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US20140363391 |
SYSTEM AND METHOD FOR ADMINISTERING POLOXAMERS AND ANESTHETICS WHILE PERFORMING CPR AND MINIMIZING REPERFUSION INJURY
According to an embodiment, a system for delivering a synthetic surfactant and an anesthetic to an individual to reduce reperfusion injury includes an anesthetic delivery device and a device for... |
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US20100310461 |
BINDING OF PATHOLOGICAL FORMS OF PROTEINS USING CONJUGATED POLYELECTROLYTES
A method for treatment of a disease caused by aggregation of misfolded proteins including subjecting a body fluid of a patient to a separation of an aggregated misfolded protein which includes... |
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US20120148660 |
CONJUGATES OF SYNTHETIC TLR AGONISTS AND USES THEREFOR
The invention provides TLR agonists and conjugates thereof useful in vaccines and to prevent, inhibit or treat a variety of disorders including pathogen infection and asthma. |
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US20100310462 |
BINDING OF PATHOLOGICAL FORMS OF PROTEINS USING CONJUGATED POLYELECTROLYTES
A method for separation of an aggregated misfolded protein from an environment including a non-aggregating normal form of the protein includes contacting both the misfolded and normal protein with... |
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US20120114590 |
IL28 AND IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on... |
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US20100316719 |
B-1,3-GLUCAN-DERIVED POLYALDEHYDE/POLYAMINE HYDROGEL
The present invention provides a combination product which comprises: (1) a polyaldehyde obtained by introducing an aldehyde group into a branched glucose in a β-1,3-glucan, and(2) a polyamine... |
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US20120076749 |
Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood... |
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US20120114589 |
SWELLABLE BIODEGRADABLE POLYMERIC MATRICES AND METHODS
The invention provides biodegradable polymeric hydrogel matrices having excellent durability and swellability. The matrices are formed from a combination of poly-α(1→4)glucopyranose macromer and a... |
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US20150157762 |
METHOD FOR BONE FORMATION BY ADMINISTERING POLY(LACTIC-CO-GLYCOLIC ACID) CROSS-LINKED ALENDRONATE
A method for bone regeneration which comprises administering a short term release composition into a bone area of a subject in need thereof, wherein the composition comprises a... |
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US20130142733 |
MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES
In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one... |
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US20140154202 |
PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer,... |
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US20150217029 |
DRUG DELIVERY SCAFFOLD OR STENT WITH A NOVOLIMUS AND LACTIDE BASED COATING SUCH THAT NOVOLIMUS HAS A MINIMUM AMOUNT OF BONDING TO THE COATING
Disclosed herein are drug delivery medical devices. A polymer coating for a medical device is provided which comprises a minimum amount of a drug bonded to the polymer in the coating. |
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US20120207700 |
SURFACE ACTIVE AGENT COMPOSITIONS AND METHODS FOR ENHANCING OXYGENATION, REDUCING BACTERIA AND IMPROVING WOUND HEALING AT A SITE OF TREATMENT
This present invention relates generally to the use of novel formulations comprising a surface active polymer to enhance oxygenation in skin and other soft tissue. The present invention also... |
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US20150250898 |
NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY
A composition (100) which includes a shell (120) comprising at least one lipid, wherein said shell defines an enclosed space, a gas (110) disposed within the enclosed space, and a coating (130) of... |
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US20130017166 |
Protein-Poly(2-oxazoline) Conjugates for Enhanced Cellular Delivery and Transport Across Biological Barriers
The present invention provides polymer conjugates and methods of use thereof. |
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US20120156164 |
IN SITU-FORMING HYDROGEL FOR TISSUE ADHESIVES AND BIOMEDICAL USE THEREOF
Disclosed herein are an in situ-forming, bioadhesive hydrogel and the medical uses thereof. Being formed by in situ crosslinking through an enzymatic reaction, the hydrogel has an advantage over... |
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US20150190421 |
POLOXAMERS FOR THE IMPROVEMENT OF RESPIRATORY FUNCTION
Methods for treating or preventing a respiratory deficiency associated with a diaphragm muscle deficiency in a subject are provided, the method comprises administering to the subject in need... |
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US20130172405 |
COMPOSITIONS AND METHODS FOR SILENCING SMAD4
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA (e.g., dsRNA such as siRNA) that target SMAD4 gene expression, lipid particles comprising... |
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US20140050689 |
TISSUE GRAFTED WITH A BIODEGRADABLE POLYMER
Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto... |
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US20130280203 |
HIGH STABLE NON-IONIC N-VINYL BUTYROLACTAM IODINE AND PREPARATION METHOD THEREOF
A preparation method of a high-stable non-ionic N-vinyl butyrolactam iodine solution is provided, wherein high-stable non-ionic N-vinyl butyrolactam iodine is dissolved in water, then citric acid,... |
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US20150104493 |
Dissolvable Strip for Treatment of Oral Thermal Burns
A consumable film adapted to adhere and to dissolve in the oral cavity that provides a local anesthetic and therapeutic agents for the treatment of oral burns or injuries. The film is designed to... |
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US20140120150 |
Dissolvable Strip for Treatment of Oral Thermal Burns
A consumable film adapted to adhere and to dissolve in the oral cavity that provides a local anesthetic and therapeutic agents for the treatment of oral burns or injuries. The film is designed to... |
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US20120014904 |
VASCULAR DELIVERY SYSTEMS
The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the... |
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US20140348772 |
PRODUCTION OF HYDROGELS BY MEANS OF DIELS-ALDER REACTION
The present invention is directed to hydrogels and their preparation by cross-linking macromonomers by means of Diels-Alder reaction. The hydrogels described in the invention, which can gel in... |
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US20130101632 |
NANOPARTICULATE FORMULATIONS OF MITHRAMYCIN OR MITHRAMYCIN ANALOGUES FOR TREATING CANCER
Methods and formulations for improving therapeutic potential of mithramycin (MTM) or MTM analogues are disclosed. For example, in certain aspects, methods for preparing a composition containing... |
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US20110060027 |
Aptamer Therapeutics Useful in the Treatment of Complement-Related Disorders
The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders. |
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US20150030559 |
COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING SKELETAL MUSCLE DEFICIENCIES
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers... |
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US20110033412 |
COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING SKELETAL MUSCLE DEFICIENCIES
The present invention relates to compositions and methods for treating and preventing skeletal muscle deficiencies. In particular, the present invention provides compositions comprising poloxamers... |
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US20140004072 |
Polyethyleneimine And Beta2-Adrenergic Receptor Based Gene Therapy For Acute Lung Injury
A method and a composition of gene therapy for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) based on polyplexes formed between linear polyethyleneimine (PEI) and... |
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US20140377209 |
SCAFFOLDS FORMED FROM POLYMER-PROTEIN CONJUGATES, METHODS OF GENERATING SAME AND USES THEREOF
Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being... |
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US20080132440 |
Poly-Gamma-Glutamic Acid-Vitamin Complex and Use Thereof
The present invention relates to PGA-vitamin complex containing poly-γ-glutamic acid(PGA), vitamin preparations containing said PGA-vitamin complex or cosmetic compositions. The inventive... |
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US20150147270 |
CONSTRUCTS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASES AND COLON CANCER
The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that... |
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US20140271526 |
ANTIMICROBIAL POLYAMIDE COMPOSITIONS AND MASTITIS TREATMENT
The present invention relates to veterinary compositions and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment... |
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US20150023875 |
System for Targeted Delivery of Therapeutic Agents
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides... |
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US20150182667 |
Composition with Biofilm Dispersal Agents
Embodiments of the presently-disclosed subject matter provide composites that comprise a tissue graft and a biofilm dispersal agent. The tissue graft can be bone tissue graft, a soft tissue graft,... |
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US20130129662 |
Compositions and Methods for the Treatment of Heart Failure
The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that proves the functioning of a diseased heart by decreasing left ventricular end-diastolic... |
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US20100297056 |
COMPOSITION BASED ON PERHYDROSQUALENE AND COLLAGEN-POLYVINYLPYRROLIDONE FOR FILLING MINOR CUTANEOUS DEPRESSIONS
The present invention concerns a composition based on collagen-polyvinylpyrrolidone and perhydrosqualene for filling by intracutaneous delivery route minor depressions of the skin in order to... |
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US20130039878 |
TRIPLE CROSS-LINKED COLLAGEN, METHOD OF MANUFACTURING THE SAME, AND USE THEREOF
The present invention relates to a method for manufacturing a triple cross-linked collagen, which comprises the following steps: providing a soluble collagen sample; mixing the collagen sample... |
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US20050191270 |
Anti-infectious hydrogel compositions
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a... |
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US20130183262 |
ANTIMICROBIAL POLYMERIC COMPOSITIONS
A compound having the formula: wherein n, y, R1 and R2 are defined herein, and others, methods of making of and using, and compositions made thereby which have an antimicrobial resistance effect... |
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US20120171152 |
Amphiphilic Polymer-Protein Conjugates and Methods of Use Thereof
Compositions and methods for transporting biologically active proteins and polypeptides, particularly across the blood-brain barrier, are provided. |
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US20060198813 |
Substituted fullerene compositions and their use in treatment of shock
This patent discloses the use of substituted fullerenes in the treatment of shock. The substituted fullerenes comprise a fullerene core (Cn) and at least one of: (i) from 1 to 6 (>CX1X2) groups... |
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US20140348773 |
ARTIFICIAL BONE IMPLANTS, OR BONE GRAFTS, OF POLYMERIC COMPOSITES WITH BONE FORMING PROPERTIES
The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present... |
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US20120100096 |
CONJUGATES PF SMALL-INTERFERING NUCLEIC ACIDS
The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the... |
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US20060177413 |
Carbohydrate modifiers of neuronal growth
Fucose galactose carbohydrates have been shown to induce neuronal outgrowth. The invention includes methods of inducing neuronal outgrowth using carbohydrates, assemblies, and polymers bearing... |
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US20110044929 |
FORMULATIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES
The present inventors have developed a novel composition and method for inhibiting inflammation and treating of symptoms of tissue ischemia, including that associated with peripheral and cardiac... |
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US20070048250 |
Methods of treating concomitant constipation in a cancer treatment regimen including imexon
Methods of treating imexon-induced constipation in patients in conjunction with their participation in a cancer treatment regimen are disclosed herein. Embodiments of the invention include the... |
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US20130330293 |
BIO-NANO POWER CELLS AND THEIR USES
The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are... |
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US20120156135 |
PARTICLES WITH MULTIPLE FUNCTIONALIZED SURFACE DOMAINS
This disclosure relates to particles (e.g., nanoparticles and microparticles) that display multiple functionalized surface domains in a controlled mosaic pattern. The disclosure also provides... |
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US20120164098 |
CROSSED-LINKED HYALURONIC ACID AND COLLAGEN AND USES THEREOF
The present invention discloses a cross-linked hyaluronic acid/collagen formulation which has improved composition for dermal filling and higher persistence than cross-linked collagen or HA alone.... |