprising same, methods of synthesizing...
US20120003695 METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS  
Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as...
US20120190068 DRAIN DOWN AND RE-FEED OF MICROCARRIER BIOREACTOR  
Disclosed is a method of increasing product yield per culture in a population of bound product-secreting cells in a bioreactor, the method comprising: semi-harvesting product by removing a volume...
US20110020870 METHODS FOR PRODUCING MODIFIED GLYCOPROTEINS  
Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been...
US20130171138 Immunoglobulin Chimeric Monomer-Dimer Hybrids  
The invention relates to a chimeric monomer-dimer hybrid protein wherein said protein comprises a first and a second polypeptide chain, said first polypeptide chain comprising at least a portion...
US20150252383 EXPRESSION VECTORS COMPRISING THE MCMV IE2 PROMOTER  
The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a...
US20110008839 Expression Vectors Comprising the MCMV IE2 Promoter  
The invention relates to an expression vector comprising the promoter of the mCMV-IE2 gene, or a functional expression promoting fragment thereof, and/or an enhancer of the mCMV-IE2 gene, or a...
US20140186432 MODIFIED POLYNUCLEOTIDES ENCODING CITED4  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
US20120308482 Monkey Homolog of Human Interferon Omega  
Cytokine IFNω nucleic acids from the Cynomolgus monkey are useful for expression of IFNω proteins that are functional homologs of human IFNω. The nucleic acids and proteins produced therefrom are...
US20140356326 BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY  
The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related...
US20120230947 BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY  
The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related...
US20140308706 RECOMBINANT FUSION INTERFERON FOR ANIMALS  
A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a Fc region of an animal immunoglobulin G (IgG). The animal interferon and the Fc...
US20140030220 RECOMBINANT FUSION INTERFERON FOR ANIMALS  
A recombinant fusion interferon for animals. The recombinant fusion interferon comprises an animal interferon and a Fc region of an animal immunoglobulin G (IgG). The animal interferon and the Fc...
US20080069800 System for High Production of Natural and Personalized Interferons  
The present invention generally relates to systems and methods for the production of high amounts of personalized interferons (IFNs), which are IFNs produced from the cells of the patient to whom...
US20090092581 Interferons of rhesus and cynomolgus origin and uses thereof  
Disclosed are interferons of Rhesus and Cynomolgus origin and methods of production and use thereof.
US20130017574 METHODS AND COMPOSITIONS FOR ENHANCED EXPRESSION AND SECRETION OF PROTEINS  
Optimized signal peptide coding sequences for enhanced expression and secretion of protein from a cell and related compositions and methods are described. The optimized signal peptide coding...
US20110189128 RECOMBINANT SUPER-COMPOUND INTERFERON  
This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor...
US20130164783 Mammalian Cell Lines for Increasing Longevity and Protein Yield from a Cell Culture  
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
US20120196326 Mammalian Cell Lines for Increasing Longevity and Protein Yield from a Cell Culture  
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies,...
US20060251619 Modified interferon-gamma polypeptides and methods for using modified interferon-gamma polypeptides  
Provided are modified interferon-gamma (IFN-γ) polypeptides and methods of generating modified interferon-gamma polypeptides. Also provided are methods of treatment using modified interferon-gamma...
US20120288477 TYPE OF CONSENSUS INTERFERON AND PREPARATION METHOD THEREOF  
The invention relates to variants of consensus interferon protein with improved properties, such as improved anti-viral activity, and use thereof The variants are also easier to renature after...
US20100003721 HUMAN INTERFERON-BETA MUTEIN  
The present invention relates to a human interferon-beta mutein. In particular, the present invention relates to the human interferon-beta mutein having one or two additional sugar chains compared...
US20120309057 METHOD FOR PRODUCING INTERFERON ALPHA 5  
A process for producing an interferon alpha 5 (IFNa5) protein by expression in an IFNa5 producing Escherichia coli host cell, wherein incorporation of an extra methionine residue in the N-terminal...
US20120129218 COFILIN KNOCKDOWN HOST CELLS AND USES THEREOF  
The present invention relates to a host cell comprising a cofilin-specific small interfering RNA (siRNA) sequence. The host cell may further comprise a nucleic acid encoding a recombinant protein....
US20120301922 NOVEL P. PASTORIS PASTORIS PROMOTERS, AND THE USE THEREOF TO DIRECT EXPRESSION OF PROTEINS IN YEAST, PREFERABLY USING A HAPLOID MATING STRATEGY  
Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the...
Matches 1 - 50 out of 116 1 2 3 >