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US20140023705 |
DOSAGE FORMS FOR ORAL ADMINISTRATION AND METHODS OF TREATMENT USING THE SAME
The invention relates to dosage forms that provide prolonged therapy. In particular, the invention relates to dosage forms including various pluralities of drug-containing resin particles. The... |
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US20130022545 |
DRUG DELIVERY SYSTEM FOR TREATMENT OF LIVER CANCER BASED ON INTERVENTIONAL INJECTION OF TEMPERATURE AND pH-SENSITIVE HYDROGEL
A drug delivery system for the treatment of liver cancer that is based on interventional injection of a temperature and pH-sensitive hydrogel is provided. The drug delivery system is composed of a... |
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US20140328933 |
NOVEL FORMULATIONS AND METHODS
Nanoparticles comprising VIP and their use in treating, e.g. pulmonary hypertension. Such nanoparticles provide improved delivery of VIP and allow for acute treatment and optionally for sustained... |
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US20110097406 |
METHODS AND COMPOSITIONS FOR RETAINING ECM MATERIALS IN HYDROGELS
The present invention provides cell-laden and/or extracellular matrix material laden hydrogels for use in tissue engineering and methods for producing such hydrogels. In some particular... |
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US20130243868 |
NOVEL FORMULATIONS
Nanoparticles comprising T3 and their use in treating, e.g., cardiac conditions, for example cardiac arrest, are provided. Such nanoparticles provide improved delivery of T3 and allow for acute... |
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US20120258162 |
CONTROLLED DELIVERY OF MOLECULES FROM A BIOINTERFACE
Disclosed are methods and apparatuses for delivery of bioactive molecules. The drug delivery systems include an implantable medical device which significantly reduces or suppresses adverse... |
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US20110123592 |
Biomaterials
The invention relates to a biomaterial having a latent form of a growth factor immobilised thereon, and to a method of producing the biomaterial, comprising immobilising the latent form of the... |
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US20120093722 |
SYNTHETIC DIBLOCK COPOLYPEPTIDE HYDROGELS FOR USE IN THE CENTRAL NERVOUS SYSTEM
This invention relates, e.g., to a composition suitable for administration to the central nervous system (CNS), comprising a block copolypeptide hydrogel, which comprises a biologically active... |
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US20140363371 |
TELODENDRIMERS WITH ENHANCED DRUG DELIVERY
The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include... |
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US20110318297 |
SINGLE PROTEIN NANOCAPSULES FOR PROTEIN DELIVERY WITH LONG-TERM EFFECT
A protein nanocapsule having a single-protein core and a thin polymer shell anchored covalently to the protein core. |
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US20120020911 |
MATRIX COMPOSED OF A NATURALLY-OCCURRING PROTEIN BACKBONE CROSS LINKED BY A SYNTHETIC POLYMER AND METHODS OF GENERATING AND USING SAME
The present invention relates to biodegradable scaffolds composed of a naturally-occurring protein backbone cross-linked by a synthetic polymer. Specifically, the present invention provides... |
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US20130052154 |
Compositions and Methods for the Treatment of Lung Inflammation
Compositions and methods for the treatment of inflammation are provided. |
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US20140161762 |
DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a... |
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US20120328555 |
DRUG DELIVERY OF TEMOZOLOMIDE FOR SYSTEMIC BASED TREATMENT OF CANCER
The present invention relates to methods of drug delivery for the treatment of a condition or disease, such as cancer. In one embodiment, the invention provides a method of preparing a... |
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US20100330025 |
Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof
The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA.... |
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US20150010491 |
POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY
A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the... |
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US20140120053 |
POLYESTERAMIDE PLATFORM FOR SITE SPECIFIC DRUG DELIVERY
A therapeutic agent delivery system formed of a specific type of poly(ester amide) (PEA), a therapeutic agent, and a water miscible solvent is described herein. A method of delivering the... |
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US20110038828 |
MATRIX COMPOSED OF A NATURALLY-OCCURRING PROTEIN BACKBONE CROSS LINKED BY A SYNTHETIC POLYMER AND METHODS OF GENERATING AND USING SAME
A method of treating a disorder characterized by tissue damage is provided. The method comprising providing to a subject in need-thereof a composition which comprises a synthetic polymer attached... |
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US20120070391 |
COSMETIC COMPOSITION COMPRISING AN AQUEOUS DISPERSION OF POLYSILOXANE/POLYUREA AND A SILANE, COSMETIC TREATMENT PROCESS AND KIT THEREFOR
The present invention relates to a cosmetic composition comprising an aqueous dispersion of polysiloxane/polyurea copolymer and a silane, and to a cosmetic treatment process using said composition. |
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US20130243696 |
Compositions and Methods for the Treatment of Traumatic Brain Injury
Compositions and methods for the inhibition and/or prevention of traumatic brain injury and the symptoms associated with it are provided. |
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US20130273122 |
Immobilised Biological Entities
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of... |
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US20130129664 |
Cancer Therapy Via Selective Uptake of Specialized Nanoparticles in Cancer Cells
Disclosed herein are polymer/fullerene nanoparticles that have selective uptake into cancer cells, and which, upon being taken into the cancer cells induce apoptosis. Induction of apoptosis can be... |
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US20140314866 |
MATERIALS AND METHODS FOR MODULATING IMMUNE RESPONSES
The present invention provides nanoparticle-coupled tolerogenic Treg cell therapy for treatment of immune and/or autoimmune disorders. In certain specific embodiments, the present invention can be... |
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US20100098654 |
TREATMENT OF NEUROBLASTOMA WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN
The present invention relates to methods of treatment of neuroblastoma. The present invention includes administering polymeric prodrugs of 7-ethyl-10-hydroxycamptothecin to patients in need thereof. |
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US20110262381 |
FORMULATION FOR TREATMENT OF VAGINAL DRYNESS
The present invention is directed to a composition for treating vaginal dryness and lack of lubrication comprising: a poloxamer component; a phospholipid component; an optional oil component; and... |
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US20140050689 |
TISSUE GRAFTED WITH A BIODEGRADABLE POLYMER
Novel implantable tissue fixation methods and compositions are disclosed. Methods and compositions of tissue, fixed using polymeric and/or variable length crosslinks, and di- or polymercapto... |
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US20120076836 |
POLYION COMPLEX OF DOUBLE-STRANDED RIBONUCLEIC ACID
Provided are a delivery system that is useful in delivering a double-stranded ribonucleic acid that functions in gene silencing in glomeruli, particularly in mesangial cells and the like, to the... |
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US20120027814 |
Polymeric Fibers Having Tissue Reactive Members
A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to a surface of the fiber via a... |
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US20140348754 |
Method of Delivering Therapeutics and Imaging Agents to the Brain by Nanoparticles that Cross the Blood Brain Barrier
Described herein are methods of delivering a nanoparticle to the brain of a subject by administering to the subject a nanoparticle having a nanoparticle core and a targeting agent. A variety of... |
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US20110135700 |
IN SITU BULKING COMPOSITION
The present invention relates to a hydrated, biocompatible tissue-augmentation compound and methodology for its implantation into mammalian tissue. The tissue-augmentation compound is comprised... |
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US20150125531 |
ACTIVE SELF-HEALING BIOMATERIAL SYSTEM
Methods and compositions are provided that load and encapsulate an agent, such as a protein, in a porous self-healing polymer. A delivery system includes a porous self-healing polymer, an ionic... |
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US20140205542 |
Perfusive Organ Hemostasis
Disclosed are compositions, methods and kits to control bleeding through the use of an internal occluder based on polymeric solutions, including use of reverse thermosensitive polymers in... |
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US20150209440 |
CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions. |
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US20120258068 |
SCAFFOLDS FORMED FROM POLYMER-PROTEIN CONJUGATES, METHODS OF GENERATING SAME AND USES THEREOF
Conjugates are provided herein which comprise a protein attached to at least two polymeric moieties, at least one of which exhibits reverse thermal gelation. The conjugates are suitable for being... |
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US20150132399 |
COMPOSITION AND METHOD FOR SULFATED NON-ANTICOAGULANT LOW MOLECULAR WEIGHT HEPARINS IN CANCER AND TUMOR METASTASIS
A nanoformulation that includes nanoparticles. Each nanoparticle includes a shell in which a glycosaminoglycan (GAG is encapsulated. The GAG is ionically or covalently bonded to the shell. The GAG... |
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US20110250162 |
DISINFECTING AND DETOXIFYING META-ARAMID PARTICLES
Porous, permeable particles of meta-aramid can be chlorinated or brominated to produce antimicrobial and detoxifying particles for use in applications such as, but not limited to, nonwoven webs,... |
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US20110206634 |
COMPOSITE MATERIAL FOR TISSUE REPAIR
The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous... |
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US20140193356 |
Compositions Comprising Citrate And Applications Thereof
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype... |
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US20150010490 |
ANTI-ADHESION POLYMER COMPOSITION CAPABLE OF SUPPORTING GROWTH FACTOR
The present invention relates to an anti-adhesion polymer composition capable of supporting growth factor, which effectively exhibits anti-adhesion function and, at the same time, has an excellent... |
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US20110135736 |
Compositions and Methods for Producing Vascular Occlusion using a Solid-phase Platelet Binding Agent
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or... |
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US20110206753 |
NANOPARTICULATE COPPER COMPOUNDS
The present invention relates to processes for the preparation of surface-modified nanoparticulate copper compounds and of aqueous suspensions which comprise surface-modified nanoparticulate... |
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US20140348896 |
Hydrophobic Tissue Adhesives
Pre-polymers for use as tissue sealants and adhesives, and methods of making and using thereof are provided. The pre-polymers have flow characteristics such that they can be applied through a... |
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US20140065093 |
Compositions For Achieving A Therapeutic Effect In An Anatomical Structure
Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect. |
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US20130028856 |
Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and... |
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US20120171153 |
Modified hyaluronidases and uses in treating hyaluronan-associated diseases and conditions
Provided are combinations, compositions and kits containing a hyaluronan degrading enzyme, such as a soluble hyaluronidase, for treatment of hyaluronan-associated conditions, diseases and... |
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US20110059010 |
DUAL PHASE DRUG RELEASE SYSTEM
The present invention relates to conjugate comprising a carrier substituted with one or more occurrences of a moiety having the structure (I): wherein each occurrence of M is independently a... |
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US20140341996 |
Nanoengineering of Functionalized Polymers and Its Manufacturing and Formulation Methods for Personalized Cancer Therapies
Nanoengineering of inert polymers to develop functionalized sulfonated polymers to harness the power of Alternate complement system to stimulate and amplify cytotoxic potentials of classical and... |
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US20110200655 |
Systems and methods that kill infectious agents (bacteria) without the use of a systemic anti-biotic
A medical product is provided that is selected from at least one of, nasal cannulas, oxygen masks, wound dressings, bandages, band aids, catheters, endotrachial tubes, condoms, surgical and other... |
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US20110212048 |
POLYMALIC ACID-BASED MULTIFUNCTIONAL DRUG DELIVERY SYSTEM
A structured drug system that is useful for delivering a drug payload to a specific tissue or cell type is disclosed. The system is based on purified polymalic acid. This polymer isolated from... |
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US20070286883 |
STRUCTURING HYDROGELS
The present invention relates to a method for the preparation of a surface structured bulk hydrogel bearing a topographic and chemical pattern, comprising the steps of: (i) providing a primary... |