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US20120184016 NOVEL PROTEIN AND GENE THAT CODES THEREFOR  
The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention...
US20130078222 Intervertebral Disc Nucleus Pulposus Stem Cell/Progenitor Cell, The Cultivation Method And Intended Use Thereof  
Provided are intervertebral disk nucleus pulposus stem cells or progenitor cells that may be used for treatment of intervertebral disk disorders. An intervertebral disk nucleus pulposus cell is...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20130164839 METHOD FOR CULTURING CELLS IN A SYSTEM COMPRISING LAMININ-5  
The present invention is directed to providing a method for culturing cells in a system containing laminin-5. The method of the present invention is characterized by a culture system containing a...
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20130177929 METHOD FOR THE THREE-DIMENSIONAL CO- CULTURE OF PODOCYTES AND ENDOTHELIAL CELLS AND RELATIVE IN VITRO CO- CULTURE SYSTEM  
The present invention relates to a new three-dimensional co-culture method of podocytes and endothelial cells, and a relative co-culture system. Furthermore, the invention relates to the use of...
US20130280801 FLOWABLE TISSUE MATRICES  
Disclosed herein are flowable tissue matrix compositions comprising small pieces of partially or completely decellularized tissue suspended in a gelatinized tissue or gelatin gel comprising...
US20150044772 CRISPR/CAS SYSTEM-BASED NOVEL FUSION PROTEIN AND ITS APPLICATIONS IN GENOME EDITING  
An inactive CRISPR/Cas system-based fusion protein and its applications in gene editing are disclosed. More particularly, chimeric fusion proteins including an inCas fused to a DNA modifying...
US20150203837 FUSION PROTEIN FOR ACTIVATING RTK SIGNAL TRANSMISSION BY MEANS OF LIGHT, AND USE THEREOF  
The present invention relates to a fusion protein for reversibly activating RTK signal transmission by means of light and relates to a use thereof, and the invention provides a fusion protein in...
US20120129254 Inducible Expression System Transcription Modulators Comprising A Distributed Protein Transduction Domain And Methods For Using The Same  
Aspects of the invention include inducible expression systems in which a transcription modulator having a distributed protein transduction domain is employed. Aspects of the invention further...
US20120142002 SPONTANEOUSLY IMMORTALIZED MULTICOMPONENT MESENCHYMAL CELL-LINE DERIVED FROM MOUSE SUBCUTANEOUS ADIPOSE TISSUE: TOOL FOR REGENERATIVE MEDICINE AND BIOACTIVE MOLECULES AND/OR DRUGS SCREENING  
Disclosed is a spontaneously immortalized multipotent mesenchymal cell-line, wherein the cell-line has been isolated from mouse subcutaneous adipose tissue, and wherein the cell-line presents...
US20140073572 TARGETING COMPLEMENT FACTOR H FOR TREATMENT OF DISEASES  
The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and...
US20110287429 USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION  
Methods for propagating haploid genomes of male or female origina and genetic screening and modification thereof are provided. These haploid genomes may be used to produce haploid embryos, and...
US20120190107 ENHANCED PROTEIN TRANSDUCTION  
Methods of enhanced protein transduction are provided. Aspects of the methods include contacting a cell with a transduction protein, where the transduction protein includes both a...
US20140255990 Genetic Element that Enhances Protein Translation  
The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods.
US20130115239 PROSTATE CANCER DNA VACCINE  
The present invention concerns an (adjuvant) treatment or prevention option for the treatment and prevention of prostate cancer. In particular, it pertains to the provision of recombinant,...
US20130079881 COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT  
The present invention relates to a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal and methods of fabrication. The IVD comprises a nucleus pulposus...
US20140220555 IN VITRO MICROPHYSIOLOGICAL SYSTEM FOR HIGH THROUGHPUT 3D TISSUE ORGANIZATION AND BIOLOGICAL FUNCTION  
Techniques for generating microtissues, including a micro-fabricated platform including at least one micro-well including a plurality of micro-cantilevers coupled thereto and surrounded by a...
US20120204281 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20120204280 DRG11-RESPONSIVE (DRAGON) GENE FAMILY  
This invention features methods and compositions useful for treating and diagnosing diseases of the nervous system, retina, skin, muscle, joint, and cartilage using a Dragon family protein....
US20120331573 DYNACTIN SUBUNIT p62 BIOMARKER FOR NEUROLOGICAL CONDITIONS  
Methods and kits for identifying neurological conditions in a patient by determining a level of expression of dynactin subunit p62 are disclosed. The neurological conditions may include, for...
US20130324440 METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS  
The present application relates to a system for designing promoters for selective expression of genes. Thereby identified transcription regulatory elements are selected according to a specific...
US20120148559 COMPOSITIONS AND METHOD FOR DEIMMUNIZATION OF PROTEINS  
The invention provides deimmunized mutant proteins having reduced immunogenicity while exhibiting substantially the same or greater biological activity as the proteins of interst from which they...
US20130116165 LIGHT-ACTIVATED FUSION PROTEINS AND USES THEREFOR  
The invention, in some aspects relates to synthetic, light-activated fusion proteins and their encoding polynucleotide molecules. In some aspects the invention additionally includes expression of...
US20130195814 TISSUE-SPECIFIC DIFFERENTIATION MATRICES AND USES THEREOF  
In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and rejuvenation extracellular matrix. In other...
US20120244577 MULTIVALENT HETEROMULTIMER SCAFFOLD DESIGN AND CONSTRUCTS  
Provided herein are multifunctional heteromer proteins. In specific embodiments is a heteromultimer that comprises: at least two monomeric proteins, wherein each monomeric protein comprises at...
US20130230852 PROTEIN KINASE CK2 GENE MUTATIONS, AMPLIFICATIONS AND POLYMORPHISMS IN HUMAN CANCERS AND METHODS OF USE  
The present disclosure provides methods and compositions for diagnosis and for providing a prognosis of a cancer patient by assessing CK2 alpha 1 pseudogene (CSNK2A1P) status. The present...
US20140255942 METHOD FOR PRODUCING PLURIPOTENT CELL USING BACTERIUM HAVING FERMENTATION ABILITY  
It is an object of the present invention to provide a method for producing pluripotent cells that are free of the risk of cellular canceration and that can be applied to regenerative medicine with...
US20140140965 LOW OXYGEN CULTURE CONDITIONS FOR MAINTAINING RETINAL PROGENITOR CELL MULTIPOTENCY  
The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors...
US20120321593 LOW OXYGEN CULTURE CONDITIONS FOR MAINTAINING RETINAL PROGENITOR CELL MULTIPOTENCY  
The present invention relates to methods for culturing human retinal progenitor cells under low oxygen conditions to allow the cells to retain the ability to differentiate into photoreceptors...
US20110244470 ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS  
The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample...
US20150026833 Mito-Ob: A Transgenic Mouse Model for Obesity  
An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These...
US20140308247 Vectors Conditionally Expressing Protein  
This invention relates to the field of therapeutics. Most specifically, the invention provides methods of generating conditionally expressing one or more proteins under the control of a gene...
US20150218243 P15 PROTEIN VARIANT AND USE THEREOF FOR PREVENTING OR TREATING CANCER  
A p15 protein variant; a polynucleotide encoding the p15 protein variant; a method for preparing the p15 protein variant; a pharmaceutical composition comprising the p15 protein variant; and a...
US20120121537 Methods and Compositions for Inhibiting Hepatitis C Virus Replication  
Compositions and methods for reducing hepatitis C virus (HCV) replication are provided. Also provided are compositions and methods of treating an HCV infection; methods of reducing the incidence...
US20150064148 METHOD FOR TREATING OR PREVENTING A PANCREATIC DYSFUNCTION  
The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and/or progeny cells...
US20110014260 SYSTEM AND METHOD FOR LIVER CELL CULTURE AND MATURATION  
The present invention relates to systems and methods for maturation, proliferation and maintenance of function in cells presenting hepatocyte characteristics and differentiated from stem cells....
US20110045053 ISOLATED POPULATION OF LUMINAL STEM CELLS THAT GIVE RISE TO PROSTATE CANCER AND METHODS OF USING SAME  
The present invention is directed to an isolated population of luminal stem cells obtained from the prostate epithelium that express Nkx3.1. The invention is also directed to methods for...
US20110305718 Recombinant Protein Body-Inducing Polypeptides  
Polypeptide sequences for inducing recombinant protein bodies are described. The sequences comprise a polyproline II (PPII) structure and/or a proline-rich sequence between two cysteine residues...
US20120304321 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20140315299 STABLE PROTEINS  
The invention provides a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a Family B G-protein coupled receptor (GPCR) that comprises transmembrane helix (TM)-1, TM2...
US20110206735 Tumorigenic CancerStemCells, Methods of Isolating and Using the Same  
The present invention provides an enriched preparation of cancer stem cells selected by a process that eliminates non-cancer stem cells under extreme culture conditions. The cancer stem cells of...
US20120202286 rbLIF PROTEIN FOR USE IN EMBRYONIC STEM CELL CULTURES  
Provided herein methods of maintaining an embryonic stem cell culture in an undifferentiated state, wherein the method includes culturing an embryonic stem cell on a rabbit feeder cell layer,...
US20140213511 COMPOSITIONS AND METHODS OF USE FOR TREATING METABOLIC DISORDERS  
Methods of treating individuals with a glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
US20120171765 Factor VII or VIIa - Like Molecules  
Conjugates of Factor VII (FVII) and Factor VIIa (FVIIA) are provided, as are methods for preparing them. Methods for producing novel polypeptides contributing to the production of such conjugates...
US20140086939 COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER  
The invention provides methods for detecting the presence of cancer initiating cells in a tissue, methods for identifying test agent for reducing cancer, and methods for reducing cancer in a...
US20110214189 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20130302880 POLYNUCLEOTIDES ENCODING MUTANT HYDROLASE PROTEINS WITH ENHANCED KINETICS AND FUNCTIONAL EXPRESSION  
The invention provides a mutant hydrolase protein with enhanced kinetics and functional expression, as well as polynucleotides encoding the mutant proteins and methods of using the polynucleotides...
US20140023723 Decellularized Extracellular Matrix  
Methods for producing compositions of decellularized extracellular matrix (DM) tissue culture are described. The compositions can be used for coating supports such as tissue culture substrates,...
US20150174239 MEMBRANE PROXIMAL REGION OF HIV GP41 ANCHORED TO THE LIPID LAYER OF A VIRUS-LIKE PARTICLE VACCINE  
Disclosed herein are isolated immunogens including variant hepatitis B surface antigens (HBsAgs). In an example, a variant HBsAg includes a HBsAg with one or more transmembrane domains of the...