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US20110318301 |
IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES THEREOF
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F... |
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US20100016241 |
METHODS AND COMPOSITIONS FOR INHIBITING C-MET DIMERIZATION AND ACTIVATION
The invention provides methods and compositions for modulating the HGF/c-met signaling pathway, in particular by regulating c-met dimerization and/or binding of ligand to c-met using a c-met... |
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US20100015144 |
Methods for dosing an activin-actriia antagonist and monitoring of treated patients
In certain aspects, the present invention provides methods for dosing a patient with an activin-ActRIIa antagonist and methods for managing patients treated with an activin-ActRIIa anatagonist. In... |
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US20100008918 |
Methods for dosing an actriib antagonist and monitoring of treated patients
In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb anatagonist. In certain... |
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US20170081388 |
CELL LINE, SYSTEM AND METHOD FOR OPTICAL CONTROL OF SECONDARY MESSENGERS
A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence... |
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US20160195516 |
Methods of Detecting Signatures of Disease or Conditions in Bodily Fluids
Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having... |
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US20160194717 |
Methods of Detecting Diseases or Conditions Using Phagocytic Cells
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to... |
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US20160160290 |
METHODS AND BIOMARKERS FOR PREDICTING EFFICACY AND EVALUATION OF AN OX40 AGONIST TREATMENT
The present disclosure provides methods for predicting responsiveness of a subject having cancer to an OX40 agonist treatment by measuring the expression level of one or more biomarkers. Also... |
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US20150338393 |
METHODS FOR TREATING NEURAL CELL SWELLING
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different... |
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US20150132747 |
Treatment of Neurodegeneration and Neuroinflammation
Methods of treating a subject having a condition characterized by at least one of neurodegeneration and neuroinflammation are provided. Methods of reducing astrogliosis in a subject having a... |
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US20150119441 |
Modulators of ATP-Binding Cassette Transporters
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including... |
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US20150094304 |
Modulators of ATP-Binding Cassette Transporters
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including... |
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US20140294796 |
AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to... |
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US20140155431 |
MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof,... |
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US20140093906 |
ORGAN MIMIC DEVICE WITH MICROCHANNELS AND METHODS OF USE AND MANUFACTURING THEREOF
System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more... |
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US20140010799 |
HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules,... |
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US20130190210 |
ENGINEERED TISSUES FOR IN VITRO RESEARCH USES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME
Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays. |
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US20130034501 |
DIARYLHYDANTOIN COMPOUNDS
The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone lefiactory prostate cancer. |
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US20120329786 |
COMPOUNDS AND THERAPEUTIC USES THEREOF
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated... |
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US20120237449 |
METHODS FOR TREATING NEURAL CELL SWELLING
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different... |
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US20120122921 |
PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent. |
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US20120070849 |
METHODS AND COMPOSITIONS FOR RISK STRATIFICATION
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of... |
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US20110319327 |
Polypeptides Homologous to VEGF and BMP1
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor... |
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US20110288020 |
Use of VEGF and homologues to treat neuron disorders
The present invention relates to neurological and physiological dysfunction associated with neuron disorders. In particular, the invention relates to the involvement of vascular endothelial growth... |
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US20110250631 |
PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and... |
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US20110243956 |
METHODS OF DIAGNOSING AND TREATING COMPLICATIONS OF PREGNANCY
Disclosed herein are methods for diagnosing a pregnancy related hypertensive disorder or a predisposition to a pregnancy related hypertensive disorder by measuring the level or biological activity... |
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US20110070203 |
MESENDODERM AND MESODERM CELL POPULATIONS
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are... |
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US20110033839 |
Methods of Detecting Signatures of Disease or Conditions in Bodily Fluids
Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having... |
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US20100331251 |
POLYPEPTIDES HOMOLOGOUS TO VEGF AND BMP1
The present invention involves the identification and preparation of vascular endothelial growth factor-E (VEGF-E). VEGF-E is a novel polypeptide related to vascular endothelial growth factor... |
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US20100310658 |
Electroprocessed Fibrin-Based Matrices and Tissues
The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can... |
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US20100298255 |
Methods for providing personalized medicine test ex vivo for hematological neoplasms
Described herein are methods, devices, and compositions for providing personalized medicine tests for hematological neoplasms. In some embodiments, the methods comprise measuring the efficacy of... |
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US20100291618 |
Methods for rapid identification and/or characterization of a microbial agent in a sample
A method of testing a specimen sample contained within a sealed specimen container. A test sample is removed from the specimen container with a disposable sampling device. Non-microbial agent... |
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US20100233755 |
PDX1-EXPRESSING DORSAL AND VENTRAL FOREGUT ENDODERM
Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising... |
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US20100203529 |
Methods and systems of using exosomes for determining phenotypes
Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of... |
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US20100086961 |
Small Volume In Vitro Analyte Sensor and Methods of Making
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at... |
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US20100086954 |
Small Volume In Vitro Analyte Sensor and Methods of Making
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at... |
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US20100081152 |
Small Volume In Vitro Analyte Sensor and Methods of Making
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at... |
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US20100018874 |
Small Volume In Vitro Sensor and Methods of Making
A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at... |
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US20090258013 |
NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
The present invention relates to compositions and methods of using those compositions for the diagnosis and treatment of immune related diseases. |
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US20090098594 |
Methods for diagnosis prognosis and methods of treatment
This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of cells present in a sample (e.g. clinical... |
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US20090094708 |
Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives
The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying... |
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US20090035217 |
Truncated Fragments of Alpha-Synuclein in Lewy Body Disease
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of... |
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US20080317753 |
SELECTING PATIENTS FOR THERAPY WITH A HER INHIBITOR
A method for selecting patients for therapy with a HER inhibitor, such as pertuzumab, based on gene expression analysis is described. A method for assessing HER phosphorylation or activation in a... |
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US20080261260 |
USE OF GELSOLIN TO TREAT INFECTIONS
The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods... |
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US20080241113 |
Procurement, isolation and cryopreservation of endometrial/menstrual cells
Compositions comprising menstrual stem cells (MSCs) and methods, processes, and system therefor are provided by the invention. MSCs are processed from menstrual flow collected during menses. MSCs... |
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US20080118945 |
USE OF GELSOLIN TO TREAT INFECTIONS
The invention relates to the use of gelsolin to treat infections and to monitor the treatment of infections. The invention also provides methods up-regulating interleukin expression and methods... |
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US20080044848 |
Placental niche and use thereof to culture stem cells
The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period... |
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US20070015274 |
DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. |
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US20050096256 |
Compositions for manipulating the lifespan and stress response of cells and organisms
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and... |
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US20160282327 |
DIAGNOSTIC METHODS FOR NEURAL DISORDERS
The invention generally relates to optical methods for the diagnosis of neuronal condition by converting a cell from a patient into a neuron and optically evaluating action potentials of that cell... |