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US20100016783 |
NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases... |
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US20160166538 |
ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF BREAST CANCER
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods... |
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US20160166537 |
ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF BRAIN CANCERS
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods... |
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US20160128976 |
ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF CANCERS
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods... |
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US20160128975 |
ANTIFUGETACTIC AGENTS FOR THE TREATMENT OF LUNG CANCER
This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods... |
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US20150315150 |
KINASE INHIBITORS AND METHODS OF THEIR USE
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In... |
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US20150050356 |
NANOPARTICLE COMPRISING RAPAMYCIN AND ALBUMIN AS ANTICANCER AGENT
The present invention features methods for treating, stabilizing, preventing, and/or delaying cancer by administering nanoparticles that comprise rapamycin or a derivative thereof. The invention... |
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US20130344138 |
METHODS OF TREATMENT FOR SOLID TUMORS
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises... |
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US20130224195 |
SUBSTITUTED BENZAZOLES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either... |
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US20120308645 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF HIF-1 ALPHA
RNA interference using small interfering RNAs which target HIF-1 alpha mRNA inhibit expression of the HIF-1 alpha gene. As HIF-1 alpha is a transcriptional regulator of VEGF, expression of VEGF is... |
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US20120276192 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ICAM-1
RNA interference using small interfering RNAs which are specific for the ICAM-1 gene inhibits expression of this gene. Diseases which involve ICAM-1-mediated cell adhesion, such as inflammatory... |
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US20120276126 |
LACTOFERRIN IN THE TREATMENT OF MALIGNANT NEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES
The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies. |
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US20120225128 |
METHOD FOR CARRYING THERAPEUTIC SUBSTANCES INTO CELLS
The present invention relates to compositions containing nanoparticies and uses of said composition for transferring therapeutically active substances into cells by means of specifically coated... |
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US20110305777 |
DIMERIC IAP ANTAGONISTS
Smac mimetics that inhibit IAPs. |
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US20110111056 |
PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION
This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates. |
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US20110076234 |
PEPTIDES COMPRISING AN ISODGR MOTIF
Disclosed herein are peptides which include an isoDGR motif and which selectively inhibit αvβ3 integrin. In some embodiments, the isoDGR motif results from the deamidation of an NGR motif. |
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US20110059187 |
PEPTIDE DICER SUBSTRATE AGENTS AND METHODS FOR THEIR SPECIFIC INHIBITION OF GENE EXPRESSION
This invention relates to compounds, compositions, and methods useful for reducing a target RNA and protein levels via use of Dicer substrate siRNA (DsiRNA)-peptide conjugates. |
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US20110059076 |
HUMAN SERUM ALBUMIN LINKERS AND CONJUGATES THEREOF
Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is... |
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US20110033451 |
INTERLEUKIN-17F ANTIBODIES AND OTHER IL-17F SIGNALING ANTAGONISTS AND USES THEREFOR
The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and... |
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US20100278811 |
VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF
Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders... |
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US20100202963 |
THERAPIES FOR HEMATOLOGIC MALIGNANCIES
The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises... |
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US20090123416 |
METHODS FOR THE TREATMENT OF BLADDER CANCER USING 3-(4-AMINO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE
Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass... |
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US20090104259 |
COMPOSITIONS AND METHODS FOR SIRNA INHIBITION OF ANGIOGENESIS
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these... |
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US20080292723 |
Bioactive acid agrichemical compositions and use thereof
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions. |
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US20080113000 |
Compositions and methods for coating medical implants
Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or... |
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US20070060637 |
Anti-cancer combinations
The present invention relates to synergistic combinations of the compound 5,6 -dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating... |
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US20070025999 |
TREATMENT WITH ANTI-VEGF ANTIBODIES
This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients... |
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US20060204591 |
Treatment of mucosal membranes
The invention relates to the use of one or more antimicrobial metals preferably selected from silver, gold, platinum, and palladium but most preferably silver, formed with atomic disorder, and... |
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US20060182718 |
Methods and compositions comprising DNA damaging agents and p53
The present invention relates to the use of tumor suppressor genes in combination with a DNA damaging agent or factor for use in killing cells, and in particular cancerous cells. A tumor... |
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US20050147562 |
Medical implants and fibrosis-inducing agents
Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between... |
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US20150352135 |
GLA Monotherapy for Use in Cancer Treatment
The present disclosure relates generally to compositions and methods for treating cancer with a glucopyranosyl lipid A (GLA) in the absence of antigen. |
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US20150307500 |
INHIBITORS OF BRUTON'S TYROSINE KINASE
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of... |
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US20150004134 |
TREATMENT OF CANCER WITH HETEROCYCLIC INHIBITORS OF GLUTAMINASE
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cancer using the novel... |
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US20140301976 |
NOVEL HYDROXAMATES AS THERAPEUTIC AGENTS
The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore... |
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US20140113005 |
COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
The present disclosure relates to pyrazine compounds of formula I: wherein L, n, R1, and R2 are as described in the specification. These compounds are useful as inhibitors of ATR protein kinase.... |
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US20130315999 |
COMPOSITIONS AND METHODS COMPRISING ENERGY ABSORBING COMPOUNDFS FOR FOLLICULAR DELIVERY
The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering... |
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US20130089626 |
Treating Cancer with ATR Inhibitors
This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in... |
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US20130004481 |
ANTICANCER THERAPY
The invention describes anti-cancer therapies comprising using dual Aurora kinase/MEK inhibitors as described herein. |
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US20120269901 |
Methods and Compounds Useful to Induce Apoptosis in Cancer Cells
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative. |
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US20120225062 |
NOVEL KINASE INHIBITORS
The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides... |
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US20120225061 |
TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS
The present invention provides a compound of formula (I): as further described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. Also provided... |
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US20120015050 |
METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for... |
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US20110293610 |
ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO B LYMPHOCYTE STIMULATOR PROTEIN
The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for... |
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US20110236428 |
COMBINATION THERAPY WITH PEPTIDE EPOXYKETONES
The invention provides combination therapy, wherein one or more other therapeutic agents are administered agents are administered with peptide epoxyketones or a pharmaceutically acceptable salt... |
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US20110097402 |
NON-ADHESIVE ELASTIC GELATIN MATRICES
The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix... |
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US20110097320 |
4-AMINOQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF
This invention relates to novel 4-aminoquinazolines, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a... |
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US20100143384 |
NOVEL 4-CYANO, 4-AMINO, AND 4-AMINOMETHYL DERIVATIVES OF PYRAZOLO[1,5-a]PYRIDINES, PYRAZOLO[1,5-c]PYRIMIDINES AND 2H-INDAZOLE COMPOUNDS AND 5-CYANO, 5-AMINO, AND 5-AMINOMETHYL DERIVATIVES OF IMIDAZO[1,2-a]PYRIDINES, AND IMIDAZO[1,5-a]PYRAZINES AS CYCLIN DEPENDENT KINASE INHIBITORS
In its many embodiments, the present invention provides a novel class of 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridine, pyrazolo[1,5-c]pyrimidine, and 2H-Indazole... |
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US20090285908 |
METHOD OF TREATING ENDOTHELIAL INJURY
The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as... |
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US20080299222 |
Bioactive agrichemical compositions and use thereof
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations. |
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US20080292721 |
Bioactive acid agrichemical compositrions and use thereof
Bioactive agrichemical concentrates and compositions having improved bioactivity comprising metal-acid solutions. |