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US20130065310 USE OF ENDOGENOUS PROMOTERS TO EXPRESS HETEROLOGOUS PROTEINS  
The present invention provides methods for using endogenous transcriptional control systems to regulate the expression of heterologous protein(s). In particular, targeted genome editing is used to...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20150133379 COSMETIC COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING FUSION PROTEIN  
The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a...
US20120039908 Control of Protein Glycosylation and Compositions and Methods Relating Thereto  
The invention relates to novel methods for controlling the glycosylation of a protein and the protein produced thereby. An exemplary method of the invention comprises producing a protein...
US20120196321 SELECTABLE MARKERS AND RELATED METHODS  
The invention relates to newly identified selectable marker systems, cells for use in a selectable marker system, and methods for using the selectable marker systems.
US20110306125 Protein Expression Methods  
The present invention relates to compositions and methods for obtaining (e.g., expressing, isolating and/or purifying) polypeptides capable of binding to and/or activating the guanylate cyclase C...
US20110294983 SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS  
The present invention relates to single-chain proteins of the formula HRS1-L1-HRS2-L2-HRS3, wherein HRS1, HRS2 and HRS3 are heptad repeat sequences and L1 and L2 are structurally flexible linker...
US20130065276 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20110281302 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20110104781 ISOLATED PHOSPHOLIPID-PROTEIN PARTICLES  
Systems and methods are provided for producing a protein of interest that is typically not amenable to expression in soluble form in in vitro expression systems. In some aspects, the invention...
US20140295545 PRE-PROGRAMMED NON-FEEDBACK CONTROLLED CONTINUOUS FEEDING OF CELL CULTURES  
A pre-programmed non-feedback continuous feeding method based on mass balance of the substrate in the bioreactor for use in culture growth and maintenance is provided. The disclosed method does...
US20120028900 METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS  
Provided herein are methods and compositions for producing Factor VIII proteins. Such methods include introducing into a cell a nucleic acid molecule encoding a Factor VIII protein operably linked...
US20140315804 FUSION PROTEINS COMPRISING PDGF AND VEGF BINDING PORTIONS AND METHODS OF USING THEREOF  
The present provides fusion proteins comprising PDGF and VEGF binding portions, and recombinant viral particles encoding the fusion proteins. Compositions comprising the fusion proteins and viral...
US20140186395 PERMISSIVE CELLS AND USES THEREOF  
Described are methods for determining the permissiveness of a cell for a virus that is a member of the family Arteriviridae or Coronaviridae or Asfarviridae, in particular, for Porcine...
US20120288895 Compositions and Methods for Modulating Hemostasis Using Variant Forms of Activated Factor V  
Methods for the treatment of coagulation disorders using Factor V/Va variants are provided.
US20130164786 FUCOSYLATION-DEFICIENT CELLS  
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
US20100304436 Fucosylation-Deficient Cells  
An isolated nucleic acid encoding an FX protein having a serine at position 79, a lysine at position 90, a leucine at position 136, an arginine at position 211, a serine at position 289, and a...
US20110311679 PREGASTRIC ESTERASE AND DERIVATIVES THEREOF  
The present invention relates to novel lipase polynucleotide sequences, their corresponding proteins as well as ways of manufacturing said sequences and said proteins and use of the proteins in...
US20140255990 Genetic Element that Enhances Protein Translation  
The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.
US20130129755 METHOD OF PRODUCING RECOMBINANT PROTEINS WITH MANNOSE-TERMINATED N-GLYCANS  
We describe a method of expressing a recombinant protein comprising mannose-terminated N-glycans from a host cell, the method comprising: (a) introducing a nucleic acid encoding a recombinant...
US20120244577 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS  
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at...
US20120315697 Cell Culture Media Containing Combinations of Proteins  
The present invention relates to cell culture media containing combinations of proteins, as well as methods of making the cell culture media, and methods of using the cell culture media to improve...
US20130230852 PROTEIN KINASE CK2 GENE MUTATIONS, AMPLIFICATIONS AND POLYMORPHISMS IN HUMAN CANCERS AND METHODS OF USE  
The present disclosure provides methods and compositions for diagnosis and for providing a prognosis of a cancer patient by assessing CK2 alpha 1 pseudogene (CSNK2A1P) status. The present...
US20130122585 SYNTHETIC GAGPOL GENES AND THEIR USES  
The present invention relates to synthetic gag and gagpol genes optimized for high level expression via codon optimization and the uses thereof for the efficient generation of vector particles....
US20150218240 p16 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER  
A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method...
US20130203162 NOVEL FLUORESCENT PROTEINS AND METHODS FOR USING SAME  
The present invention provides nucleic acid molecules encoding novel red fluorescent proteins from Entacmaea quadricolor and mutants thereof. Also of interest are proteins that are substantially...
US20150218243 P15 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER  
A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a...
US20150246960 Methods Of Producing A Secreted Protein  
The invention is directed to methods of producing a polypeptide or a variant thereof, wherein the polypeptide or variant thereof is dependent on LIMP-2 for trafficking, localization, stabilization...
US20110150925 CELL-BASED SYSTEMS FOR PRODUCING INFLUENZA VACCINES  
The present invention relates to a cell-based method for producing influenza virus vaccines by enriching the population of surface-bound α2,6-sialic acid receptors on a cell surface, such as on a...
US20120252878 USE OF CATHEPSIN H  
Present invention concerns the use of Cathepsin H. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain.
US20120121537 Methods and Compositions for Inhibiting Hepatitis C Virus Replication  
Compositions and methods for reducing hepatitis C virus (HCV) replication are provided. Also provided are compositions and methods of treating an HCV infection; methods of reducing the incidence...
US20110318376 RECOMBINANT EXPRESSION OF SELF-FOLDING NEUTRALIZING EPITOPE-BEARING SUBDOMAINS OF THE RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT AND FUSION PROTEINS  
The present invention is directed to self-folding, soluble, stable RSV G and F polypeptides that contain a neutralizing epitope. Fusion proteins and immunogenic conjugates containing the RSV G and...
US20110305718 Recombinant Protein Body-Inducing Polypeptides  
Polypeptide sequences for inducing recombinant protein bodies are described. The sequences comprise a polyproline II (PPII) structure and/or a proline-rich sequence between two cysteine residues...
US20120317664 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20120304321 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20140242692 MAMMALIAN GENES INVOLVED IN TOXICITY AND INFECTION  
The present invention relates to cellular proteins that are involved in toxicity and infection or are otherwise associated with the life cycle of one or more pathogens.
US20120077706 METHOD FOR ASSAYING PROTEIN-PROTEIN INTERACTION  
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the...
US20150044769 CELL LINE ADAPTED TO A PROTEIN-FREE AND LIPID-FREE MEDIUM, A METHOD FOR PRODUCING THE CELL LINE, AND A MEDIUM FOR THE CELL LINE  
A cell of a cell line adapted to a protein-free and lipid-free medium, which is derived from CHO cells, can be stably used for production of recombinant proteins and can proliferate in a suspended...
US20130295593 TRUNCATED HUMAN VITAMIN D BINDING PROTEIN AND MUTATION AND FUSION THEREOF AND RELATED MATERIALS AND METHODS OF USE  
Vitamin D binding proteins (DBP), in particular truncated DBP and mutated, truncated DBP, as well as fusion proteins thereof, nucleic acid molecules encoding same, vectors, host cells, and...
US20120003735 Methods for Improving Viability and Productivity in Cell Culture  
Methods for increasing viability and production of secreted proteins in fed batch eukaryotic cell culture are disclosed.
US20140120156 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20140004181 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20130252282 OPTICAL CONTROL OF PROTEIN ACTIVITY AND LOCALIZATION BY FUSION TO PHOTOCHROMIC PROTEIN DOMAINS  
Engineered fusion proteins comprising photochromic protein domains are disclosed. In particular, the inventors have constructed fusion proteins containing photoswitchable photochromic fluorescent...
US20150099705 PROTOXIN -II VARIANTS AND METHODS OF USE  
The present invention relates to Protoxin-II variants, polynucleotides encoding them, and methods of making and using the foregoing.
US20130310324 HUWENTOXIN-IV VARIANTS AND METHODS OF USE  
The present invention relates to Huwentoxin-IV variants, polynucleotides encoding them, and methods of making and using the foregoing.
US20130316962 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
US20150056271 COMPOSITIONS AND METHODS FOR ENHANCING COAGULATION FACTOR VIII FUNCTION  
Factor VIII variants and methods of use thereof are disclosed.
US20150023960 Compositions and Methods of Use for Treating Metabolic Disorders  
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US20140213511 COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS  
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US20110008393 NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 58P1D12 USEFUL IN TREATMENT AND DETECTION OF CANCER  
A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...