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US20130059296 Compositions and Methods For High Fidelity Assembly of Nucleic Acids  
Aspects of the invention relate to methods, compositions and algorithms for designing and producing a target nucleic acid. The method can include: (1) providing a plurality of blunt-end...
US20120322057 POLYMERASE COMPOSITIONS AND METHODS  
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of...
US20120058483 MITOCHONDRIAL MUTATIONS AND REARRANGEMENTS AS A DIAGNOSTIC TOOL FOR THE DETECTION OF SUN EXPOSURE, PROSTATE CANCER AND OTHER CANCERS  
Mitochondrial DNA deletions useful for the detection of cancers and sun exposure are provided. In particular, methods and kits for detecting mitochondrial DNA deletions for the early detection,...
US20120021409 Common Light Chain Mouse  
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided...
US20110318301 IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF  
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F...
US20110014612 POLYMERASE COMPOSITIONS & METHODS  
Disclosed herein are modified polymerase compositions exhibiting altered polymerase activity, which can be useful in a variety of biological applications. Also disclosed herein are methods of...
US20090325169 RNASE H-BASED ASSAYS UTILIZING MODIFIED RNA MONOMERS  
The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel...
US20070172819 Enzymatic nucleic acid synthesis: compositions including pyrophosphorolysis inhibitors  
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for...
US20160194717 Methods of Detecting Diseases or Conditions Using Phagocytic Cells  
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to...
US20160046679 LOW MOLECULAR WEIGHT SILK COMPOSITIONS AND STABILIZING SILK COMPOSITIONS  
The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions....
US20150087530 Low-Volume Sequencing System and Method of Use  
Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than...
US20140356370 METHODS FOR TREATING AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA ASSOCIATED WITH PCSK9 GAIN-OF-FUNCTION MUTATIONS  
The present invention provides methods for treating autosomal dominant hypercholesterolemia (ADH). According to certain embodiments, the ADH is caused by or associated with a gain-of-function...
US20140336079 LABELING AND DETECTION OF NUCLEIC ACIDS  
Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20140329703 METHODS AND COMPOSITIONS FOR PREPARING RNA FROM A FIXED SAMPLE  
The present invention provides improved methods and compositions for RNA isolation. In particular embodiments the present invention concerns the use of methods and compositions for the isolation...
US20120295794 COMPOSITIONS, METHODS, AND KITS FOR DETECTING RIBONUCLEIC ACID  
Compositions, methods, and kits for detecting one or more species of RNA molecules are disclosed. In one embodiment, a first adaptor and a second adaptor are ligated to the RNA molecule using a...
US20120258449 METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES  
The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases,...
US20120252010 LABELLED NUCLEOTIDES  
Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
US20120214861 METHODS AND COMPOSITIONS FOR TREATING NEUROLOGICAL DISEASE  
This invention relates to methods and compositions for treating neurological disease, and more particularly to methods of delivering iRNA agents to neural cells for the treatment of neurological...
US20120184602 METABOLICALLY ACTIVATED RECOMBINANT VIRAL VECTORS AND METHODS FOR THEIR PREPARATION AND USE  
Recombinant viral vectors, especially parvovirus vectors such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction...
US20120035062 ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS  
A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in...
US20110281741 Method and Apparatus for Rapid Nucleic Acid Sequencing  
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods...
US20110275522 Method and Apparatus for Rapid Nucleic Acid Sequencing  
Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods...
US20110269643 MASS SPECTROMETRIC METHODS FOR DETECTING MUTATIONS IN A TARGET NUCLEIC ACID  
Fast and highly accurate mass spectrometry-based processes for detecting particular nucleic acid molecules and mutations in the molecules are provided.
US20110200991 AUTOMATED SYSTEM FOR ISOLATING, AMPLIFYING AND DETECTING A TARGET NUCLEIC ACID SEQUENCE  
A system and method for preparing and testing of targeted nucleic acids is presented. The system integrates a pipetter, extractor, assay reader, and other components, including a selectively...
US20110195426 NUCLEIC ACIDS ANALYSIS  
The present invention is partly based on the discovery that adverse factors can prevent an effective extraction of nucleic acids from a biological sample and that novel and unexpected agents and...
US20110195404 SYSTEMS AND METHODS FOR DETERMINING CALCIUM LEVELS  
Systems and methods for determining calcium levels. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially...
US20110195403 SYSTEMS AND METHODS FOR FERTILITY ANALYSIS  
Systems and methods for fertility analysis. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent...
US20110195402 SYSTEMS AND METHODS FOR DETECTING DRUG USE  
Systems and methods for detecting drug use. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent...
US20110195401 SYSTEMS AND METHODS FOR DETERMINING FOOD ALLERGIES  
Systems and methods for determining food allergies. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially...
US20110195400 SYSTEMS AND METHODS FOR DIAGNOSING CANCER  
Systems and methods for diagnosing cancer. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or...
US20110195399 SYSTEMS AND METHODS FOR THE INHIBITION OF GALACTOSE OXIDASE  
Systems and methods for the inhibition of galactose oxidase. According to least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to...
US20110195398 SYSTEMS AND METHODS FOR DETECTING INSULIN RESISTANCE BIOMARKERS  
Systems and methods for detecting insulin resistance biomarkers. At least one embodiment of a system of the present disclosure comprises a stabilizing agent useful to completely or substantially...
US20110195397 DRINK MIXTURE FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Drink mixture for the stabilization of diagnostic biomarkers. In at least one embodiment of an ingestible beverage useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent...
US20110195396 CHEWABLE COMPOSITIONS FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Chewable compositions for the stabilization of diagnostic biomarkers. In at least one embodiment of a chewing gum composition useful to stabilize a diagnostic marker, the a chewing gum composition...
US20110195395 RINSE COMPOSITION FOR THE STABILIZATION OF DIAGNOSTIC BIOMARKERS  
Rinse composition for the stabilization of diagnostic biomarkers. In at least one embodiment of a rinse useful to stabilize a diagnostic marker, the rinse comprises a stabilizing agent useful to...
US20110195394 SYSTEMS AND METHODS FOR DIAGNOSING VIRAL INFECTIONS  
Systems and methods for diagnosing viral infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to...
US20110021605 MEANS AND METHODS FOR THE SPECIFIC INHIBITION OF GENES IN CELLS AND TISSUE OF THE CNS AND/OR EYE  
Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded...
US20100297626 Reagents, Methods, and Libraries for Bead-Based Sequencing  
The present invention provides methods for determining a nucleic acid sequence by performing successive cycles of duplex extension along a single stranded template. The cycles comprise steps of...
US20100261181 LABELING AND DETECTION OF NUCLEIC ACIDS  
Provided in certain embodiments are new methods for forming azido modified nucleic acid conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20100069465 METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF GENE EXPRESSION BY DOUBLE-STRANDED RNA  
The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the...
US20090226926 MATERIALS AND METHODS FOR DETECTION OF NUCLEIC ACIDS  
Assays using non-natural bases are described. In one embodiment, the method involves contacting a sample suspected of containing the target nucleic acid with a polymerase and first and second...
US20090220978 METHODS FOR DETECTION AND QUANTIFICATION OF ANALYTES IN COMPLEX MIXTURES  
The invention provides a diverse population of uniquely labeled probes, containing about thirty or more target specific nucleic acid probes each attached to a unique label bound to a nucleic acid....
US20090162866 COMPOSITIONS AND METHODS FOR OBTAINING NUCLEIC ACIDS FROM SPUTUM  
The present invention relates to compositions and methods for preserving and extracting nucleic acids from saliva. The compositions include a chelating agent, a denaturing agent, buffers to...
US20080020389 Methods of detecting a target nucleic acid  
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by...
US20070212726 Methods for detection of a target nucleic acid  
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by...
US20070212724 Methods of detecting a target nucleic acid  
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by...
US20070212722 Methods of detecting a target nucleic acid  
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by...
US20070172860 Enzymatic nucleic acid synthesis: compositions and methods  
Nucleotide triphosphate probes containing a molecular and/or atomic tag on a a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for...
US20070105138 Method for detection of a target nucleic acid with a FEN nuclease  
The invention relates to compositions and methods of generating a signal indicative of the presence of a target nucleic acid in a sample, where the method includes forming a cleavage structure by...
US20070092892 METHODS AND COMPOSITIONS FOR IDENTIFYING BIOMARKERS USEFUL IN DIAGNOSIS AND/OR TREATMENT OF BIOLOGICAL STATES  
The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular transcription factor biomarkers and genes that can be regulated...