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US20110002904 |
SYNOVIAL VILLI FOR USE WITH TISSUE ENGINEERING
Synovial villi derived explants and related surgical tools used to repair or prevent damage to injured or diseased tissue, including connective tissue. The tools including a harvesting tool for... |
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US20130274114 |
MULTIPOTENT STEM CELL-BASED CULTURE SYSTEMS AND MODELS
This invention generally relates to multipotent stem cell-based research tools. More particularly, the present invention relates to culture systems and 3-dimensional tissue models that may be used... |
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US20130065310 |
USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS
The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to... |
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US20110045588 |
METHOD FOR CULTURING HUMAN PERIOSTEUM
The present invention provides a method for forcingly culturing a piece of human periosteum tissue in a shorter culture period, the method including the steps of: (1) placing a periosteum piece... |
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US20130230884 |
Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents... |
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US20140186947 |
Activation and Expansion of T-Cells Using an Engineered Multivalent Signaling Platform as a Research Tool
Provided are a system and methods for selectively inducing expansion of a population of T cells in the absence of exogenous growth factors, such as lymphokines, and accessory cells for research... |
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US20140273209 |
ARTIFICIAL IMMUNE SYSTEM: METHODS OF USE
The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the... |
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US20140377861 |
Precise Control of Recombinant Protein Levels by Engineering Translation
Compositions and methods are provided for user-specified fine-tuned protein expression levels, by controlling the initiation of protein translation; and a model for analysis of expression. This... |
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US20120184016 |
NOVEL PROTEIN AND GENE THAT CODES THEREFOR
The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention... |
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US20130078222 |
Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is... |
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US20140341864 |
METHODS FOR PRODUCING RETINAL TISSUE AND RETINA-RELATED CELL
The invention provides a method for producing a retinal tissue by (1) subjecting pluripotent stem cells to floating culture in a serum-free medium containing a substance inhibiting the Wnt signal... |
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US20120142097 |
FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of... |
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US20120142096 |
FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of... |
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US20120108464 |
TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system... |
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US20140335612 |
SUPPORTS AND METHODS FOR PROMOTING INTEGRATION OF CARTILAGE TISSUE EXPLANTS
The present disclosure provides tissue supports and methods for preparing a cartilage composition for repairing cartilage defects, which is prepared by expanding and integrating small cartilage... |
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US20130177980 |
SYNTHETIC MATRICES FOR SELF-RENEWAL AND EXPANSION OF STEM CELLS
Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also... |
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US20110217239 |
SYSTEM AND METHOD OF EVALUATING A PROTEIN OF INTEREST ON TUMOR GROWTH INHIBITION WHILE FOLLOWING THE TUMOR IN VIVO OR IN VITRO
Disclosed herein are systems and methods for evaluating a protein of interest on growth inhibition of a tumor while following the tumor in vivo or in vitro through a co-expressed visible marker.... |
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US20120301497 |
Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any... |
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US20120114619 |
PROTEIN WITH PROMOTING EFFECTS FOR AXONAL GROWTH OF NEURONS OF CENTRAL NERVOUS SYSTEM
This invention comprises a polypeptide, a recombinant vector, a recombinant organism as well as RNA- and DNA-sequences. Furthermore, the use of polypeptides and recombinant vectors is described.... |
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US20120039908 |
Control of Protein Glycosylation and Compositions and Methods Relating Thereto
The invention relates to novel methods for controlling the glycosylation of a protein and the protein produced thereby. An exemplary method of the invention comprises producing a protein... |
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US20120135520 |
UNSHRUNKEN TISSUE EQUIVALENT, SKIN EQUIVALENT COMPRISING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT, AND METHODS FOR PRODUCING SUCH AN UNSHRUNKEN TISSUE EQUIVALENT AND SUCH A SKIN EQUIVALENT
The invention relates to a method for producing an unshrunken tissue equivalent. Said method is comprising in that: a mixture is produced that contains at least one element of an extracellular... |
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US20120315699 |
STACKED, PATTERNED BIOMATERIALS AND/OR TISSUE ENGINEERING SCAFFOLDS
Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering... |
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US20120322147 |
DIRECT PROTEIN DELIVERY WITH ENGINEERED MICROVESICLES
The present invention relates to direct protein delivery with engineered micro vesicles. |
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US20140356354 |
THERAPY FOR FILOVIRUS INFECTION
The present invention addresses a need for improved treatments for filovirus infections. |
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US20140243523 |
HUMAN EPITHELIAL CELL LINE FOR 3-D MODELIZING OF CANCER AND TREATMENT THEREOF
A cellular model is described that targets dysregulation or inappropriate activation of the Sonic Hedgehog/Patched (SHH/PTCH) pathway. Also described, is a screening method using this cellular... |
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US20130164839 |
METHOD FOR CULTURING CELLS IN A SYSTEM COMPRISING LAMININ-5
The present invention is directed to providing a method for culturing cells in a system containing laminin-5. The method of the present invention is characterized by a culture system containing a... |
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US20140099290 |
ENDOTHELIAL SCAFFOLDS
Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells... |
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US20140120091 |
FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease. |
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US20120196321 |
SELECTABLE MARKERS AND RELATED METHODS
The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems. |
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US20130323220 |
TAL-Tet1 Fusion Proteins and Methods of Use Thereof
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines... |
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US20110165130 |
Methods for Preparing Human Skin Substitutes from Human Pluripotent Stem Cells
The present invention relates to an ex vivo method for obtaining a population of human keratinocytes derived from human pluripotent stem cells comprising a step of co-culturing human pluripotent... |
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US20130344597 |
CELL CULTURE METHOD AND AUTOMATIC CULTURE SYSTEM USING THE METHOD
A culturing method according to the present invention including a step of injecting cells extracted from a human body and a culture medium into a culture container, (2) a step of culturing cells... |
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US20100317102 |
Cell Culture Method and Automatic Culture System Using the Method
A culturing method according to the present invention including a step of injecting cells extracted from a human body and a culture medium into a culture container, (2) a step of culturing cells... |
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US20130209499 |
VACCINES FOR USE IN THE PROPHYLAXIS AND TREATMENT OF INFLUENZA VIRUS DISEASE
Provided herein are polypeptides comprising portions of the influenza virus hemagglutinin, compositions comprising such polypeptides that can be used as immunogens in vaccines and methods of their... |
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US20110318730 |
MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS
Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite... |
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US20130280801 |
FLOWABLE TISSUE MATRICES
Disclosed herein are flowable tissue matrix compositions comprising small pieces of partially or completely decellularized tissue suspended in a gelatinized tissue or gelatin gel comprising... |
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US20140212968 |
SYNTHETIC MATRICES FOR LONG TERM EXPANSION OF PLURIPOTENT HUMAN EMBRYONIC STEM CELLS
Provided herein is a synthetic polymer-based hydrogel for the self-renewal and expansion of human stem cells such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Also... |
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US20110070204 |
MEDIUM FOR HANDLING AND STORING BIOLOGICAL TISSUES OF THE MUSCULOSKELETAL SYSTEM OUTSIDE AN ORGANISM
The present disclosure relates to a medium for handling, including storing, cultivating, coating, impregnating and/or preserving musculoskeletal tissues such as bone, cartilage, tendon, muscle,... |
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US20110020810 |
TRPC6 INVOLVED IN GLOMERULONEPHRITIS
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a... |
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US20140170122 |
ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS
Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and... |
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US20110110899 |
Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells
The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency. |
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US20120251504 |
PLURIPOTENT STEM CELLS OBTAINED FROM DENTAL PULP
The present invention relates to pluripotent stem cells obtained from the dental pulp of patients of different ages, the invention furthermore comprises cultures of said cells, means for obtaining... |
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US20130115234 |
Ectodomains of Influenza Matrix 2 Protein, Expression System, and Uses Thereof
The present invention provides a polynucleotide, polypeptide, recombinant modified vaccinia virus Ankara (rMVA) and related vaccine compositions and methods useful in the prevention and treatment... |
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US20120148553 |
METHODS OF GENERATING NATURAL KILLER CELLS
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of... |
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US20130236959 |
FGF-2 HAVING ENHANCED STABILITY
Thermostable FGF-2 proteins having enhanced ability to support human pluripotent stem cell cultures are provided. Also provided are methods and compositions utilizing thermostable FGF-2 proteins. |
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US20120100116 |
NEURON GENERATION, REGENERATION AND PROTECTION
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth... |
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US20110201110 |
EFFICIENT METHOD FOR ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
The present invention provides a method of producing induced pluripotent stem (iPS) cells, comprising bringing a nuclear reprogramming substance into contact with dental pulp stem cells. By using... |
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US20120064537 |
USE OF PERFUSION DECELLULARIZED ORGANS FOR MATCHED RECELLULARIZATION
The invention provides a method for preparing a perfusion based 3D cell culture system, a recellularized matrix culture system, and methods of using the culture system. |
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US20150044772 |
CRISPR/CAS SYSTEM-BASED NOVEL FUSION PROTEIN AND ITS APPLICATIONS IN GENOME EDITING
An inactive CRISPR/Cas system-based fusion protein and its applications in gene editing are disclosed. More particularly, chimeric fusion proteins including an inCas fused to a DNA modifying... |
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US20120237519 |
PESTVIRUS SPECIES
The application relates to a pestivirus, designated PMC virus, that is associated with porcine myocarditis syndrome, and the gene and protein sequences derived therefrom. The application further... |