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US20130274114 MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS  
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used...
US20110045477 HUMAN SKIN EXPLANT CULTURE SYSTEM AND USE THEREFOR  
The present invention features a human skin explant culture system and uses thereof.
US20100330046 HUMAN SKIN SUBSTITUTES EXPRESSING IL-12  
The present invention relates generally to compositions for treating patients that have skin cancer or have recently had skin cancers removed. More specifically, the present invention provides...
US20150133379 COSMETIC COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING FUSION PROTEIN  
The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a...
US20140234852 HUMAN KERATINOCYTES PTCH1 CELL LINE  
A cellular model is described for targeting dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular...
US20110286985 METHOD OF TREATMENT USING ORGANOTYPICALLY CULTURED SKIN TISSUE COMPRISING NIKS CELLS THAT EXPRESS EXOGENOUS HIF-1A  
The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the...
US20150132267 FIBROBLAST MIXTURES AND METHODS OF MAKING AND USING THE SAME  
The present disclosure provides a non-autologous product that is a mixture of two or more cells or tissue cultures of fibroblast, or extracts from cultures, or media cultures, isolated from...
US20130295124 ORF7 DEFICIENT VARICELLA VIRUS, VACCINE COMPRISING THE VIRUS AND USE THEREOF  
Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.
US20110027333 STEM CELL-DERIVED RETIN RETINAL PIGMENT EPITHELIAL CELLS  
The present invention concerns RPE cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the...
US20120148559 COMPOSITIONS AND METHOD FOR DEIMMUNIZATION OF PROTEINS  
The invention provides deimmunized mutant proteins having reduced immunogenicity while exhibiting substantially the same or greater biological activity as the proteins of interst from which they...
US20130316452 Modalities for the treatment of degenerative diseases of the retina  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20100299765 MODALITIES FOR THE TREATMENT OF DEGENERATIVE DISEASES OF THE RETINA  
This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment...
US20100323440 PROCESS FOR STERILIZING ACELLULAR SOFT TISSUE UNDER PRESSURE  
The present invention relates to a process for preparing skin removed from a human donor, removal of cellular components and sterilizing the decellularized skin. The process comprises the...
US20130059388 METHODS FOR GENERATING ENDOGENOUSLY TAGGED PROTEINS  
The present disclosure provides a method for endogenously tagging an endogenous protein in a cell, and a cell comprising an endogenously tagged protein. Also described are cells produced using...
US20110212541 COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS  
Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target...
US20140099355 METHOD AND COMPOSITION FOR THE TREATMENT OF MODERATE TO SEVERE KERATOCONJUNCTIVITIS SICCA  
The present invention relates to topical ophthalmic compositions for treating or preventing epithelial lesions or ophthalmic disorders, including dry eye or keratoconjunctivitis sicca.
US20110268709 Generation of Histocompatible Tissues Using Nuclear Transplantation  
Tissues produced by culture of cells produced by nuclear transfer on a matrix derived from nuclear transfer embryos or embryos and pluripotent cells provided by other methods are provided. These...
US20120295804 Compositions and Methods for Diagnosis and Treatment of Breast Cancer  
The present invention is a population of breast cancer cells with preference for establishing dormancy in bone marrow. The breast cancer cells have characteristics of stem cells and express high...
US20060088505 Hair follicle mesenchymal stem cells and use thereof  
The present invention relates to a method for isolating hair follicle mesenchymal stem cells and to the use thereof for therapy and prophylaxis as well as for cosmetic treatments.
US20100317049 Stable Cell Lines and Methods for Evaluating Gastrointestinal Absorption of Chemicals  
Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines...
US20100311082 Stable Cell Lines and Methods for Evaluating Gastrointestinal Absorption of Chemicals  
Nucleic acids and vectors for interfering with the expression of membrane efflux transport proteins in cells that express such proteins are provided. Also provided are cells and cell lines...
US20150159159 MICRORNAs SENSITIZE CANCERS TO THERAPY  
The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including...
US20120084871 NPC1L1 ORTHOLOGUES  
The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
US20120252117 OPTIMIZED MESSENGER RNA  
The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The...
US20120122213 METHOD FOR CULTURING STEM CELLS  
In the field of biological technology, a stem cell culture method is provided. The method includes preparing an amniotic epithelial cell feeder layer that is not treated to lose the division...
US20150191511 Genetically Modified Organisms to Produce Organic Compounds  
Disclosed herein are embodiments for a genetically modified organism or cell line; a composition containing the same; and a method of harvesting at least one organic compound from an organism or...
US20050089512 Skin/hair equivalent with reconstructed papillae  
The invention relates to a skin/hair equivalent, more particularly a hair model with reconstructed papillae (pseudopapillae; PP) in a reconstructed dermis (pseudodermis; PD), to its production and...
US20140141045 Allogeneic Tumor Cell Vaccination  
The present invention relates to cancer immunotherapy, specifically to allogeneic tumor cell vaccines. According to some embodiments, the invention provides novel cell lines useful as therapeutic...
US20120122716 CELL LINE DERIVED FROM THE EPITHELIAL LINING OF THE HUMAN ENDOLYMPHATIC SAC IN THE INNER EAR  
In some embodiments, the invention relates to a stable, long-term human ES cell line. In other aspects, the invention relates to methods for establishing a stable long-term ES cell line and...
US20090239254 Functional pigmented skin equivalent  
An in vitro skin equivalent includes at least one epidermis equivalent and at least one dermis equivalent, and further includes melanocytes constitutively producing melanin and fibroblasts.
US20150232444 THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS  
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic...
US20100330043 GPR125 AS A MARKER FOR STEM AND PROGENITOR CELLS AND METHODS USE THEREOF  
The present invention relates to GPR1 25 as a marker of stem and progenitor cells, including multipotent adult spermatogonial-derived stem cells (MASCs), spermatogonial stem and progenitor cells,...
US20110097795 Desiccated Biologics And Methods Of Preparing The Same  
The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least...
US20150225696 Methods for Efficient Immortalization Of Normal Human Cells  
Methods for inducing non-clonal immortalization of normal epithelial cells by directly targeting the two main senescence barriers encountered by cultured epithelial cells. In human mammary...
US20130045539 MEGANUCLEASE RECOMBINATION SYSTEM  
The invention relates to a set of genetic constructs which comprises at least a first recombinogenic construct (i) with at least two portions homologous to the genomic regions preceding and...
US20120009271 METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION  
Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present...
US20120282674 METHOD FOR THE PREPARATION OF AN INFLUENZA VIRUS  
The present invention relates to a method for the preparation of a pharmaceutical composition for the prevention or/and treatment of an influenza virus infection.
US20140044690 High-Energy Compounds for Use in Alzheimer's and Other Neurodegenerative Diseases  
A method of treating or preventing a neurodegenerative disease includes administering an effective amount of a compound to a subject in need thereof. The compound includes a high-energy compound,...
US20120058119 HUMAN TUMOR NECROSIS FACTOR TR21 AND METHODS BASED THEREON  
The present invention relates to TR21 polypeptides. In particular, isolated nucleic acid molecules are provided encoding human TR21 protein. TR21 polypeptides are also provided as are vectors,...
US20130059378 HUMAN EPIDERMIS-DERIVED MESENCHYMAL STEM CELL-LIKE PLURIPOTENT CELLS AND PREPARATION METHOD THEREOF  
The invention discloses a cell culture medium, human epidermis-derived mesenchymal stem cell-like pluripotent cells and a preparation method thereof. The culture medium is formed by adding fetal...
US20120237981 AMYLASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM  
In one aspect, the invention is directed to polypeptides having an amylase activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and...
US20130142792 RAGE Fusion Protein Compositions And Methods Of Use  
Disclosed are fusion proteins comprising a RAGE polypeptide, wherein the RAGE polypeptide comprises a fragment of a mammalian wild type RAGE peptide and at least one point mutation in the RAGE...
US20060014282 Cell and tissue engineering utilizing LIF  
Leukemia Inhibitory Factor (“LIF”), an LIF analogue, an LIF mimetic and a product capable of stimulating the expression of endogenous LIF, and mixtures thereof are useful, for (i) promoting the...
US20130012570 GNAQ TARGETED dsRNA COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION  
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a G-alpha q subunit (GNAQ) of a heterotrimeric G gene, and methods of using the dsRNA to inhibit expression of GNAQ.
US20130059362 BIOSENSORS COMPRISING PROTEIN-BINDING DOMAINS AND FLUORESCENT PROTEINS  
The present invention provides compositions and methods for monitoring cellular signal transduction events. In particular, signal transduction events may be monitored by the use of biosensors...
US20100310630 COATED SURFACE FOR CELL CULTURE  
The invention makes available a keratin coating of a support substrate and a method for the production thereof. This keratin coating is suitable particularly for the in vitro or in vivo culturing...
US20120189595 INDUCED PLURIPOTENT STEM CELLS AND METHODS OF USE  
The invention relates to the field of stem cells and, specially, to the reprogramming of adult somatic cells; to obtain pluripotent cells by the transfection of specific genes. Thus, the invention...
US20120288480 CELL POPULATION COMPRISING ORBITAL FAT-DERIVED STEM CELLS (OFSCS) AND THEIR ISOLATION AND APPLICATIONS  
The invention relates to a cell population comprising minimal volume of orbital fat-derived stem cells (OFSCs) and its isolation, purification, characterization and application. The OFSCs of the...
US20120064041 Efficient Generation of Neurally-Induced Mesenchymal Stem Cells and Applications Thereof  
The present invention provides methods and compositions for reprogramming mammalian mesenchymal stem cells, as well as to methods for using such cells, for example, to prevent or treat various...
US20120315643 Alternative Splicing Constructs and Methods of Use  
Provided are alternative splicing constructs and methods for their use. In particular, CD44 based alternative splicing constructs are provided that include CD44 exon 5. These alternative splicing...

Matches 1 - 50 out of 247 1 2 3 4 5 >