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US20110117168 |
METHODS AND COMPOSITIONS FOR SOFT TISSUE REPAIR
Compositions and methods for tissue repair are provided including cell binding peptides and growth factor binding peptides. The cell binding peptides bind to one or more of stem cells,... |
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US20060198814 |
Anti-infectious hydrogel compositions
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a... |
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US20160136292 |
METAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION
Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is... |
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US20150023875 |
System for Targeted Delivery of Therapeutic Agents
The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides... |
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US20130039954 |
CONTROL OF ANTIBODY RESPONSES TO SYNTHETIC NANOCARRIERS
Disclosed are synthetic nanocarrier compositions that comprise B cell antigen for desired antibody production and an off-target response attenuating polymeric coating as well as related methods. |
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US20070185216 |
ANTIVIRAL METHOD
This invention provides a method of inactivating non-enveloped virus particles. The method includes the step of contacting the virus with a virucidally-enhanced alcoholic composition that includes... |
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US20060177415 |
Once a day formulation for phosphate binders
A method for reducing serum phosphate in a subject in need thereof comprising administering once per day to said subject a phosphate binder, wherein the phosphate binder has a phosphate binding... |
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US20050255082 |
Polymeric coupling agents and pharmaceutically-active polymers made therefrom
A pharmaceutically-active polymeric compound of the general formula (I), Y-[Yn-LINK B-X]m-LINK B (I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio-LINK A-Bio... |
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US20050191270 |
Anti-infectious hydrogel compositions
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a... |
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US20050053577 |
Therapeutic polyanhydride compounds for drug delivery
Polyanhydrides which link low molecular weight drugs containing a carboxylic acid group and an amine, thiol, alcohol or phenol group within their structure into polymeric drug delivery systems are... |
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US20140377209 |
SCAFFOLDS FORMED FROM POLYMER-PROTEIN CONJUGATES, METHODS OF GENERATING SAME AND USES THEREOF
Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being... |
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US20100151029 |
Anti-infectious hydrogel compositions
The present invention provides a hydrogel composition capable of preventing the intrusion of micro-organisms into body cavities or body openings of mammals comprising of a poly(N-vinyl lactam), a... |
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US20060210527 |
Cyclodextrin-based polymers for therapeutics delivery
The present invention relates to novel compositions of therapeutic polymeric compounds designed as carriers for small molecule therapeutics delivery and pharmaceutical compositions thereof. In... |
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US20050239686 |
Methods and compositions for optimization of oxygen transport by cell-free systems
Compositions, and methods of use thereof, for use as blood substitute products comprise aqueous mixtures of oxygen-carrying and non-oxygen carrying plasma expanders and methods for the use... |
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US20050208093 |
Phosphoryl choline coating compositions
A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES... |
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US20150297791 |
Multilayer Fibrous Polymer Scaffolds, Methods of Production and Methods of Use
Fibrous polymer scaffolds and methods of manufacture are provided. The scaffolds can be formed of multiple layers and the extent and direction of alignment of each layer can be controlled.... |
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US20150283171 |
POLYMERS FOR REVERSING HEPARIN-BASED ANTICOAGULATION
Embodiments presented herein relate to various polymers. Some of the polymer embodiments are heparin binding polymers. Some embodiments of the heparin binding polymers can be employed to bind to... |
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US20120114590 |
IL28 AND IL29 TRUNCATED CYSTEINE MUTANTS AND ANTIVIRAL METHODS OF USING SAME
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on... |
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US20120076749 |
Modified Blood Factors Comprising a Low Degree of Water Soluble Polymer
The present invention relates, in general, to materials and methods for the preparation of modified blood factors which have low levels of water soluble polymer molecules conjugated to the blood... |
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US20110044929 |
FORMULATIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES
The present inventors have developed a novel composition and method for inhibiting inflammation and treating of symptoms of tissue ischemia, including that associated with peripheral and cardiac... |
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US20100239517 |
NOVEL CONJUGATED PROTEINS AND PEPTIDES
The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide... |
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US20050255079 |
Polymeric coupling agents and pharmaceutically-active polymers made therefrom
A pharmaceutically-active polymeric compound of the general formula (I), Y−[Yn−LINK B−X]m−LINK B (I) wherein (i) X is a coupled biological coupling agent of the general formula (II) Bio−LINK A−Bio... |
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US20100247669 |
POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms... |
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US20080057025 |
Method for promoting bone formation
Amine polymers, particularly aliphatic amine polymers, are useful in the treatment and prevention of bone disease and in methods for promoting bone formation. Sevelemer, polyallylamine crosslinked... |
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US20070166344 |
Non-leaching surface-active film compositions for microbial adhesion prevention
Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings... |
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US20080112916 |
CHEMICALLY MODIFIED POLYCATION POLYMER FOR siRNA DELIVERY
The present invention provides a unique non-viral carrier for nucleic acid delivery in vitro and in vivo, and methods of using thereof. |
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US20140112880 |
SUBCUTANEOUS DELIVERY OF POLY(OXAZOLINE) POLYMER CONJUGATES
The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety. |
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US20130337078 |
PARTICULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo... |
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US20060110356 |
Ophthalmic drug delivery system using polymer micelle
The current situation is such that it is difficult for drugs to reach posterior tissues of an eyeball, such as choroid and retina, with the result that treating diseases in such regions is... |
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US20050042194 |
Semi-solid delivery vehicle and pharmaceutical compositions
A semi-solid delivery vehicle contains a polyorthoester and an excipient, and a semi-solid pharmaceutical composition contains an active agent and the delivery vehicle. The pharmaceutical... |
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US20100028416 |
DRUG CARRIERS
Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a... |
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US20070025952 |
Linear cyclodextrin copolymers
Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described.... |
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US20070059272 |
Modulation of microbial pathogen-host cell interactions
The invention provides methods of screening for modulators of microbial PA-I lectin/adhesin activity, including modulators of PA-I expression, as well as the modulators so identified,... |
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US20050226844 |
Valency platform molecules comprising carbamate linkages
This invention pertains generally to valency molecules, such as valency platform molecules which act as scaffolds to which one or more molecules may be covalently tethered to form a conjugate.... |
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US20150182667 |
Composition with Biofilm Dispersal Agents
Embodiments of the presently-disclosed subject matter provide composites that comprise a tissue graft and a biofilm dispersal agent. The tissue graft can be bone tissue graft, a soft tissue graft,... |
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US20060228325 |
Water soluble multi-biotin-containing compounds
Water-soluble discrete multi-biotin-containing compounds with at least three (3) biotin moieties are disclosed. The water-soluble biotin-containing compounds may additionally comprise one or more... |
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US20120052040 |
POLYMER COMPOSITIONS AND METHODS FOR THEIR USE
Compositions comprising anti-fibrotic agent(s) and/or polymeric compositions can be used in various medical applications including the prevention of surgical adhesions, treatment of inflammatory... |
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US20070202074 |
Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
The present invention is directed toward an injectable, single- or multiple-component polymeric liquid precursor of an in situ-forming, non-absorbable, flexible, and resilient hydrogel or... |
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US20070154457 |
Use of eIF-5A to kill multiple myeloma cells
The present invention relates to eucaryotic initiation factor 5A and the use of polynucleotides encoding the same to inhibit cancer cell growth and inhibit metastases. In a preferred embodiment,... |
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US20070003513 |
Polymerized and modified rapamycins and their use in coating medical prostheses
Compositions of matter comprise linked pluralities of mTOR-binding molecules, such as rapamycin. The compositions may be directly polymerized or may comprise rapamycin or other mTOR-binding... |
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US20050123502 |
Nicotine containing oral compositions
An oral composition comprising a nicotine active, a polycarbophil component or a salt thereof, and an alginic acid component or a salt thereof, is provided. The oral composition provides high... |
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US20140193510 |
Polymer-Agent Conjugates, Particles, Compositions, and Related Methods of Use
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms... |
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US20140154202 |
PROCESS FOR THE IDENTIFICATION OF COMPOUNDS FOR TREATING CANCER
Process for the identification of compounds for treating cancer. The invention relates to a method for identifying candidate compounds for use as therapeutic agents for the treatment of cancer,... |
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US20130129662 |
Compositions and Methods for the Treatment of Heart Failure
The invention provides a therapeutic composition comprising an aqueous buffer, and a therapeutic agent that proves the functioning of a diseased heart by decreasing left ventricular end-diastolic... |
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US20070098800 |
Therapeutic compositions
The present invention provides new formulations of injectable particles (e.g. microspheres) useful for intra-articular (i.a.) injection. The formulations are made of biocompatible polymers that... |
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US20050158271 |
Pharmaceutical applications of hydrotropic polymer micelles
Hydrotropic polymer micelles effective for increasing the water solubility of poorly soluble drugs are described. Such hydrotropic polymer micelles have the combined properties of polymer micelles... |
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US20160045439 |
COMPOSITIONS FOR INHIBITING INFLAMMATION IN A SUBJECT WITH A SPINAL CORD INJURY AND METHODS OF USING THE SAME
Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-α signaling and a... |
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US20050249695 |
Antimicrobial polymeric surfaces
Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are... |
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US20130071482 |
BLOCK COPOLYMER CROSS-LINKED NANOASSEMBLIES AS MODULAR DELIVERY VEHICLES
A nanoassembly includes a core protected by a biocompatible shell. The nanoassembly includes a plurality of block copolymers including drug-binding linkers and block copolymer cross-linkers. A... |
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US20060204472 |
Multifunctional dendrimers and hyperbranched polymers as drug and gene delivery systems
The present invention deals with the synthesis of multifunctional dendrimeric and hyperbranched polymers for application as drug delivery systems of bioactive pharmaceutical compounds and as gene... |