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US20110212162 LYMPHATIC ZIP CODES IN TUMORS AND PRE-MALIGNANT LESIONS  
Disclosed herein are compositions and methods for and involving selectively targeting tumor lymphatics.
US20100297085 Synthetic Herpes Simplex Viruses Type-1 for Treatment of Cancers  
A recombinant herpes simplex virus type-1 (HSV-1) has been constructed that carries a deletion of one of the two viral γ1 34.5 genes and other immediate early genes, which render the virus able to...
US20150218649 BIOMARKER ASSOCIATED WITH RISK OF MELANOMA REOCCURRENCE  
The present invention provides a method of predicting the risk of reoccurrence of melanoma in a patient from whom melanoma tissue was previously removed which comprises the following: a. obtaining...
US20120010599 INORGANICALLY SURFACE-MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THEM  
In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned)...
US20130189305 METHODS OF PRODUCING INFLENZA VACCINE COMPOSITIONS  
Methods and compositions for the optimization of production of influenza viruses suitable as influenza vaccines are provided.
US20120156265 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY  
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
US20110097381 CONFORMABLE TISSUE REPAIR IMPLANT CAPABLE OF INJECTION DELIVERY  
A conformable tissue implant is provided for use in repairing or augmenting a tissue defect or injury site. The tissue implant contains a tissue carrier matrix comprising a plurality of...
US20140341858 NEURON GENERATION, REGENERATION AND PROTECTION  
The invention demonstrates that, contrary to apoptotic rabies virus G proteins, certain non-apoptotic rabies virus G proteins, such as the G protein of the CVS-NIV strain, have a neurite outgrowth...
US20130336884 NANOPARTICLE FABRICATION METHODS, SYSTEMS, AND MATERIALS FOR FABRICATING ARTIFICIAL RED BLOOD CELLS  
A plurality of artificial red blood cell particles includes each particle of the plurality being substantially monodisperse and each particle having a largest common linear dimension of about 5 μm...
US20140037587 BENEFICIAL EFFECTS OF BACTERIOPHAGE TREATMENTS  
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is...
US20140377221 BIOMARKERS AND COMBINATION THERAPIES USING ONCOLYTIC VIRUS AND IMMUNOMODULATION  
The invention disclosed herein describes biomarkers useful for prognosis, selection and monitoring of oncolytic virus therapy for patients with various types of cancer. In particular, the present...
US20140322237 NEURODEGENERATIVE DISEASES AND METHODS OF MODELING  
Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1...
US20110014228 IL23 MODIFIED VIRAL VECTOR FOR RECOMBINANT VACCINES AND TUMOR TREATMENT  
The present invention relates to recombinant replicable viral vectors and viruses which are modified with IL23. This IL23 modified virus is highly immunogenic and attenuated for neurotropic...
US20150086581 Fast Diagnosis and Personalized Treatment for Acne  
Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne...
US20110047631 HEAT SHOCK PROTEIN DEFICIENCIES AS MODEL SYSTEMS FOR BRAIN PATHOLOGY AND CANCER  
The invention provides non-human transgenic animals as models of neurodegenerative brain pathology, including, but not limited to, Alzheimer's disease (AD), and cancer. The non-human transgenic...
US20120027797 Preservation of Bioactive Materials by Freeze Dried Foam  
This invention provides methods and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents at...
US20110217268 THERAPY OR PROPHYLAXIS OF KLEBSIELLA PNEUMONIAE INFECTIONS WITH A LYTIC BACTERIOPHAGE SPECIFICALLY AGAINST THE K. PNEUMONIAE  
A therapy or prophylaxis of K. pneumoniae infections with a lytic bacteriophage specifically against K. pneumoniae, provides a lytic bacteriophage (DSMZ 24329) to a K. pneumoniae infected organism...
US20110305634 Methods and systems for adenovirus interaction with desmoglein 2 (DSG2)  
The present invention provides compositions and methods for treating disorders associated with epithelial tissues.
US20110008294 METHODS FOR TREATING CANCER WITH MVA  
The invention relates to compositions, kits, and methods for cancer therapy using recombinant MVA viruses encoding a tumor-associated antigen, such as HER-2, particularly in combination with...
US20110086005 MODULATING INTERSTITIAL PRESSURE AND ONCOLYTIC VIRAL DELIVERY AND DISTRIBUTION  
Provided herein are methods of treating a proliferative disorder in a subject comprising decreasing interstitial pressure and/or increasing vascular permeability in the subject and administering...
US20140248243 VIRUS-LIKE PARTICLES FOR TREATMENT OF VIRAL INFECTIONS  
The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a...
US20140086880 METHOD FOR TREATING NEURODEGENERATIVE TAUOPATHY  
The present invention is directed to a filamentous bacteriophage for use in treating a neurodegenerative tauopathy or susceptibility to a neurodegenerative tauopathy and a method of using the...
US20150037287 Method of Treating a Malignancy in a Subject and a Pharmaceutical Composition for Use in Same  
There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement...
US20140193371 Method for the Prevention and Treatment of Cancer, Tuberculosis and Related Diseases  
A method for preventing and treating one or more disease states including the steps of altering the diet of an individual and then administering a drug to the individual. Plasma vitamin C level is...
US20110182948 METHOD FOR TREATING DISEASE CHARACTERIZED BY PLAQUE  
The present invention relates to the use of a filamentous agent other than a filamentous bacteriophage to disaggregate aggregated proteins in plaque or to treat a patient suffering from or...
US20110027310 Compositions and Methods for Cancer Treatment  
Compositions and methods for delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery...
US20140328904 GLA MONOTHERAPY FOR USE IN CANCER TREATMENT  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
US20110195052 BONE MATRIX COMPOSITIONS AND METHODS  
The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or...
US20120052003 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20110064650 MICROORGANISMS FOR PREVENTING AND TREATING NEOPLASMS ACCOMPANYING CELLULAR THERAPY  
Provided are methods for using cellular compositions in combination with oncolytic viruses. The methods include administering oncolytic viruses for the inhibition and treatment of tumors caused by...
US20110200561 Method for Bacteriophage Delivery and Amplification  
Disclosed are methods of selecting wide host range bacteriophage capable of growing in a plurality of bacteria including pathogenic and non-pathogenic bacteria and bacteriophage selected by the...
US20140030229 NEW CLONE OF NEWCASTLE DISEASE VIRUS, ITS MANUFACTURE AND ITS APPLICATION IN THE MEDICAL TREATMENT OF CANCER  
A new clone of Newcastle disease virus which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases.
US20110129446 Clone of newcastle disease virus, its manufacture and its application in the medical treatment of cancer  
A new clone of Newcastle disease virus which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases.
US20150044280 TREATMENT METHODS USING ADENOVIRUS  
The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor or inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient...
US20140322173 Oncolytic Vaccinia Virus Combination Cancer Therapy  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia...
US20120230958 ONCOLYTIC VACCINIA VIRUS COMBINATION CANCER THERAPY  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia...
US20140348798 SENECA VALLEY VIRUS BASED COMPOSITIONS AND METHODS FOR TREATING DISEASE  
The present invention relates to a novel RNA picornavirus that is called Seneca Valley virus (“SVV”). The invention provides isolated SVV nucleic acids and proteins encoded by these nucleic acids....
US20120141465 VIRUS VACCINATION AND TREATMENT METHODS WITH OX40 AGONIST COMPOSITIONS  
The invention relates to compositions and methods that employ OX40 (CD134), a TNFR superfamily protein, agonists. The invention includes among other things administering an OX40 agonist alone or...
US20120171256 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING  
The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications...
US20120076771 SURFACE MODIFICATION OF SILK FIBROIN MATRICES WITH POLY(ETHYLENE GLYCOL) USEFUL AS ANTI-ADHESION BARRIERS AND ANTI-THROMBOTIC MATERIALS  
The present invention provides compositions and methods for the production of silk fibroin matrices surface-PEGylated on one or more surfaces. Such surface-PEGylated silk fibroin matrices can be...
US20130084263 Pharmaceutical kit and method for treating cancer  
This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new...
US20120237483 Oncolytic Virotherapy for Prevention of Tumor Recurrence  
Described is a parvovirus for preventing recurrence of a tumor, preferably a malignant brain tumor or pancreas tumor.
US20110110896 Modulating levels of RNA-binding proteins for the treatment of breast cancer  
The present invention relates to methods of using RNA-binding protein modulating agents to treat of cancer, particularly patients that are susceptible to or diagnosed with estrogen...
US20110195053 Treatment of Non-Neuronal Cancer using HSV-1 Variants  
A mutant herpes simplex virus which has been modified in the γ34.5 gene such that the gene is non-functional is used to treat a non-neuronal cancer such as a mesothelioma, ovarian carcinoma,...
US20140255353 COMPOSITIONS, KITS AND METHODS FOR TREATING OBESITY, DIABETES AND HYPERGLYCEMIA  
Described herein are compositions, kits and methods for treating and preventing obesity and overweight, as well as treating and preventing hyperglycemia, in a subject (e.g., a human), based on the...
US20140056854 VIRAL VECTORS WITH MODIFIED TRANSDUCTION PROFILES AND METHODS OF MAKING AND USING THE SAME  
The present invention provides AAV capsid proteins, virus capsids comprising said capsid proteins and virus vectors comprising said capsid proteins, wherein the AAV capsid proteins have one or...
US20140242037 APC-MEDIATED TOLERANCE INDUCTION FOR THERAPY OF MULTIPLE SCLEROSIS  
The invention relates to transgene expression constructs—particularly self inactivating lentiviral vectors—comprising a dendritic cell specific promoter controlling the expression of autoantigen...
US20120308484 Clonal strains of attenuated vaccinia viruses and methods of use thereof  
Clonal strains of vaccinia viruses are provided. Also provided are methods of identifying and isolating attenuated and oncolytic clonal strains from virus preparations. Modified recombinant forms...
US20110117060 CANCER TREATMENT USING VIRUSES, FLUOROPYRIMIDINES AND CAMPTOTHECINS  
Mammalian subjects having a neoplasm are treated with a virus, a fluoropyrimidine, for example 5-fluorouracil, and a camptothecin compound. The virus is selected from the group consisting of a...
US20100297231 PRESERVATION OF BIOACTIVE MATERIALS BY FREEZE DRIED FOAM  
This invention provides methods, systems and compositions to preserve bioactive materials in a dried foam matrix. Methods provide non-boiling foam generation and penetration of preservative agents...