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US20140178350 DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS OF USE THEREOF  
Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having...
US20150079066 MEANS AND METHODS FOR GENERATING IMPROVED PROTEINS  
The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to...
US20140099296 TOPICALLY OR ORALLY APPLIED ALOE, DISTILLED WATER, SODIUM CHLORIDE, AND LYSOZYME MIXTURE AND METHOD OF PRODUCING THE MIXTURE  
A skin and/or oral treatment mixture for treating tattooed or pierced skin such as that resulting from a body piercing, oral piercing, or tattoo procedure includes non-iodized sodium chloride,...
US20150005172 Compositions Comprising Pesticide Precursors and Methods of Making and Use  
Disclosed is a two-part pesticide formulation and methods of making and using. The pesticide formulation comprises a first part comprising a glucosinolate concentrate, and a second part comprising...
US20140007292 Novel Insecticidal Proteins and Methods for Their Use  
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic...
US20120219538 STABILIZED PROTEIN FORMULATIONS AND USE THEREOF  
The present invention is directed to stable protein formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing therapeutic proteins in aqueous...
US20150024050 DRY POWDER FORMULATIONS OF DNASE I  
DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder...
US20140219988 RRECOMBINANT HUMAN SAPOSIN B PROTEIN CONTAINING PHOSPHORYLATED GLUCOSE RING AND USE THEREOF  
The present invention provides a means to ensure a further increase in the therapeutic effects provided by enzyme replacement therapy against lysosomal disease. The present invention is directed...
US20130189241 REGULATED DELIVERY SYSTEMS FOR INNER EAR DRUG APPLICATION AND USES THEREOF  
The invention relates to a controlled release delivery compositions and methods of using them for pathologies associated with Otorhinolaryngology and Head and Neck. Specifically, the invention...
US20110286937 SYNTHETIC GLYCOLIPID-CONTAINING LIPOSOME  
The present invention provides a glycolipid-containing liposome. In such a glycolipid-containing liposome, the glycolipid includes a plant ceramide portion and a sugar chain portion. The present...
US20110002908 TREATMENT OF A-GALACTOSIDASE A DEFICIENCY  
The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included.
US20150258180 ß-HEXOSAMINIDASE PROTEIN VARIANTS AND ASSOCIATED METHODS FOR TREATING GM2 GANGLIOSIDOSES  
Embodiments herein include variants of β-hexosaminidase that are useful for hydrolyzing GM2 ganglioside, polynucleotides encoding the same, and related methods. In various embodiments, a variant...
US20120164087 Human Serum Albumin-Based Topical Ointment for Treatment of Acne, Psoriasis, Egfr-Induced Toxicity, Premature Skin Aging and Other Skin Conditions  
Dermatological compositions and method for treating psoriasis, eczema, acne and like skin conditions for sanitization pharmaceutical compounding and protection of the skin from extreme...
US20120282231 HUMAN LYSOSOMAL PROTEINS FROM PLANT CELL CULTURE  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
US20110250181 HUMAN LYSOSOMAL PROTEINS FROM PLANT CELL CULTURE  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
US20150086530 DOSING REGIMENS FOR THE TREATMENT OF POMPE DISEASE  
The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxynojirimycin and enzyme replacement therapy for the treatment of Pompe disease....
US20140219986 DOSING REGIMENS FOR THE TREATMENT OF FABRY DISEASE  
The presently disclosed subject matter provides a dosing regimen and administration schedule for the use of 1-deoxygalactonojirimycin and enzyme replacement therapy for the treatment of Fabry...
US20140348816 USE OF COMPLEX FORMS OF CALMODULIN-LIKE SKIN PROTEIN CLSP  
The invention also relates to the use of these complex forms for the purposes of screening for biological or chemical compounds capable of modulating a biological activity of said complex forms...
US20130156750 Compositions and Methods for Using Human YKL-40 to Treat Acute Lung Injury  
The invention includes methods of treating oxidant-mediated acute lung injury in a subject by administration of a chitinase-like protein molecule, or an activator thereof. The invention also...
US20120321552 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or...
US20120093802 BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME  
A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic...
US20110033461 Combination Therapy for the Treatment of Cancer  
Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
US20130224172 METHODS OF TREATING BEHAVIORAL SYMPTOMS OF NEUROLOGICAL AND MENTAL DISORDERS  
Disclosed herein are methods of using coated digestive enzyme preparations and enzyme delivery systems and pharmaceutical compositions comprising the preparations for treatment of subjects having...
US20130149318 PAINTING THE PIA, ARACHNOID, AND SPINAL CORD PARENCHYMA  
A PEG based hydrogel and a procedure for its topical application to the surface of the pia mater of the spinal cord that can be used for intrathecal delivery of diverse drug and biomolecular...
US20120114627 DIAGNOSIS, PREVENTION AND TREATMENT OF DISORDERS CHARACTERIZED BY UNDESIRABLE CELL PROLIFERATION  
The present invention relates to compositions and methods for the reduction of atherosclerotic plaques and the decrease in the level of total serum cholesterol, triglycerides, serum LDL...
US20120039985 DENDRITIC CELL MODULATION IN POST-ISCHEMIC WOUNDS  
Compositions and methods useful for targeted depletion or modulation of dendritic cells are provided. The compositions and methods can be used to promote healing of ischemia-related injury,...
US20140099380 Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture  
Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging...
US20100310545 Dry treatment mixture and methods of production and use  
A dry treatment mixture is provided including: a quantity of a dry formulation of a salt; and a quantity of a dry formulation of lysozyme. The salt preferably is sea salt. The dry treatment...
US20150064161 PHARMACOLOGICAL VITREOLYSIS  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
US20130295077 TREATMENT OF SANFILIPPO SYNDROME TYPE B  
Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A...
US20110318327 TREATMENT OF SANFILIPPO SYNDROME TYPE B  
Among other things, the present invention provides methods and compositions of treating Sanfilippo syndrome type B (Sanfilippo B) by, e.g., intrathecal (IT) administration of a Naglu protein. A...
US20110236366 PRODUCTION AND USES OF TYPE I RIBOSOME INACTIVATING PROTEINS  
Described herein are methods to express and purify recombinant type 1 ribosome inactivating proteins. Included are methods for using recombinant cucurmosin as a therapeutic to treat cancer and...
US20150050263 Novel Compounds For Preventing And/Or Treating Lysosomal Storage Disorders And/Or Degenerative Disorders Of The Central Nervous System  
Described are novel salts of the compound (3R,4R,5S)-5-(difluoromethyl) piperidine-3,4-diol, as well as methods of using the same for preventing and/or treating lysosomal storage disorders and/or...
US20110070219 HIGH PRESSURE PROTEIN CRYSTALLIZATION  
The present disclosure provides an effective method for the crystallization of proteins at high pressure. A preferential excluding agent, and optionally other reagents may be incorporated into the...
US20150150953 PHARMACEUTICAL COMPOSITION ADAPTED FOR ORAL ADMINISTRATION AND THE PROCESS FOR ITS PREPARATION, FOR THE PREVENTION AND TREATMENT OF IRRITABLE BOWEL SYNDROME, BASED ON AN INTESTINAL MOTILITY MODIFIER AND a-D-GALACTOSIDASE  
The invention relates to a pharmaceutical formulation or composition in the form of a tablet, coated tablet, capsule or powder tor reconstitution, for use in irritable bowel syndrome, comprising...
US20120219589 FORMULATION OF DRUGS AND VACCINES IN THE FORM OF PERCUTANEOUS INJECTABLE NEEDLES  
The invention relates to percutaneous administration of drugs and vaccines in form of solid penetrating needles, “injectable needles”, comprising a polymeric matrix resulting from the...
US20100158889 ENHANCING THE EFFECT OF THERAPEUTIC PROTEINS ON THE CENTRAL NERVOUS SYSTEM  
The present invention provides a polypeptide therapeutic agent, useful in enzyme replacement therapy, with increased therapeutic benefits for the central nervous system. The invention provides a...
US20130164365 FORMULATIONS FOR TREATMENT WITH GLUCOSINOLATES  
The application relates to topical formulations comprising a phase II enzyme inducer precursor and an activating agent. Methods for producing and using the topical formulations are also provided.
US20150152436 THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS  
Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
US20140072549 STREPTOCOCCUS BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF GRAM POSITIVE BACTERIA  
The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including...
US20140193391 Method And Compositions For Improving Selective Catabolysis And Viability In Cells Of Keratin Surfaces  
A composition for treating keratin surfaces to stimulate selective catabolysis and improve cellular viability comprising at least one autophagy activator and at least one DNA repair enzyme, and a...
US20130280239 ARRAY OF COMPLEMENTARY INFANT/YOUNG CHILD NUTRITIONAL COMPOSITIONS  
The present invention relates to infant/young child nutrition. A set of nutritional compositions having beneficial effects to infants/young children is disclosed. The set of nutritional...
US20130084313 SUPPLEMENT FOR OSTOMY PATIENTS  
The present application describes a supplement containing an enteric coated alpha-D-galactosidse and the use thereof to treat an ostomy patient.
US20150017150 Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract  
The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes...
US20130156703 Methods, Compounds, and Compositions For Treatment and Prophylaxis in the Respiratory Tract  
The present invention provides a method of reducing the quanitity of mucus in the respiratory tract of a subject with elevated levels of mucus in said respiratory tract. The method includes...
US20130058913 Lactase Formulations  
A particulate composition comprising a plurality of particles comprising lactase and a protective material are provided. The particles have a size that is not perceptible or is minimally...
US20110196319 COMPOSITION AND SYSTEM FOR WOUND DECONTAMINATION  
The present disclosure is directed to a cleansing solution and system for administering the cleansing solution to decontaminate a wound surface. A method and kit for decontaminating a wound...
US20120204282 METHODS AND COMPOSITIONS FOR TREATING OCCULAR DISORDERS  
Disclosed herein are methods and compositions for treating ocular disorders.
US20130236443 SURFACE PROTECTION OF EXPOSED BIOLOGICAL TISSUES  
The invention relates to a biodegradable barrier network comprising at least two macromolecular substances, one being anionic and the other one cationic. The invention also relates to applicators...
US20100151009 FORMULATIONS FOR DELIVERING INSULIN  
Oral insulin formulations and processes for preparing oral insulin formulations are provided.