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US20130058863 4-Protein Biomarker Panel for the Diagnosis of Lymphoma from Biospecimen  
A panel of lymphoma related biomarkers are provided. The panel allows the identification of a subject at risk for a lymphoma. Further provided are methods of optimizing therapeutic efficacy...
US20130287717 METHOD FOR IMPROVING SKIN APPEARANCE AND REDUCING HAIR LOSS  
A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein...
US20110142812 SUPPRESSIVE MACROPHAGES, C-REACTIVE PROTEIN AND THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS AND IMMUNE THROMBOCYTOPENIC PURPURA  
The present invention relates to the use of suppressive macrophage or dendritic cells (activated with C-reactive protein or CRP-related compounds), for the treatment of various disease states and...
US20110020310 ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD  
Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or...
US20120156265 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY  
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
US20110097381 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY  
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
US20150139946 DETECTING MUTATIONS IN DISEASE OVER TIME  
Provided is a method for monitoring a gene mutation associated with a cancer in a patient over time. Also provided is a method of selecting and/or applying treatment or therapy for a subject.
US20120148553 METHODS OF GENERATING NATURAL KILLER CELLS  
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of...
US20130236418 Immunomodulatory Methods and Systems for Treatment and/or Prevention of Aneurysms  
Immunomodulatory agents, T cell, compositions, methods and systems for treating and/or preventing an aneurysm and/or a condition associated thereto in an individual.
US20140356339 SEQUENCE-BASED MEASURES OF IMMUNE RESPONSE  
The invention is directed to methods of measuring an immune response by comparing sequence-based clonotype frequency data from successively measured clonotype profiles. In particular, the...
US20140363411 HUMAN MONOCYTE SUB-POPULATION FOR TREATMENT OF CENTRAL NERVOUS SYSTEM INJURY  
A subpopulation of peripheral blood mononuclear cells (PBMCs) that is substantially devoid of CD3+ cells, CD19+ cells, CD56+ cells and optionally of CD16+ cells, for use in treatment of CNS injury...
US20140369984 BIOMATERIAL FOR ARTICULAR CARTILAGE MAINTENANCE AND TREATMENT OF ARTHRITIS  
The present disclosure provides biomaterials and methods for preventing and minimizing progression of cartilage and/or connective tissue damage. Also provided herein are biomaterials and methods...
US20140072545 GENERATION OF NATURAL KILLER CELLS AND LYMPHOID TISSUE INDUCER-LIKE (LTI-LIKE) NK-22 CELLS  
The present invention relates generally to methods to prepare NK and LTi-like, NK22 cells from HSCs and uses of those cells.
US20150064153 HIGH EFFICIENCY MICROFLUIDIC PURIFICATION OF STEM CELLS TO IMPROVE TRANSPLANTS  
Described herein is a novel, highly efficient system to remove erythrocytes and purify leukocytes would raise the quality of UCB and other transplant grafts, thereby significantly improving...
US20120263693 Methods for Treating Progressive Multifocal Leukoencephalopathy (PML)  
The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
US20120034249 Methods for Treating Progressive Multifocal Leukoencephalopathy (PML)  
The present invention relates generally to the treatment of PML by infusion of activated and expanded autologous lymphocytes.
US20120282234 Medium, Solutions And Methods For The Washing, Culturing And Storage Of White Blood Cells  
White blood cell products and storage media for white blood cells are disclosed. The storage medium includes sodium chloride, sodium acetate, sodium citrate, sodium phosphate, magnesium chloride,...
US20140356318 ADOPTIVE CELL THERAPY WITH SPECIFIC REGULATORY LYMPHOCYTES  
The present invention comprises a method of treatment of an autoimmune disease involving a specific tolerance induction (“STI”) event, wherein the method includes: collecting a first sample from...
US20110091412 MUTANT INTERLEUKIN-2 (IL-2) POLYPEPTIDES  
The present invention relates to mutant IL-2 polypeptides that act as receptor antagonists. The mutant IL-2 polypeptides bind CD 25 but do not activate the IL-2 receptor. Also provided are methods...
US20100310504 METHODS FOR TREATING FIBROSIS BY MODULATING CELLULAR SENESCENCE  
Fibrosis arises as part of a wound healing response that maintains organ integrity following catastrophic tissue damage, but can also contribute to a variety of human pathologies, including liver...
US20130052158 USE OF AUTOLOGOUS EFFECTOR CELLS FOR TREATMENT OF MULTIPLE MYELOMA  
The present disclosure provides methods for treating multiple myeloma using autologous expanded and activated NK cells.
US20140335046 Compositions, Methods and Systems for Regenerative Cosmetics  
A method of inducing or promoting hair growth on the scalp of a subject, comprising the steps of (i) providing an ECM composition including at least one ECM material, (ii) administering inciting...
US20140341809 High-Affinity DMF5 T Cell Receptor (TCR) Variants  
High-affinity variants of the DMF5 TCR, and methods of use thereof for the treatment and imaging of cancer in a patient.
US20110014210 CHLAMYDIA VACCINE  
Compositions and methods for the treatment of Chlamydial infection are disclosed. The compositions provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen...
US20150218518 INDUSTRIAL PREPARATION OF NATURAL KILLER CELLS (NKS) AND INJECTION USING HUMAN ALLO-GENEIC KARYOCYTES  
Disclosed is an industrial preparation of natural killer cells (NKs) and an injection using human allogeneic karyocytes comprising: using umbilical cord blood and peripheral blood from legitimate...
US20110159017 TRYTOPHAN CATABOLISM IN CANCER TREATMENT AND DIAGNOSIS  
The unexpected expression of tryptophan 2,3-dioxygenase (TDO2) in cancer cells and tumors has been established. Methods for diagnosing cancer based on the expression of TDO2 are provided, as are...
US20140335149 WOUND-HEALING PROMOTING MATERIAL  
The object of the present invention is to provide a means for utilizing cells that have effects on wound healing as wound-healing promoting materials by efficiently concentrating such cells within...
US20130302351 ANTAGONISM OF THE VIP SIGNALING PATHWAY  
The disclosure relates to inhibition of the VIP signaling pathway. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering a...
US20150152387 METHOD FOR THE INDUCTION AND EXPANSION OF NATURAL KILLER CELLS DERIVED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS  
The present invention relates to a method for inducing and expanding natural killer cells derived from peripheral blood mononuclear cells, which comprises co-culturing, as feeder cells, irradiated...
US20140079678 Method for Activating Natural Killer Cells by Tumor Cell Preparation In Vitro  
The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumour cell preparation (ATCP). The invention also provides...
US20120328587 Method for Activating Natural Killer Cells by Tumor Cell Preparation In Vitro  
The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumour cell preparation (ATCP). The invention also provides...
US20150202231 Modulation of the Immune Response  
Methods for increasing the numbers of regulatory T cells (Treg), e.g., in a population of T cells or in a patient.
US20130024957 GENETICALLY MODIFIED MICE AND ENGRAFTMENT  
A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mII2rg subunit gene; and optionally a humanization of the TPO gene is described....
US20130273002 MULTIVALENT BREAST CANCER VACCINE  
Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided comprising immunogenic polypeptides...
US20140356321 MATERIALS AND METHODS FOR TREATMENT OF LIVER CANCER  
Granulin-epithelin precursor (GEP), a pluripotent growth factor, is a hepatic oncofetal protein defining a cancer stem cell (CSC) population in liver cancer. The present invention provides the use...
US20110064709 USE OF ECDI-FIXED CELL TOLERANCE AS A METHOD FOR PREVENTING ALLOGRAFT REJECTION  
The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells...
US20100310534 T CELL SUBPOPULATIONS CAPABLE OF TREATING CANCER  
A method of determining responsiveness to cancer treatment is disclosed. The method comprises analyzing a frequency of tumor infiltrating lymphocytes (TILs) having a CD8+CD28−CD152− signature in a...
US20150140041 PERSONALIZED CANCER VACCINES AND ADOPTIVE IMMUNE CELL THERAPIES  
Cancer antigens containing mutations in an expressed gene of cancer cells from a cancer patient are identified. Sequences from cancer cells obtained using a parallel sequencing platform are...
US20140369955 METHODS FOR AUTOLOGOUS STEM CELL TRANSPLANTATION  
Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and...
US20140271725 Small Molecule Enhancer for Dendritic Cell Cancer Vaccines  
Disclosed is a method of treating cancer, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that inhibits a plurality of mammalian dipeptidyl...
US20140308260 METHODS AND COMPOSITIONS COMPRISING A NITRITE-REDUCTASE PROMOTER FOR TREATMENT OF MEDICAL DISORDERS AND PRESERVATION OF BLOOD PRODUCTS  
The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and...
US20150004176 REGULATORY T CELLS AND METHODS OF IDENTIFYING, OBTAINING AND USING TO TREAT IMMUNO-BASED DISORDERS  
The present specification discloses regulatory T cells, compositions including regulatory T cells, methods of identifying, isolating, enriching, obtaining, and/or expanding regulatory T cells or...
US20130344034 Parovirus Having a CpG-Enriched Genome Useful for Cancer Therapy  
A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of...
US20120016489 TEXTURED BONE BLOCK IMPLANTS  
Implantable pliable bone blocks comprising a solid block of cortical bone characterized by a length, width and thickness, having a first and a second face on opposite sides of the block. The first...
US20130273017 METHODS AND PRODUCTS FOR TISSUE REPAIR  
Methods and devices for the repair of articular tissue using collagen material are provided. Compositions of collagen material and related kits are also provided.
US20150225697 NATURAL KILLER CELLS AND USES THEREOF  
Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of...
US20140037606 CELL-BASED, ANTI-CANCER VACCINES  
The present invention relates to cancer vaccines and more particularly to compositions and methods for producing activated antigen presenting cells (dendritic cells, macrophages, monocytes, or...
US20150258145 TISSUE TRANSPLANT COMPOSITIONS AND METHODS FOR USE  
Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult...
US20120230966 TISSUE TRANSPLANT COMPOSITIONS AND METHODS FOR USE  
Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult...
US20140377291 GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES  
Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by...