Matches 1 - 50 out of 71 1 2 >


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US20110044911 Use of Functionalized Magnetic Nanoparticles in Cancer Detection and Treatment  
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized...
US20120039803 PRETARGETING KIT, METHOD AND AGENTS USED THEREIN  
Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal...
US20140341808 CONTRAST AGENT FOR IMAGINING MYOCARDIAL PERFUSION  
Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient...
US20110008260 Use of Nanocrystals for Drug Delivery from a Balloon  
A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also...
US20100086491 Capsule Used for Measuring Flow Information Using X-Rays and Method of Measuring Flow Information Using the Same  
The present invention relates to a capsule used for measuring flow information using X-rays and a method of measuring flow information using the same. More particularly, the present invention...
US20110142757 NOVEL COMPOUNDS AND THEIR USES IN DIAGNOSIS  
A compound of formula (I) wherein, X and Y independently bind TSPO, wherein X and Y are the same or different; and L is a linker that links X to Y; or a salt or solvate thereof. For preference, X...
US20140341813 INDOCYANINE GREEN-CONTAINING PARTICLE AND METHOD OF PRODUCING THE PARTICLE  
To encapsulate indocyanine green (ICG) at a high concentration in a liposome without causing the agglomeration of ICG so that ICG remains as a monomer in an ICG-containing particle to be used as,...
US20110110858 Gold nanoparticle imaging agents and uses thereof  
Overexpression of angiotensin-converting enzyme (ACE) has been associated with a number of pathophysiologies, including those associated with cancer and the cardiovascular system. Thus, targeted...
US20140134105 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY  
The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable...
US20130022549 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY  
The present invention relates to a composition and method for the detection of a detectable product formed from a compound of the present invention in the body of an individual. The detectable...
US20090252676 N-ALKOXYAMIDE CONJUGATES AS IMAGING AGENTS  
The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides...
US20150056146 COMPOSITION USED FOR CONTRAST IMAGING  
There is provided a composition used for contrast imaging, the composition containing an aqueous solution containing a J-aggregate of indocyanine green and at least one storage stabilizer selected...
US20140161731 3,6-DISUBSTITUTED XANTHYLIUM SALTS  
Described are a compound of formula (II) or (III): The compounds are effective in the treatment of disease, including a tauopathy condition or a disease of tau protein aggregation.
US20110081297 Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles  
The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More...
US20120244079 TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY  
The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at...
US20140072513 SUGAR AND PEG FUNCTIONALIZED POLYACETALS WITH CONTROLLED PH-DEPENDENT DEGRADATION  
The present invention relates to degradable polyacetal polymers having a C(O)—(CH2CH2O)n—R5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent...
US20100322855 Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using  
Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes...
US20110212026 BUTYRYLCHOLINESTERASE LIGANDS AS DIAGNOSTIC TOOLS AND TREATMENT FOR DESEASES OF THE NERVOUS SYSTEM  
Compounds useful for the early diagnosis of malignant tumors, multiple sclerosis, and especially Alzheimer's Disease and related dementias; especially compounds of Formula (I) wherein R1 is...
US20150110722 IMAGEABLE POLYMERS  
The present invention relates to hydrogels comprising 1,2-diol or 1,3-diol groups acetalised with a radiopaque species of one or more covalently bound radiopaque halogens which are imageable...
US20110200535 DAA-PYRIDINE AS PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND FOR DIAGNOSTIC IMAGING AND PHARMACEUTICAL TREATMENT  
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such...
US20120039816 USE OF 7-CHLORO-N,N,5-TRIMETHYL-4-OXO-3-PHENYL-3,5-DIHYDRO-4H-PYRIDAZINO[4,5-B] INDOLE-1-ACETAMIDE AS A BIOMARKER OF PERIPHERAL BENZODIAZEPINE RECEPTOR LEVELS  
Use of a radiolabelled form of 7-chloro-Λ/,Λ/,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4/-/-p yridazino[4,5-b]indole-1-acetamide as a biomarker for the detection, in an individual, of PBR levels...
US20140170066 INTEGRIN TARGETING AGENTS AND IN-VIVO AND IN-VITRO IMAGING METHODS USING THE SAME  
The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other...
US20110165075 INTEGRIN TARGETING AGENTS AND IN-VIVO AND IN-VITRO IMAGING METHODS USING THE SAME  
The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other...
US20090123372 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY  
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof...
US20140248213 COMPOSITIONS AND METHODS FOR TUMOR IMAGING AND TARGETING BY A CLASS OF ORGANIC HEPTAMETHINE CYANINE DYES THAT POSSESS DUAL NUCLEAR AND NEAR-INFRARED PROPERTIES  
The present invention provides for heptamethine cyanine dyes that possess both nuclear and near-infrared imaging capabilities. These dyes can be used for imaging, targeting and detecting tumors in...
US20140004051 CO-CRYSTALS AND SALTS OF CONTRAST AGENTS AND IMAGING  
The invention provides co-crystals and salts of contrast agents as well as methods to use and prepare the co-crystals and salts.
US20080286202 Method of Diagnosing Prodromal Forms of Diseases Associated With Amyloid Deposition  
A method of identifying a patient as prodromal to a disease associated with amyloid deposition by imaging techniques is provided. In addition, a method of identifying amyloid deposition diseases...
US20110085985 NOVEL SUBSTITUTED AZABENZOXAZOLES  
The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients....
US20090010844 Imaging Infection With Compounds That Bind to Thymidine Kinase  
The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the...
US20140037542 NOVEL THERANOSTIC PLATFORM FOR TARGETED CANCER THERAPY AND DRUG DELIVERY MONITORING  
A compound that includes a quaterrylene dye moiety as core, and a dendrimeric shell. For example, the compound may comprise at least four dendronized polyamides covalently attached to a...
US20140341812 BETA-AMYLOID PET IMAGING AGENTS  
Novel derivatives of imidazopyridinylbenzeneamines and novel derivatives of benzothiazolylbenzeneamines are disclosed that offer improved behavior when used as imaging agents for positron emission...
US20100166668 CT NEGATIVE CONTRAST MEDIUM OF AQUEOUS MATRIX FOR DIGESTIVE TRACT AND THE PREPARATION METHOD THEREOF  
An aqueous negative contrast agent for CT imaging of the gastrointestinal tract and the preparation method thereof. The agent is used in biological and pharmaceutical field. Its components and the...
US20110250135 Piperazine Derivatives for Binding and Imaging Amyloid Plaques and Their Use  
The invention relates to compounds of formula I, their synthesis and their use, in particular for detecting amyloid deposits in a patient.
US20090142276 ALPHA-FLUOROALKYL DIHYDROTETRABENAZINE IMAGING AGENTS AND PROBES  
The present invention provides novel alpha-fluoroalkyl dihydrotetrabenazine compounds I wherein R1 is a C1-C10 fluorinated aliphatic radical; R2 is hydrogen or a C1-C10 aliphatic radical; R3 is...
US20140241985 Chelated PSMA Inhibitors  
Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention...
US20130045168 RADIOGRAPHIC CONTRAST AGENT FOR POSTMORTEM, EXPERIMENTAL AND DIAGNOSTIC ANGIOGRAPHY  
A contrast agent for angiography is disclosed, in particular, for examining animal or human bodies or components thereof such as members or organs thereof, comprising an essentially oil-based...
US20090191129 COMPOUNDS FOR USE IN IMAGING, DIAGNOSING AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR OF TUMORS  
This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such...
US20110264027 B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING  
Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95...
US20150157744 TREATMENT OF MENINGIOMAS USING PHENYLBENZOTHIAZOLE, STILBENE, BIPHENYLALKYNE, OR PYRIDINE DERIVATIVES  
A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition...
US20080317676 Biocompatible Fluorescent Imaging Agents  
This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
US20100119459 Use of ivabradine as diagonstic agent in the method of coronary angiography by multislice computed tomography  
Use of ivabradine, or 3-{3-[{[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-y l]-methyl}(methyl)amino]propyl}-7,8-dimethoxy- 1,3,4,5-tetrahydro-2H-3-benzazepin-2-one, of its addition salts...
US20100166665 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING  
Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The...
US20070189970 Contrast medium for thrombus formation  
It is intended to provide a contrast medium for thrombus capable of binding specifically to a thrombus, lowering background noise and thus improving the resolution in a contrast examination for...
US20090123373 AMYLOID-IMAGING AGENTS  
A molecular probe for use in the detection of amyloid in a subject includes a dibenzothiazole derivative.
US20120171116 Arginase Inhibitors and Methods of Use Thereof  
The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally...
US20140017165 DNA REPAIR ENZYME INHIBITOR NANOPARTICLES AND USES THEREOF  
This invention relates generally to the discovery of novel nanoparticles for delivery of DNA double-stranded break (DSB) repair enzyme inhibitors such as wortmannin or wortmannin analogues. In one...
US20100111875 TRISUBSTITUTED TRIAZAMACROCYCLIC COMPOUNDS AND THEIR USE AS CONTRAST AGENTS  
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine...
US20090104116 COMPOUNDS FOR THE INHIBITION OF INTEGRINS AND USE THEREOF  
The present invention is related to a compound of formula (I), wherein A is a nonaromatic heterocyclic ring, Ar is either absent or phenylene; Ψ is a radical of formula (II), R2 is a hydrophobic...
US20130039858 NIR MATERIALS AND NANOMATERIALS FOR THERANOSTIC APPLICATIONS  
Novel fluorescent dye comprising metal oxide nanoparticles are prepared where the nanoparticles are as small as 3 nm or up to 7000 nm in diameter and where the dye is bound within the metal oxide...
US20120039815 CONTRAST AGENTS  
The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine...

Matches 1 - 50 out of 71 1 2 >