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US20130137116 METHOD AND KIT FOR DETECTING THE EARLY ONSET OF RENAL TUBULAR CELL INJURY  
A method and kit for detecting the early onset of renal tubular cell injury, utilizing NGAL as an early urinary biomarker. NGAL is a small secreted polypeptide that is protease resistant and...
US20080171325 METHOD AND DEVICE FOR DETECTING THE PRESENCE OF A SINGLE TARGET NUCLEIC ACID IN A SAMPLE  
A method comprising loading a sample portion into a sample chamber inside a microcapillary device, subjecting the sample portion to at least a first amplification step, and then determining...
US20080014589 Microfluidic devices and methods of use thereof  
The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of...
US20050148027 Very large scale immobilized polymer synthesis  
A method and apparatus for preparation of a substrate containing a plurality of sequences. Photoremovable groups are attached to a surface of a substrate. Selected regions of the substrate are...
US20160194702 Device, System, And Method For Depositing Processed Immiscible-Fluid-Discrete-Volumes  
Various embodiments relate to systems and/or methods for sample preparation that can be used for biochemical and/or molecular biology procedures involving small volumes, for example, micro volumes...
US20160169923 SYSTEMS AND METHODS FOR MULTI-ANALYSIS  
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection...
US20160169880 SYSTEMS AND METHODS FOR MULTI-ANALYSIS  
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection...
US20160033448 ACTIVE CHEMICALLY-SENSITIVE SENSORS WITH RESET SWITCH  
Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to...
US20160025721 MODULAR POINT-OF-CARE DEVICES, SYSTEMS, AND USES THEREOF  
The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The...
US20150217291 SYSTEM AND METHOD INCLUDING THERMAL CYCLER MODULES  
Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different...
US20150087530 Low-Volume Sequencing System and Method of Use  
Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than...
US20140186843 METHODS, SYSTEMS, AND APPARATUS FOR IDENTIFYING TARGET SEQUENCES FOR CAS ENZYMES OR CRISPR-CAS SYSTEMS FOR TARGET SEQUENCES AND CONVEYING RESULTS THEREOF  
Disclosed are locational or positional methods concerning CRISPR-Cas systems, and apparatus therefor.
US20130210020 SYSTEMS AND METHODS FOR MONITORING THE AMPLIFICATION AND DISSOCIATION BEHAVIOR OF DNA MOLECULES  
The present invention relates to systems and methods for monitoring the amplification of DNA molecules and the dissociation behavior of the DNA molecules. The present invention in one embodiment...
US20130137166 SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS  
Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different...
US20130004956 DNA ANALYZER  
Aspects of the disclosure provide a microfluidic chip to facilitate DNA analysis. The microfluidic chip includes a first domain configured for polymerase chain reaction (PCR) amplification of DNA...
US20120309636 SYSTEMS AND METHODS FOR SAMPLE USE MAXIMIZATION  
The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection...
US20120053088 MICROFLUIDIC TEST MODULE FOR BIOCHEMICAL PROCESSING AND ANALYSIS  
A test module for biochemical processing and analysis, the test module having an outer casing dimensioned for hand-held portability, the outer casing having a receptacle for receiving biochemical...
US20120052562 TEST MODULE WITH MICROFLUIDIC DEVICE HAVING LAMINAR STRUCTURE AND SAMPLE RECEPTACLE  
A test module having an outer casing for hand held portability, and, a microfluidic device for processing a biological sample mounted in the outer casing, the microfluidic device having a...
US20120035062 ALTERNATIVE NUCLEOTIDE FLOWS IN SEQUENCING-BY-SYNTHESIS METHODS  
A method for sequencing a polynucleotide strand by using sequencing-by-synthesis techniques. To address the problem of incomplete extension (IE) and/or carry forward (CF) errors that can occur in...
US20110312836 MICROFLUIDIC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION OF TARGET SEQUENCES  
A microfluidic device for detecting target nucleic acid sequences in a sample, the microfluidic device having reagent reservoirs for adding reagents to the sample prior to detection of the target...
US20110312835 GENETIC ANALYSIS LOC DEVICE WITH ELECTROCHEMILUMINESCENT PROBES AND INTEGRATED PHOTOSENSOR FOR DETECTION OF TARGET SEQUENCES  
A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence...
US20110312834 LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION USING A RUTHENIUM ORGANIC COMPLEX  
A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target...
US20110312831 LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCE WITH ELECTROCHEMILUMINESCENT METALORGANIC COMPLEX  
A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having a supporting substrate, probes with a nucleic acid sequence complementary to the target...
US20110312826 TEST MODULE WITH LASER FOR EXCITATION OF OLIGONUCLEOUTIDE PROBES  
A test module having an outer casing dimensioned for hand-held portability, the outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, probes in...
US20110312825 LOC DEVICE FOR ELECTROCHEMILUMINESCENT DETECTION WITH ELECTRODE PAIRS HAVING COMPLEMENTARY AND MUTUALLY INTERDIGITATED FINGER FORMATIONS  
A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence...
US20110312821 MICROFLUIDIC DEVICE WITH WASTE STORAGE  
A microfluidic device having a supporting substrate, a microsystems technologies (MST) layer on the supporting substrate for analyzing a fluid, and, a waste reservoir for storage of waste material...
US20110312819 LOC DEVICE FOR DETECTING TARGET NUCLEIC ACID SEQUENCES USING ELECTROCHEMILUMINESCENCE OF A LUMINOPHORE IN THE PRESENCE OF AN ELECTROCHEMICAL COREACTANT  
A lab-on-a-chip (LOC) device for detecting a target nucleic acid sequence in a sample, the LOC device having probes with a nucleic acid sequence complementary to the target nucleic acid sequence...
US20110312804 MICROFLUIDIC DEVICE WITH APERTURE WITH GEOMETRY TO PROMOTE UNPINNED FLOW-THROUGH OF FLUID  
A microfluidic device having a channel having an inlet, an outlet and an aperture between the inlet and the outlet, wherein, the aperture has a geometry that does not allow a meniscus of the fluid...
US20110312802 TEST MODULE WITH PROBES SUSPENDED IN FLUID  
A test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, probes in the outer casing for hybridization with the target...
US20110312800 TEST MODULE FOR GRAVITY-INDEPENDENT OPERATION  
A test module for analyzing genetic material in a biological sample, the test module having an outer casing with a receptacle for receiving the biological sample, functional sections for...
US20110312798 TEST MODULE WITH INBUILT LANCET  
A test module for processing and analyzing a blood sample, the test module having an outer casing with a receptacle for receiving blood, functional sections for processing and analyzing the...
US20110312796 TEST MODULE THAT UPDATES MEDICAL DATABASES  
A test module for analyzing a sample fluid and communicating data to a medical database, the test module having a receptacle for receiving the sample, functional sections for processing and...
US20110312794 TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES WITH LOCATION DATA  
A test module for analyzing a sample fluid and communicating location data to an epidemiological database, the test module having a receptacle for receiving the sample, functional sections for...
US20110312793 MICROFLUIDIC TEST MODULE WITH LOW MASS OF PROBES  
A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing,...
US20110312792 TEST MODULE THAT UPDATES EPIDEMIOLOGICAL DATABASES  
A test module for analyzing a sample fluid and communicating epidemiological data to a database, the test module having a receptacle for receiving the sample, functional sections for processing...
US20110312791 TEST MODULE WITH FAULT-TOLERANT MULTIPLE VALVE ASSEMBLY  
A test module for genetic analysis having a casing for hand held portability, an inlet for receiving a liquid containing nucleic acid sequences, an outlet downstream of the inlet, and, a...
US20110312790 MICROFLUIDIC TEST MODULE WITH LOW-VOLUME HYBRIDIZATION CHAMBER  
A microfluidic test module having an outer casing having an inlet for receiving a biological sample containing a target nucleic acid sequence, and, a hybridization chamber mounted in the casing,...
US20110312789 LOC DEVICE WITH FLASH MEMORY  
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a supporting substrate, a sample inlet for receiving the sample, a microsystems technology (MST) layer with...
US20110312787 LOC HAVING USB DEVICE DRIVER FOR USE IN A TEST MODULE TO CONTROL USB CONNECTION  
A lab-on-a-chip (LOC) device for installation in a test module for analyzing a sample fluid and communicating test results to an external device, the LOC device having a supporting substrate, a...
US20110312786 GENETIC ANALYSIS LOC WITH HYBRIDIZATION ARRAY WITH CALIBRATION CHAMBER CONTAINING PROBE DESIGNED TO BE NONCOMPLEMENTARY TO NUCLEIC ACID SEQUENCES IN THE AMPLICON  
A microfluidic device having a supporting substrate, an inlet for receiving a biological sample containing a target nucleic acid sequences, a hybridization chamber containing probes each having a...
US20110312781 LOC WITH DIGITAL MEMORY TO STORE GENETIC DATA UPDATES  
A lab-on-a-chip (LOC) device for analyzing a sample fluid, the LOC device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for...
US20110312777 TEST MODULE WITH DIGITAL MEMORY  
A test module for analyzing a sample fluid, the test module having a receptacle for receiving the sample, functional sections for processing and analyzing the sample, and, digital memory for...
US20110312775 MICROFLUIDIC DEVICE WITH DIGITAL MEMORY  
A microfluidic device for analyzing a sample fluid, the microfluidic device having a sample inlet for receiving the sample, a microsystems technology (MST) layer with functional sections for...
US20110312772 LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH PCR AMPLIFICATION USING LINKER PRIMERS  
A LOC device for amplifying nucleic acid sequences and detecting target nucleic acid sequences, the LOC device having a supporting substrate, restriction enzymes for digesting double stranded...
US20110312770 LOC FOR DETECTION OF HYBRIDIZATION OF NUCLEIC ACID SEQUENCES WITH NUCLEIC ACID AMPLIFICATION USING PRIMERS COVALENTLY ATTACHED TO LINEAR PROBES  
A LOC device having a supporting substrate, a primer-linked, linear probe with a nucleic acid sequence that matches a target nucleic acid sequence, and a primer for elongating against the target...
US20110312763 GENETIC ANALYSIS LOC WITH IN-LOC STORAGE OF ALL REQUIRED REAGENTS  
A lab-on-a-chip (LOC) device for genetic analysis having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an inlet for receiving a...
US20110312759 GENETIC ANALYSIS LOC WITH REAGENT RESERVOIR  
A LOC device for performing a genetic diagnostic assay, the LOC device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST layer having an...
US20110312756 MICROFLUIDIC DEVICE WITH LOW REAGENT VOLUMES  
A microfluidic device for biochemical processing and analysis, the microfluidic device having a supporting substrate, a microsystems technology (MST) layer supported on the substrate, the MST...
US20110312754 MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA ELECTROCHEMILUMINESCENCE MODULATED HYBRIDIZATION  
A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing...
US20110312753 LOC WITH INTEGRAL LED DRIVER FOR EXCITATION LED  
A microfluidic device having a supporting substrate, a probe with a nucleic acid sequence for hybridization with a target nucleic acid sequence to form a probe-target hybrid and generate a...