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US20150079580 |
Systems and Methods for Ex Vivo Organ Care
The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo. |
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US20130011823 |
ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS
An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution. |
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US20120264103 |
Compositions And Method For Tissue Preservation
Methods and compositions for resuscitating, storing, and preserving functional integrity of organs and tissues. Metabolic function is maintained by sustaining ATP levels, mitochondrial function,... |
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US20150175959 |
POST-PARTUM MAMMALIAN PLACENTA, ITS USE AND PLACENTAL STEM CELLS THEREFROM
The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human... |
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US20070122794 |
DEVICES AND METHODS FOR PHARMACOKINETIC-BASED CELL CULTURE SYSTEM
Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. |
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US20150150240 |
EVALUATION AND PRESERVATION SOLUTION
An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and... |
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US20130295552 |
COMPOSITIONS, METHODS AND DEVICES FOR MAINTAINING AN ORGAN
Compositions, methods, systems/devices and media are provided for maintaining a harvested organ in a functioning and viable state prior to implantation. The organ perfusion apparatus includes a... |
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US20060223048 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one... |
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US20060223046 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one... |
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US20060210959 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one... |
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US20140308654 |
ORGAN PERFUSION SYSTEMS
An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in... |
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US20090156488 |
USE OF NEUREGULIN FOR ORGAN PRESERVATION
The present invention provides compositions and methods for preservation, perfusion or reperfusion of an organ, such as heart, for transplantation. The compositions comprise a preservation... |
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US20060223049 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one... |
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US20160184391 |
TREATMENT OF GRAFT REJECTION BY ADMINISTERING A COMPLEMENT INHIBITOR TO AN ORGAN PRIOR TO TRANSPLANT
Methods of prolonging survival of a transplanted organ, as well as methods of preventing or attenuating rejection of a transplanted organ are provided. These methods involve contacting the organ... |
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US20100196461 |
RESUSCITATION FLUID
A method for treating conditions related to lack of blood supply with a resuscitation fluid is disclosed. The resuscitation fluid contains a lipophilic component and a polar liquid carrier. The... |
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US20110217689 |
FLUIDICS BASED PULSATILE PERFUSION PRESERVATION DEVICE AND METHOD
In one embodiment, a preservation apparatus is described that includes a storage compartment. The storage compartment is configured to hold an organ or tissue and a preservation fluid. A cover... |
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US20150208643 |
REPAIRED ORGAN AND METHOD FOR MAKING THE SAME
A repaired ex vivo organ suitable for transplantation in a human, said repaired ex vivo organ having undergone ex vivo organ perfusion for a maintenance period, wherein said organ had been... |
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US20150024010 |
METHODS OF THERAPEUTIC TREATMENT OF EYES
Provided are electrokinetically-altered aqueous fluids (e.g., gas-enriched electrokinetic fluids) comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures in an... |
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US20120330438 |
REPAIRED ORGAN AND METHOD FOR MAKING THE SAME
A repaired ex vivo organ suitable for transplantation in a human, said repaired ex vivo organ having undergone ex vivo organ perfusion for a maintenance period, wherein said organ had been... |
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US20120315618 |
ASSESSING, MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS/TISSUES
Methods for ex vivo perfusion of organs (and/or tissues) with a perfusate designed to condition the organ with the desired effect being that upon transplant, said organ, having been administered... |
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US20070243518 |
Continuous cardiac perfusion preservation with PEG-HB for improved hypothermic storage
Efforts to extend myocardial preservation for transplantation by perfusion with prior crystalloid based solutions have been limited by edema and compromised function. Hypothermic perfusion... |
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US20170049096 |
ORGAN PERFUSION SYSTEMS
An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in... |
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US20150093738 |
Administration And Monitoring Of Nitric Oxide In Ex Vivo Fluids
Described are systems and methods for monitoring administration of nitric oxide (NO) to ex vivo fluids. Examples of such fluids include blood in extracorporeal membrane oxygenation (ECMO) circuits... |
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US20140087357 |
Organ Transplant Solutions and Methods for Transplanting Organs
A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a... |
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US20130109006 |
APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS
Methods of monitoring, maintaining, and/or restoring viability of at least one organ in at least one device selected from an organ transporter, perfusion apparatus, cassette, and organ diagnostic... |
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US20160309707 |
METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING
Method and device for treatment of a heart after harvesting and before transplantation. The device comprises a container intended to comprise the heart; a first line for connection to an aorta of... |
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US20170015963 |
LUNG BIOREACTOR
Presented is an airway organ bioreactor apparatus, and methods of use thereof, as well as bioartificial airway organs produced using the methods, and methods of treating subjects using the... |
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US20120183945 |
METHOD, DEVICE AND FLUID FOR TREATMENT OF A HEART AFTER HARVESTING
Method and device for treatment of a heart after harvesting and before transplantation. The device includes a container intended to comprise the heart; a first line for connection to an aorta of... |
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US20120183944 |
DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES
The invention provides for methods and materials to decellularize an organ or portion thereof and to recellularize such a decellularized organ or portion thereof to thereby generate an organ or... |
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US20120148542 |
MACHINE PERFUSION WITH COMPLEMENT INHIBITORS
Methods for perfusing one or more organs, tissues or the like (hereinafter “organs”) with a composition comprising at least one complement inhibitor to sustain, maintain or improve the viability... |
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US20140370490 |
HEART-LUNG PREPARATION AND METHOD OF USE
An isolated heart or heart-lung preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with... |
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US20070048727 |
Biliary barrier
Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be... |
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US20140017666 |
FILTRATION IN ORGAN PERFUSION APPARATUS
A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an... |
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US20130295551 |
MICROFLUIDIC DEVICE AND METHOD FOR MODULATING A GAS ENVIRONMENT OF CELL CULTURES AND TISSUES
A microfluidic device having a perfusion chamber, the perfusion chamber having a base, a bath opening in the base, a supply inlet and an exhaust outlet. The device further includes a gas permeable... |
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US20140314881 |
NOVEL MEDICAL USES FOR NO AND NO DONOR COMPOUNDS
A body part is preserved using nitric oxide and/or a nitric oxide donor that does not directly release nitric oxide or a red blood cell nitrosylating agent, preferably ethyl nitrite to facilitate... |
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US20120094268 |
TISSUE MAINTENANCE
The invention provides a method of reducing damage to a tissue, organ or cell from surgical procedures comprising administering a composition comprising a potassium channel opener/agonist and/or... |
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US20110177487 |
METHODS AND APPARATUS FOR PERFUSION OF AN EXPLANTED DONOR HEART
Described herein are methods and apparatus that may be used in various applications, such as to extend the viability of a donor heart, promote the efficacy for transportation of a donor heart,... |
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US20140302481 |
System and Method for Electrophoretic Decellularization
A device for decellularizing a tissue includes a container, first and second electrodes disposed within the container and defining a space between the first and second electrodes to receive the... |
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US20130323708 |
ISOLATED ADULT CELLS, ARTIFICIAL ORGANS, REHABILITATED ORGANS, RESEARCH TOOLS, ORGAN ENCASEMENTS, ORGAN PERFUSION SYSTEMS, AND METHODS FOR PREPARING AND UTILIZING THE SAME
One aspect of the invention provides a method for harvesting adult cells from an organ. The method includes perfusing the organ with a perfusate and isolating adult cells from the organ, thereby... |
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US20160278365 |
ORGAN PERFUSION METHOD AND ORGAN PERFUSION DEVICE
Disclosed is an organ perfusion method including introducing a perfusion solution into an organ extracted from the living body and deriving the perfusion solution from the organ, wherein the organ... |
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US20150373967 |
METHODS AND SYSTEMS FOR ASSESSING THE SUITABILITY OF AN ORGAN FOR TRANSPLANT
Methods of determining the health of an organ, such as a transplant organ, by measuring the ex-situ oxygen consumption rate of the organ. Systems for preserving and transporting organs while... |
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US20110305772 |
COMPOSITIONS AND METHODS FOR EX VIVO HEPATIC NUCLEIC ACID DELIVERY
The invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to... |
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US20110129810 |
Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ... |
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US20160302406 |
ORGAN PRESERVATION AND/OR PERFUSION
The present invention relates to a solution for preservation, perfusion, and/or reperfusion of an organ, especially the heart, for transplantation. The solution contains peptide inhibitor(s) of... |
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US20130040281 |
Procurement of Placental Stem Cells
Methods and solutions for the preservation and procurement of placental stem cells. A method for collecting stem cells from a placenta comprises: draining cord blood from the placenta; perfusing... |
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US20050015064 |
Skin cell perfusion unit
This invention concerns a unit for skin cell perfusion for the culture-, preservation-, proliferation-, and utilization of skin cells, skin fibroblasts, skin progenitor cells in vitro, as well as... |
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US20140017664 |
TEMPERATURE SENSING IN ORGAN PRESERVATION APPARATUS
A temperature sensor for monitoring an organ or tissue is configured to measure a temperature inside of a container configured to contain the organ or tissue. The temperature sensor is disposed... |
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US20070009881 |
Perfusion circuit
A perfusion system for the extracorporeal preservation of vitality or regeneration of organs, limbs or tissue lobes for use in transplant surgery, extracorporeal support of the liver, or for... |
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US20060121439 |
Organ preservation and transportation apparatus and method
Apparatus and method for preserving an organ via perfusion at hypothermic and/or normothermic temperature in which an organ-receiving container is arranged in a housing and contains a medium... |
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US20140349273 |
SYSTEM FOR HYPOTHERMIC TRANSPORT OF SAMPLES
A method for preserving an extracorporeal organ during hypothermic transport of the organ. The method includes placing an organ in a self-purging preservation apparatus to suspend the sample in... |