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US20150086993 MICROFLUIDIC THREE-DIMENSIONAL OSTEOCYTE NETWORK RECONSTRUCTED WITH MICROBEADS AS SCAFFOLD  
A bed of microbeads is used as a foundation for reconstructing a three-dimensional osteocyte network by culturing osteocytes within the bed. The osteocytes are cultured such that they form a...
US20140341864 METHODS FOR PRODUCING RETINAL TISSUE AND RETINA-RELATED CELL  
The invention provides a method for producing a retinal tissue by (1) subjecting pluripotent stem cells to floating culture in a serum-free medium containing a substance inhibiting the Wnt signal...
US20130274124 ADHESION SIGNATURES  
The present invention provides arrays comprising polypeptides associated with extracellular matrix that can be used to isolate, differentiate, or culture certain cell types including stem cells,...
US20140273220 Self-Organized Vascular Networks from Human Pluripotent Stem Cells in a Synthetic Matrix  
A bicellular vascular population derived from human pluripotent stem cells (hPSCs) undergoes morphogenesis and assembly in a synthetic hydrogel. It is shown that hPSCs can be induced to...
US20110171712 SELF-ASSEMBLING TISSUE MODULES  
The invention relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way. In particular, the invention is...
US20130164839 METHOD FOR CULTURING CELLS IN A SYSTEM COMPRISING LAMININ-5  
The present invention is directed to providing a method for culturing cells in a system containing laminin-5. The method of the present invention is characterized by a culture system containing a...
US20150166960 METHOD FOR PRODUCING FUNCTIONAL FUSION TISSUE  
The present invention relates to a universal method for producing functional tissue. The invention relates to the method for producing functional fusion tissue, the functional fusion tissue...
US20120311729 Immunomodulatory Methods and Systems for Treatment and/or Prevention of Atherosclerosis  
Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
US20150159134 METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS  
The invention relates to a method for producing retinal pigment epithelial cells.
US20110256204 RAPID PREPARATION AND USE OF ENGINEERED TISSUE AND SCAFFOLDS AS INDIVIDUAL IMPLANTS  
Methods, technical apparatus and compositions to achieve short term processing for the manufacture of a graft or a transplant in the form of a scaffold that can be used to treat or to heal...
US20140099709 ENGINEERED THREE-DIMENSIONAL CONNECTIVE TISSUE CONSTRUCTS AND METHODS OF MAKING THE SAME  
Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent...
US20130273536 COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS  
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
US20110110899 Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells  
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
US20120251504 PLURIPOTENT STEM CELLS OBTAINED FROM DENTAL PULP  
The present invention relates to pluripotent stem cells obtained from the dental pulp of patients of different ages, the invention furthermore comprises cultures of said cells, means for obtaining...
US20150072425 METHODS OF GENERATING NATURAL KILLER CELLS  
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
US20120148553 METHODS OF GENERATING NATURAL KILLER CELLS  
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
US20120064537 USE OF PERFUSION DECELLULARIZED ORGANS FOR MATCHED RECELLULARIZATION  
The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system.
US20140356368 APPLICATIONS OF AN IMMUNE SYSTEM-RELEASED ACTIVATING AGENT (ISRAA)  
The present invention relates to applications of an immune system-released activating agent (ISRAA) polypeptide, which is induced by a nervous stimulus and which has been found to mediate the...
US20130150293 METHOD FOR PREVENTING AND TREATING DIABETES USING NEURTURIN  
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
US20110256113 METHOD FOR PREVENTING AND TREATING DIABETES USING NEURTURIN  
The present invention relates generally to methods for preventing and/or treating pancreatic disorders, particularly those related to diabetes, by administering a neurturin protein product.
US20150132847 ENCAPSULATION AND CARDIAC DIFFERENTIATION OF hiPSCs IN 3D PEG-FIBRINOGEN HYDROGELS  
The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures...
US20120141456 Use of DR6 and p75 Antagonists to Promote Survival of Cells of the Nervous System  
The present invention relates to Death Receptor-6 (DR6) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to be important for regulating...
US20120156232 CANCER VACCINES AND VACCINATION METHODS  
Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.
US20110177996 REGULATORY PROTEINS IN LUNG REPAIR AND TREATMENT OF LUNG DISEASE  
The DNA-binding protein Sox17 has been found to play an important role in repair of pulmonary tissue after damage, disease, or injury. Nucleic acids encoding proteins involved in pulmonary repair,...
US20110274742 Cartilage Repair Systems and Applications Utilizing A Glycosaminoglycan Mimic  
The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and,...
US20140377233 METHOD OF PREPARING AN ARTIFICIAL TOOTH PRIMORDIUM IN VITRO AND ARTIFICIALTOOTH PRIMORDIUM DERIVED THEREFROM  
The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the...
US20140341965 Compositions and Methods Comprising Biodegradable Scaffolds and Retinal Pigment Epithelial Cells  
The invention relates to compositions comprising a monolayer of functional retinal pigment epithelial (RPE) cells attached to a transplantable, biodegradable scaffold. The invention also relates...
US20140206028 Stable Electrically Active Neurons from Adult Tissue  
Disclosed are compositions and methods of making stable electrically active adult neurons from adult neural tissue. The disclosed compositions can be used with microelectrode arrays in vitro to...
US20130209571 BIOENGINEERED HUMAN CORNEAL STROMAL TISSUE  
Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct...
US20120094328 FERMENTATION PRODUCT OF CEREAL PLANT-DERIVED MATERIAL AND IMMUNOMODULATOR  
The present invention provides dendritic cells (DCs) having reduced inflammatory activity, a method for producing DCs capable of inducing regulatory T cells and regulatory T cells, and substances...
US20130267030 EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS  
The invention provides a method of improving the efficiency of establishment of induced pluripotent stem cells by increasing, in a nuclear reprogramming step of somatic cell, the level of...
US20150225700 ARTIFICIAL THREE-DIMENSIONAL MICROENVIRONMENT NICHE CULTURE AND METHODS OF USING THE SAME  
The present invention provides three-dimensional microenvironment niches prepared from biomaterial compositions that supports growth and self renewal of stem cells. The invention also provides...
US20130004469 ENGINEERED LUMENIZED VASCULAR NETWORKS AND SUPPORT MATRIX  
Disclosed herein are capillary fabrication devices comprising living cells within a support medium. Culture of the cells produces viable lumenized capillary networks with natural or pre-determined...
US20140072545 GENERATION OF NATURAL KILLER CELLS AND LYMPHOID TISSUE INDUCER-LIKE (LTI-LIKE) NK-22 CELLS  
The present invention relates generally to methods to prepare NK and LTi-like, NK22 cells from HSCs and uses of those cells.
US20110223140 METHOD FOR DIFFERENTIATION INTO RETINAL CELLS FROM STEM CELLS  
Disclosed is a method for inducing stem cells to differentiate into retinal cells at high yield within a short period of time, without gene implantation and co-culture with retinal tissues, by...
US20120034694 CELL CULTURE SUPPORT AND CELL CULTURE METHOD  
The present invention relates to a cell culture support for culturing mesenchymal stem cells, which includes en upper surface including a plurality of wells, in which the upper surface has a root...
US20110008297 OXYSTEROLS FOR ACTIVATION OF HEDGEHOG SIGNALING, OSTEOINDUCTION, ANTIADIPOGENESIS, AND WNT SIGNALING  
Synthetic oxysterols can be made and can be used for the treatment of bone disorders, obesity, cardiovascular disorders, and neurological disorders.
US20140364467 CHEMICAL INDUCERS OF NEUROGENESIS  
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as...
US20130236552 NANOTOPOGRAPHY-MEDIATED REVERSE UPTAKE PLATFORM FOR NUCLEIC ACID DELIVERY AND APPLICATIONS THEREOF  
This application discloses a nanotopography-mediated reverse uptake (NanoRU) platform useful for intracellular delivery of nucleic acids into mammalian cells, in particular stem cells, as well as...
US20110117063 Methods For Producing Enriched Populations of Human Retinal Pigment Epithelium Cells For Treatment of Retinal Degeneration  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20130195814 TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF  
In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and rejuvenation extracellular matrix. In other...
US20130236964 METHODS, NUCLEIC ACID CONSTRUCTS AND CELLS FOR TREATING NEURODEGENERATIVE DISORDERS  
A method of treating a neurodegenerative disorder is provided. The method is effected by administering to an individual in need thereof cells capable of exogenously regulatable neurotransmitter...
US20130143810 Virally-Inactivated Growth Factors-Containing Platelet Lysate Depleted of PDGF and VEGF and Preparation Method Thereof  
The invention concerns human platelet extracts rich in growth factors (PGF) for wound healing and stem cell expansion. Accordingly the subject invention relates to a virally-inactivated growth...
US20150175964 Methods and Compositions for the Rapid Production of Retinal Pigmented Epithelial Cells from Pluripotent Cells  
The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell...
US20120121550 PRODUCTION OF OLIGODENDROCYTES FROM PLACENTA-DERIVED STEM CELLS  
The present invention provides methods and compositions for the production of glial cells and oligodendrocytes from placenta stem cells. The invention further provides for the use of these glia...
US20130302426 Modalities for the treatment of degenerative diseases of the retina  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20140255942 METHOD FOR PRODUCING PLURIPOTENT CELL USING BACTERIUM HAVING FERMENTATION ABILITY  
It is an object of the present invention to provide a method for producing pluripotent cells that are free of the risk of cellular canceration and that can be applied to regenerative medicine with...
US20130316454 Methods for Producing Tissue Scaffold Directing Differentiation of Seeded Cells and Tissue Scaffolds Produced Thereby  
Methods for producing a tissue scaffold which direct differentiation of seeded stem cells on the scaffold to a selected cell type and tissue scaffolds produced thereby are provided.
US20140140965 LOW OXYGEN CULTURE CONDITIONS FOR MAINTAINING RETINAL PROGENITOR CELL MULTIPOTENCY  
The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors...
US20130052211 VACCINES WITH ONCOFETAL ANTIGEN/ILRP-LOADED AUTOLOGOUS DENDRITIC CELLS AND USES THEREOF  
Disclosed are compositions containing isolated monocyte-derived mature dendritic cells loaded with OFA/iLRP, or a fragment thereof that selectively stimulates T cytotoxic lymphocytes, and a...