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US20130059296 |
Compositions and Methods For High Fidelity Assembly of Nucleic Acids
Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end... |
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US20120322057 |
POLYMERASE COMPOSITIONS AND METHODS
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of... |
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US20120058483 |
MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS
Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection,... |
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US20120021409 |
Common Light Chain Mouse
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided... |
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US20110318301 |
IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F... |
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US20110014612 |
POLYMERASE COMPOSITIONS & METHODS
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of... |
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US20090325169 |
RNASE H-BASED ASSAYS UTILIZING MODIFIED RNA MONOMERS
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel... |
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US20070172819 |
Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for... |
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US20160194717 |
Methods of Detecting Diseases or Conditions Using Phagocytic Cells
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to... |
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US20160046679 |
LOW MOLECULAR WEIGHT SILK COMPOSITIONS AND STABILIZING SILK COMPOSITIONS
The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions.... |
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US20150087530 |
Low-Volume Sequencing System and Method of Use
Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than... |
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US20140356370 |
METHODS FOR TREATING AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA ASSOCIATED WITH PCSK9 GAIN-OF-FUNCTION MUTATIONS
The present invention provides methods for treating autosomal dominant hypercholesterolemia (ADH). According to certain embodiments, the ADH is caused by or associated with a gain-of-function... |
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US20140336079 |
LABELING AND DETECTION OF NUCLEIC ACIDS
Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided... |
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US20140329703 |
METHODS AND COMPOSITIONS FOR PREPARING RNA FROM A FIXED SAMPLE
The present invention provides improved methods and compositions for RNA isolation. In particular embodiments the present invention concerns the use of methods and compositions for the isolation... |
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US20120295794 |
COMPOSITIONS, METHODS, AND KITS FOR DETECTING RIBONUCLEIC ACID
Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a... |
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US20120258449 |
METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES
The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases,... |
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US20120252010 |
LABELLED NUCLEOTIDES
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group. |
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US20120214861 |
METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE
This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological... |
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US20120184602 |
METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction... |
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US20120035062 |
ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS
A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in... |
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US20110281741 |
Method and Apparatus for Rapid Nucleic Acid Sequencing
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods... |
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US20110275522 |
Method and Apparatus for Rapid Nucleic Acid Sequencing
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods... |
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US20110269643 |
MASS SPECTROMETRIC METHODS FOR DETECTING MUTATIONS IN A TARGET NUCLEIC ACID
Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided. |
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US20110200991 |
AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE
A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively... |
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US20110195426 |
NUCLEIC ACIDS ANALYSIS
The present invention is partly based on the discovery that adverse factors can prevent an effective extraction of nucleic acids from a biological sample and that novel and unexpected agents and... |
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US20110195404 |
SYSTEMS AND METHODS FOR DETERMINING CALCIUM LEVELS
Systems and methods for determining calcium levels. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially... |
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US20110195403 |
SYSTEMS AND METHODS FOR FERTILITY ANALYSIS
Systems and methods for fertility analysis. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent... |
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US20110195402 |
SYSTEMS AND METHODS FOR DETECTING DRUG USE
Systems and methods for detecting drug use. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent... |
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US20110195401 |
SYSTEMS AND METHODS FOR DETERMINING FOOD ALLERGIES
Systems and methods for determining food allergies. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially... |
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US20110195400 |
SYSTEMS AND METHODS FOR DIAGNOSING CANCER
Systems and methods for diagnosing cancer. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or... |
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US20110195399 |
SYSTEMS AND METHODS FOR THE INHIBITION OF GALACTOSE OXIDASE
Systems and methods for the inhibition of galactose oxidase. According to least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to... |
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US20110195398 |
SYSTEMS AND METHODS FOR DETECTING INSULIN RESISTANCE BIOMARKERS
Systems and methods for detecting insulin resistance biomarkers. At least one embodiment of a system of the present disclosure comprises a stabilizing agent useful to completely or substantially... |
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US20110195397 |
DRINK MIXTURE FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
Drink mixture for the stabilization of diagnostic biomarkers. In at least one embodiment of an ingestible beverage useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent... |
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US20110195396 |
CHEWABLE COMPOSITIONS FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
Chewable compositions for the stabilization of diagnostic biomarkers. In at least one embodiment of a chewing gum composition useful to stabilize a diagnostic marker, the a chewing gum composition... |
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US20110195395 |
RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS
Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to... |
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US20110195394 |
SYSTEMS AND METHODS FOR DIAGNOSING VIRAL INFECTIONS
Systems and methods for diagnosing viral infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to... |
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US20110021605 |
MEANS AND METHODS FOR THE SPECIFIC INHIBITION OF GENES IN CELLS AND TISSUE OF THE CNS AND/OR EYE
Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded... |
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US20100297626 |
Reagents, Methods, and Libraries for Bead-Based Sequencing
The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of... |
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US20100261181 |
LABELING AND DETECTION OF NUCLEIC ACIDS
Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided... |
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US20100069465 |
METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the... |
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US20090226926 |
MATERIALS AND METHODS FOR DETECTION OF NUCLEIC ACIDS
Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second... |
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US20090220978 |
METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES IN COMPLEX MIXTURES
The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid.... |
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US20090162866 |
COMPOSITIONS AND METHODS FOR OBTAINING NUCLEIC ACIDS FROM SPUTUM
The present invention relates to compositions and methods for preserving and extracting nucleic acids from saliva. The compositions include a chelating agent, a denaturing agent, buffers to... |
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US20080020389 |
Methods of detecting a target nucleic acid
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by... |
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US20070212726 |
Methods for detection of a target nucleic acid
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by... |
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US20070212724 |
Methods of detecting a target nucleic acid
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by... |
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US20070212722 |
Methods of detecting a target nucleic acid
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by... |
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US20070172860 |
Enzymatic nucleic acid synthesis: compositions and methods
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for... |
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US20070105138 |
Method for detection of a target nucleic acid with a FEN nuclease
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by... |
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US20070092892 |
METHODS AND COMPOSITIONS FOR IDENTIFYING BIOMARKERS USEFUL IN DIAGNOSIS AND/OR TREATMENT OF BIOLOGICAL STATES
The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated... |