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US20140065710 METHODS TO CONTROL PROTEIN HETEROGENEITY  
The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.
US20120276631 METHODS FOR CONTROLLING THE GALACTOSYLATION PROFILE OF RECOMBINANTLY-EXPRESSED PROTEINS  
The present invention relates to methods for modulating the glycosylation profile of recombinantly-expressed proteins. In particular, the present invention relates to methods of controlling the...
US20110070204 MEDIUM FOR HANDLING AND STORING BIOLOGICAL TISSUES OF THE MUSCULOSKELETAL SYSTEM OUTSIDE AN ORGANISM  
The present disclosure relates to a medium for handling, including storing, cultivating, coating, impregnating and/or preserving musculoskeletal tissues such as bone, cartilage, tendon, muscle,...
US20110151011 Decellularized Adipose Tissue  
This invention provides a method for decellularizing adipose tissue, comprising subjecting the adipose tissue to one or more incubations in an enzymatic digestion solution containing one or more...
US20120264190 Decellularized and Delipidized Extracellular Matrix and Methods of Use  
Compositions comprising decellularized and delipidized extracellular matrix derived from adipose or loose connective tissue, and therapeutic uses thereof. Methods for treating, repairing or...
US20110274742 Cartilage Repair Systems and Applications Utilizing A Glycosaminoglycan Mimic  
The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and,...
US20140370594 BIOLOGICAL CONVERSION OF BIOMASS-DERIVED SUGARS TO VALUE ADDED CHEMICALS  
A method of growing a microorganism by culturing the microorganism in a an aqueous solution of carbohydrates containing C6-sugar monomers or C5-sugar monomers, wherein the aqueous solution of...
US20140228246 ECM COMPOSITION, TUMOR MICROENVIRONMENT PLATFORM AND METHODS THEREOF  
The present disclosure relates to an Extra Cellular Matrix composition specific for cancer type and a tumor microenvironment platform for long term culturing of tumor tissue, wherein said...
US20150175964 Methods and Compositions for the Rapid Production of Retinal Pigmented Epithelial Cells from Pluripotent Cells  
The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell...
US20110313541 METHODS FOR GENERATING CARTILAGE TISSUE  
A hyaline-like, single layer cartilage tissue construct includes chondrogenic cells dispersed within an endogenously produced extracellular matrix. The single layer cartilage tissue construct has...
US20150175955 CRYOPRESERVATION TOOLS AND METHODS  
Provided herein are methods for the cryopreservation of stem cells and/or progenitor cells, comprising the steps of (a) contacting stem cells and/or progenitor cells with a cryopreservation...
US20110300114 METHOD OF CELL CULTURE AND METHOD OF TREATMENT COMPRISING A vEPO PROTEIN VARIANT  
In one aspect the present invention is concerned with a method of cell culture, comprising the steps of (i) obtaining a stem or progenitor cell sample, (ii) culturing the stem or progenitor cell...
US20100310544 COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES  
The invention is based on the finding that calcium ions and proteolytic enzymes, particularly papain, act in a synergetic way in the regeneration of skin and connective tissues. Thus, such a...
US20110212489 CULTURE MEDIUM FOR EUKARYOTIC CELLS  
A proteolysate of a seed material derived from a plant species of the Asteraceae family, such as sunflower, has improved properties as a constituent of a culture medium for culturing eukaryotic,...
US20120258533 Protein-Free Culture Media Products for Manufacturing Viral-Based Vaccines  
Disclosed herein are compositions and methods for a substantially protein-free media (PFM) optimized for cultivation of mammalian and/or avian cell-lines for manufacturing viral-based vaccines.
US20110250690 Microfluidic Embryo and Gamete Culture Systems  
A robotic microfluidic incubator system has a thin transparent sidewall and close proximity of the embryo/oocyte/cultured cells to the sidewall allow close approach of a side view microscope with...
US20130337566 RESPONSIVE CELL CULTURE HYDROGEL  
The present invention provides devices, compositions and methods for maintaining conditions in a cell culture and for measurement of conditions in the cell culture. In particular, the invention...
US20130196429 Protein-Free Gamete and Embryo Handling and culture Media Products  
This invention discloses a substantially protein-free cell culture solution for assisted reproductive technologies and methods of use thereof.
US20130189670 Protein-Free Gamete and Embryo Handling and culture Media Products  
This invention discloses a substantially protein-free cell culture solution for assisted reproductive technologies and methods of use thereof.
US20140255907 UNIQUE BUFFERING SYSTEM FOR CELL CULTURE MEDIA AND GAMETE AND EMBRYO CULTURE MEDIA AND METHODS  
The invention relates to compositions and methods for continuous stabilization of pH of cell culture medium notwithstanding change from one distinct environment to another environment. The methods...
US20110256095 Tissue Matrix System  
The present application discloses matrix compositions to support the repair of tissue defects such as an injury to tendon tissue, ligament tissue, vascular tissue, dermal tissue, or muscle tissue....
US20110008886 METHODS AND MATERIALS FOR ISOLATING ISOGENIC ISLET CELLS  
Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients.
US20140308707 METHOD FOR PRODUCTION OF FACTOR VIII  
The present invention relates to methods of producing a Factor VIII polypeptide in mammalian cell cultures.
US20130302406 Biomimetic Emulsions  
A biomimetic system is provided for use in modeling cell-cell adhesion mechanisms comprising functionalized emulsion droplets. Further, a cell culture medium and a drug delivery system using said...
US20120202291 SIMPLIFIED BASIC MEDIA FOR HUMAN PLURIPOTENT CELL CULTURE  
Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving...
US20120178166 SIMPLIFIED BASIC MEDIA FOR HUMAN PLURIPOTENT CELL CULTURE  
Fully defined media that support pluripotent cell viability, proliferation, cloning, and derivation, as well as methods and compositions including these media are described. Methods for deriving...
US20120315343 SYNCHRONIZED WATER AND PRODUCTION AND USE THEREOF  
A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in...
US20140356910 METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS  
The present invention relates to methods of upregulating the high mannose glycoform content of a recombinant protein during a mammalian cell culture by manipulating the mannose to total hexose...
US20120107936 CULTURED PANCREAS ISLETS  
Methods of preparing pancreatic islets that may comprise pancreatites are provided. The methods may involve subjecting a pancreas and/or pieces thereof to disruption, such as, for example, an...
US20100297090 HEMATOPOIETIC CELL CULTURE NUTRIENT SUPPLEMENT  
The present invention provides a serum-free supplement which supports the growth of hematopoietic cells in culture. Also provided are a medium comprising a basal medium supplemented with the...
US20120028353 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME  
The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class...
US20110053266 Methods, kits, and compositions for stem cell self-renewal  
The present invention relates to methods and kits for expanding a stem cell population. More particularly, the invention relates, inter alia, to methods, kits, and compositions for expanding a...
US20110269173 Method for Producing Polarized Retinal Progenitor Cells from Pluripotent Stem Cells and their Differentiation into Retinal Pigment Epithelium Cells  
The present invention relates to a method and components for producing polarized retinal progenitor cells (RPC) from pluripotent stem cells in high yield and purity. The polarized retinal...
US20150240214 INDUCTION OF PLURIPOTENT CELLS  
The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we...
US20130109094 Dry powder cell culture products and methods of production thereof  
The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium...
US20110129926 DRY POWDER CELL CULTURE PRODUCTS AND METHODS OF PRODUCTION THEREOF  
The present invention relates to nutritive medium, medium supplement, media subgroup and buffer formulations. The present invention provides powder nutritive medium, medium supplement and medium...
US20110151512 OLIGOPEPTIDE-FREE CELL CULTURE MEDIA  
The present invention relates to oligopeptide-free cell culture media comprising at least 0.5 mg/L of a polyamine and to methods for cultivating cells in said oligopeptide-free cell culture media...
US20140120620 Culturing solution and method of using the same, which solution is used for in-vitro support of the growth of fertilized oocytes though embryonic development to the implantation stage  
This invention relates to a media solution, which has been shown to be a stabilized balance of growth media, which may contain a combination of proteins, insulin, growth hormones, and/or steroids...
US20150087058 STEM CELL CULTURE MEDIUM AND METHOD FOR CULTURING STEM CELLS USING SAME  
The present invention relates to a stem cell culture medium which can be substituted for a conventional stem cell culture medium containing the heterologous protein fetal bovine serum, and more...
US20150240211 Media for Culturing, Preserving, and Administering Regenerative Cells  
A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The...
US20130058903 Stem-Cell Material and Method of Use  
Provided herein are mesenchymal stem cells which have been modified by the introduction of polynucleotides encoding for a mammalian Cdk1 protein. These cells do not sense in culture and are...
US20120171766 MEDIUM COMPOSITION COMPRISING NEUROPEPTIDE Y FOR THE GENERATION, MAINTENANCE, PROLONGED UNDIFFERENTIATED GROWTH OF PLURIPOTENT STEM CELLS AND METHOD OF CULTURING PLURIPOTENT STEM CELL USING THE SAME  
The present invention relates to a medium composition comprising neuropeptide Y, effective for proliferation and maintenance of undifferentiated pluripotent stem cells, and a method for culturing...
US20130004465 ADHERENT CELLS FROM PLACENTA AND USE OF SAME IN DISEASE TREATMENT  
Methods for treating conditions by administration of placenta derived adherent stromal cells to a subject in thereof are provided. Such conditions include skeletal muscle defects, neuropathic...
US20110224233 STEM CELL CULTURES  
The present invention relates compounds for stabilizing cells and methods of their use.
US20140286913 COMPOSITIONS FOR THE MOBILIZATION, HOMING, EXPANSION AND DIFFERENTIATION OF STEM CELLS AND METHODS OF USING THE SAME  
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.
US20130267027 DRY GRANULATED CELL CULTURE MEDIA  
The present invention relates dry granulated cell culture media which do not comprise peptones or tryptones, especially to dry granulated cell culture media formulations that support the growth of...
US20110039333 DEFINED CONDITIONS FOR HUMAN EMBRYONIC STEM CELL CULTURE AND PASSAGE  
The invention relates to human pluripotent cells. More specifically, the invention provides a chemically defined xeno-free culture system that allows for long term expansion of human pluripotent...
US20140099329 TREATMENT OF DISEASES AND DISORDERS USING SELF-RENEWING COLONY FORMING CELLS CULTURED AND EXPANDED IN VITRO  
The present invention relates to methods and uses of cells for the prevention and treatment of a wide variety of diseases and disorders and the repair and regeneration of tissues and organs using...
US20120156192 Treatment of Diseases and Disorders Using Self-Renewing Colony Forming Cells Cultured and Expanded In Vitro  
The present invention relates to methods and uses of cells for the prevention and treatment of a wide variety of diseases and disorders and the repair and regeneration of tissues and organs using...
US20150056702 METHOD AND KIT FOR CULTURING STEM CELLS  
A method is provided, including adding a phthalide to a stem cell medium to provide a phthalide-containing medium, and then culturing a stem cell using the phthalide-containing medium. The use of...