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US20130129706 |
Crotoxin Administration for Cancer Treatment and Pain Relief
Disclosed is a method for treating cancer and/or pain using an intra-patient dose escalation procedure to deliver dosages of crotoxin. |
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US20150110770 |
Crotoxin Administration for Cancer Treatment
A method for treating cancer using an intra-patient dose escalation procedure to deliver dosages of Crotalus durissus terrificus venom. |
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US20140294843 |
DIAGNOSIS AND TREATMENT OF COPD
Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a... |
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US20110262422 |
ORALLY ADMINISTRABLE DOSAGE FORMS COMPRISING ANGIOGENIN AND USES THEREOF
The invention provides a method of treatment of any disorder in which administration of angiogenin is beneficial wherein the angiogenin is administered orally. Particularly, the oral angiogenin... |
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US20140178350 |
DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS OF USE THEREOF
Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having... |
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US20150071906 |
DELIVERY SYSTEM FOR FUNCTIONAL NUCLEASES
Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are provided.... |
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US20150071903 |
USE OF CATIONIC LIPIDS TO DELIVER CAS9
Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are provided.... |
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US20150071992 |
CONCENTRATED, INHALABLE ANTIBIOTIC FORMULATION
A concentrated inhalable formulation of an antibiotic drug such as ciprofloxacin is disclosed. The antibiotic is formulated with sodium acetate and liposome which incorporate antibiotic. The... |
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US20150071879 |
Stabilization of Aqueous Compositions of Proteins with Displacement Buffers
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least... |
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US20150110767 |
METHODS FOR TREATING LUNG INFECTIONS AND INFLAMMATION
Methods of treating, reducing, or preventing lung infections or lung inflammation include identifying a patient in need of treatment and administering a therapeutically effective amount of at... |
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US20120321610 |
METHOD TO INHIBIT NEUROPATHIC PAIN BY INTRATHECAL INJECTION OF PROTEIN PHOSPHATASES
A method and corresponding pharmaceutical composition to inhibit neuropathic pain by injecting intrathecally into a mammalian subject a neuropathic pain-inhibiting amount of a phosphatase falling... |
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US20140219985 |
DISEASE CONTROL WITH TICK PHOSPHOLIPASE A2
The present invention relates to reagents and methods for the modulation of viability of bacteria. A process is provided wherein a protein sequence from A. americanum saliva effective in reducing... |
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US20110293596 |
DISEASE CONTROL WITH TICK PHOSPHOLIPASE A2
The present invention relates to reagents and methods for the modulation of viability of bacteria. A process is provided wherein a protein sequence from A. americanum saliva effective in reducing... |
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US20130022661 |
BIO-REMODABLE BONE AUGMENTATION DEVICE AND METHOD
A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having... |
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US20110311507 |
Methods for Diagnosing and Treating Autoimmune Disorders
Provided herein are, inter alia, methods of identifying patients who are at risk of developing an autoimmune disorder, and treating patients suffering from autoimmune disorders. |
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US20140007292 |
Novel Insecticidal Proteins and Methods for Their Use
Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic... |
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US20120201747 |
System and Method for Diagnosis and Treatment
This invention relates to a low cost rapid response diagnostic system to determine cortisol levels in patients selected as potential candidates for GCR (glucocorticoid receptor) antagonist therapy... |
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US20150231272 |
METHODS OF TREATMENT WITH ARGININE DEIMINASE
The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase. |
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US20150132278 |
METHODS OF TREATMENT WITH ARGININE DEIMINASE
The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase. |
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US20140377244 |
STABLE FORMULATIONS FOR CNS DELIVERY OF ARYLSULFATASE A
The present invention provides, among oilier things, compositions and methods for CNS delivery of lysosomal enzymes (e.g., recombinant human arylsulfatase A (rhASA)) for effective treatment of... |
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US20150024050 |
DRY POWDER FORMULATIONS OF DNASE I
DNase I formulations for pulmonary administration and, more particularly, but not exclusively, a dry powder formulation comprising, as an active ingredient, human DNase I, methods, dry powder... |
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US20130309219 |
Treatment and Prevention of Bacterial Vaginosis and Gardnerella Vaginalis Infections
G. vaginalis infection, a major cause of bacterial vaginosis (BV), is associated with biofilm formation. The present invention relates to treatment of G. vaginalis infections and BV with DNase.... |
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US20140341877 |
MCPIP AS WOUND THERAPY
Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP... |
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US20130295076 |
MCPIP AS WOUND THERAPY
Disclosed herein are methods and compositions of treating a subject suffering from a wound. In exemplary examples, the method involves elevating MCPIP levels in a subject in need. Elevating MCPIP... |
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US20110002981 |
MCPIP Protection Against Cardiac Dysfunction
Disclosed herein are methods and compositions of treating a patient at risk of experiencing sepsis induced cardiac dysfunction. In exemplary examples, the method involves elevating MCPIP levels in... |
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US20150086526 |
SUBCUTANEOUS ADMINISTRATION OF IDURONATE- 2-SULFATASE
The present invention provides, among other things, compositions, kits and methods for subcutaneous delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some... |
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US20150139946 |
DETECTING MUTATIONS IN DISEASE OVER TIME
Provided is a method for monitoring a gene mutation associated with a cancer in a patient over time. Also provided is a method of selecting and/or applying treatment or therapy for a subject. |
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US20150125439 |
CERAMIDE LEVELS IN THE TREATMENT AND PREVENTION OF INFECTIONS
The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject... |
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US20140112896 |
METHODS AND COMPOSITIONS FOR THE PROVISION OF PROTEINS DEFICIENT IN LYSOSOMAL STORAGE DISEASES
Nucleases and methods of using these nucleases for inserting a sequence encoding a therapeutic protein such as an enzyme into a cell, thereby providing proteins or cell therapeutics for the... |
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US20120207739 |
TREATMENT OF PRE-TERM NEONATES
This invention relates to the treatment of pre-term neonates with paraoxonase 3 (PON3) or serum amyloid A like protein 3 (SAA3) to reduce or prevent the morbidity and mortality associated with... |
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US20120058102 |
PHARMACOLOGICALLY INDUCED TRANSGENE ABLATION SYSTEM
The present invention relates to gene therapy systems designed for the delivery of a therapeutic product to a subject using replication-defective virus composition(s) engineered with a built-in... |
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US20150010525 |
Catalytic Tagging System to Study Macro-Molecular Interactions Using Engineered Ubiquitin Ligase and Ubiquitin-Like Proteins to Facilitate Substrate Identification
The present invention describes an unbiased catalytic tagging system to search for target substrates. Identification of substrates for specific baits is accomplished by utilizing an orthogonal... |
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US20130171124 |
Compositions And Methods Of Treating Head And Neck Cancer
The present invention provides methods related to the treatment of head and neck squamous cell carcinoma (HNSCC) and its associated premalignant lesions. In particular, the invention features... |
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US20110110918 |
ROLE OF (DE)ACETYLATION IN COUNTERACTING PROTEIN AGGREGATION
The invention provides a method for influencing an activity of a heat shock protein which is a member of the Hsp40/DnaJ family, the method comprising acetylating or deacetylating said heat shock... |
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US20130213398 |
DRY POWDER FORMULATIONS AND METHODS FOR TREATING PULMONARY DISEASES
The present invention is directed toward respirable dry particles for delivery of divalent metal cation salts and/or monovalent cation salts to the respiratory tract and methods for treating a... |
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US20150164984 |
Colicins for Treating Bacterial Infections
The Invention relates to materials and methods for the treatment of conditions associated with bacterial biofilms, intracellular bacterial infections and/or adherent-invasive Escherichia coli... |
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US20140294802 |
METHODS AND COMPOSITIONS TO REDUCE SERUM LEVELS OF TRIACYLGLYCERIDES IN HUMAN BEINGS USING A FUNGAL LIPASE
The invention relates to methods and compositions for reducing serum levels of triacylglycerides in human subjects. In particular, the invention relates to the oral administration of an effective... |
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US20150166985 |
METHODS FOR CORRECTING VON WILLEBRAND FACTOR POINT MUTATIONS
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a... |
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US20110311478 |
Combinatorial Methods For Treating Cellular Proliferative Disorders And Immune Deficiencies Using Salicinium
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become... |
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US20130302306 |
BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA
The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin,... |
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US20120114663 |
METHODS TO TREAT ALLERGIC CONDITIONS
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are... |
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US20110177054 |
USE OF ENDO-LYSOSOMAL SYSTEM AND SECRETED VESICLES (EXOSOME-LIKE) IN TREATMENTS AND DIAGNOSTICS BASED ON SMALL RNA AND EXPERIMENTAL STUDY OF SMALL RNA
The present invention relates to a method for determining the delivery rates and/or efficiency of a siRNA, miRNA or related molecule to target organs or cells, a kit and the use of proteins or... |
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US20110250192 |
USE OF MICRORNA SIGNATURES FOR ASSESSING RISK LEVELS OF NEUROBLASTOMA PATIENTS
Methods for assessing the risk level or survival/death probability of a neuroblastoma patient based on a number of microRNA signatures, optionally in combination with Dicer, Drosha, and age at... |
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US20110002907 |
Methods, Systems, Compositions And Dosage Forms For Diagnosing And Treating Male Infertility
Methods and systems are provided for diagnosing male infertility relating to inadequate production of phosphatidic acid and are complementary to the routine tests, assessing sperm count, motility,... |
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US20120148559 |
COMPOSITIONS AND METHOD FOR DEIMMUNIZATION OF PROTEINS
The invention provides deimmunized mutant proteins having reduced immunogenicity while exhibiting substantially the same or greater biological activity as the proteins of interst from which they... |
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US20120128651 |
ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) BIOMARKERS
The present invention concerns the use of biomarkers for acute lymphoblastic leukemia (ALL) to prognose or evaluate a patient with ALL who is Ph+. Methods and compositions are provided that... |
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US20150166983 |
METHODS FOR CORRECTING PRESENILIN POINT MUTATIONS
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a... |
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US20120321552 |
Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or... |
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US20110104050 |
Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin
Screening and diagnostic reagents, kits and methods for primary and/or metastatic stomach or esophageal cancer are disclosed. Compositions for and methods of imaging and treating primary and/or... |
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US20130202579 |
USE OF CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE-ALPHA (CCT-ALPHA) AS A BIOMARKER FOR CANCER PROGNOSIS
It has previously been demonstrated that positive 8F1 immunohistochemistry is an indicator of a poor cancer prognosis and poor response to chemotherapy. The 8F1 antibody was generated by... |