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US20130004981 |
SYSTEM AND METHOD FOR SELECTING MOLECULE INTERACTING WITH PROTEIN PHOSPHATASE
A system and a method for selecting a molecule interacting with protein phosphatase are disclosed. The fluorescence protein detecting system for selecting a molecule interacting with protein... |
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US20100322974 |
Targeting the histone code as a bacterial strategy for selectively modulating gene expression
The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein... |
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US20100297667 |
METHOD FOR DIAGNOSIS OF DISEASE USING QUANTITATIVE MONITORING OF PROTEIN TYROSINE PHOSPHATASE
The present invention relates to a method for quantifying protein tyrosine phosphatase (referred as PTP hereinafter) in biosamples, precisely a diagnostic method for disease by quantifying PTP... |
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US20140242595 |
HEPATOCYTE PRODUCTION VIA FORWARD PROGRAMMING BY COMBINED GENETIC AND CHEMICAL ENGINEERING
The present invention provides methods comprising both genetic and chemical means for the production of hepatocytes from a variety of cell sources, particularly pluripotent stem cells. |
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US20110137131 |
RISK FACTORS AND PREDICTION OF MYOCARDIAL INFARCTION
Biomarkers and methods are disclosed for diagnosing the risk of a myocardial infarction in an individual by measuring the levels of a set of biomarkers in a sample from an individual. A risk score... |
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US20110269162 |
UBIQUITIN PROTEASOME SYSTEM PROFILING FOR DIAGNOSIS OF CHRONIC LIVER DISEASE
Provided herein are methods for the diagnosis, staging, prognosis, or management of liver disease, e.g. chronic liver disease, and other diseases using profiles of the ubiquitin-proteasome system... |
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US20150087552 |
METHODS FOR SCREENING VOLTAGE-GATED PROTEINS
In one aspect, the invention relates to a method for identifying a compound which modulates the activity of a voltage-gated protein. In certain embodiments, the voltage gate protein is a... |
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US20130203059 |
Method for Diagnosis of Bladder Cancer and Related Kits
The invention refers to a novel molecular biomarker, namely PTPD1, that is markedly increased in human bladder cancers. PTPD1 expression positively correlated with the grading and invasiveness... |
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US20140242092 |
VHZ FOR DIAGNOSIS AND TREATMENT OF CANCER
We provide VHZ for use in a method of treatment, prophylaxis or alleviation of a cancer, such as breast cancer, in an individual. We provide an anti-VHZ agent for the treatment, prophylaxis or... |
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US20120208210 |
Post-Translational Modifications Indentified by Elemental Analysis
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate... |
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US20110076708 |
Cartilage intermediate layer protein 2 C1 and its use to differentiate osteoarthritis from rheumatoid arthritis and non-disease conditions
A method for differentiation of osteoarthritis from rheumatoid arthritis and non-disease conditions in a sample, comprising measuring in the sample the concentration of human cartilage... |
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US20120164671 |
METHODS FOR MONITORING IMMUNOSUPPRESSANT DRUG LEVELS, RENAL FUNCTION, AND HEPATIC FUNCTION USING SMALL VOLUME SAMPLES
Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume... |
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US20110217281 |
METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER
A method for diagnosing an early stage melanoma which includes detecting the expression level of dual specificity phosphatase 1 protein (DUSP1) and a method for determining a prognosis for a... |
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US20150191523 |
TOLL-LIKE RECEPTORS
The present invention relates to toll-like receptors, to cells comprising such toll-like receptors, to methods for the detection of immunostimulatory oligodeoxynucleotides wherein such methods use... |
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US20140249150 |
ACTIVATORS OF PYRUVATE KINASE M2 AND METHODS OF TREATING DISEASE
The invention described herein features methods, compositions, and kits that utilize activators of pyruvate kinase M2 (PKM2) for the treatment or amelioration of disorders related to PKM2 function... |
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US20120009592 |
ENPP1 (PC-1) GENE HAPLOTYPE ASSOCIATED WITH THE RISK OF OBESITY AND TYPE 2 DIABETES AND THEIR APPLICATIONS
The present invention is directed to a method for determining if a subject is at increased risk to develop obesity or pathology related to obesity by determining the presence of a haplotype... |
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US20120121515 |
METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS
Methods of treating and evaluating subjects having neoactive mutants are described herein. |
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US20120227134 |
Plants with Increased Yield
A method for producing a plant with increased yield as compared to a corresponding wild type plant whereby the method comprises at least the following step: increasing or generating in a plant or... |
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US20120252698 |
ISOLATED AUSTRALIAN CORAL REEF FLUORESCENT PROTEINS AND CELL-BASED KINASE OR PHOSPHATASE PLATFORMS FOR CANCER DRUG DEVELOPMENT
The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are... |
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US20120071343 |
BIOMARKERS FOR DIFFERENTIATING MELANOMA FROM BENIGN NEVUS IN THE SKIN
Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method... |
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US20130122524 |
Methods for Diagnosis, Prognosis and Methods of Treatment
This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical... |
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US20110265197 |
Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof
The present invention provides methods of detecting cancer using biomarkers. |
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US20150005193 |
QUALITATIVE AND QUANTITATIVE POINT-OF-CARE ASSAYS
Disclosed herein are “equipment-free” flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous, hydrophilic media are patterned... |
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US20110124009 |
COMPOSITION, KIT AND METHOD FOR ASSAYING NEUROPATHY
The present invention relates to a method for detecting a disease accompanied with neuropathy such as glaucoma, comprising measuring and/or detecting one or more of polypeptides shown in SEQ ID... |
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US20120302604 |
Modulation of Phospholipase D for the Treatment of the Acute and Chronic Effects of Ethanol
The present invention relates to methods of decreasing the negative effects of alcohol on behavior as well as inhibiting the toxic effects of alcohol, comprising administering, to a subject, an... |
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US20120195875 |
DETECTION OF IMMUNE MODULATION RESULTING FROM REDUCED PROTEIN PHOSPHATASE 2A ACTIVITY
The inventors demonstrate herein that measuring the level of protein phosphatase 2A activity (PP2A) is useful for assessing immune modulation and susceptibility to infection in an individual. This... |
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US20110191873 |
Methods of Protein Destabilization and Uses Thereof
This invention is directed towards methods of destabilizing proteins in living cells, and their use for the development of novel assays. In one embodiment, the invention comprises the use of... |
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US20110294874 |
DIAGNOSIS AND THERAPY OF ORGAN DYSFUNCTION USING SPHINGANINE-1-PHOSPHATE
The invention relates to the treatment and diagnosis of organ dysfunction caused by ischemia reperfusion injury. In particular, the invention relates to sphinganine-1-phosphate, a sphingolipid... |
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US20110275101 |
METHOD FOR USING DIVISION ARRESTED CELLS IN SCREENING ASSAYS
Division arrested cells are used in screening assays to determine the effect of a substance of interest on the cells. The division arrested cells can be used in drug screening assays, signal... |
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US20110256565 |
METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES OR DISORDERS
The present invention provides methods that are useful for the diagnosis of neurodegenerative disease or disorder and for the screening of compounds or therapeutic agents for treating a... |
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US20100311095 |
ASSESSMENT OF PHYSIOLOGICAL CONDITIONS
The present invention relates to a method for assessing in vitro the balance and the overall dynamics of a physiological condition, wherein a) a first biochemical marker representing a first... |
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US20140147875 |
DISEASE SEVERITY INDEX FOR ASSESSMENT OF CHRONIC LIVER DISEASE AND METHOD FOR DIAGNOSIS OF THREE DISTINCT SUBTYPES OF PRIMARY SCLEROSING CHOLANGITIS
A Disease Severity Index (DSI) is provided for assessment of chronic liver disease in a patient using non-invasive liver function test results. A DSI was derived from non-invasive liver function... |
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US20120071339 |
BIOMARKERS
The invention relates to a method of diagnosing or monitoring multiple sclerosis. |
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US20130266977 |
METHODS AND SYSTEMS FOR DETECTION OF MICROBES
Provided herein are methods, test units, systems, assays and kits for qualitative and/or quantitative detection of microorganisms or microbes. Some aspects of the invention utilize a test strip... |
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US20110305677 |
HUMAN EMBRYONIC STEM CELL CULTURES, AND COMPOSITIONS AND METHODS FOR GROWING SAME
Human pluripotential embryonic stem cell cultures are provided, as are human feeder cells useful for growing the human embryonic stem cells, conditioned medium obtained from cultures of the human... |
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US20110306521 |
SEPARATION OF PYROPHOSPHATE RELEASE AND PYROPHOSPHATE DETECTION
The present technology relates to methods and systems for detection of pyrophosphate. As such, disclosed herein are methods and systems that permit improved pyrophosphate detection. Also disclosed... |
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US20120095086 |
PROTEIN TYROSINE PHOSPHATASE MUTATIONS IN CANCERS
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine... |
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US20150240274 |
REDUCING INSOLUBLE DEPOSIT FORMATION IN ETHANOL PRODUCTION
The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt... |
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US20140093898 |
REDUCING INSOLUBLE DEPOSIT FORMATION IN ETHANOL PRODUCTION
The present inventors have surprisingly discovered that phytic acid tenaciously precipitates with soluble metals in food or fuel ethanol-processing fluid, producing insoluble organometallic salt... |
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US20110256108 |
METHODS OF SELECTION OF CELLS FOR TRANSPLANTATION
A method of selecting a population of adherent cells of a placenta tissue suitable for transplantation is disclosed. The method comprising: (a) determining prior to transplantation in a candidate... |
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US20120021937 |
DETECTION OF CARCINOMA IN SITU IN SEMEN SPECIMENS
The present invention provides a method for the detection of testicular cancer and/or precursors hereof by screening a sample for the presence of at least two markers in the same cell, wherein the... |
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US20150140124 |
METHOD OF DIAGNOSING, TREATING AND DETERMINING PROGRESSION AND SURVIVAL OF CANCER CELLS USING BCL-2 ANTAGONIST OF CELL DEATH (BAD) PATHWAY GENE SIGNATURE
The present invention relates to the BAD pathway's influence on development, progression, chemo-sensitivity, and overall survival for multiple human cancers and its potential as a therapeutic... |
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US20150051097 |
Methods for Screening Inhibitors of Tau Phosphorylation By Casein Kinase I
Methods of screening for candidate compounds capable of inhibiting activity of fyn in phosphorylating tau protein at Y394 or binding to fyn to inhibit interaction with tau protein at Y394,... |
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US20120010240 |
CUT-POINT IN PTEN PROTEIN EXPRESSION THAT ACCURATELY IDENTIFIES TUMORS AND IS PREDICTIVE OF DRUG RESPONSE TO A PAN-ErbB INHIBITOR
A cut-point in the quantitative measurement of PTEN protein expression that accurately identifies tumors with two inactivated alleles of the PTEN gene. Patients with a normalized PTEN score of... |
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US20130224779 |
METHOD FOR LARGE SCALE PREPARATION OF THE ACTIVE DOMAIN OF HUMAN PROTEIN TYROSINE PHOSPHATASE WITHOUT FUSION PROTEIN
The present invention relates to methods for identifying inhibitors or activators of protein tyrosine phosphatase (PTP). In some examples, the methods utilize a PTP active domain with high... |
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US20140323339 |
METHODS TO ASSAY KINASE ACTIVITY
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate... |
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US20150011422 |
METHODS TO ASSAY PHOSPHATASE ACTIVITY
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate... |
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US20110251091 |
THYROID TUMORS IDENTIFIED
The invention relates to methods and kits for detecting thyroid cancer by detecting differences in the expression of genes that are differentially expressed in thyroid cancer cells. |
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US20100216643 |
CONTROL OF PLANT STRESS TOLERANCE, WATER USE EFFICIENCY AND GENE EXPRESSION USING NOVEL ABA RECEPTOR PROTEINS AND SYNTHETIC AGONISTS
The present invention provides methods of regulating plant stress tolerance. |
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US20130191931 |
FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT PIGS AND USES THEREOF
Described herein is the generation of Fah+/− heterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fah−/− homozygote pigs. The Fah-deficient... |