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US20100016783 NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION  
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases...
US20160166538 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF BREAST CANCER  
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods...
US20160166537 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF BRAIN CANCERS  
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods...
US20160128976 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS  
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods...
US20160128975 ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF LUNG CANCER  
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods...
US20150315150 KINASE INHIBITORS AND METHODS OF THEIR USE  
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In...
US20150050356 NANOPARTICLE COMPRISING RAPAMYCIN AND ALBUMIN AS ANTICANCER AGENT  
The present invention features methods for treating, stabilizing, preventing, and/or delaying cancer by administering nanoparticles that comprise rapamycin or a derivative thereof. The invention...
US20130344138 METHODS OF TREATMENT FOR SOLID TUMORS  
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises...
US20130224195 SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE  
New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either...
US20120308645 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA  
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is...
US20120276192 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1  
RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory...
US20120276126 LACTOFERRIN IN THE TREATMENT OF MALIGNANT NEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES  
The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies.
US20120225128 METHOD FOR CARRYING THERAPEUTIC SUBSTANCES INTO CELLS  
The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated...
US20110305777 DIMERIC IAP ANTAGONISTS  
Smac mimetics that inhibit IAPs.
US20110111056 PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION  
This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates.
US20110076234 PEPTIDES COMPRISING AN ISODGR MOTIF  
Disclosed herein are peptides which include an isoDGR motif and which selectively inhibit αvβ3 integrin. In some embodiments, the isoDGR motif results from the deamidation of an NGR motif.
US20110059187 PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION  
This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates.
US20110059076 HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF  
Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is...
US20110033451 INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR  
The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and...
US20100278811 VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF  
Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders...
US20100202963 THERAPIES FOR HEMATOLOGIC MALIGNANCIES  
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises...
US20090123416 METHODS FOR THE TREATMENT OF BLADDER CANCER USING 3-(4-AMINO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE  
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass...
US20090104259 COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS  
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
US20080292723 Bioactive acid agrichemical compositions and use thereof  
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions.
US20080113000 Compositions and methods for coating medical implants  
Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or...
US20070060637 Anti-cancer combinations  
The present invention relates to synergistic combinations of the compound 5,6 -dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating...
US20070025999 TREATMENT WITH ANTI-VEGF ANTIBODIES  
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients...
US20060204591 Treatment of mucosal membranes  
The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and...
US20060182718 Methods and compositions comprising DNA damaging agents and p53  
The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor...
US20050147562 Medical implants and fibrosis-inducing agents  
Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between...
US20150352135 GLA Monotherapy for Use in Cancer Treatment  
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen.
US20150307500 INHIBITORS OF BRUTON'S TYROSINE KINASE  
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of...
US20150004134 TREATMENT OF CANCER WITH HETEROCYCLIC INHIBITORS OF GLUTAMINASE  
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel...
US20140301976 NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS  
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore...
US20140113005 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE  
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase....
US20130315999 COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING COMPOUNDFS FOR FOLLICULAR DELIVERY  
The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering...
US20130089626 Treating Cancer with ATR Inhibitors  
This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in...
US20130004481 ANTICANCER THERAPY  
The invention describes anti-cancer therapies comprising using dual Aurora kinase/MEK inhibitors as described herein.
US20120269901 Methods and Compounds Useful to Induce Apoptosis in Cancer Cells  
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
US20120225062 NOVEL KINASE INHIBITORS  
The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides...
US20120225061 TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS  
The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided...
US20120015050 METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY  
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for...
US20110293610 ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN  
The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for...
US20110236428 COMBINATION THERAPY WITH PEPTIDE EPOXYKETONES  
The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt...
US20110097402 NON-ADHESIVE ELASTIC GELATIN MATRICES  
The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix...
US20110097320 4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF  
This invention relates to novel 4-aminoquinazolines, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a...
US20100143384 NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS  
In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole...
US20090285908 METHOD OF TREATING ENDOTHELIAL INJURY  
The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as...
US20080299222 Bioactive agrichemical compositions and use thereof  
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
US20080292721 Bioactive acid agrichemical compositrions and use thereof  
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions.