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US20110263026 Construction of Protein-Responsive shRNA/RNAi Control System Using RNP Motif  
An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence...
US20150252415 ARID1B AND NEUROBLASTOMA  
Neuroblastomas are tumors of peripheral sympathetic neurons and are the most common solid tumor in children. We performed whole-genome sequencing (6 cases), exome sequencing (16 cases),...
US20100330046 HUMAN SKIN SUBSTITUTES EXPRESSING IL-12  
The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides...
US20130254909 SYNTHETIC REGULATION OF GENE EXPRESSION  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
US20110135620 PRODRUG ACTIVATION IN CANCER CELLS USING MOLECULAR SWITCHES  
The present invention features a novel protein engineering strategy by combining the domains of two independent proteins into a molecular switch. The invention features polypeptides comprising a...
US20140234852 HUMAN KERATINOCYTES PTCH1 CELL LINE  
A cellular model is described for targeting dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular...
US20120196321 SELECTABLE MARKERS AND RELATED METHODS  
The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.
US20110021611 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 5A  
The present inventors developed 5a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and all of or part of NS2 were replaced by the corresponding genes of the...
US20110287050 RECOMBINANT KOI HERPESVIRUS (KHV) OR CYPRINID HERPESVIRUS 3 (CYHV-3) AND A VACCINE FOR THE PREVENTION OF A DISEASE CAUSED BY KHV/CYHV-3 IN CYPRINUS CARPIO CARPIO OR CYPRINUS CARPIO KOI  
The present invention refers to a recombinant koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3), which is immunogenic in fish, preferably in carps, more preferably in Cyprinus carpio, and...
US20140080795 NRF2 Deficiency Influences Susceptibility to Steroid Resistance via HDAC2 Reduction  
Methods for the treatment or prevention of diseases which are caused by the decreased concentrations of histone deacetylase 2 (HDAC2) in cells are described. The diseases which may be treated by...
US20100322911 USE OF MICROWAVE IRRADIATION FOR DELIVERY OF MACROMOLECULES  
The present invention is directed to methods of delivering macromolecules to a target cell or tissue by microwave irradiation. A target cell or tissue is exposed to one or more macromolecules to...
US20120213738 Cardiac Repair By Reprogramming of Cardiac Fibroblasts Into Cardiomyocytes  
The present invention involves the use of transcription factors including Tbx5, Mef2C, Hand2, myocardin and Gata4 to reprogram cardiac fibroblasts into cardiomyocytes, both in vitro and in vivo....
US20110178164 APPLICATION ON MONOOLEIN AS A NEW HELPER LIPID IN TRANSFECTION  
An application of monoolein-based cationic lipid systems can be used for the complexation, transport and transfection of genetic material into target cells. The lipid systems can be prepared...
US20140242595 HEPATOCYTE PRODUCTION VIA FORWARD PROGRAMMING BY COMBINED GENETIC AND CHEMICAL ENGINEERING  
The present invention provides methods comprising both genetic and chemical means for the production of hepatocytes from a variety of cell sources, particularly pluripotent stem cells.
US20140087469 SYSTEM AND PROCESS FOR GENETIC AND EPIGENETIC TREATMENT  
Transplantation of total or partial organs or tissues from one person to another creates severe immunologic problems and does not obtain a genetic rejuvenation, for example, of half the biological...
US20140127743 METHODS FOR PRODUCING RECOMBINANT PROTEINS  
Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
US20120302464 METHODS FOR PRODUCING RECOMBINANT PROTEINS  
Methods for producing recombinant cell populations are disclosed. The disclosed methods may be used to produce therapeutic polyclonal proteins.
US20110124591 COMPOUNDS AND METHODS FOR MODULATING PROTEIN EXPRESSION  
The present invention provides compounds and methods for modulating expression of a protein, including, but not limited to, modulating splicing of a pre-mRNA to modulate the amount of one or more...
US20110105735 METHODS OF PRODUCING AND PURIFYING PROTEINS  
Methods of producing and purifying proteins that comprise a glycan tag are provided. In some embodiments, a protein may be modified to include a glycan tag so as to facilitate production of the...
US20130045479 METHODS FOR EVALUATING THE STAGE OF OVARIAN CANCER OR THE SURVIVAL RATE OF AN OVARIAN CANCER PATIENT  
An object of the present invention is to provide a method for detecting cancer through identification of genes exhibiting characteristic behavior in the cases of cancer such as ovarian cancer, and...
US20130225664 METHODS AND COMPOSITIONS FOR DECREASING CHRONIC PAIN  
The present invention provides compositions and methods for the selective silencing of neurons in pain pathway by using a combination of inhibitory light-sensitive protein gene transfer and...
US20110171211 HEAT SHOCK PROTEIN GP96 VACCINATION AND METHODS OF USING SAME  
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of...
US20140170123 Hepatocyte Based Insulin Gene Therapy For Diabetes  
A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first,...
US20120315255 Hepatocyte Based Insulin Gene Therapy For Diabetes  
A method and vectors for controlling blood glucose levels in a mammal are disclosed. In one embodiment, the method comprises the steps of: treating the hepatocyte cells of a patient with a first,...
US20140186395 PERMISSIVE CELLS AND USES THEREOF  
Described are methods for determining the permissiveness of a cell for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular, for Porcine...
US20130236974 METHOD FOR INCREASING THE PRODUCTION OF A PROTEIN OF INTEREST  
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed...
US20110294219 USE OF THE FOAMY VIRUS BET PROTEIN FOR INACTIVATING APOBEC  
Described is the foamy virus Bet-mediated inactivation of the mutagenic, genome-modifying and vector-inactivating cellular enzyme ABOBEC. Such inactivation is useful for the treatment or...
US20150098954 Compositions and Methods Related to CRISPR Targeting  
Disclosed herein include embodiments related to addition, deletion, or modification of DNA, RNA, or protein in a subject. In an embodiment, the DNA, RNA, or protein is endogenous. In an...
US20120304318 CANCER DIAGNOSIS AND TREATMENT  
The invention concerns materials and methods relating to the use of OMD (osteomodulin) and\or PRELP (Proline/arginine-rich end leucine-rich repeat protein) expression, particularly...
US20120178168 METHOD FOR REGULATING PROTEIN FUNCTION IN CELLS USING SYNTHETIC SMALL MOLECULES  
Methods and compositions for the rapid and reversible destabilizing of specific proteins using cell-permeable, synthetic molecules are described. Stability-affecting proteins, e.g., derived from...
US20130012573 METHODS FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS  
A method for intracellular delivery of isolated naked nucleic acids into a biological tissue or organ, that includes (a) contacting the tissue or organ with an efficient amount of at least one...
US20130260467 MOLECULAR DELIVERY WITH NANOWIRES  
A molecular delivery device including a plurality of nanowires (e.g., Si NWs) coated with an electrically conductive layer. Also disclosed are methods for delivering a molecule by...
US20140072545 GENERATION OF NATURAL KILLER CELLS AND LYMPHOID TISSUE INDUCER-LIKE (LTI-LIKE) NK-22 CELLS  
The present invention relates generally to methods to prepare NK and LTi-like, NK22 cells from HSCs and uses of those cells.
US20150150912 CEACAM1 MEDIATED PROTECTIVE IMMUNITY  
The presently described technology relates to the modulation of specific immune responses to create a protective immunity in the treatment of autoimmune diseases and diseases requiring the...
US20130116165 LIGHT-ACTIVATED FUSION PROTEINS AND USES THEREFOR  
The invention, in some aspects relates to synthetic, light-activated fusion proteins and their encoding polynucleotide molecules. In some aspects the invention additionally includes expression of...
US20120110693 TARGETING NUCLEIC ACIDS IN MITOCHONDRIA  
The present invention relates to a shuttle system with which nucleic acids of interest may be imported into a mitochondrion. This system is based on the use of a fusion protein between a...
US20140308247 Vectors Conditionally Expressing Protein  
This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing one or more proteins under the control of a gene...
US20150017727 METHODS OF INDUCING REGULATED PANCREATIC HORMONE PRODUCTION IN NON-PANCREATIC ISLET TISSUES  
Disclosed are methods and pharmaceutical compositions for inducing pancreatic hormone production.
US20150166618 METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA  
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins involved in clotting into the genome of a cell for treating conditions including hemophilias.
US20150093433 TARGETED AND MODULAR EXOSOME LOADING SYSTEM  
Disclosed are exosomes that include a packaging protein and a cargo RNA in which the packaging protein binds specifically to the cargo RNA. The packaging protein is a fusion protein that includes...
US20110190730 METHODS OF INDUCING PLURIPOTENCY INVOLVING OCT4 PROTEIN  
The invention relates to a method of inducing pluripotency in a responsive mammalian cell, which comprises introducing into the cell an effective amount for initiating pluripotency within the cell...
US20140356957 Biological Pacemaker  
Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac...
US20120328584 Biological Pacemaker  
Disclosed are methods and systems for modulating electrical behavior of cardiac cells. Preferred methods include administering a polynucleotide or cell-based composition that can modulate cardiac...
US20120115938 COMPOSITIONS AND METHODS FOR GENETIC MODIFICATION OF CELLS HAVING COSMETIC FUNCTION TO ENHANCE COSMETIC APPEARANCE  
Disclosed are methods and compositions to genetically modify substantially intact cells having cosmetic function to enhance the cosmetic appearance in mammals so as to enhance and/or maintain a...
US20130267028 Recombinant Influenza Viruses for Vaccines and Gene Therapy  
The invention provides a composition useful to prepare influenza A viruses, e.g., in the absence of helper virus.
US20130244277 Gene Expression Technique  
The present invention provides a host cell suitable for enhanced production of a protein product of choice characterised in that the host cell is genetically modified to cause over-expression of...
US20110123553 Use of LINGO-4 Antagonists in the Treatment of Conditions Involving Demyelination  
The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a LINGO-4 antagonist.
US20120115232 METHOD FOR INDUCING DEGRADATION OF PROTEIN IN MAMMALIAN CELL  
Provided is a system which can induce the degradation of a protein of interest in a mammalian cell system reliably and stably within a short time. A mammalian cell inducible for protein...
US20140115728 DOUBLE KNOCKOUT (GT/CMAH-KO) PIGS, ORGANS AND TISSUES  
The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional ╬▒GAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are...
US20130005794 METHODS AND SEQUENCES TO SUPPRESS PRIMATE HUNTINGTON GENE EXPRESSION  
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatto and Homo sapiens. These...