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US20110262422 ORALLY ADMINISTRABLE DOSAGE FORMS COMPRISING ANGIOGENIN AND USES THEREOF  
The invention provides a method of treatment of any disorder in which administration of angiogenin is beneficial wherein the angiogenin is administered orally. Particularly, the oral angiogenin...
US20150099290 INSERTION OF CHARGE IN THE HYDROPHOBIC INTERIOR OF PROTEINS AS A STRATEGY FOR ENGINEERING PH-SENSITIVE SWITCHES  
Methods are provided for engineering non-naturally occurring proteins comprising artificial pH-sensitive conformational switches that respond to a change in pH by causing a global unfolding of the...
US20130029400 GENETIC ELEMENTS, PROTEINS, AND ASSOCIATED METHODS INCLUDING APPLICATION OF ADDIITNAL GENETIC INFORMATION TO GRAM (+) THERMOACIDOPHILES  
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering...
US20150164984 Colicins for Treating Bacterial Infections  
The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli...
US20130095551 METHOD FOR CHANGING CONFORMATION OF GLOBULAR PROTEINS  
A method for changing conformation of globular proteins is provided. The method controls the concentration of the globular proteins and the adsorption time of the globular proteins from the...
US20120331574 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20150159172 METHODS AND COMPOSITIONS FOR GENOME ENGINEERING  
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease.
US20130330778 METHOD OF ADAPTOR-DIMER SUBTRACTION USING A CRISPR CAS6 PROTEIN  
A method of processing a target RNA is provided. In certain embodiments, this method comprises: contacting the products of an RNA ligase-mediated ligation reaction with an CAS6 protein, wherein:...
US20140234975 METHOD FOR INCREASING THE EFFICIENCY OF DOUBLE-STRAND-BREAK INDUCED MUTAGENESIS  
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering,...
US20130210151 ENDONUCLEASE FOR GENOME EDITING  
A chimeric endonuclease is provided comprising the GIY-YIG nuclease domain which is linked to a DNA-targeting domain by a linking domain. The endonuclease is useful in gene editing.
US20140249094 SENSATION-IMPROVING AGENT  
An object of the present invention is to provide a safety sensation-improving agent that can improve dulled peripheral sensations through daily ingestion or application to the skin. Another object...
US20130216579 METHODS AND COMPOSTITIONS FOR GENE EDITING OF A PATHOGEN  
Disclosed herein are methods and compositions for genome editing of the malarial parasite Plasmodium, and for the use of the edited Plasmodium in the development of vaccines and therapeutics.
US20110167519 HEAT STABLE VARIANTS OF PLANT ADENOSINE DIPHOSPHATE GLUCOSE PYROPHOSPHORYLASE SMALL SUBUNIT  
The subject invention concerns polynucleotides encoding a small subunit of plant AGP having one or more mutations in the amino acid sequence wherein the mutation confers increased heat stability...
US20150093802 ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOF  
The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
US20130136727 Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases  
Methods and compositions for treating neurodegenerative disorders using angiogenin and/or angiogenin variants are provided.
US20120329709 PRODUCTION OF GLYCOPROTEINS  
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein...
US20130273606 SECRETION YIELD OF A PROTEIN OF INTEREST BY IN VIVO PROTEOLYTIC PROCESSING OF A MULTIMERIC PRECURSOR  
The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The...
US20140212928 METHODS AND COMPOSITIONS FOR TARGETED SINGLE-STRANDED CLEAVAGE AND TARGETED INTEGRATION  
Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
US20130198878 ORGANISMS HOMOZYGOUS FOR TARGETED MODIFICATION  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20110086354 METHODS AND COMPOSITIONS FOR MULTIPLEX PCR AMPLIFICATIONS  
The present invention concerns in general PCR reaction mixtures comprising a mixture of hot-start primers and non-hot-start primers for a given target sequence, including multiplex PCR reaction...
US20130150251 METHODS FOR ANALYZING LARIAT RNA  
The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of RNA is specifically treated to...
US20140295556 Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing  
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
US20140273234 ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION  
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and...
US20150225728 CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE  
The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific...
US20150209415 THERAPEUTIC RIBONUCLEASES  
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease.
US20120070877 RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY  
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
US20150184199 METHODS FOR GENOMIC INTEGRATION  
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting...
US20150079064 GENETIC CORRECTION OF MUTATED GENES  
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
US20150094209 AUTONOMOUS REPLICATION SEQUENCES AND EPISOMAL DNA MOLECULES  
The present invention provides autonomous replication sequences (ARSs) isolated from Nannochloropsis that support the replication of episomal DNA molecules (EDMs) in eukaryotic cells. The ARSs and...
US20140163084 METHODS AND COMPOSITIONS FOR CONTROLLING EFFICACY OF RNA SILENCING  
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining,...
US20140359798 CORRECTION OF CRB1 MUTATIONS  
Genetically engineered mice having a corrected Cbr1rd8 mutation and methods for correcting the Cbr1rd8 mutation to produce the genetically engineered mice are provided according to aspects of the...
US20110020878 Method of Removing Nucleic Acid Contamination in Reverse Transcription and Amplification Reactions  
The invention provides methods of removing nucleic acid contamination from reverse transcription reactions and hot-start PCR, wherein said hot-start PCR is a barrier hot-start PCR set up and/or...
US20110251094 BIOMARKERS FOR HYPERTENSIVE DISORDERS OF PREGNANCY  
The application discloses new biomarkers for hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders...
US20120045797 NUCLEIC ACID AMPLIFICATION PROCEDURE  
The invention provides methods for amplification of polynucleotide sequences using primers containing single-Cstranded RNA. The methods employ use of an enzyme capable of cleaving single-stranded...
US20140242702 METHODS AND COMPOSITIONS FOR ENHANCING NUCLEASE-MEDIATED GENE DISRUPTION  
Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided.
US20150152398 Endoribonuclease and Methods of Use Thereof  
The present disclosure provides variant Cas endoribonucleases, nucleic acids encoding the variant Cas endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Cas...
US20070105123 IRE-1alpha substrates  
IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity.
US20110117610 Modified Dicer Polypeptide and Methods of Use Thereof  
A modified Dicer polypeptide is provided, which modified Dicer polypeptide exhibits enhanced catalytic activity. Also provided is a method for producing small regulatory RNAs from a dsRNA,...
US20140157458 ENGINEERED ZINC FINGER PROTEINS TARGETING PLANT GENES INVOLVED IN FATTY ACID BIOSYNTHESIS  
The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene...
US20150037842 MODIFIED BACTERIAL CELL  
The disclosure relates to a Gram negative bacterial cell that is transformed with a nucleic acid molecule that encodes a Gram positive twin-arginine translocase and including methods for the...
US20110076720 NICKING ENDONUCLEASE METHODS AND COMPOSITIONS  
A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding...
US20140099696 Technology for the Preparation of Microparticles  
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful...
US20120141590 Technology for the Preparation of Microparticles  
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful...
US20130224799 METHOD FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS  
A method is disclosed for improved isothermal amplification of nucleic acids comprising the step of release of an essential component from a matrix under predetermined conditions. Furthermore, the...
US20140294758 LIGHT CHAIN IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF USE THEREOF  
Provided are recombinant antibodies comprising one or more peptides fused to the C-terminus of the light chain constant region. Recombinant immunocytokines comprising a cytokine fused to the...
US20150152399 Therapeutic Nuclease Compositions and Methods  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20140044711 Therapeutic Nuclease Compositions and Methods  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20130177561 THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS  
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal.
US20130267009 Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences  
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a...
US20110256537 OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE SCREENING, DETECTION, ISOLATION, QUANTITATION, MONITORING AND SEQUENCING OF PROSTATE CANCER ASSOCIATED VIRUSES AND HOST BIOMARKERS  
Described herein are oligonucleotides useful for screening, detecting, isolating, quantitating, monitoring and sequencing of viruses and host biomarkers associated with prostate cancer and methods...

Matches 1 - 50 out of 398 1 2 3 4 5 6 7 8 >