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US20140127731 Method And System For Detecting and Differentiating Cancer and Sepsis in Mammals Using Biomarkers  
The invention provides a method and system for developing and using diagnoses of cancer and sepsis in canine subjects using Thymidine kinase (TK), c-reactive protein (CRP), and C-type natriuretic...
US20140314673 TREATMENT OF CANCER WITH DIHYDROPYRAZINO-PYRAZINES  
Provided herein are methods for treating or preventing head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression,...
US20150110718 METHODS AND KITS FOR DETERMINING A PLACEBO PROFILE IN SUBJECTS FOR CLINICAL TRIALS AND FOR TREATMENT OF PATIENTS  
The present invention is directed to methods and assays for identifying subjects participating in clinical trials that may exhibit a placebo response and identifying treatments for subjects with...
US20120108464 TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN  
The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system...
US20120003243 YEAST ECTOPICALLY EXPRESSING ABNORMALLY PROCESSED PROTEINS AND USES THEREFOR  
Disclosed are yeast ectopically expressing abnormally processed proteins and methods of screening to identify compounds that modulate the function of such abnormally processed proteins in yeast....
US20140038186 ALZHEIMER'S DISEASE-SPECIFIC ALTERATIONS OF PROTEIN KINASE C EPSILON (PKC-EPSILON) PROTEIN LEVELS  
The present invention relates to methods of diagnosing Alzheimer's Disease in a human patient by detecting alterations in the ratio of PKC epsilon protein levels in a human patient compared with...
US20110257035 IDENTIFICATION OF SIGNATURE GENES ASSOCIATED WITH HEPATOCELLULAR CARCINOMA  
The present invention relates to, for example, (1) a novel method for identification of clinically useful serum and/or tumor biomarkers and expression signatures that can be used for detection,...
US20120231015 FRAGILE X MENTAL RETARDATION PROTEIN (FMRP), COMPOSITIONS, AND METHODS RELATED THERETO  
The invention relates to fragile X mental retardation protein (FMKP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder...
US20150071857 STEROID HORMONE AND CHOLESTEROL PATHWAYS AS ONE UNIFIED HOMEOSTATIC SYSTEM  
A unified homeostatic system of cholesterol and steroid hormone pathways is described, in which the uses or modulations of function of the homeostatic system of cholesterol and steroid hormone...
US20140051104 METHODS FOR PROTEIN PURIFICATION AND ANALYSIS  
Methods to separate complex protein mixtures into individual proteins while maintaining protein function or enzyme activity are disclosed. They are designed to provide high resolution and...
US20110039789 Use of Huntingtin Protein for the Diagnosis and the Treatment of Cancer  
The present invention relates to new methods of treatment of cancer, in particular of breast cancer, and methods of screening of compounds useful in the treatment of cancer. The present invention...
US20120171693 Methods for Generating Novel Stabilized Proteins  
The disclosure provides methods for identifying and producing stabilized chimeric proteins.
US20130288250 SIGNATURES OF CLINICAL OUTCOME IN GASTRO INTESTINAL STROMAL TUMORS AND METHOD OF TREATMENT OF GASTROINTESTINAL STROMAL TUMORS  
A method for in vitro predicting survival and/or metastatic outcome of gastrointestinal stromal tumors (GISTs), characterized in that it comprises the measure of the level, in a patient-derived...
US20110014191 BREAST CANCER EXPRESSION PROFILING  
The present invention relates to a method for analyzing cancer. e.g., breast cancer including detection of differential expression of at least one of the 16 genes encoding serine/threonine kinases...
US20130078660 METHODS AND COMPOSITIONS FOR DETECTING PROTEIN MODIFICATIONS  
Methods and compositions for detecting a protein modification in vitro and in vivo are disclosed. In certain embodiments, the protein modification detected is phosphorylation.
US20150203589 FUSION PROTEINS AND METHODS THEREOF  
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
US20150051096 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS  
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20110212101 MATERIALS AND METHODS FOR EXPLOITING SYNTHETIC LETHALITY IN MISMATCH REPAIR-DEFICIENT CANCERS  
Therapeutic approaches to the treatment of DNA mismatch repair (MMR) deficient cancers are disclosed based on the use of complimentary gene-function and drug screening synthetic lethality...
US20120244566 Methods and materials for in vitro analysis and/or use of membrane-associated proteins, portions thereof or variants thereof  
Methods and materials use template-directed assembly of polypeptides and optionally additional reagents to analyze the functionality of membrane-associated proteins, such as, for example, portions...
US20150031061 COMPOSITIONS AND METHODS RELATING TO FUSION PROTEIN BIOMARKERS  
The present invention provides fusion proteins as biomarkers specific for chromosomal translocation-based conditions (e.g., cancer), related methods for detecting fusion protein biomarkers...
US20120171190 METHODS FOR DIAGNOSING CHRONIC DIARRHEA THROUGH PROTEIN SECRETION ANALYSIS  
Methods for diagnosing chronic diarrhea and other gastrointestinal conditions. In the methods, a sample of gastrointestinal secretions is obtained from a control group; or a group who has been...
US20150203837 FUSION PROTEIN FOR ACTIVATING RTK SIGNAL TRANSMISSION BY MEANS OF LIGHT, AND USE THEREOF  
The present invention relates to a fusion protein for reversibly activating RTK signal transmission by means of light and relates to a use thereof, and the invention provides a fusion protein in...
US20150030572 IDENTIFICATION OF MOLECULAR PATHWAYS AND METHODS OF USE THEREOF FOR TREATING RETINAL NEURODEGENERATION AND OTHER NEURODEGENERATIVE DISORDERS  
Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
US20120115176 METHOD FOR DETECTING COMPOUNDS MODULATING DIMERS OF VFT DOMAIN MEMBRANE PROTEINS  
The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT-domain proteins expressed in cell membranes present in a measuring...
US20140227284 SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER  
Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the...
US20150141361 USE OF EPIGENOME-MODIFYING COMPOUNDS FOR THE TREATMENT OF GENETIC MUSCULAR DISEASES LINKED TO A PROTEIN-CONFORMATIONAL DISORDER  
A pharmaceutical composition including at least one epigenome-modifying compound, for a use thereof in the treatment of genetic muscular diseases linked to a conformational disorder of at least...
US20110207627 EX VIVO THERAPEUTICS SCREENING OF LIVING BONE MARROW CELLS FOR MULTIPLE MYELOMA  
Methods of selecting a treatment for a patient with multiple myeloma are provided. Prior to commencing a treatment regime, bone marrow aspirates are isolated from a patient and incubated with one...
US20110177974 NEURAL PROTEINS AS BIOMARKERS FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS  
The present invention identities biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree...
US20140057967 METHOD OF SCREENING FOR CHAPERONIN MODULATOR  
The present invention relates to a method of screening for modulator of chaperonin that is involved in protein aggregation inducing neurodegenerative diseases such as Alzheimer's disease,...
US20110230372 GENE EXPRESSION CLASSIFIERS FOR RELAPSE FREE SURVIVAL AND MINIMAL RESIDUAL DISEASE IMPROVE RISK CLASSIFICATION AND OUTCOME PREDICTION IN PEDIATRIC B-PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA  
The present invention relates to the identification of genetic markers patients with leukemia, especially including acute lymphoblastic leukemia (ALL) at high risk for relapse, especially high...
US20120302624 BIOMARKER FOR IDENTIFYING SUBGROUP OF EARLY-STAGE LUNG ADENOCARCINOMA PATIENTS  
The preset invention relates to a biomarker for identifying the subgroup of early-stage lung adenocarcinoma patients in early-stage non-small cell lung cancer (NSCLC), which is...
US20150044712 METHOD AND KIT FOR ANALYZING PROTEIN-PROTEIN INTERACTION USING NANOCLUSTER FORMATION  
For efficient analysis of a protein-protein interaction, the present disclosure provides a kit for analyzing a protein-protein interaction, the kit including: a 1st expression vector including a...
US20150218636 Mutations In Calmodulin Genes  
The present invention relates to an isolated polynucleotide encoding at least a part of calmodulin and an isolated polypeptide comprising at least a part of a calmodulin protein, wherein the...
US20130231305 Method of Modulating Protein 14-3-3 Functionality By Facilitating or Inhibiting Phosphorylation  
The present invention relates to a method of modulating cellular activity. More particularly, the present invention provides a method of modulating apoptosis by modulating protein 14-3-3...
US20110171203 METHODS FOR TREATING NEOPLASTIC DISEASE TARGETING O-LINKED N-ACETYLGLUCOSAMINE MODIFICATIONS OF CELLULAR PROTEIN  
Methods for treating a neoplastic disease in a mammalian subject are provided. The method provides administering an inhibitor of O-GlcNAc transferase in an amount effective to reduce or eliminate...
US20110250179 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoK╬▓) activity as well as to methods for the design of...
US20110189173 PHOSPHORYLATED C-ErbB2 AS A SUPERIOR PREDICTIVE THERANOSTIC MARKER FOR THE DIAGNOSIS AND TREATMENT OF CANCER  
The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate...
US20130078644 Post-Translational Modifications Identified by Elemental Analysis  
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate...
US20120208210 Post-Translational Modifications Indentified by Elemental Analysis  
Methods and kits for enzymes involved in post-translational modifications are provided. The methods employ elemental analysis, including ICP-MS. The methods allow for the convenient and accurate...
US20150190397 Treatment of Cancers Expressing p95 ErbB2  
The truncated ErbB2 receptor (p95ErbB2) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with...
US20140234882 Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations  
A biosensing system that measures the concentration of halogenated alkenes is disclosed.
US20120164671 METHODS FOR MONITORING IMMUNOSUPPRESSANT DRUG LEVELS, RENAL FUNCTION, AND HEPATIC FUNCTION USING SMALL VOLUME SAMPLES  
Systems and methods are provided for monitoring a immunosuppressant drug level and renal function, hepatic function, or a combination thereof in a patient, comprising obtaining a small volume...
US20110195074 Ephrin Type-A Receptor 7 Protein  
The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of bladder cancer, breast cancer, colorectal cancer, gastric cancer, head and neck cancer,...
US20120214174 GENE AND POLYPEPTIDE RELATING TO BREAST CANCER  
Herein disclosed are methods of identifying substances suitable for the treatment and prevention of cancer, particularly cancers associated with the overexpression of GALNT6 gene. Methods of the...
US20110008348 SOLUBLE FRAGMENTS OF INFLUENZA VIRUS PB2 PROTEIN CAPABLE OF BINDING RNA-CAP  
A plastic container includes an upper portion having a mouth defining an opening into the container. A shoulder region extends from the upper portion. A sidewall portion extends between the...
US20130011870 Method For Assaying Diseases Characterized By Dyslipidemia  
A method for diagnosing a disease or for evaluating the risk to develop a disease which is characterized by dyslipidemia in humans, in particular for diagnosing atherosclerosis, coronary heart...
US20140378525 MATERIALS AND METHODS FOR TREATING PTEN MUTATED OR DEFICIENT CANCER  
The use of inhibitors of mitotic kinases, such as TTK protein kinase, is described for use in the treatment of cancers which are characterized as Phosphatase and Tensin Homolog (PTEN) mutated or...
US20120046199 METHOD FOR DETERMINING THE ESTROGEN RECEPTOR STATUS OF BREAST CANCER  
The present invention relates to a method for determining the estrogen receptor status of patients suffering from breast cancer. The present invention also aims to provide methods and devices for...
US20140023657 IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY  
The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder...
US20130130291 Labelling of Fusion Proteins with Synthetic Probes  
The invention relates to new proteins called alkylcytosine transferases (ACTs) derived from O6-alkylguanine-DNA alkyltransferase, and to substrates for ACTs specifically transferring a label to...