Matches 1 - 50 out of 129 1 2 3 >


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US20110117168 METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR  
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells,...
US20060198814 Anti-infectious hydrogel compositions  
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a...
US20160136292 METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION  
Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is...
US20150023875 System for Targeted Delivery of Therapeutic Agents  
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides...
US20130039954 CONTROL OF ANTIBODY RESPONSES TO SYNTHETIC NANOCARRIERS  
Disclosed are synthetic nanocarrier compositions that comprise B cell antigen for desired antibody production and an off-target response attenuating polymeric coating as well as related methods.
US20070185216 ANTIVIRAL METHOD  
This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes...
US20060177415 Once a day formulation for phosphate binders  
A method for reducing serum phosphate in a subject in need thereof comprising administering once per day to said subject a phosphate binder, wherein the phosphate binder has a phosphate binding...
US20050255082 Polymeric coupling agents and pharmaceutically-active polymers made therefrom  
A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B (I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio...
US20050191270 Anti-infectious hydrogel compositions  
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a...
US20050053577 Therapeutic polyanhydride compounds for drug delivery  
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are...
US20140377209 SCAFFOLDS FORMED FROM POLYMER-PROTEIN CONJUGATES, METHODS OF GENERATING SAME AND USES THEREOF  
Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being...
US20100151029 Anti-infectious hydrogel compositions  
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a...
US20060210527 Cyclodextrin-based polymers for therapeutics delivery  
The present invention relates to novel compositions of therapeutic polymeric compounds designed as carriers for small molecule therapeutics delivery and pharmaceutical compositions thereof. In...
US20050239686 Methods and compositions for optimization of oxygen transport by cell-free systems  
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use...
US20050208093 Phosphoryl choline coating compositions  
A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES...
US20150297791 Multilayer Fibrous Polymer Scaffolds, Methods of Production and Methods of Use  
Fibrous polymer scaffolds and methods of manufacture are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled....
US20150283171 POLYMERS FOR REVERSING HEPARIN-BASED ANTICOAGULATION  
Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to...
US20120114590 IL28 AND IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME  
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on...
US20120076749 Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer  
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood...
US20110044929 FORMULATIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES  
The present inventors have developed a novel composition and method for inhibiting inflammation and treating of symptoms of tissue ischemia, including that associated with peripheral and cardiac...
US20100239517 NOVEL CONJUGATED PROTEINS AND PEPTIDES  
The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide...
US20050255079 Polymeric coupling agents and pharmaceutically-active polymers made therefrom  
A pharmaceutically-active polymeric compound of the general formula (I), Y−[Yn−LINK B−X]m−LINK B (I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio−LINK A−Bio...
US20100247669 POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE  
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms...
US20080057025 Method for promoting bone formation  
Amine polymers, particularly aliphatic amine polymers, are useful in the treatment and prevention of bone disease and in methods for promoting bone formation. Sevelemer, polyallylamine crosslinked...
US20070166344 Non-leaching surface-active film compositions for microbial adhesion prevention  
Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings...
US20080112916 CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY  
The present invention provides a unique non-viral carrier for nucleic acid delivery in vitro and in vivo, and methods of using thereof.
US20140112880 SUBCUTANEOUS DELIVERY OF POLY(OXAZOLINE) POLYMER CONJUGATES  
The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
US20130337078 PARTICULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS  
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo...
US20060110356 Ophthalmic drug delivery system using polymer micelle  
The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is...
US20050042194 Semi-solid delivery vehicle and pharmaceutical compositions  
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical...
US20100028416 DRUG CARRIERS  
Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a...
US20070025952 Linear cyclodextrin copolymers  
Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described....
US20070059272 Modulation of microbial pathogen-host cell interactions  
The invention provides methods of screening for modulators of microbial PA-I lectin/adhesin activity, including modulators of PA-I expression, as well as the modulators so identified,...
US20050226844 Valency platform molecules comprising carbamate linkages  
This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate....
US20150182667 Composition with Biofilm Dispersal Agents  
Embodiments of the presently-disclosed subject matter provide composites that comprise a tissue graft and a biofilm dispersal agent. The tissue graft can be bone tissue graft, a soft tissue graft,...
US20060228325 Water soluble multi-biotin-containing compounds  
Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more...
US20120052040 POLYMER COMPOSITIONS AND METHODS FOR THEIR USE  
Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory...
US20070202074 Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof  
The present invention is directed toward an injectable, single- or multiple-component polymeric liquid precursor of an in situ-forming, non-absorbable, flexible, and resilient hydrogel or...
US20070154457 Use of eIF-5A to kill multiple myeloma cells  
The present invention relates to eucaryotic initiation factor 5A and the use of polynucleotides encoding the same to inhibit cancer cell growth and inhibit metastases. In a preferred embodiment,...
US20070003513 Polymerized and modified rapamycins and their use in coating medical prostheses  
Compositions of matter comprise linked pluralities of mTOR-binding molecules, such as rapamycin. The compositions may be directly polymerized or may comprise rapamycin or other mTOR-binding...
US20050123502 Nicotine containing oral compositions  
An oral composition comprising a nicotine active, a polycarbophil component or a salt thereof, and an alginic acid component or a salt thereof, is provided. The oral composition provides high...
US20140193510 Polymer-Agent Conjugates, Particles, Compositions, and Related Methods of Use  
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms...
US20140154202 PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER  
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer,...
US20130129662 Compositions and Methods for the Treatment of Heart Failure  
The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that proves the functioning of a diseased heart by decreasing left ventricular end-diastolic...
US20070098800 Therapeutic compositions  
The present invention provides new formulations of injectable particles (e.g. microspheres) useful for intra-articular (i.a.) injection. The formulations are made of biocompatible polymers that...
US20050158271 Pharmaceutical applications of hydrotropic polymer micelles  
Hydrotropic polymer micelles effective for increasing the water solubility of poorly soluble drugs are described. Such hydrotropic polymer micelles have the combined properties of polymer micelles...
US20160045439 COMPOSITIONS FOR INHIBITING INFLAMMATION IN A SUBJECT WITH A SPINAL CORD INJURY AND METHODS OF USING THE SAME  
Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-α signaling and a...
US20050249695 Antimicrobial polymeric surfaces  
Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are...
US20130071482 BLOCK COPOLYMER CROSS-LINKED NANOASSEMBLIES AS MODULAR DELIVERY VEHICLES  
A nanoassembly includes a core protected by a biocompatible shell. The nanoassembly includes a plurality of block copolymers including drug-binding linkers and block copolymer cross-linkers. A...
US20060204472 Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems  
The present invention deals with the synthesis of multifunctional dendrimeric and hyperbranched polymers for application as drug delivery systems of bioactive pharmaceutical compounds and as gene...

Matches 1 - 50 out of 129 1 2 3 >