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US20120029074 |
CONTROLLING TRANSGENE EXPRESSION ACROSS THE SKIN
The invention relates to the use of a skin permeating compound such as phloretin for controlling transgene expression under control of the Pseudomonas putida DOT-T1E-derived bacterial repressor... |
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US20110117131 |
Production of OspA for Lyme Disease Control
The present invention relates, generally, to the production of one or more OspA proteins in plant cells. Heterologous DNA comprising genes encoding one or more desired OspA protein(s) are... |
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US20130219556 |
Viral Based Transient-Expression Vector System That Allows Multiple Applications
Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for... |
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US20120204287 |
VIRAL BASED TRANSIENT-EXPRESSION VECTOR SYSTEM THAT ALLOWS MULTIPLE APPLICATIONS
Disclosed herein are viral vectors suitable for transfection into woody trees for purposes of delivering and expressing beneficial genes. Specifically exemplified herein are vectors for... |
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US20110171315 |
Oral recombinant helicobacter pylori vaccine and preparing method thereof
The invention relates to a recombinant protein used for immunoprophylaxis of human Helicobacter pylori infection and a degradable slow-releasing microsphere-encapsulated oral vaccine preparation... |
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US20130274441 |
General Method for Designing Self-Assembling Protein Nanomaterials
Methods and systems for computationally designing self-assembling polypeptides are disclosed. A representation of a docked configuration of a symmetric protein architecture can be determined by a... |
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US20120225454 |
SYNTHETIC OPERON
The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a... |
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US20150051267 |
BICISTRONIC GENE TRANSFER TOOLS FOR DELIVERY OF miRNAS AND PROTEIN CODING SEQUENCES
Compositions and methods relating to microRNA (miRNA) technology are disclosed. In particular, microRNA (miRNA) expression vectors and methods for the treatment of sensory disorders, e.g., for the... |
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US20140220106 |
LYMPHATIC ZIP CODES IN TUMORS AND PRE-MALIGNANT LESIONS
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics. |
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US20110212162 |
LYMPHATIC ZIP CODES IN TUMORS AND PRE-MALIGNANT LESIONS
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics. |
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US20120204276 |
METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement... |
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US20140357521 |
TOOLS AND METHODS FOR EXPRESSION OF MEMBRANE PROTEINS
The disclosure relates cells or cellular systems that express both a membrane protein and a binding domain directed to the membrane protein. Also, methods are provided that use such cells or... |
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US20150125429 |
GENE TARGETING METHODS AND TOOLS
Provided herein is a general method of correcting a gene, for example a gene with many known mutations, such as a gene with mutations in many different exons which could vary from subject to... |
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US20130160166 |
ORAL INSULIN THERAPY
This disclosure relates in part to synthesizing a cleavable proinsulin construct in transgenic plants by chloroplast expression. |
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US20130230884 |
Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation
The present invention provides reagents and methods for identifying translation enhancing elements, as well as isolated translation enhancing elements and their use in protein expression reagents... |
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US20110263026 |
Construction of Protein-Responsive shRNA/RNAi Control System Using RNP Motif
An object of the present invention is to provide an RNAi control system using an RNA-protein interaction motif. The present invention provides an shRNA comprising: a guide strand having a sequence... |
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US20130115230 |
DELIVERY PROTEINS
Disclosed herein are materials and methods related to vaccines. Materials and methods for delivery of a payload, e.g., an immunogen, to the reticuloendothelial system via non-circulating lymphoid... |
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US20110179503 |
PROTEIN PRODUCTION IN A HOST
Recombinant DNA constructs that provide for expression of desired target proteins as protein bodies in various host cells, tissues, and organisms are disclosed. Such recombinant DNA constructs... |
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US20120284871 |
PROTEIN EXPRESSION SYSTEMS
Disclosed herein are methods and materials, and particularly viral derived sequences, for boosting gene expression in plants and other eukaryotic cells. The methods and materials may be used for... |
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US20120005782 |
CHEMICALLY INDUCIBLE CUCUMBER MOSAIC VIRUS PROTEIN EXPRESSION SYSTEM
The invention relates to a novel chemically inducible plant viral amplicon (CMViva) expression system that permits controllable, high level expression of foreign genes in plant hosts. This system... |
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US20130071429 |
BUNYAVIRUS VACCINE
The present invention provides attenuated viruses for use as vaccines and for the treatment and/or prevention of viral diseases and/or infections. |
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US20120017340 |
F-Box Protein Targeted Plant Oil Production
Disclosed are genetic constructs, transgenic plant cells and transgenic plants, as well as associated methods, for increasing oil production in a plant using F-box gene sequences. |
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US20150079123 |
LIVE, ATTENUATED RUBELLA VECTOR TO EXPRESS VACCINE ANTIGENS
Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) without an in-frame deletion, a rubella structural protein ORF,... |
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US20110256620 |
NUCLEIC ACID ENCODING A SELF-ASSEMBLING SPLIT-FLUORESCENT PROTEIN SYSTEM
The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with... |
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US20140377861 |
Precise Control of Recombinant Protein Levels by Engineering Translation
Compositions and methods are provided for user-specified fine-tuned protein expression levels, by controlling the initiation of protein translation; and a model for analysis of expression. This... |
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US20120207784 |
INSERTION OF FOREIGN GENES IN RUBELLA VIRUS AND THEIR STABLE EXPRESSION IN A LIVE, ATTENUATED VIRAL VACCINE
Disclosed herein are isolated rubella viral vector constructs that include a rubella non-structural protein open reading frame (ORF) with an in-frame deletion, a rubella structural protein ORF,... |
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US20120184016 |
NOVEL PROTEIN AND GENE THAT CODES THEREFOR
The present invention provides a novel protein having neuraminidase activity and/or β-galactoside-α2,6-sialyltransferase activity and a nucleic acid encoding the protein. The present invention... |
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US20110086059 |
NON-HEMOLYTIC CLYA FOR EXCRETION OF PROTEINS
The disclosure below provides a protein export system utilizing non-hemolytic variants of HlyE family member proteins for efficiently producing recombinant protein from a host cell. In a preferred... |
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US20120164140 |
HEMOJUVELIN FUSION PROTEINS AND USES THEREOF
The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also... |
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US20150211015 |
ENGINEERED PLANT BIOMASS FOR BIODIESEL AND BIOETHANOL PRODUCTION
The disclosure encompassed herein relates, in part, to a method for increasing energy density of plant biomass that can be used for production of renewable fuel, such as biodiesel oil and/or... |
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US20130123346 |
SYNTHETIC CONSTRUCTS FOR POLYNUCLEOTIDE & PROTEIN EXPRESSION
The present invention features, inter alia, nucleic acid constructs that include nucleotide sequences for regulating the expression of a sequence of interest. The sequences in the construct are... |
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US20150099297 |
CHIMERIC PROTEINS FOR TREATMENT OF DISEASES
A chimeric protein is made from the combination of (i) a pathogen recognition module derived from a scavenger receptor and (ii) an anchor domain from a different scavenger receptor. The chimeric... |
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US20120263756 |
VACCINES CONTAINING CANINE PARVOVIRUS GENETIC VARIANTS
Canine parvovirus vaccines and diagnostics and methods for their use are provided. The vaccines are effective against emerging canine parvovirus variants. |
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US20130197247 |
GENETICALLY ENGINEERED MICROBIAL STRAINS INCLUDING PROTOTHECA LIPID PATHWAY GENES
Genetically engineered microbial, e.g., Prototheca, cells provide microbial oil useful as a food additive and a source of renewable fuels and industrial chemicals. |
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US20150238591 |
Multifunctional Oral Vaccine Based on Chromosome Recombineering
A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome... |
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US20120255066 |
TRANSGENIC EXPRESSION OF ACYL-CO-A BINDING PROTEINS IN PLANTS
Disclosed are methods for modification of fatty acid composition and/or seed oil content in plants. In particular are methods to over-express acyl-CoA binding proteins (ACBPs) within the cells of... |
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US20100317073 |
MOLECULAR APPROACHES FOR THE OPTIMIZATION OF BIOFUEL PRODUCTION
Embodiments of the present invention utilize rationale genetic and chemical engineering strategies to achieve even greater efficiencies in biofuel production from microalgae. These increased... |
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US20120142096 |
FUSION PROTEINS OF HIV REGULATORY/ACCESSORY PROTEINS
The invention relates to fusion proteins comprising the amino acid sequence of at least three HIV proteins selected from Vif, Vpr, Vpu, Rev, and Tat or derivatives of the amino acid sequence of... |
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US20130028926 |
BIOSYNTHETIC SYSTEM THAT PRODUCES IMMUNOGENIC POLYSACCHARIDES IN PROKARYOTIC CELLS
The invention is directed to bioconjugate vaccines comprising N-glycosylated proteins. Further, the present invention is directed to a recombinant prokaryotic biosynthetic system comprising... |
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US20150093404 |
PCV2 ORF2 PROTEIN VARIANT AND VIRUS LIKE PARTICLES COMPOSED THEREOF
Vaccination methods to control PCV2 infection with different PCV2 subtypes are disclosed. Specifically, a PCV2 subtype b (PCV2b) ORF2 proteins or immunogenic compositions comprising a PCV2b ORF2... |
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US20120282217 |
FOOT AND MOUTH DISEASE VIRUS (FMDV) CONSENSUS PROTEINS, CODING SEQUENCES THEREFOR AND VACCINES MADE THEREFROM
Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as... |
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US20110035841 |
Lipid Metabolism Proteins, Combinations of Lipid Metabolism Proteins and Uses Thereof
Described herein are inventions in the field of genetic engineering of plants, including combinations of polynucleotides encoding LMPs to improve agronomic, horticultural, and quality traits. This... |
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US20110171250 |
Synthetic Gene Construct Coding for an HIV1 GAG and Use Thereof for Obtaining Anti-HIV-1 Vaccines
The invention relates to a synthetic gene coding for the Gag protein of the human immunodeficiency virus HIV-1. Said gene may optionally be fused with one or more other HIV sequences. The... |
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US20130254909 |
SYNTHETIC REGULATION OF GENE EXPRESSION
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a... |
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US20120108464 |
TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system... |
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US20130239853 |
HOT SPRING BACTERIAL STRAIN BKH1 AND PROTEIN ISOLATED THEREFROM, CONCRETE COMPOSITIONS, AND USES THEREOF
Disclosed is a Thermoanaerobacter sp. bacterial strain (BKHI) isolated from a hot spring, a purified protein (bioremediase) isolated from bacterial strain BKH1, as well as concrete compositions... |
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US20110100263 |
Hot Spring Bacterial Strain BKH1 and Protein Isolated Therefrom, Concrete Compositions, and Uses Thereof
Disclosed is a Thermoanaerobacter sp. bacterial strain (BKH1) isolated from a hot spring, a purified protein (bioremediase) isolated from bacterial strain BKH1, as well as concrete compositions... |
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US20130022707 |
GRAIN QUALITY THROUGH ALTERED EXPRESSION OF SEED PROTEINS
The present invention is directed to compositions and methods for altering the levels of seed proteins in cereal grain. The invention is directed to the alteration of seed protein levels in plant... |
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US20150133379 |
COSMETIC COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING FUSION PROTEIN
The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a... |
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US20110287053 |
Recombinant Foot and Mouth Disease Vaccine
A foot and mouth disease virus (FMDV) vaccine and method for producing same is described wherein the N terminal portion of the FMDV polyprotein, encoding the four structural proteins, 1A, 1B, 1C,... |