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US20090136465 |
Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof
The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene... |
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US20070134293 |
Devices and methods for the delivery of blood clotting materials to bleeding wounds
An apparatus for promoting the clotting of blood comprises a receptacle, at least a portion of which is defined by a mesh having openings therein, and particles of clay retained in the receptacle.... |
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US20060195176 |
Coated implantable medical device
Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device... |
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US20050079201 |
Implants with functionalized carbon surfaces
The invention relates to a method of producing medical implants having functionalized surfaces by providing a medical implant with at least one carbon-based layer on at least one part of the... |
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US20160213812 |
BIODEGRADABLE POLYMER AND TISSUE COMBINATIONS
A biodegradable bioprosthesis can include a biodegradable tissue and a biodegradable polymer combined with the biodegradable tissue. The biodegradable tissue can be non-crosslinked tissue, EDC... |
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US20080166391 |
Zero-order prolonged release coaxial implants
A coaxial implant has been developed using entirely biodegradable polymeric materials. As referred to herein, a coaxial implant is a device having a core containing drug, surrounded by a... |
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US20080075833 |
Rate-reducing membrane for release of an agent
A membrane that reduces the rate at which a therapeutic substance is released from an implantable medical device, such as a stent, is disclosed. |
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US20050004558 |
Flexible vascular inducing implants
Implants and associated delivery systems for promoting angiogenesis in ischemic tissue are provided. The implants may be delivered percutaneously, thoracically or surgically and are particularly... |
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US20070026039 |
Composite self-cohered web materials
The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting... |
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US20110027188 |
Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers
An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the... |
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US20050070989 |
Medical devices having porous layers and methods for making the same
The present invention relates generally to medical devices with therapy eluting components and methods for making same. More specifically, the invention relates to implantable medical devices... |
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US20050060044 |
Methods and devices for maintaining patency of surgically created channels in a body organ
This is directed to methods and devices suited for maintaining an opening in a wall of a body organ for an extended period. More particularly devices and methods are directed maintaining patency... |
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US20090238855 |
LAMINATE SHEET ARTICLES FOR TISSUE REGENERATION
The invention is to articles of extracellular matrix. The articles comprise one or more sheets of mammalian extracellular matrix laminated together. A single sheet can be folded over and laminated... |
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US20070269483 |
Method and apparatus for installation of dental implant
An organ derived from genetic material is inserted in a patient's body. Genetic material is inserted at a selected site in the body to grow an organ. |
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US20080286332 |
Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer, an acrylate copolymer layer containing a therapeutic agent, and their... |
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US20070026040 |
Composite self-cohered web materials
The present invention is directed to implantable bioabsorbable non-woven self-cohered web materials having a high degree of porosity. The web materials are very supple and soft, while exhibiting... |
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US20050100580 |
Hydrophilic coated medical device
A medical device comprises a main body, a therapeutic agent and a radiation-curable hydrophilic coating. The hydrophilic coating allows for easy insertion of medical devices, which may include... |
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US20170157294 |
OPTIMIZATION OF ALGINATE ENCAPSULATION OF ISLETS FOR TRANSPLANTATION
Apparatus is provided, including a plurality of islets, and a hydrogel configured to macroencapsulate the plurality of islets. The hydrogel is implantable in a subcapsular space (21) of a kidney... |
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US20070243227 |
Coatings for surgical staplers
A material with a first state and a second state is applied to a surgical stapler. The stapler is applied to tissue in a surgical field while the material is in the first state. Subsequently, the... |
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US20110086083 |
IMPLANT DEVICES FOR MODULATING BIOACTIVE AGENT RELEASE PROFILES
Described herein are implant devices comprising at least one exposed biodegradable inner core surface, the inner core being surrounding partially by a membrane sheath which comprises a... |
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US20090287072 |
POLYMER COMPOSITIONS, COATINGS AND DEVICES, AND METHODS OF MAKING AND USING THE SAME
The disclosure provides for a biocompatible, thromboresistant coating including a chalcogenide compound that induces nitric oxide formation; and a biocompatible matrix incorporating the... |
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US20060062826 |
Process for the production of sustained release drug delivery devices
Disclosed is an improved sustained release drug delivery device and method of producing such device. The device comprises a drug core in an impermeable cup or impermeable coating layer that is... |
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US20050118229 |
Implantable drug delivery device for sustained release of therapeutic agent
An implantable drug-delivery device that utilizes a nanopore diffusion membrane in combination with a microporous hydration membrane for achieving long-term, zero-order release of a therapeutic... |
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US20100255059 |
Artificial micro-gland
A micro-scale artificial gland is disclosed in the form of an independent unit for promoting biological activity. The artificial gland includes cells formed in a membrane enclosing a reservoir.... |
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US20070116736 |
Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury
Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to... |
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US20060029639 |
Biodegradable substrate, prosthetic material for tissue regeneration, and cultured tissue
A biodegradable substrate usable as a prosthetic material (i.e., for tissue regeneration) facilitates the invasion of cells into a substrate and has a thick structure similar to woven fabrics. The... |
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US20150030657 |
SMOOTH MUSCLE CELL CONSTRUCTS
The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or... |
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US20090035350 |
Polymers for implantable devices exhibiting shape-memory effects
The present invention is directed to polymeric compositions comprising a biodegradable copolymer that possesses shape-memory properties and implantable devices (e.g., drug-delivery stents) formed... |
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US20070231364 |
Biocompatible Membrane and Process for Producing the Same
The present invention provides a biocompatible membrane which has a configuration that conforms well to an affected part and can be used in fields such as dentistry, oral surgery, orthopedics,... |
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US20070134292 |
Synthetic, bioabsorbable polymer materials and implants
The invention relates to synthetic, bioabsorbable polymer materials and implants, like fibres, sutures, meshes and other tissue management, wound closure or tissue engineering devices, which... |
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US20100310627 |
Xenotransplant for Stroke Therapy
Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal. |
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US20140248328 |
Methods of treating amniotic membranes using supercritical fluids and compositions and apparatuses prepared therefrom
A method of sterilizing compositions prepared from amniotic membrane tissues may include harvesting placental tissue, separation of amniotic membrane tissue, and treatment of the amniotic membrane... |
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US20140255462 |
Xenotransplant Compositions and Methods of Stroke Therapy
Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal. |
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US20070213835 |
PLASTIC IMPLANT IMPREGNATED WITH AN ANTIBIOTIC
A plastic device containing an effective amount of an antibiotic to minimize bacterial and/or fungal infection at the site of implantation is disclosed. |
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US20070087032 |
Composition of cartilage therapeutic agents and its application
A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of... |
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US20150024024 |
Cell Lines That Produce Prostaglandin F2 Alpha (PGF2A) And Uses Thereof
Cells and cell lines that are genetically modified to express the hCox-2 enzyme, which results in the upregulation of prostaglandin F2 alpha (PGF2a) on the cells have been obtained. Encapsulated... |
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US20100196439 |
Angiogenesis Mechanism and Method, and Implantable Device
Various methods and devices are provided for providing therapy to a living body. In one embodiment, an implanted permeable container has living cells provided therein, and various nutrients and/or... |
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US20160058911 |
MULTI-STEP METHOD FOR FABRICATING TISSUE ENGINEERING BONE
A multi-step method for fabricating a tissue engineering bone comprises the following steps: (1) scaffold repair and pre-vascularization: fabricating a tissue engineering bone scaffold at a bone... |
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US20090269389 |
ARPE-19 as a Platform Cell Line for Encapsulated Cell-Based Delivery
ARPE-19 cells were evaluated as a platform cell line for encapsulated and unencapsulated cell-based delivery technology. ARPE-19 cells were found to be hardy (the cell line is viable under... |
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US20160067390 |
METHODS FOR IN VIVO AND IN VITRO USE OF GRAPHENE AND OTHER TWO-DIMENSIONAL MATERIALS
Two-dimensional materials, particularly graphene-based materials, having a plurality of apertures thereon can be formed into enclosures for various substances and introduced to an environment,... |
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US20110045055 |
MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS
According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after... |
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US20070067045 |
Systems and methods for skin wrinkle removal
An implant is disclosed that reduces wrinkles. The implant may be in the shape of a cylinder with a constant or a varying cross-section and length. The implant contains a gel that has limited flow... |
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US20160296670 |
BONE SEMI-PERMEABLE DEVICE
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to... |
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US20100316690 |
Modular assembly of tissue engineered constructs
Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct... |
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US20100203101 |
BIO-MEMBRANE FOR TISSUE REGENERATION
A bio-membrane with angiogenic activity for implant in tissue regeneration and repair, including bone reconstruction and the repair of skin and soft tissue lesions is described, essentially... |
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US20100260816 |
INDUCTION OF IMMUNOLOGICAL TOLERANCE
A method of creating tolerance to transplanted cells, tissue, or organs without the need for continuous immunosuppression. A tolerizing dose of a cell or tissue within a membrane structure is... |
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US20070154518 |
Photoactive biocompatible coating composition
The present invention discloses a biocompatible coating composition that can be photo crosslinked when exposed to long wavelength ultraviolet light. The biocompatible coating composition comprises... |
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US20090010991 |
Nasal Passage Stent
A drug coated nasal stent implant that provides filtration of environmental pollutants and airborne allergens from inhaled air regulating the air before it is ingested into the remainder of the... |
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US20060034886 |
Bonded fiber structures for use in controlling fluid flow
A flow control element is provided for use in selectively controlling the flow of a liquid through an annular conduit. The flow control element comprises a self-sustaining, three dimensional... |
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US20050222688 |
Transmural concentric multilayer ingrowth matrix within well-defined porosity
A multilayer ingrowth matrix is constructed within well-defined porosity of a prosthetic material. The matrix consists of either proteinaceous or synthetic layers or gradients, or a combination of... |