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US20140357702 MicroRNA Expression Profile Associated With Pancreatic Cancer  
Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological...
US20120058483 MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS  
Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection,...
US20060084111 Method for gene identification signature (GIS) analysis  
An isolated oligonucleotide comprising at least one ditag, wherein the ditag comprises two joined first and second sequence tags, wherein the first tag comprises the 5′-terminus sequence and the...
US20050255501 Method for gene identification signature (GIS) analysis  
A method of identifying at least a nucleic acid molecule fragment to which a protein of interest binds, comprising: (i) preparing at least one nucleic acid molecule fragment to which a protein...
US20150176082 PLASMA MICRORNAS FOR THE DETECTION OF EARLY COLORECTAL CANCER  
The present invention relates in general to the field of colorectal cancer detection, and more particularly, to plasma microRNAs for the detection of early colorectal cancer. Specifically, the...
US20140147495 MicroRNA-Based Methods and Compositions For the Diagnosis, Prognosis and Treatment of Breast Cancer  
The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of breast cancer. The invention also provides methods of identifying anti-breast cancer agents.
US20140105918 METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF PROSTATE CANCER METASTASIS  
The present invention relates to a method for the diagnosis or the prognosis of metastasis in prostate cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample....
US20130344066 METHODS OF MONITORING CONDITIONS BY SEQUENCE ANALYSIS  
There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA...
US20130225662 METHODS AND COMPOSITIONS OF MOLECULAR PROFILING FOR DISEASE DIAGNOSTICS  
The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to gene expression product markers, alternative exon...
US20120202206 PHARMACEUTICAL COMPOSITIONS AND METHODS USEFUL FOR MODULATING ANGIOGENESIS, INHIBITING METASTASIS AND TUMOR FIBROSIS, AND ASSESSING THE MALIGNANCY OF COLON CANCER TUMORS  
Methods and compositions suitable for modulating angiogenesis in a mammalian tissue are provided. Further provided are methods suitable for inhibiting metastasis and fibrosis in a mammalian tissue...
US20110195400 SYSTEMS AND METHODS FOR DIAGNOSING CANCER  
Systems and methods for diagnosing cancer. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or...
US20110195397 DRINK MIXTURE FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Drink mixture for the stabilization of diagnostic biomarkers. In at least one embodiment of an ingestible beverage useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent...
US20110195396 CHEWABLE COMPOSITIONS FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Chewable compositions for the stabilization of diagnostic biomarkers. In at least one embodiment of a chewing gum composition useful to stabilize a diagnostic marker, the a chewing gum composition...
US20110195395 RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to...
US20110171646 MICRORNA EXPRESSION PROFILE ASSOCIATED WITH PANCREATIC CANCER  
Methods are provided for diagnosing whether a subject has, or is at risk of developing, pancreatic cancer. The methods include measuring the level of at least one miR gene product in a biological...
US20100317005 Modified Nucleotides and Methods for Making and Use Same  
Labeled nucleotide triphosphates are disclosed having a label bonded to the gamma phosphate of the nucleotide triphosphate. Methods for using the gamma phosphate labeled nucleotide are also...
US20100298408 Oligonucleotide Compositions with Enhanced Efficiency  
The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2...
US20100151478 METHODS FOR DISEASE DETECTION  
The present invention provides methods for detecting disease by analysis of a patient sample to determine the integrity of nucleic acids in the sample.
US20100099111 ANTIBODIES AGAINST A PROTEIN ENTITLED 161P2F10B  
Antibodies and methods of using same against products of the gene designated 161P2F10B and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult...
US20100015167 COMPOSITIONS AND METHODS FOR IDENTIFYING AND TARGETING CANCER CELLS OF ALIMENTARY CANAL ORIGIN  
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of...
US20090275608 Methods of diagnosing and treating parp-mediated diseases  
Disclosed are methods of identifying a disease treatable with modulators of differentially expressed genes in a disease, including at least PARP modulators, by identifying the level of expression...
US20090181393 Methods for the identification, assessment, and treatment of patients with proteasome inhibition therapy  
The present invention is directed to the identification of markers that can be used to determine whether patients with cancer are clinically responsive or non-responsive to a therapeutic regimen...
US20090155174 RNA Interference Mediating Small RNA Molecules  
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we...
US20090148847 RAPID MAGNETIC FLOW ASSAYS  
Disclosed is an improvement in methods for nucleic acid and immunological bioassays. The methods comprise a step for “sweeping” paramagnetic bead: target molecule complexes so as to capture them...
US20080305490 AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS  
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting...
US20080241064 COMPOSITIONS AND METHODS FOR IDENTIFYING AND TARGETING CANCER CELLS OF ALIMENTARY CANAL ORIGIN  
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Compounds, compositions and methods of...
US20080182255 Gene Expression Profiling in Biopsied Tumor Tissues  
The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets...
US20080176243 Gene regulator  
The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method...
US20070298424 Nucleic acids and corresponding proteins entitled 273P4B7 useful in treatment and detection of cancer  
A novel gene 273P4B7 and its encoded protein, and variants thereof, are described wherein 273P4B7 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
US20070212721 Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor  
Screening methods for identifying patients with an increased likelihood of having ovarian cancer are provided. The screening methods involve the detection of expression of a plurality of...
US20070212704 COMPOSITIONS, METHODS, AND KITS FOR AMPLIFYING NUCLEIC ACIDS  
The present teachings are directed to compositions, methods, and kits for amplifying target nucleic acids while reducing non-specific fluorescence and undesired amplification products, sometimes...
US20070178504 Methods and marker combinations for screening for predisposition to lung cancer  
The present invention relates to certain immunoreactive polypeptides, methods for aiding in the diagnosis of lung cancer in a subject and kits for performing said methods.
US20070134253 Novel serpentine transmembrane antigens expressed in human cancers and uses thereof  
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate...
US20070066554 Immunostimulatory nucleic acids  
The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T...
US20070065859 Methods and materials for identifying the origin of a carcinoma of unknown primary origin  
The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two...
US20070054311 Amplification and analysis of whole genome and whole transcriptome libraries generated by a DNA polymerization process  
The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is...
US20070031880 Chemical treatment of biological samples for nucleic acid extraction and kits therefor  
A composition and method for the purification of nucleic acid are disclosed. The composition includes at least one alkaline agent and at least one detergent. The composition preferably also...
US20070031878 Methods and compositions for polypeptide engineering  
Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods...
US20070031873 Predicting bone relapse of breast cancer  
A method of providing predicting relapse of breast cancer in bone is conducted by analyzing the expression of a group of genes. Gene expression profiles in a variety of medium such as microarrays...
US20070020653 DNA polymerase  
The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant...
US20060141497 Molecular analysis of cellular fluid and liquid cytology specimens for clinical diagnosis, characterization, and integration with microscopic pathology evaluation  
The application relates to methods, materials, kits, and devices for characterizing fluid specimens of any type or source that may or may not contain cells. The methods, materials, kits, and...
US20060121044 Selecting patients for therapy with a her inhibitor  
A method for selecting patients for therapy with a HER inhibitor, such as pertuzumab, based on gene expression analysis is described. A method for assessing HER phosphorylation or activation in a...
US20060115844 Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of DNA  
The specification provides materials and methods for enhancing the amplifiability of nucleic acids that are present in minute amounts. Preferably, the materials and methods are utilized in...
US20060088871 Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens  
Provided are materials, methods, platforms, and kits for diagnosing, prognosing, and/or determining the biological aggressiveness of a tumor (malignant and non-malignant) based in part on the...
US20060063190 Methods and compositions for evaluating breast cancer prognosis  
Methods and compositions for evaluating the prognosis of a breast cancer patient, particularly an early-stage breast cancer patient, are provided. The methods of the invention comprise detecting...
US20060030787 Devices and methods for obtaining mammary fluid samples for evaluating breast diseases, including cancer  
Biological samples of mammary fluid or components thereof are obtained using a breast pump device coupled with a solid phase sample collection medium, alternatively facilitated by administering...
US20060024725 Oncofetal fibronectin as a marker for pregnancy-related indications  
Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided...
US20060024724 Oncofetal fibronectin as a marker for health and disease  
Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided...
US20060024722 Samples for detection of oncofetal fibronectin and uses thereof  
Methods and products for the detection of oncofetal fibronectin indicating molecules in samples are provided. Methods for imaging of oncofetal fibronectin are provided. In some methods provided...
US20050202500 Expression monitoring to high density oligonucleotide arrays  
This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide...