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US20130231262 ENGINEERED PROTEIN: "2-COLOR SERCA", AN ION-MOTIVE ATPase FUSED TO CERULEAN AND YELLOW FLUORESCENT PROTEIN  
A method and engineered proteins for use therewith suitable for studying SERCA that are capable of being used in vivo and do not require protein purification or chemical labeling of SERCA, or...
US20150099664 PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR AUTOIMMUNE AND ALLOIMMUNE DISEASES  
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the...
US20110257035 IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA  
The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection,...
US20120122132 Protein Structural Biomarkers to Guide Targeted Chemotherapies  
A rapid, infrared spectroscopic method has been developed to assess the efficacy of targeted chemotherapeutics against the structure of the polypeptide target, based on the effect of natural...
US20110065141 Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains  
The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors...
US20120171693 Methods for Generating Novel Stabilized Proteins  
The disclosure provides methods for identifying and producing stabilized chimeric proteins.
US20150031061 COMPOSITIONS AND METHODS RELATING TO FUSION PROTEIN BIOMARKERS  
The present invention provides fusion proteins as biomarkers specific for chromosomal translocation-based conditions (e.g., cancer), related methods for detecting fusion protein biomarkers...
US20150023929 ORAL UNIT DOSAGE FORMS AND USES OF SAME FOR THE TREATMENT OF GAUCHER DISEASE  
A method of treating Gaucher's disease in a subject in need thereof is provided. The method comprising orally administering to the subject a therapeutically effective amount of recombinant...
US20140031327 NON-SURGICAL METHOD OF TREATMENT FOR CATARACT  
The invention provides inhibitors of α-crystallin aggregation and methods of using α-crystallin aggregation inhibitors to, e.g., treat or prevent cataracts in a subject having or at risk of...
US20120065147 USE OF THE GTPASE RAB27B TO DIAGNOSE AND TREAT POOR PROGNOSIS ESTROGEN-RECEPTOR-POSITIVE BREAST CANCER  
The present invention relates to evaluating the prognosis of patients with estrogen receptor-positive breast cancer on the basis of Rab27B expression. The invention further relates to a kit...
US20130295595 MODIFIED PROKARYOTIC UBIQUITIN-LIKE PROTEIN AND METHODS OF USE THEREOF  
Methods for making and using substrates of deamidase of prokaryotic ubiquitin-like protein (Dop) are described herein. More particularly, modified prokaryotic ubiquitin-like protein (Pup) and...
US20120115176 METHOD FOR DETECTING COMPOUNDS MODULATING DIMERS OF VFT DOMAIN MEMBRANE PROTEINS  
The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring...
US20100317040 METHODS AND KITS FOR DIAGNOSING CANCER  
A method of diagnosing oral cancer or oral pharyngeal cancer in a subject in need thereof is provided. The method comprising determining a level or activity of at least one marker in a saliva...
US20150141361 USE OF EPIGENOME-MODIFYING COMPOUNDS FOR THE TREATMENT OF GENETIC MUSCULAR DISEASES LINKED TO A PROTEIN-CONFORMATIONAL DISORDER  
A pharmaceutical composition including at least one epigenome-modifying compound, for a use thereof in the treatment of genetic muscular diseases linked to a conformational disorder of at least...
US20110002908 TREATMENT OF A-GALACTOSIDASE A DEFICIENCY  
The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included.
US20110070601 CLASSIFICATION OF INDIVIDUALS SUFFERING FROM CARDIOVASCULAR DISEASES ACCORDING TO SURVIVAL PROGNOSES AS FOUND BY MEASURING THE LEVELS OF BIOMARKER YKL-40  
The present invention relates to the method of measuring the YKL-40 level and using this measurement as a prognosis for survival of an individual suffering from heart disease caused by...
US20110110918 ROLE OF (DE)ACETYLATION IN COUNTERACTING PROTEIN AGGREGATION  
The invention provides a method for influencing an activity of a heat shock protein which is a member of the Hsp40/DnaJ family, the method comprising acetylating or deacetylating said heat shock...
US20120311744 Marked Cannabis For Indicating Medical Marijuana  
The invention involves transforming Cannabis with a transgene(s) or chemical(s) expressing biological, chemical, luminescent, and fluorescent markers from the UV, visible, near, mid, and far...
US20100311096 IDENTIFYING MOLECULES MODULATING PROTEIN-PROTEIN INTERACTIONS USING PROTEASE ACTIVATED REPORTERS  
Assay methods and systems use enzymatic cleavage resulting from protein-protein interaction to modulate (activate or inactivate) a reporter.
US20140057285 COMPOSITIONS AND METHODS TARGETING FORCE GENERATION IN KINESIN  
In some aspects, the invention provides chimeric kinesin proteins. In other aspects the invention provides nucleic acids encoding chimeric kinesin proteins. Compositions and kits are provided that...
US20130156750 Compositions and Methods for Using Human YKL-40 to Treat Acute Lung Injury  
The invention includes methods of treating oxidant-mediated acute lung injury in a subject by administration of a chitinase-like protein molecule, or an activator thereof. The invention also...
US20110045518 YKL-40 AS A GENERAL MARKER FOR NON-SPECIFIC DISEASE  
The present invention relates to methods of diagnosing the presence of a non-specific disease or disorder in a subject, wherein a determined level of YKL-40 above a reference level indicates the...
US20140234882 Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations  
A biosensing system that measures the concentration of halogenated alkenes is disclosed.
US20110244499 METHODS OF ENZYMATIC HYDROLYSIS  
In one embodiment the instant invention generally pertains to a method for producing glucose for fermentation. The method comprises first treating a biomass with acid and heat under conditions...
US20110104727 ASSAYS FOR DIAGNOSING AND EVALUATING TREATMENT OPTIONS FOR FABRY DISEASE  
Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
US20120171302 COMPOSITIONS AND METHODS FOR INHIBITING REDOX-SENSITIVE GTPASES  
The invention provides compositions for inhibiting a redox-sensitive GTPase protein, including a Rho or Rab family GTPase, comprising an effective amount of a redox-sensitive purine compound and...
US20130281440 DDX3 AS A BIOMARKER FOR CANCER AND METHODS RELATED THERETO  
The invention encompasses methods for treating or preventing diseases and disorders associated abnormal cell growth, for example, treating or preventing cancer or tumor growth, by administering to...
US20140141017 METHODS OF DIAGNOSING ATHEROSCLEROSIS BY MEASURING APOCI  
The present invention provides methods and compositions for identifying compounds which inhibit ApoCI and which are useful in the treatment or prevention of atherosclerosis, plaque rupture,...
US20110091892 Methods for the Diagnosis and Treatment of Lung Cancer  
The present invention provides methods for aiding in the diagnoses of the neoplastic condition of a lung cell and methods of screening for a potential therapeutic agent for the reversal of the...
US20150140576 CANCER SPECIFIC GLYCANS AND USE THEREOF  
The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer...
US20120077706 METHOD FOR ASSAYING PROTEIN-PROTEIN INTERACTION  
The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the...
US20140342944 IN VITRO TEST SYSTEM TO EVALUATE XENOBIOTICS AS IMMUNE-MODULATORS OF DRUG TRANSPORT AND METABOLISM IN HUMAN HEPATOCYTES  
A kit and method for evaluating in vitro the effect of a xenobiotic (e.g., a biologic drug) on drug metabolism in hepatocytes. The kit comprises a first culture of hepatocytes, a portion of in...
US20120276568 DRY TEST STRIP AND METHOD FOR MEASURING CREATININE  
A dry test strip for measuring creatinine comprises: a support; a reagent layer that is disposed on the support; a reagent holding layer that is disposed on the reagent layer; and a connection...
US20120234678 QUANTITATIVE FLUORESCENT PROTEIN STANDARDS  
The present invention provides dual labeled protein standards useful for the simultaneous determination of the molecular weight of a subject protein as well as the relative mass (i.e., amount) of...
US20120014927 METHODS AND KITS FOR DETERMINING PREDISPOSITION TO CANCER  
Provided are methods and kits for determining predisposition to cancer by determining the presence or absence in a heterozygote form of the KLOTHO functional variant. Also provided are methods of...
US20140162299 RAPID AND ACCURATE ANALYSIS OF PROTEIN SIALYLATION  
The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with...
US20130252983 ACTIVATING PHOSPHORYLATION SITE ON GLUTAMINASE C  
A method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting activating phosphorylation of glutaminase C under conditions...
US20120283290 QUANTITATION OF GL3 IN URINE  
The present invention is directed to the quantitation of GL3 in human urine which can be used for the diagnosis of Fabry disease as well as for the assessment of treatment efficacy thereof.
US20120107853 Use of Genetically Modified Organisms to Generate Biomass Degrading Enzymes  
The present invention provides a method and compositions for high throughput screening of genetically modified photosynthetic organisms for plasmic state. The present invention provides methods of...
US20100317541 Method of Determining the Probability of a Therapeutic Response in Cancer Chemotherapy With Cardiac Glycoside  
A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment...
US20130315934 Methods and Compositions for Assessing and Treating Cancer  
The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for...
US20110263441 COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF HEPATIC DISORDERS  
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating hepatic disorders such as hepatocellular carcinoma and/or cirrhosis. A variety of...
US20110212974 METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS  
The present invention concerns a method for identifying a compound which inhibits the activation of RAC GTPase by DOCK5 protein comprising the steps of (i) coexpressing the DOCK5 and the RAC...
US20130184180 CHARACTERIZATION OF N-GLYCANS USING EXOGLYCOSIDASES  
The present disclosure provides methods for analyzing structure and/or composition of N-glycans. Such methods often involve digestion of N-glycans with multiple exoglycosidases. In some...
US20120220610 INHIBITIONS OF GLUTAMINASE C  
The present invention relates to a method of reducing the production of glutamate from glutamine by glutaminase C in a cell or tissue. The method involves inhibiting glutaminase C activity in the...
US20110265197 Signatures and PCDeterminants Associated with Prostate Cancer and Methods of Use Thereof  
The present invention provides methods of detecting cancer using biomarkers.
US20120237503 Screening Method and Therapy with Agonists of DDAH I  
The present invention derives from the finding that decreased levels of DDAH I are associated with increased portal pressure and that by increasing DDAH I levels in vivo, portal pressure may be...
US20150005193 QUALITATIVE AND QUANTITATIVE POINT-OF-CARE ASSAYS  
Disclosed herein are “equipment-free” flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous, hydrophilic media are patterned...
US20140272947 METHODS AND COMPOSITIONS FOR SCREENING MODULATORS OF ONCOGENE-INDUCED SENESCENCE  
A high-throughput method for identifying a compound or biomolecule that modulates cell senescence involves simultaneously measuring in a cell population exposed to the test compound or...
US20150005243 NMR-BASED METABOLITE SCREENING PLATFORM  
Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading...