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US20140242111 Engineered Bacteria for Oral Delivery of Glucoregulatory Proteins  
Disclosed is an oral delivery system that overcomes major barriers encountered in the gastrointestinal tract, particularly rapid proteolytic degradation and low intestinal permeability. Provided...
US20150165011 DNA VACCINE FOR USE IN PANCREATIC CANCER PATIENTS  
The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding a VEGF receptor protein. In particular, the present invention relate to...
US20130143281 Chimeric PUFA Polyketide Synthase Systems and Uses Thereof  
Disclosed are chimeric polyunsaturated fatty acid (PUFA) olyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from...
US20120021470 Chimeric PUFA Polyketide Synthase Systems and Uses Thereof  
Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from...
US20150044256 Oral Vaccine For Borrelia  
The present invention relates to vaccines for control of Borrelia infections in animal and human populations. In particular, the present invention provides compositions and methods comprising...
US20120225454 SYNTHETIC OPERON  
The present invention relates to synthetic operons. In particular, the present invention relates to a synthetic operon for integration into a bacterial chromosome of a bacterium comprising a...
US20120204276 METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS  
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement...
US20130071429 BUNYAVIRUS VACCINE  
The present invention provides attenuated viruses for use as vaccines and for the treatment and/or prevention of viral diseases and/or infections.
US20110243980 METHODS AND SYSTEMS FOR O-GLYCOSYLATING PROTEINS  
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like...
US20120171230 ORAL VACCINES PRODUCED AND ADMINISTERED USING EDIBLE MICRO-ORGANISM  
The anti-pathogen vaccine of the present invention is produced in recombinant bacteria and/or transgenic plants and then administered through standard vaccine introduction method or through the...
US20150238591 Multifunctional Oral Vaccine Based on Chromosome Recombineering  
A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome...
US20130239853 HOT SPRING BACTERIAL STRAIN BKH1 AND PROTEIN ISOLATED THEREFROM, CONCRETE COMPOSITIONS, AND USES THEREOF  
Disclosed is a Thermoanaerobacter sp. bacterial strain (BKHI) isolated from a hot spring, a purified protein (bioremediase) isolated from bacterial strain BKH1, as well as concrete compositions...
US20110100263 Hot Spring Bacterial Strain BKH1 and Protein Isolated Therefrom, Concrete Compositions, and Uses Thereof  
Disclosed is a Thermoanaerobacter sp. bacterial strain (BKH1) isolated from a hot spring, a purified protein (bioremediase) isolated from bacterial strain BKH1, as well as concrete compositions...
US20150133379 COSMETIC COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING FUSION PROTEIN  
The present invention relates to a fusion protein comprising a skin-penetrating peptide, a polynucleotide encoding the fusion protein, an expression vector comprising the polynucleotide, a...
US20130345400 IDENTIFICATION OF A HUMAN GYROVIRUS AND APPLICATIONS  
The present invention relates to HGyV, a human gyrovirus related to the chicken anemia virus (CAV). The present invention also relates to a new proteins encoded by HGyV, which proteins display...
US20150175671 OIL GLOBULE PROTEIN AND USES THEREOF  
An isolated novel oil globule protein encoded by a polynucleotide sequence is provided together with a composition which includes the isolated protein. A transgenic organism transformed by a...
US20120225453 SYSTEMS AND METHODS FOR THE SECRETION OF RECOMBINANT PROTEINS IN GRAM NEGATIVE BACTERIA  
Disclosed herein are systems and methods for producing recombinant proteins utilizing mutant E. coli strains containing expression vectors carrying nucleic acids encoding the proteins, and...
US20150210751 Method and Composition for Crystallizing G Protein-Coupled Receptors  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising: a) a first portion of a G-protein coupled receptor (GPCR), where the first portion...
US20120301497 Plasmodium vivax Hybrid Circumsporozoite Protein and Vaccine  
Described in this application is a synthetic P. vivax circumsporozoite protein useful as a diagnostic reagent, for antibody production, and as a vaccine protective against infection with any...
US20130115208 HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM  
The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other...
US20120195928 VACCINES AND METHODS FOR USING THE SAME  
Compositions comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with one or more of CTACK protein, TECK protein, MEC protein and functional fragments...
US20110117655 METHODS AND COMPOSITIONS FOR GENETICALLY MANIPULATING CLOSTRIDIA AND RELATED BACTERIA WITH HOMOLOGOUS RECOMBINATION ASSOCIATED PROTEINS  
Methods for effecting homologous recombination in a bacterium of the Clostridia family are described. These methods provide enhanced capability to genetically modify clostridia.
US20140283208 Novel Insecticidal Proteins and Methods of Use  
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic...
US20130298264 SYNTHETIC GENES AND GENETIC CONSTRUCTS  
The present invention relates generally to synthetic genes for modifying endogenous gene expression in a cell, tissue or organ of a transgenic organism, in particular a transgenic animal or plant....
US20140007292 Novel Insecticidal Proteins and Methods for Their Use  
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic...
US20110287520 SALMONELLA MARKER VACCINE  
The present invention relates to a Salmonella strain suitable as a marker vaccine having an inactivated gene.
US20140273238 TRANSCRIPTIONAL CONTROL IN ALICYCLOBACILLUS ACIDOCALDARIUS AND ASSOCIATED GENES, PROTEINS, AND METHODS  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods of modulating transcription...
US20130203170 METHODS AND COMPOSITIONS FOR GENETICALLY MANIPULATING CLOSTRIDIA AND RELATED BACTERIA WITH HOMOLOGOUS RECOMBINATION ASSOCIATED PROTEINS  
Methods for enhancing single cross-over homologous recombination in gram positive bacteria are presented. These methods provide enhanced capability to genetically modify gram positive bacteria.
US20110256177 YERSINIA PESTIS VACCINE  
The present invention encompasses a recombinant Yersinia pestis bacterium and a vaccine comprising a recombinant Yersinia pestis bacterium.
US20110257041 BIO-FIELD PROGRAMMABLE GATE ARRAY AND BIO-PROGRAMMABLE LOGIC ARRAY: RECONFIGURABLE CHASSIS CONSTRUCTION  
Aspects of the invention relate to reconfigurable chassis that allow for rapid construction and optimization of biocircuits.
US20120045475 LIVE ATTENUATED VACCINES  
The present invention relates to a bacterium attenuated by a mutation in at least one ABC transporter gene wherein the mutation renders the corresponding ABC transporter protein non-functional and...
US20120210462 SYNTHETIC INSECTICIDAL PROTEINS ACTIVE AGAINST CORN ROOTWORM  
Traditionally, the primary method for impacting insect pest populations is the application of broad-spectrum chemical insecticides. However, there is increasing concern about the environmental...
US20130115655 METHOD FOR THE PRODUCTION OF A LYSATE USED FOR CELL-FREE PROTEIN BIOSYNTHESES  
The invention relates to a method for producing a lysate used for cell-fee protein biosynthesis, comprising the following steps: a) a genomic sequence in an organism, which codes for an essential...
US20130287810 VACCINE COMPOSITIONS AND USES THEREOF  
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems...
US20110091493 VACCINE COMPOSITIONS AND USES THEREOF  
The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems...
US20130345398 Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy  
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The...
US20110294983 SINGLE-CHAIN ANTIPARALLEL COILED COIL PROTEINS  
The present invention relates to single-chain proteins of the formula HRS1-L1-HRS2-L2-HRS3, wherein HRS1, HRS2 and HRS3 are heptad repeat sequences and L1 and L2 are structurally flexible linker...
US20130007922 METHOD FOR MODIFYING PLANT MORPHOLOGY, BIOCHEMISTRY AND PHYSIOLOGY  
The present invention provides methods and compositions for increasing seed size and/or weight, embryo size and/or weight, and cotyledon size and/or weight. The methods comprise expression of a...
US20130344033 RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)  
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the...
US20120195859 RECOMBINANT PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY BOWEL DISEASE (IBD) AND IRRITABLE BOWEL SYNDROME (IBS)  
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the...
US20130337011 RECOMBINANT MYCOBCTERIUM AS A VACCINE  
The invention relates to a recombinant Mycobacterium cell for use as a vaccine.
US20110225676 Two Novel Alkylresorcinol Synthase Genes from Sorghum; Cloning, Expression, Transformation and Characterization  
Sorghum is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone (2-hydroxy-5-methoxy-3-[(Z,Z)-8′,11′,14′-pentadecatriene]-p- benzoquinone)...
US20130116412 Production of Post-Translationally Hydroxylated Recombinant Proteins in Bacteria  
Bacterial cells capable of producing recombinant proteins, such as post-translationally hydroxylated recombinant proteins, methods and kits for producing recombinant proteins, such as...
US20110126305 Mutant blue fluorescent protein and method of using the same for fluorescence resonance energy transfer and blue fluorescent fish  
The present invention discloses a mutant blue fluorescent protein (BFP) exhibiting, at an aerobic or anaerobic system, larger fluorescent intensity than a BFPvv D7 of SEQ ID NO:2 derived from a...
US20130203133 BUOYANT TRIACYLGLYCEROL-FILLED GREEN ALGAE AND METHODS THEREFOR  
Cultures of Chlamydomonas are disclosed comprising greater than 340 mg/l triacylglycerols (TAG). The cultures can include buoyant Chlamydomonas. Methods of forming the cultures are also disclosed....
US20130045525 METHOD OF CANCER TREATMENT  
A method and composition for treating cancer comprising administering to a patient an effective amount of attenuated Salmonella typhimurium containing a plasmid carrying the coding sequence...
US20110312044 EXTRACTION SOLVENTS DERIVED FROM OIL FOR ALCOHOL REMOVAL IN EXTRACTIVE FERMENTATION  
In an alcohol fermentation process, oil derived from biomass is chemically converted into an extractant available for in situ removal of a product alcohol such as butanol from a fermentation...
US20120219992 METHOD AND COMPOSITION FOR CRYSTALLIZING A FAMILY C GPCR  
Certain embodiments provide a method for crystallizing a GPCR. The method may employ a fusion protein comprising, from N-terminus to C-terminus: a) a first portion of a family C G-protein coupled...
US20140038297 Genes and Proteins for the Biosynthesis of the Lantibiotic 107891  
The Invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the...
US20120015418 GENES AND PROTEINS FOR THE BIOSYNTHESIS OF THE LANTIBIOTIC 107891  
The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the...