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US20170137791 |
METHODS AND COMPOSITIONS FOR TREATING INEFFECTIVE ERYTHROPOIESIS
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly... |
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US20160243207 |
AGENT FOR USE IN THE CASE OF FRUCTOSE INTOLERANCE
There is provided a method for treating or reducing the effects of fructose intolerance and health problems associated with excessive fructose intake by administration of glucose isomerase. Other... |
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US20160152687 |
ALBUMIN FUSION PROTEINS
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors... |
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US20150291975 |
ENHANCED NUCLEIC ACID CONSTRUCTS FOR EUKARYOTIC GENE EXPRESSION
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and... |
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US20140023632 |
PHARMACEUTICAL FORMULATION
A pharmaceutical formulation for a PKC modulatory peptide and a transport moiety comprising the aforementioned components and an anti-aggregant. |
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US20140010799 |
HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules,... |
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US20130202696 |
Agent for use in the case of fructose intolerance
There is provided in accordance with embodiments of the invention a method of treating or reducing the effects in a subject of a condition selected from fructose intolerance and impaired fructose... |
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US20130177531 |
Inhibitors of Serine Proteases
This invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof wherein C* represents a diastereomeric carbon comprising a mixture of R and S isomers... |
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US20120177661 |
HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR
The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules,... |
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US20110318351 |
NOVEL METHODS OF CANCER DIAGNOSIS AND THERAPY TARGETED AGAINST A CANCER STEM LINE
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous... |
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US20110020312 |
METHODS FOR TREATMENT OF METABOLIC DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS
Methods and formulations for treating metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described. |
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US20100278802 |
COMPOSITIONS OF PROKARYOTIC PHENYLALANINE AMMONIA-LYASE AND METHODS OF TREATING CANCER USING COMPOSITIONS THEREOF
The present invention is directed to phenylalanine ammonia-lyase (PAL) variants produced by prokaryotes, wherein such prokaryotic PAL variant has a greater phenylalanine-converting activity and/or... |
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US20070280920 |
PHARMACEUTICAL COMPOSITION COMPRISING A FACTOR VIIa AND A FACTOR XIII
The present invention relates to the use of a factor VIIa and a factor XIII in the treatment or prophylaxis of bleeding episodes. |
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US20160376663 |
METHODS FOR ANALYSIS OF SOMATIC MOBILE ELEMENTS, AND USES THEREOF
Methods and compositions related to the use of Mobile Element Insertions and their adjacent genomic sequences. Methods using MEIs as markers for cellular proliferation, as targets for... |
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US20160108379 |
ACTRIIB-FC POLYNUCLEOTIDES, POLYPEPTIDES, AND COMPOSITIONS
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of a tissue, such as bone, cartilage, muscle, fat, and/or neuron. The... |
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US20150139974 |
RCA LOCUS ANALYSIS TO ASSESS SUSCEPTIBILITY TO AMD AND MPGNII
The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD and/or MPGNII. The... |
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US20140314735 |
PROCESS FOR CONCENTRATION OF A POLYPEPTIDE
The present invention comprises a method of concentrating a composition comprising a polypeptide of interest and the use of such a concentrated composition for the treatment of diseases in... |
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US20140248253 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF CNS INJURIES
The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective... |
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US20120195857 |
Hepatitis C Virus Inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such... |
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US20100260739 |
Mirac Proteins
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly... |
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US20170137799 |
PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and... |
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US20160199457 |
MODULATION OF AXON DEGENERATION
The invention relates generally to treatment of neurological disorders and nervous system injuries. The invention specifically provides methods of using modulators of particular target proteins to... |
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US20130273024 |
METHODS FOR TREATING ATHEROSCLEROSIS
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, inflammation, thrombosis and other conditions and for decreasing or prevention of... |
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US20130084300 |
DIAGNOSIS AND PREVENTION OF CANCER CELL INVASION
The present invention relates to diagnostic and therapeutic methods in the field of malignant disorders. More particularly, the invention provides methods of determining the invasivity of... |
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US20120027744 |
MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of... |
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US20100291058 |
Sealants for Skin and Other Tissues
The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may... |
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US20100092434 |
THROMBOPOIETIC ACTIVITY OF TYROSYL-TRNA SYNTHETASE POLYPEPTIDES
Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are methods of using such compositions in the... |
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US20080260714 |
Fibrin Compositions Containing Strontium Compounds
A composition for use in bone healing and bone regeneration in the form of a viscoelastic hydrogel gel or liquid formulation comprising fibrinogen, thrombin and an inorganic component comprising a... |
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US20080226589 |
Compositions and methods of use of phorbol esters
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means... |
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US20070172469 |
Methods For Inhibiting Viral Replication In Vivo
The present invention is directed to methods of modulating viral replication in vivo comprising administering to an individual a therapeutically or prophylactically effective amount of a... |
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US20160199464 |
ALGINATE AND ALGINATE LYASE COMPOSITIONS AND METHODS OF USE
The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions... |
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US20140234318 |
TUMOR SPECIFIC OLIGOSACCHARIDE EPITOPES AND USE THEREOF
The present invention describes oligosaccharide sequences, which are specifically expressed by human tumors. The present invention is related to a method of determining an oligosaccharide... |
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US20140134222 |
TOPICAL BENFOTIAMINE AND PYRIDOXAMINE COMPOSITIONS
The present invention provides a composition comprising an effective amount of benfotiamine and an effective amount of pyridoxamine in a suitable vehicle for topical application. The present... |
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US20130336952 |
PHARMACEUTICAL COMPOSITIONS AND RELATED METHODS
The present disclosure relates to compositions and methods for accelerating the healing process of wounds, increasing the closure of skin wounds, and decreasing inflammation at the site of a skin... |
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US20120009172 |
INTRAVENOUS AND ORAL DOSING OF A DIRECT-ACTING AND REVERSIBLE P2Y12 INHIBITOR
The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: alone or in... |
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US20110311506 |
PIGGYBAC TRANSPOSON VARIANTS AND METHODS OF USE
The present invention provides hyperactive piggyBac transposons, in particular hyperactive piggyBac transposons from Trichoplusia ni (cabbage looper moth) that transpose at a higher frequency than... |
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US20100196445 |
SYSTEMS AND METHODS FOR DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
The invention provides methods and devices for the delivery of therapeutic or biologically active agents to tissue, for example by facilitating the transport of said agents through the skin of a... |
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US20080025961 |
Methods of stimulating cellular growth, synaptic remodeling and consolidation of long-term memory
The present invention provides methods of slowing or reversing the loss of memory and learning comprising the steps of contacting an effective amount of a PKC activator with a protein kinase C... |
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US20070098807 |
Matrices for drug delivery and methods for making and using the same
In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain... |
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US20160022784 |
PURINE NUCLEOSIDE PHOSPHORYLASE AS ENZYMATIC ACTIVATOR OF NUCLEOSIDE PRODRUGS
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside... |
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US20160011211 |
METHODS TO PREDICT AND PREVENT RESISTANCE TO TAXOID COMPOUNDS
Embodiments of the invention are directed to methods for predicting the resistance of cancer to members of the taxoid family by measuring the levels of prohibitin. Methods for treating cancer and... |
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US20150132277 |
Monomeric Forms of Human Aminoacyl-tRNA Synthetases Having Non-Canonical Biological Activities
Isolated monomeric aminoacyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto. |
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US20140199285 |
PURINE NUCLEOSIDE PHOSPHORYLASE AS ENZYMATIC ACTIVATOR OF NUCLEOSIDE PRODRUGS
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside... |
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US20140037717 |
Detection of Mutations in a Gene Associated with Resistance to Viral Infection, OAS1
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided... |
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US20110243912 |
Growth Factor Binding Constructs Materials and Methods
The present invention provides materials and methods for antagonizing the function of vascular endothelial growth factor receptors, platelet derived growth factor receptors and other receptors.... |
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US20110020272 |
COMBINATION THERAPY FOR TREATING HEPATITIS VIRAL INFECTION
Disclosed are methods of using proteasome inhibitors (PI) in combinations with other pharmaceutically active agents for treating viral hepatitis infections, for example, for treating... |
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US20090285792 |
Compositions and methods for treatment of neovascular diseases
The present invention provides compositions and methods of treating neovascular diseases, such as a retinal neovascular diseases and tumors, by administering to a patient suffering from a... |
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US20090047309 |
COSMETIC METHODS AND COMPOSITIONS FOR REPAIRING HUMAN SKIN
The present invention relates to methods and compositions for repairing adverse effects of the environment, daily stress, sun exposure, or pre-mature aging on human skin, comprising applying to... |
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US20090041741 |
MODIFIED ENZYME AND TREATMENT METHOD
There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to... |
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US20060110379 |
Linkage of agents using microparticles
Methods, products and kits are provided for attaching agents to a skin surface via microparticles using endogenous or exogenous transglutaminase. |