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US20140193386 METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN  
A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or...
US20110086014 METHOD FOR ENZYMATIC CROSS-LINKING OF A PROTEIN  
A method for cross-linking albumin for use as a sealant or glue for a biological system, for example to induce hemostasis and/or prevent leakage of any other fluid from a biological tube or...
US20140314732 CROSS-LINKED COMPOSITIONS  
Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and...
US20110110882 CROSS-LINKED COMPOSITIONS  
Improved compositions comprising a cross-linkable protein or polypeptide, and a non-toxic material which induces cross-linking of the cross-linkable protein. The compositions are optionally and...
US20120093797 COMBINED USE OF CREATINE PHOSPHATE AND CREATINE PHOSPHOKINASE FOR TREATMENT OF ARTERIOSCLEROSIS  
Disclosed are a creatine phosphate (CP) and creatine phosphokinase (CPK) in association for use in the treatment of an atherosclerotic plaque present in the wall of an artery of a patient.
US20130142781 PEG BASED HYDROGEL FOR PERIPHERAL NERVE INJURY APPLICATIONS AND COMPOSITIONS AND METHOD OF USE OF SYNTHETIC HYDROGEL SEALANTS  
Hydrogels that may be used for treating peripheral nerves and related methods are provided. Synthetic hydrogel sealants, methods of forming synthetic hydrogel sealants, and the use of synthetic...
US20150216949 METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM  
A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an...
US20110070218 METHODS OF TREATING CANCER OF THE CENTRAL NERVOUS SYSTEM  
A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an...
US20120171190 METHODS FOR DIAGNOSING CHRONIC DIARRHEA THROUGH PROTEIN SECRETION ANALYSIS  
Methods for diagnosing chronic diarrhea and other gastrointestinal conditions. In the methods, a sample of gastrointestinal secretions is obtained from a control group; or a group who has been...
US20060142193 Selective inhibition of rock1 in cardiac therapy  
The present invention is directed to the treatment and/or prevention of disease as it relates to Rho kinase. In specific embodiments, disease is treated and/or prevented through the administration...
US20110262453 Markers for Assessing the Susceptibility of Cancer to IGF-1R Treatment  
The present invention relates to a method of predicting response of a cancer cell tissue to IGF-IR treatment. The inventors have observed a direct relationship between the expression of survivin,...
US20140322192 PROTEOGLYCAN DEGRADING MUTANTS FOR TREATMENT OF CNS  
The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and...
US20110117072 HYPERACTIVE VARIANTS OF THE TRANSPOSASE PROTEIN OF THE TRANSPOSON SYSTEM SLEEPING BEAUTY  
The present invention refers to hyperactive variants of a transposase of the transposon system Sleeping Beauty (SB). The invention further refers to corresponding nucleic acids producing these...
US20140271601 CROSSLINKABLE TREHALOSE FOR THE COVALENT INCORPORATION IN HYDROGELS AND METHODS OF USE  
Methods of controlled delivery of bioactive therapeutics are provided. Compositions comprising therapeutic implants are provided.
US20110110914 METHODS FOR TREATMENT OF ONCOLOGICAL DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS  
Methods and formulations for treating oncological disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
US20110020312 METHODS FOR TREATMENT OF METABOLIC DISORDERS USING EPIMETABOLIC SHIFTERS, MULTIDIMENSIONAL INTRACELLULAR MOLECULES, OR ENVIRONMENTAL INFLUENCERS  
Methods and formulations for treating metabolic disorders in humans using epimetabolic shifters, multidimensional intracellular molecules or environmental influencers are described.
US20130136796 Acellular Bioabsorbable Tissue Regeneration Matrices  
The present invention provides methods and compositions useful in the regeneration of damaged, lost and/or degenerated tissue in humans and animals. In certain embodiments, the present invention...
US20120114663 METHODS TO TREAT ALLERGIC CONDITIONS  
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are...
US20110177054 USE OF ENDO-LYSOSOMAL SYSTEM AND SECRETED VESICLES (EXOSOME-LIKE) IN TREATMENTS AND DIAGNOSTICS BASED ON SMALL RNA AND EXPERIMENTAL STUDY OF SMALL RNA  
The present invention relates to a method for determining the delivery rates and/or efficiency of a siRNA, miRNA or related molecule to target organs or cells, a kit and the use of proteins or...
US20150196683 GELATIN-TRANSGLUTAMINASE HEMOSTATIC DRESSINGS AND SEALANTS  
An adhesive material for medical use comprising gelatin and a non-toxic cross-linking material such as transglutaminase. An optional embodiment of the invention includes dressings in which a layer...
US20150098927 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoKβ) activity as well as to methods for the design of...
US20110250179 METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER  
The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoKβ) activity as well as to methods for the design of...
US20150004205 BIOMATERIALS HAVING NANOSCALE LAYERS AND COATINGS  
The invention generally relates to surfaces having a protein-resistant hydrogel layer and methods for preparing a protein-resistant hydrogel layer on a surface. The protein-resistant hydrogel...
US20150023942 COMPOSITIONS AND METHODS FOR PROMOTING NEURONAL OUTGROWTH  
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the...
US20120207732 COMPOSITIONS AND METHODS FOR PROMOTING NEURONAL OUTGROWTH  
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the...
US20110082482 Materials and Methods for Nerve Repair  
The subject invention pertains to compositions and methods for promoting repair of damaged nerve tissue. The compositions and methods of the subject invention can be employed to restore the...
US20110066182 Tissue Sealant for Use in Non Compressible Hemorrhage  
ClotFoam is a surgical sealant and hemostatic agent designed to be used in cases of non-compressible hemorrhage. It can be applied in the operating room through laparoscopic ports, or directly...
US20120093802 BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME  
A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic...
US20110104138 USE OF THE INNATE IMMUNITY GENE OASL FOR PREVENTING OR TREATING INFECTION WITH NEGATIVE STRAND RNA VIRUSES  
A method to treat a disease, disorder or condition caused by a negative-sense single-strand RNA virus in an individual in need, comprising at least the step of administering to said individual in...
US20120027742 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME  
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary...
US20150203827 MODIFIED TAFAZZIN PROTEINS AND METHODS OF MAKING AND USING THE SAME  
Fusion proteins comprising a tafazzin peptide and a cellular permeability peptide are disclosed. The tafazzin peptide may be coupled to the permeability peptide through a polypeptide linker....
US20120021045 Methods for Inhibiting Cancer Cell Proliferation  
The present invention concerns methods of treating cancer and methods of inhibiting cancer cell proliferation, particularly methods of treating breast cancer.
US20100310544 COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES  
The invention is based on the finding that calcium ions and proteolytic enzymes, particularly papain, act in a synergetic way in the regeneration of skin and connective tissues. Thus, such a...
US20130164274 KIT FOR MONITORING, DETECTING AND STAGING GVHD  
A method and kit for detecting Graft versus Host Disease (GVHD) in a mammal including a human comprising the steps of; obtaining a sample from the patient or subject; measuring the level of GSK-3β...
US20110318351 NOVEL METHODS OF CANCER DIAGNOSIS AND THERAPY TARGETED AGAINST A CANCER STEM LINE  
Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous...
US20120087980 STIMULATION OF NEUROREGENERATION BY FLAVONOID GLYCOSIDES  
Flavonoid glycosides, such as isoquercitrin, are shown to stimulate the formation of neuritis and neuronal synapses in neurons and neuronal progenitor (stem) cells.
US20140271600 NON-CELLULAR BANDAGE, METHOD OF USING THE SAME, AND METHOD OF PREPARING THE SAME  
There is provided a non-cellular bandage and a method of treating damaged tissue derived from a disease or symptom by applying the non-cellular bandage that includes serum, fibrin, and collagen....
US20150247134 TATk-CDKL5 FUSION PROTEINS, COMPOSITIONS, FORMULATIONS, AND USE THEREOF  
Disclosed herein are compositions and formulations containing a TATk-CDKL5 fusion protein. Also disclosed are methods of producing a TATk-CDKL5 fusion protein from vectors containing a TATk-CDKL5...
US20150023949 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDER  
Methods for treatment and diagnosis of pervasive developmental disorders in humans are described.
US20110014158 COMPOSITIONS AND METHODS OF USING CHONDROITINASE ABCI MUTANTS  
The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance...
US20120276019 TISSUE KALLIKREIN FOR THE TREATMENT OF PARKINSON'S DISEASE  
Provided herein are methods of treating Parkinson's disease, dementia with Lewy bodies, and conditions associated with Parkinson's disease and dementia with Lewy bodies. These methods include...
US20110289605 Animal Model for Osteoarthritis and Intervertebral Disc Disease  
Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated...
US20150139974 RCA LOCUS ANALYSIS TO ASSESS SUSCEPTIBILITY TO AMD AND MPGNII  
The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of alternative complement cascade deregulation disease such as AMD and/or MPGNII. The...
US20110081331 CANCER THERAPY  
The present invention provides a method for treating a hyperproliferative disorder characterized by expression of a mutant form of p53 in a subject, the method comprising administering to the...
US20120093722 SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM  
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active...
US20120039985 DENDRITIC CELL MODULATION IN POST-ISCHEMIC WOUNDS  
Compositions and methods useful for targeted depletion or modulation of dendritic cells are provided. The compositions and methods can be used to promote healing of ischemia-related injury,...
US20140248253 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CNS INJURIES  
The present invention is directed to a method of improving functional recovery following a central nervous system contusion injury. The method includes administering a therapeutically effective...
US20110123573 Methods and compositions for treating phenylketonuria  
Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase (“PAH”) and/or a phenylalanine ammonia lyase (“PAL”) to the subject...
US20130224223 Compositions and Methods for Treating Neurological Disorders  
Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or...
US20120039881 COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS  
Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or...