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US20160193299 |
MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS
The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed... |
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US20160250153 |
NOVEL METHODS
The present invention relates to the field of methods for providing components of pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to... |
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US20160058716 |
PHARMACEUTICAL FORMULATION CONTAINING GELLING AGENT
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically... |
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US20090148517 |
MELT-EXTRUSION MULTIPARTICULATES
A unit dose sustained-release oral dosage form containing a plurality of melt-extruded particles, each consisting essentially of a therapeutically active agent, one or more retardants, and an... |
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US20070196478 |
ANTIVIRAL COMPOSITIONS
The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These... |
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US20160143844 |
Drug Delivery Systems and Use Thereof
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such... |
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US20140328937 |
Drug Delivery Systems and Use Thereof
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such... |
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US20140065234 |
POLYMERSOMES, LIPOSOMES, AND OTHER SPECIES ASSOCIATED WITH FLUIDIC DROPLETS
The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be... |
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US20130209570 |
DRUG DELIVERY SYSTEMS AND USE THEREOF
The invention provides a microsphere formulation for the sustained delivery of an aptamer, for example, an anti-Vascular Endothelial Growth Factor aptamer, to a preselected locus in a mammal, such... |
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US20100221352 |
PHARMACEUTICAL COMPOSITION FOR THE ONCE-A-DAY ORAL ADMINISTRATION OF TROSPIUM CHLORIDE
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum... |
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US20080317854 |
PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED SOLID DOSAGE FORM
The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a binder with a breaking... |
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US20080311182 |
MULTISTAGE DELIVERY OF ACTIVE AGENTS
Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage... |
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US20080050450 |
Active Agent Formulations, Methods of Making, and Methods of Use
Active agent compositions comprising active agent particles having an effective average particle size of less than 2000 nm, wherein the compositions comprise a particle sequestrant are disclosed.... |
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US20150328160 |
REHYDRATABLE PHARMACEUTICAL PRODUCT
A pharmaceutical product comprising lyophilised polymer matrix including a biologically active compound, of particular utility for embolisation, having improved rehydration properties is packaged... |
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US20140030352 |
NANODISPERSION
The present invention provides a nanodispersion comprising nanoparticles having a mean size less than 300 nm dispersed in a vehicle comprising a water miscible solvent and water, said... |
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US20110293701 |
MULTIVALENT SYNTHETIC NANOCARRIER VACCINES
The invention relates, at least in part, to compositions comprising populations of synthetic nanocarriers that comprise different sets of antigens as well as related methods. |
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US20100297252 |
NANOPARTICULATE MELOXICAM FORMULATIONS
The present invention is directed to nanoparticulate compositions comprising meloxicam particles having an effective average particle size of less than about 2000 nm. |
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US20090232901 |
POLYMERIC MICROSPHERES
The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell... |
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US20090087487 |
Paliperidone sustained release formulation
The present invention provides sustained release dosage forms comprising Paliperidone and processes for preparing the same. |
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US20090074830 |
ANTI-ANGIOGENIC COMPOSITIONS AND METHODS OF USE
The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic... |
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US20090004262 |
Nanoparticulate formulations and methods for the making and use therof
The present invention is directed to size-stabilized drug nanoparticulate compositions and methods of preparation thereof. |
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US20070196491 |
DRUG DELIVERY SYSTEMS COMPRISING WEAKLY BASIC DRUGS AND ORGANIC ACIDS
A pharmaceutical dosage form such as a capsule, a conventional or orally disintegrating tablet capable of delivering a nitrogen (N)-containing therapeutic agent having a pKa in the range of from... |
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US20100247668 |
POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms... |
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US20100247606 |
INTRAOCULAR SUSTAINED RELEASE DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING OCULAR CONDITIONS
Biocompatible, bioerodible sustained release implants and microspheres for intracameral or anterior vitreal placement include an anti-hypertensive agent and a biodegradable polymer effective to... |
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US20100221356 |
PHARMACEUTICAL COMPOSITION FOR ONCE A DAY ADMINISTRATION OF TROSPIUM CHLORIDE
A pharmaceutical composition of a pharmaceutically acceptable trospium salt, with upon administration to a human patient generates an average steady state blood levels of trospium with a minimum... |
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US20100203153 |
SUSTAINED-RELEASE NANOPARTICLE COMPOSITIONS AND METHODS USING THE SAME
The present invention is a composition composed of a therapeutic agent encapsulated in a copolymer of an N-alkylacrylamide, a vinyl monomer, and a polyethylene glycol (PEG) conjugate and a method... |
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US20090081309 |
Stabilized Oral Suspension Formulation
Orally deliverable pharmaceutical compositions are provided comprising a drug of tow water solubility suspended in an aqueous liquid vehicle comprising a wetting agent, a thixotropic thickening... |
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US20160354320 |
DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME
The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such... |
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US20100272822 |
NANOCELL DRUG DELIVERY SYSTEM
Nanocells allow the sequential delivery of two different therapeutic agents with different modes of action or different pharmacokinetics. A nanocell is formed by encapsulating a nanocore with a... |
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US20100247669 |
POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms... |
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US20100196437 |
MEDICAL DEVICES HAVING A SURFACE INCLUDING A BIOLOGICALLY ACTIVE AGENT THEREIN
The present invention provides a medical device, and methods of preparing and using a medical device. The medical device has a surface including a biologically active agent therein. The methods... |
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US20100104654 |
PROSTAGLANDIN AND PROSTAMIDE DRUG DELIVERY SYSTEMS AND INTRAOCULAR THERAPEUTIC USES THEREOF
Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma. |
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US20100074957 |
INTRAOCULAR FORMULATION
Biodegradable therapeutic agent incorporating microspheres formulated in a high viscosity carrier suitable for intraocular administration to treat an ocular condition. The formulation can also be... |
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US20080069857 |
Compositions And Methods For Inhibiting Adhesions
The present invention provides compositions and methods for inhibiting adhesions. The methods involve administering solutions containing hydrogel precursors such as polysaccharide derivatives,... |
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US20150037429 |
Controlled Release Microparticles
Formulations for controlled, sustained release of biologically active agents for the treatment of ocular disorders have been developed. These formulations are based on solid microparticles formed... |
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US20110033553 |
Embolization
A composition includes a plurality of particles. At least some of the plurality of particles include cross-linked polyvinyl alcohol and have a diameter of about 500 microns or less. The particles... |
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US20080292714 |
BONE TARGETING OF DEGRADABLE DRUG FILLED NANOPARTICLES
This invention provides a method of modifying a cellular response in a mammal. The method comprises administering to the mammal an effective amount of biodegradable nanoparticles, each of said... |
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US20080145439 |
NANOPARTICLE DRUG FORMULATIONS
A suspension of nanoparticles in a liquid medium provides a mechanism for delivery of gacyclidine base or other drug that is substantially insoluble in the liquid medium. |
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US20160346382 |
CARBOHYDRATE-MODIFIED PARTICLES AND PARTICULATE FORMULATIONS FOR MODULATING AN IMMUNE RESPONSE
Disclosed are compositions, kits, and methods for modulating an immune response. The compositions and kits include and the methods utilize carbohydrate-modified particles having an immune... |
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US20160089336 |
Octreotide depot formulation with constantly high exposure levels
The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two different linear... |
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US20140099263 |
POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE
Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms... |
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US20130337078 |
PARTICULATE CONSTRUCTS FOR RELEASE OF ACTIVE AGENTS
Particulate constructs stabilized by amphiphilic copolymers and comprising at least one active coupled to a hydrophobic moiety provide sustained release of the active in both in vitro and in vivo... |
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US20090148527 |
INTRAOCULAR FORMULATION
Biodegradable therapeutic agent incorporating microspheres formulated in a high viscosity carrier suitable for intraocular administration to treat an ocular condition. The formulation can also be... |
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US20090004283 |
Sustained Release Formulation Comprising Octreotide and Two or More Polylactide-Co-Glycolide Polymers
The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two or more different... |
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US20080279954 |
Method of preparing a supramolecular complex containing a therapeutic agent and a multi-dimensional polymer network
A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the... |
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US20140348936 |
GASTRORETENTIVE CONTROLLED RELEASE VEHICLES THAT INCLUDE ETHYLENE COPOLYMERS, ETHYL CELLULOSES, AND/OR THERMOPLASTIC POLYURETHANES
Gastroretentive controlled release vehicles may, in some embodiments, (1) comprise a polymeric matrix and agents for the treatment, prevention, and/or mitigation of a disease and/or side effect... |
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US20110064821 |
ENCAPSULATION OF BIOLOGICALLY ACTIVE AGENTS
The present invention provides methods of encapsulating biologically active agents such as proteins in particulate carriers such as nanoparticles. Also provided are methods of delivery of proteins... |
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US20100098772 |
DRUG DELIVERY SYSTEMS AND METHODS FOR TREATING NEOVASCULARIZATION
Anti-angiogenesis compositions, and methods of using such compositions, useful for intraocular to treat neovascularization. The compositions can have viscosities at about 25° C. of at least about... |
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US20090053318 |
Forming Embolic Particles
Methods of making polymer particles, as well as related particles, compositions, and methods are disclosed. |
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US20080181965 |
Loaded latex optical molecular imaging probes
The present invention relates to a loaded latex particle comprising a latex material made from a mixture represented by formula (X)m-(Y)n-(Z)o-(W)p, wherein Y is at least one monomer with at least... |