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US20130231262 |
ENGINEERED PROTEIN: "2-COLOR SERCA", AN ION-MOTIVE ATPase FUSED TO CERULEAN AND YELLOW FLUORESCENT PROTEIN
A method and engineered proteins for use therewith suitable for studying SERCA that are capable of being used in vivo and do not require protein purification or chemical labeling of SERCA, or... |
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US20150099664 |
PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR AUTOIMMUNE AND ALLOIMMUNE DISEASES
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the... |
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US20110257035 |
IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA
The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection,... |
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US20120122132 |
Protein Structural Biomarkers to Guide Targeted Chemotherapies
A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target, based on the effect of natural... |
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US20110065141 |
Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains
The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors... |
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US20120171693 |
Methods for Generating Novel Stabilized Proteins
The disclosure provides methods for identifying and producing stabilized chimeric proteins. |
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US20150031061 |
COMPOSITIONS AND METHODS RELATING TO FUSION PROTEIN BIOMARKERS
The present invention provides fusion proteins as biomarkers specific for chromosomal translocation-based conditions (e.g., cancer), related methods for detecting fusion protein biomarkers... |
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US20150023929 |
ORAL UNIT DOSAGE FORMS AND USES OF SAME FOR THE TREATMENT OF GAUCHER DISEASE
A method of treating Gaucher's disease in a subject in need thereof is provided. The method comprising orally administering to the subject a therapeutically effective amount of recombinant... |
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US20140031327 |
NON-SURGICAL METHOD OF TREATMENT FOR CATARACT
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of... |
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US20120065147 |
USE OF THE GTPASE RAB27B TO DIAGNOSE AND TREAT POOR PROGNOSIS ESTROGEN-RECEPTOR-POSITIVE BREAST CANCER
The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit... |
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US20130295595 |
MODIFIED PROKARYOTIC UBIQUITIN-LIKE PROTEIN AND METHODS OF USE THEREOF
Methods for making and using substrates of deamidase of prokaryotic ubiquitin-like protein (Dop) are described herein. More particularly, modified prokaryotic ubiquitin-like protein (Pup) and... |
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US20120115176 |
METHOD FOR DETECTING COMPOUNDS MODULATING DIMERS OF VFT DOMAIN MEMBRANE PROTEINS
The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring... |
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US20100317040 |
METHODS AND KITS FOR DIAGNOSING CANCER
A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva... |
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US20150141361 |
USE OF EPIGENOME-MODIFYING COMPOUNDS FOR THE TREATMENT OF GENETIC MUSCULAR DISEASES LINKED TO A PROTEIN-CONFORMATIONAL DISORDER
A pharmaceutical composition including at least one epigenome-modifying compound, for a use thereof in the treatment of genetic muscular diseases linked to a conformational disorder of at least... |
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US20110002908 |
TREATMENT OF A-GALACTOSIDASE A DEFICIENCY
The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included. |
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US20110070601 |
CLASSIFICATION OF INDIVIDUALS SUFFERING FROM CARDIOVASCULAR DISEASES ACCORDING TO SURVIVAL PROGNOSES AS FOUND BY MEASURING THE LEVELS OF BIOMARKER YKL-40
The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by... |
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US20110110918 |
ROLE OF (DE)ACETYLATION IN COUNTERACTING PROTEIN AGGREGATION
The invention provides a method for influencing an activity of a heat shock protein which is a member of the Hsp40/DnaJ family, the method comprising acetylating or deacetylating said heat shock... |
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US20120311744 |
Marked Cannabis For Indicating Medical Marijuana
The invention involves transforming Cannabis with a transgene(s) or chemical(s) expressing biological, chemical, luminescent, and fluorescent markers from the UV, visible, near, mid, and far... |
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US20100311096 |
IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS
Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter. |
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US20140057285 |
COMPOSITIONS AND METHODS TARGETING FORCE GENERATION IN KINESIN
In some aspects, the invention provides chimeric kinesin proteins. In other aspects the invention provides nucleic acids encoding chimeric kinesin proteins. Compositions and kits are provided that... |
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US20130156750 |
Compositions and Methods for Using Human YKL-40 to Treat Acute Lung Injury
The invention includes methods of treating oxidant-mediated acute lung injury in a subject by administration of a chitinase-like protein molecule, or an activator thereof. The invention also... |
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US20110045518 |
YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE
The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the... |
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US20140234882 |
Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations
A biosensing system that measures the concentration of halogenated alkenes is disclosed. |
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US20110244499 |
METHODS OF ENZYMATIC HYDROLYSIS
In one embodiment the instant invention generally pertains to a method for producing glucose for fermentation. The method comprises first treating a biomass with acid and heat under conditions... |
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US20110104727 |
ASSAYS FOR DIAGNOSING AND EVALUATING TREATMENT OPTIONS FOR FABRY DISEASE
Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone. |
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US20120171302 |
COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES
The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and... |
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US20130281440 |
DDX3 AS A BIOMARKER FOR CANCER AND METHODS RELATED THERETO
The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to... |
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US20140141017 |
METHODS OF DIAGNOSING ATHEROSCLEROSIS BY MEASURING APOCI
The present invention provides methods and compositions for identifying compounds which inhibit ApoCI and which are useful in the treatment or prevention of atherosclerosis, plaque rupture,... |
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US20110091892 |
Methods for the Diagnosis and Treatment of Lung Cancer
The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the... |
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US20150140576 |
CANCER SPECIFIC GLYCANS AND USE THEREOF
The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer... |
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US20120077706 |
METHOD FOR ASSAYING PROTEIN-PROTEIN INTERACTION
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the... |
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US20140342944 |
IN VITRO TEST SYSTEM TO EVALUATE XENOBIOTICS AS IMMUNE-MODULATORS OF DRUG TRANSPORT AND METABOLISM IN HUMAN HEPATOCYTES
A kit and method for evaluating in vitro the effect of a xenobiotic (e.g., a biologic drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in... |
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US20120276568 |
DRY TEST STRIP AND METHOD FOR MEASURING CREATININE
A dry test strip for measuring creatinine comprises: a support; a reagent layer that is disposed on the support; a reagent holding layer that is disposed on the reagent layer; and a connection... |
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US20120234678 |
QUANTITATIVE FLUORESCENT PROTEIN STANDARDS
The present invention provides dual labeled protein standards useful for the simultaneous determination of the molecular weight of a subject protein as well as the relative mass (i.e., amount) of... |
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US20120014927 |
METHODS AND KITS FOR DETERMINING PREDISPOSITION TO CANCER
Provided are methods and kits for determining predisposition to cancer by determining the presence or absence in a heterozygote form of the KLOTHO functional variant. Also provided are methods of... |
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US20140162299 |
RAPID AND ACCURATE ANALYSIS OF PROTEIN SIALYLATION
The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with... |
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US20130252983 |
ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C
A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions... |
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US20120283290 |
QUANTITATION OF GL3 IN URINE
The present invention is directed to the quantitation of GL3 in human urine which can be used for the diagnosis of Fabry disease as well as for the assessment of treatment efficacy thereof. |
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US20120107853 |
Use of Genetically Modified Organisms to Generate Biomass Degrading Enzymes
The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of... |
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US20100317541 |
Method of Determining the Probability of a Therapeutic Response in Cancer Chemotherapy With Cardiac Glycoside
A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment... |
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US20130315934 |
Methods and Compositions for Assessing and Treating Cancer
The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for... |
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US20110263441 |
COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating hepatic disorders such as hepatocellular carcinoma and/or cirrhosis. A variety of... |
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US20110212974 |
METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS
The present invention concerns a method for identifying a compound which inhibits the activation of RAC GTPase by DOCK5 protein comprising the steps of (i) coexpressing the DOCK5 and the RAC... |
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US20130184180 |
CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES
The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some... |
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US20120220610 |
INHIBITIONS OF GLUTAMINASE C
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the... |
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US20110265197 |
Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof
The present invention provides methods of detecting cancer using biomarkers. |
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US20120237503 |
Screening Method and Therapy with Agonists of DDAH I
The present invention derives from the finding that decreased levels of DDAH I are associated with increased portal pressure and that by increasing DDAH I levels in vivo, portal pressure may be... |
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US20150005193 |
QUALITATIVE AND QUANTITATIVE POINT-OF-CARE ASSAYS
Disclosed herein are “equipment-free” flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous, hydrophilic media are patterned... |
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US20140272947 |
METHODS AND COMPOSITIONS FOR SCREENING MODULATORS OF ONCOGENE-INDUCED SENESCENCE
A high-throughput method for identifying a compound or biomolecule that modulates cell senescence involves simultaneously measuring in a cell population exposed to the test compound or... |
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US20150005243 |
NMR-BASED METABOLITE SCREENING PLATFORM
Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading... |