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US20110262422 |
ORALLY ADMINISTRABLE DOSAGE FORMS COMPRISING ANGIOGENIN AND USES THEREOF
The invention provides a method of treatment of any disorder in which administration of angiogenin is beneficial wherein the angiogenin is administered orally. Particularly, the oral angiogenin... |
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US20150099290 |
INSERTION OF CHARGE IN THE HYDROPHOBIC INTERIOR OF PROTEINS AS A STRATEGY FOR ENGINEERING PH-SENSITIVE SWITCHES
Methods are provided for engineering non-naturally occurring proteins comprising artificial pH-sensitive conformational switches that respond to a change in pH by causing a global unfolding of the... |
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US20130029400 |
GENETIC ELEMENTS, PROTEINS, AND ASSOCIATED METHODS INCLUDING APPLICATION OF ADDIITNAL GENETIC INFORMATION TO GRAM (+) THERMOACIDOPHILES
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for modulating or altering... |
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US20150164984 |
Colicins for Treating Bacterial Infections
The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli... |
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US20130095551 |
METHOD FOR CHANGING CONFORMATION OF GLOBULAR PROTEINS
A method for changing conformation of globular proteins is provided. The method controls the concentration of the globular proteins and the adsorption time of the globular proteins from the... |
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US20120331574 |
USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA. |
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US20150159172 |
METHODS AND COMPOSITIONS FOR GENOME ENGINEERING
Disclosed herein are methods and compositions for insertion of transgene sequences encoding proteins that is aberrantly expressed in disease or disorder such as a lysosomal storage disease. |
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US20130330778 |
METHOD OF ADAPTOR-DIMER SUBTRACTION USING A CRISPR CAS6 PROTEIN
A method of processing a target RNA is provided. In certain embodiments, this method comprises: contacting the products of an RNA ligase-mediated ligation reaction with an CAS6 protein, wherein:... |
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US20140234975 |
METHOD FOR INCREASING THE EFFICIENCY OF DOUBLE-STRAND-BREAK INDUCED MUTAGENESIS
The present invention relates to a method for increasing double-strand-break induced mutagenesis at a genomic locus of interest in a cell, thereby giving new tools for genome engineering,... |
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US20130210151 |
ENDONUCLEASE FOR GENOME EDITING
A chimeric endonuclease is provided comprising the GIY-YIG nuclease domain which is linked to a DNA-targeting domain by a linking domain. The endonuclease is useful in gene editing. |
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US20140249094 |
SENSATION-IMPROVING AGENT
An object of the present invention is to provide a safety sensation-improving agent that can improve dulled peripheral sensations through daily ingestion or application to the skin. Another object... |
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US20130216579 |
METHODS AND COMPOSTITIONS FOR GENE EDITING OF A PATHOGEN
Disclosed herein are methods and compositions for genome editing of the malarial parasite Plasmodium, and for the use of the edited Plasmodium in the development of vaccines and therapeutics. |
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US20110167519 |
HEAT STABLE VARIANTS OF PLANT ADENOSINE DIPHOSPHATE GLUCOSE PYROPHOSPHORYLASE SMALL SUBUNIT
The subject invention concerns polynucleotides encoding a small subunit of plant AGP having one or more mutations in the amino acid sequence wherein the mutation confers increased heat stability... |
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US20150093802 |
ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOF
The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene. |
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US20130136727 |
Angiogenin and Variants Thereof for Treatment of Neurodegenerative Diseases
Methods and compositions for treating neurodegenerative disorders using angiogenin and/or angiogenin variants are provided. |
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US20120329709 |
PRODUCTION OF GLYCOPROTEINS
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein... |
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US20130273606 |
SECRETION YIELD OF A PROTEIN OF INTEREST BY IN VIVO PROTEOLYTIC PROCESSING OF A MULTIMERIC PRECURSOR
The invention relates to a nucleic acid molecule encoding a multimeric precursor which after transcription is specifically cleaved in vivo to form multiple copies of a protein of interest. The... |
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US20140212928 |
METHODS AND COMPOSITIONS FOR TARGETED SINGLE-STRANDED CLEAVAGE AND TARGETED INTEGRATION
Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences. |
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US20130198878 |
ORGANISMS HOMOZYGOUS FOR TARGETED MODIFICATION
Disclosed herein are homozygously modified organisms and methods of making and using these organisms. |
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US20110086354 |
METHODS AND COMPOSITIONS FOR MULTIPLEX PCR AMPLIFICATIONS
The present invention concerns in general PCR reaction mixtures comprising a mixture of hot-start primers and non-hot-start primers for a given target sequence, including multiplex PCR reaction... |
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US20130150251 |
METHODS FOR ANALYZING LARIAT RNA
The present invention relates to compositions and methods useful for analyzing lariat RNA, which plays a role in the regulation of gene expression. A sample of RNA is specifically treated to... |
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US20140295556 |
Using RNA-guided FokI Nucleases (RFNs) to Increase Specificity for RNA-Guided Genome Editing
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems. |
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US20140273234 |
ENGINEERING AND OPTIMIZATION OF IMPROVED SYSTEMS, METHODS AND ENZYME COMPOSITIONS FOR SEQUENCE MANIPULATION
The invention provides for engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are compositions and... |
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US20150225728 |
CELL MODIFICATION METHOD USING ESSENTIAL GENES AS MARKERS AND OPTIONALLY RECYCLING THESE
The invention relates to a method for modification of a host cell at a target locus, which method comprises: providing a host cell comprising, at a first locus, at least two site-specific... |
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US20150209415 |
THERAPEUTIC RIBONUCLEASES
The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. |
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US20120070877 |
RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and... |
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US20150184199 |
METHODS FOR GENOMIC INTEGRATION
Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting... |
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US20150079064 |
GENETIC CORRECTION OF MUTATED GENES
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes. |
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US20150094209 |
AUTONOMOUS REPLICATION SEQUENCES AND EPISOMAL DNA MOLECULES
The present invention provides autonomous replication sequences (ARSs) isolated from Nannochloropsis that support the replication of episomal DNA molecules (EDMs) in eukaryotic cells. The ARSs and... |
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US20140163084 |
METHODS AND COMPOSITIONS FOR CONTROLLING EFFICACY OF RNA SILENCING
Based at least in part on an understanding of the mechanisms by which small RNAs (e.g., naturally-occurring miRNAs) mediate RNA silencing in plants, rules have been established for determining,... |
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US20140359798 |
CORRECTION OF CRB1 MUTATIONS
Genetically engineered mice having a corrected Cbr1rd8 mutation and methods for correcting the Cbr1rd8 mutation to produce the genetically engineered mice are provided according to aspects of the... |
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US20110020878 |
Method of Removing Nucleic Acid Contamination in Reverse Transcription and Amplification Reactions
The invention provides methods of removing nucleic acid contamination from reverse transcription reactions and hot-start PCR, wherein said hot-start PCR is a barrier hot-start PCR set up and/or... |
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US20110251094 |
BIOMARKERS FOR HYPERTENSIVE DISORDERS OF PREGNANCY
The application discloses new biomarkers for hypertensive disorders of pregnancy and particularly preeclampsia; methods for the diagnosis, prediction, prognosis and/or monitoring said disorders... |
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US20120045797 |
NUCLEIC ACID AMPLIFICATION PROCEDURE
The invention provides methods for amplification of polynucleotide sequences using primers containing single-Cstranded RNA. The methods employ use of an enzyme capable of cleaving single-stranded... |
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US20140242702 |
METHODS AND COMPOSITIONS FOR ENHANCING NUCLEASE-MEDIATED GENE DISRUPTION
Methods and compositions for increasing nuclease-mediated genomic modification using DNA repair inhibitors are provided. |
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US20150152398 |
Endoribonuclease and Methods of Use Thereof
The present disclosure provides variant Cas endoribonucleases, nucleic acids encoding the variant Cas endoribonucleases, and host cells genetically modified with the nucleic acids. The variant Cas... |
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US20070105123 |
IRE-1alpha substrates
IRE-1α substrates useful for identifying agonists and antagonists of IRE-1α RNase activity. |
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US20110117610 |
Modified Dicer Polypeptide and Methods of Use Thereof
A modified Dicer polypeptide is provided, which modified Dicer polypeptide exhibits enhanced catalytic activity. Also provided is a method for producing small regulatory RNAs from a dsRNA,... |
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US20140157458 |
ENGINEERED ZINC FINGER PROTEINS TARGETING PLANT GENES INVOLVED IN FATTY ACID BIOSYNTHESIS
The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene... |
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US20150037842 |
MODIFIED BACTERIAL CELL
The disclosure relates to a Gram negative bacterial cell that is transformed with a nucleic acid molecule that encodes a Gram positive twin-arginine translocase and including methods for the... |
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US20110076720 |
NICKING ENDONUCLEASE METHODS AND COMPOSITIONS
A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or gutamic acid corresponding... |
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US20140099696 |
Technology for the Preparation of Microparticles
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful... |
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US20120141590 |
Technology for the Preparation of Microparticles
Microspheres are produced by contacting a solution of a macromolecule or small molecule in a solvent with an antisolvent and a counterion, and chilling the solution. The microspheres are useful... |
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US20130224799 |
METHOD FOR ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS
A method is disclosed for improved isothermal amplification of nucleic acids comprising the step of release of an essential component from a matrix under predetermined conditions. Furthermore, the... |
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US20140294758 |
LIGHT CHAIN IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF USE THEREOF
Provided are recombinant antibodies comprising one or more peptides fused to the C-terminus of the light chain constant region. Recombinant immunocytokines comprising a cytokine fused to the... |
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US20150152399 |
Therapeutic Nuclease Compositions and Methods
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. |
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US20140044711 |
Therapeutic Nuclease Compositions and Methods
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. |
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US20130177561 |
THERAPEUTIC NUCLEASE COMPOSITIONS AND METHODS
Hybrid nuclease molecules and methods for treating an immune-related disease or disorder in a mammal, and a pharmaceutical composition for treating an immune-related disease in a mammal. |
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US20130267009 |
Rationally-Designed Single-Chain Meganucleases With Non-Palindromic Recognition Sequences
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a... |
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US20110256537 |
OPTIMIZED OLIGONUCLEOTIDES AND METHODS OF USING SAME FOR THE SCREENING, DETECTION, ISOLATION, QUANTITATION, MONITORING AND SEQUENCING OF PROSTATE CANCER ASSOCIATED VIRUSES AND HOST BIOMARKERS
Described herein are oligonucleotides useful for screening, detecting, isolating, quantitating, monitoring and sequencing of viruses and host biomarkers associated with prostate cancer and methods... |