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US20140178350 DEPHOSPHORYLATED LYSOSOMAL STORAGE DISEASE PROTEINS AND METHODS OF USE THEREOF  
Provided are substantially dephosphorylated forms of lysosomal storage disease (LSD) proteins, including dephosphorylated forms of iduronate-2-sulfatase (IDS, or I2D) and iduronidase (IDU), having...
US20110223240 COMPOUNDS FOR REVERSING AND INHIBITING PROTEIN AGGREGATION, AND METHODS FOR MAKING AND USING THEM  
The invention provides compositions for increasing the clearance of protein aggregates, and pharmaceutical compositions comprising them, and methods for making and using them, including methods...
US20150071903 USE OF CATIONIC LIPIDS TO DELIVER CAS9  
Compositions, methods, strategies, kits, and systems for the supercharged protein-mediated delivery of functional effector proteins into cells in vivo, ex vivo, or in vitro are provided....
US20120328591 METHODS FOR IMPROVING ORAL DELIVERY  
The invention provides a method of improving the oral delivery of a therapeutic agent, comprising the step of linking the therapeutic agent to a carrier protein comprising angiogenin, fusion...
US20150150959 BACTERIAL BIOFILM MATRIX AS A PLATFORM FOR PROTEIN DELIVERY  
Some aspects of this disclosure provide engineered exopolysaccharide-associated proteins, engineered bacteria expressing such proteins, and engineered biofilms comprising such proteins. Some...
US20120244137 Method of Purifying Pegylated Proteins  
The invention relates to a method of purifying PEGylated proteins by removing impurities from samples containing PEGylated proteins, in particular, but not exclusively vitamin K-dependent blood...
US20130323220 TAL-Tet1 Fusion Proteins and Methods of Use Thereof  
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines...
US20130149335 PROTEIN FORMULATIONS  
The invention relates to the discovery that the addition of aromatic carboxylate ions inhibit protein instability caused by aromatic preservatives. Thus, the invention relates to compositions,...
US20140072547 COSMETIC  
A composition is provided that includes a fish spawn protein isolate. A natural product extract is also present that includes unsaturated fatty acids and sterols. An emulsifier is provided to form...
US20130336948 COSMETIC  
A composition is provided that includes a fish spawn protein isolate. A natural product extract is also present that includes unsaturated fatty acids and sterols. An emulsifier is provided to form...
US20130336946 FUSION PROTEINS AND METHODS FOR TREATING HIV INFECTION AND AIDS RELATED SYMPTOMS  
The present invention discloses pharmaceutical compositions and methods for using a fusion protein comprising a superoxide dismutase and a transit peptide. The present invention also discloses...
US20130344049 METHODS FOR TREATMENT OF OCULAR DISEASES  
Methods and therapeutic treatments of ocular diseases are provided including applying peg-Arginase I to affected eyes. Methods are provided that simultaneously treat inflammation and...
US20110008455 Crosslinked Protein Nanocrystals, Crosslinked Protein Nanoaggregates and Method of Preparation Thereof  
This invention relates to crosslinked protein nanoparticles and a method for producing the same. The method comprises the preparation and nanonization (i.e., size reduction to the nanoscale) of...
US20110110911 Methods of Treating Cancer Using Tachykinin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
US20110070215 METHODS OF TREATING CANCER USING NEUROTROPHIN RETARGETED ENDOPEPTIDASES  
The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
US20110064713 Methods of Treating Cancer Using Opioid Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such TVEMPs and methods of treating cancer in a mammal using such TVEMP compositions.
US20140227350 Annexin A2 and Tissue Plasminogen Activator For Treating Vascular Disease  
The use of tPA to treat hemorrhagic transformation, neurotoxicity has been limited to short treatment time windows because a high dose of tPA required to generate sufficient amounts of the enzyme...
US20140193425 TREATMENT OF CANCER WITH ALK1 ANTAGONISTS  
Methods for evaluating responsiveness of a subject having cancer to treatment with an activin receptor-like kinase 1 (ALK1) antagonist are provided. Methods for selecting a subject for treatment...
US20110123591 TUMORICIDAL, BACTERICIDAL, OR VIRICIDAL MACROPHAGE ACTIVATION  
The activation of macrophages and methods for treating cancer, bacterial pathogens and viral pathogens are disclosed. In particular, Gc protein is converted to Gc-macrophage activating factor...
US20120027743 Method for the Treatment of Hemophilia  
The present invention is directed to a method for the treatment of hemophilia.
US20100303787 Methods of Treating Urogenital-Neurological Disorders Using Galanin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating urogenital-neurological disorders in a mammal using such TVEMPs and compositions.
US20100303789 Methods of Treating Chronic Neurogenic Inflammation Using Neurotrophin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
US20100303788 Methods of Treating Chronic Neurogenic Inflammation Using Galanin Retargeted Endopepidases  
The present specification discloses TVEMPs, compositions comprising such toxins and methods of treating chronic neurogenic inflammation in a mammal using such TVEMPs and compositions.
US20130011335 Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and SRC  
This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation...
US20120076779 STABILIZATION OF IMMUNOGLOBULINS AND OTHER PROTEINS THROUGH AQUEOUS FORMULATIONS WITH SODIUM CHLORIDE AT WEAK ACIDIC TO NEUTRAL ph  
The present invention provides, among other aspects, storage stabile aqueous formulations of labile proteins at a mildly acidic to neutral pH. The present invention also provides methods for...
US20120141450 RISK MARKERS FOR CARDIOVASCULAR DISEASE  
The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above...
US20150165054 METHODS FOR CORRECTING CASPASE-9 POINT MUTATIONS  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a nucleic acid encoding a...
US20130202564 Systems and Methods of Cell Activated, Controlled Release Delivery of Growth Factors for Tissue Repair and Regeneration  
This invention provides a composition for controlled-release of polypeptide growth factors useful in tissue repair or engineering. The composition include a polypeptide growth factor covalently...
US20140193358 TREATING CANCER STEM CELLS USING TARGETED CARGO PROTEINS  
The disclosure provides targeted cargo proteins that are useful for targeting cancer stem cells, and methods of their use in treating cancer.
US20120027742 METHODS FOR TREATING ADULT RESPIRATORY DISTRESS SYNDROME  
We have discovered that the activated phosphorylated form of focal adhesion kinase (hereafter “FAKp”) strengthens the microvascular endothelial cell (EC) junctions that form a barrier in pulmonary...
US20120064075 CHIMERIC FACTOR VII MOLECULES WITH ENHANCED HALF LIFE AND METHODS OF USE  
The present invention relates to novel proteins and methods of using chimeric Factor VIIa polypeptides.
US20140099294 Biotherapy for Pain  
The present invention is directed to analgesic Clostridial neurotoxin derivatives comprising polypeptides having a long-lasting SNARE protein-selective endopeptidase activity. These derivatives...
US20110142756 Method And Composition For The Treatment Of Cancer By The Enzymatic Conversion Of Soluble Radioactive Toxic Precipitates In The Cancer  
The invention features compositions and methods for treating or alleviating a symptom of cancer. The compositions and methods of the invention direct supra-lethal doses of radiation, called...
US20100297219 Methods and Compositions for Modifying Apolipoprotein B mRNA Editing  
Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods...
US20140120156 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20140004181 COMPOSITIONS AND METHODS FOR EXOSOME TARGETED EXPRESSION  
The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell...
US20140271598 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE  
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the...
US20110318323 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF IDURONATE-2-SULFATASE  
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the...
US20120093722 SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM  
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active...
US20130183279 Fibrin Formulations for Wound Healing  
Fibrin formulations, fibrin matrices and kits for wound healing, use of the formulation, matrices and foams, and kits and methods of using thereof, are described herein. In a preferred aspect, the...
US20070154534 Use of secretin in the treatment of schizophrenia  
The treatment of schizophrenia by administration of secretin to a patient in need thereof is disclosed.
US20130302304 PHARMACOLOGICAL VITREOLYSIS  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
US20130195887 PHARMACOLOGICAL VITREOLYSIS  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
US20110171190 PHARMACOLOGICAL VITREOLYSIS  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
US20120141376 PROSTATE SPECIFIC TRANSCRIPTS AND THE USE THEREOF FOR PROSTATE CANCER THERAPEUTICS AND DIAGNOSTICS  
Genes that are up regulated in human prostate tumor tissues and the corresponding proteins are identified. These genes and the corresponding antigens are suitable targets for the treatment,...
US20130121958 STREPTAVIDIN AND BIOTIN-BASED ANTIGEN DELIVERY SYSTEM  
The present invention provides an innovative versatile system, which allows delivery of one or several antigens or biologically active molecules into or onto targeted subset of cells. The...
US20130243765 CHIMERIC PROTEIN  
A chimeric protein is disclosed for promoting repair and regeneration of neurons damaged by disease or physical injury wherein the chimeric protein is a combination of a first polypeptide...
US20140255377 PHARMACEUTICAL COMPOSITION COMPRISING ALBUMIN-BINDING ARGININE DEIMINASE FOR CANCER TARGETING TREATMENT  
The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase fusion protein (AAD) for treating cancer or other arginine-dependent diseases. The AAD...
US20120027785 CHIMERA COMPRISING BACTERIAL CYTOTOXIN AND METHODS OF USING THE SAME  
This invention provides, a recombinant polypeptide encoding a chimera. The chimera includes a DNase I fragment or a homologue thereof and a Cdt fragment or a homologue thereof. Further, the...
US20120014936 METHODS AND COMPOSITIONS FOR CNS DELIVERY OF HEPARAN N-SULFATASE  
The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the...