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US20100310627 |
Xenotransplant for Stroke Therapy
Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal. |
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US20100316690 |
Modular assembly of tissue engineered constructs
Scaleable, vascularised tissue constructs that are composed of a multiplicity of cell containing, discrete and separable modules, methods of fabricating same and uses thereof. The tissue construct... |
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US20120258162 |
CONTROLLED DELIVERY OF MOLECULES FROM A BIOINTERFACE
Disclosed are methods and apparatuses for delivery of bioactive molecules. The drug delivery systems include an implantable medical device which significantly reduces or suppresses adverse... |
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US20140127280 |
INTRAUTERINE DELIVERY SYSTEM FOR CONTRACEPTION
The invention relates to a method for contraception and for reducing menstrual problems and inducing amenorrhea, wherein an intrauterine delivery device is used for the controlled release of a... |
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US20120052108 |
MACROCYCLIC LACTONE DRUG DELIVERY SYSTEM
Disclosed is a drug delivery system from which a macrocyclic lactone can be released with a desirable zero order release profile. The system is based on the use of thermoplastic polymers, and... |
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US20110236457 |
Micronized Device for the Delivery of Biologically Active Molecules and Methods of Use Thereof
The invention provides micronized encapsulated cell therapy devices that are capable of delivering a biologically active molecule to the eye. Also provided are methods of using the same to deliver... |
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US20110027339 |
POROUS IMPLANTS AND STENTS AS CONTROLLED RELEASE DRUG DELIVERY CARRIERS
The common premise of synthetic implants in the restoration of diseased tissues and organs is to use inert and solid materials. Here, a porous titanium implant enables the delivery of... |
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US20140255462 |
Xenotransplant Compositions and Methods of Stroke Therapy
Disclosed are implant compositions and methods for treatment of neurological diseases of the central nervous system of a mammal. |
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US20100303887 |
DHA and PEDF, a Therapeutic Composition for Nerve and Retinal Pigment Epithelial Cells
The combination of pigment epithelium-derived factor (PEDF) and docosahexaenoic acid (DHA) has been discovered to act synergistically to enhance cell survival and decrease apoptosis in retinal... |
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US20110027188 |
Methods, Compositions and Devices for Treating Lesioned Sites Using Bioabsorbable Carriers
An implantable medical device is disclosed having a plurality of smaller particles contained in a plurality of larger particles and configured to be released from the larger particles when the... |
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US20090263454 |
ALPHA AND BETA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF PAIN AND / OR INFLAMMATION
Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist and at least one beta adrenergic agonist... |
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US20150030657 |
SMOOTH MUSCLE CELL CONSTRUCTS
The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or... |
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US20130039966 |
Bone Semi-Permeable Device
Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to... |
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US20130053938 |
SURFACE PROTECTIVE AND RELEASE MATRICES
A molecular plasma deposition (MPD) method in combination with an atomic layer deposition (ALD) procedure is used to produce amorphous, nonconformal thin metal film coatings on a variety of... |
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US20090047325 |
XENOTRANSPLANT FOR CNS THERAPY
Disclosed are compositions and methods for the xenotransplantation treatment of neurological diseases of the central nervous system of a mammal. |
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US20100098743 |
MEDICAL SUBSTITUTE MEMBRANE, USE THEREOF, AND METHOD FOR REPAIR OF MEMBRANE TISSUE IN LIVING BODY
An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not... |
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US20110104233 |
FLOWABLE COMPOSITION THAT SETS TO A SUBSTANTIALLY NON-FLOWABLE STATE
Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent,... |
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US20110008408 |
SOLID DOSAGE FORM FOR TREATING HEADACHES
A retrievable, sustained release, solid dosage form is provided for implanting into cranial bony canals and for prolonged release of an anesthetic, whereby treating neurovascular conditions, such... |
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US20100203101 |
BIO-MEMBRANE FOR TISSUE REGENERATION
A bio-membrane with angiogenic activity for implant in tissue regeneration and repair, including bone reconstruction and the repair of skin and soft tissue lesions is described, essentially... |
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US20070213835 |
PLASTIC IMPLANT IMPREGNATED WITH AN ANTIBIOTIC
A plastic device containing an effective amount of an antibiotic to minimize bacterial and/or fungal infection at the site of implantation is disclosed. |
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US20060293757 |
Osteograft treatment to promote osteoinduction and osteograft incorporation
The invention provides a bone implant, or osteograft, with improved retention of bioactive agents within the surface of the osteograft. Pits or pits formed within the surface of the osteograft... |
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US20110086083 |
IMPLANT DEVICES FOR MODULATING BIOACTIVE AGENT RELEASE PROFILES
Described herein are implant devices comprising at least one exposed biodegradable inner core surface, the inner core being surrounding partially by a membrane sheath which comprises a... |
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US20110045055 |
MEDICAL DEVICES CONTAINING THERAPEUTIC AGENTS
According to one aspect of the invention, implantable or insertable medical devices are provided which can delay release of one or more therapeutic agents for a predetermined time after... |
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US20050100580 |
Hydrophilic coated medical device
A medical device comprises a main body, a therapeutic agent and a radiation-curable hydrophilic coating. The hydrophilic coating allows for easy insertion of medical devices, which may include... |
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US20120165795 |
THERAPEUTIC AGENT RESERVOIR DELIVERY SYSTEM
A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least... |
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US20050079201 |
Implants with functionalized carbon surfaces
The invention relates to a method of producing medical implants having functionalized surfaces by providing a medical implant with at least one carbon-based layer on at least one part of the... |
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US20100074941 |
Absorbable, permeability-modulated barrier composites and applications thereof
Absorbable barrier composites are designed for modulated gas and water permeability depending on clinical use and are formed of at least two physicochemically distinct components, one of which is... |
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US20090248172 |
POROUS MEMBRANE COMPRISING A BIOCOMPATIBLE BLOCK-COPOLYMER
The invention relates to a membrane comprising a biocompatible block copolymer and has a porous structure with regularly distributed pores. A method for preparing said membranes is also provided. |
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US20070087032 |
Composition of cartilage therapeutic agents and its application
A cartilage therapeutic composition is developed for clinical transplantation into articulatio genu (knee joints) or ankle joints. It has clinical significance for symptomatic cartilage defects of... |
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US20090202608 |
Devices, formulations, and methods for delivery of multiple beneficial agents
The present invention relates to osmotic delivery devices, formulations, and methods for delivery of two or more beneficial agents. In one aspect, the present invention provides osmotic delivery... |
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US20070243227 |
Coatings for surgical staplers
A material with a first state and a second state is applied to a surgical stapler. The stapler is applied to tissue in a surgical field while the material is in the first state. Subsequently, the... |
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US20100330146 |
CONTACT LENSES FOR EXTENDED RELEASE OF BIOACTIVE AGENTS CONTAINING DIFFUSION ATTENUATORS
An appliance for the delivery of at least one bioactive agent to the eye has at least one diffusion attenuator within a hydrophilic or silicone-hydrogel contact lens. The bioactive agent can be a... |
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US20100034866 |
Fused stem cells useful for the treatment of diabetes and methods thereof
Methods disclosed include methods of treating T1DM, said method comprising delivering a therapeutic amount of β-MSC to a subject in need thereof. Further disclosed are fusion cells comprising and... |
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US20150024024 |
Cell Lines That Produce Prostaglandin F2 Alpha (PGF2A) And Uses Thereof
Cells and cell lines that are genetically modified to express the hCox-2 enzyme, which results in the upregulation of prostaglandin F2 alpha (PGF2a) on the cells have been obtained. Encapsulated... |
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US20070067045 |
Systems and methods for skin wrinkle removal
An implant is disclosed that reduces wrinkles. The implant may be in the shape of a cylinder with a constant or a varying cross-section and length. The implant contains a gel that has limited flow... |
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US20080286332 |
Implantable medical devices with a topcoat layer of phosphoryl choline acrylate polymer for reduced thrombosis, and improved mechanical properties
The present invention relates to implantable medical devices coated with phosphoryl choline acrylate polymer topcoat layer, an acrylate copolymer layer containing a therapeutic agent, and their... |
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US20100285090 |
METHODS AND COMPOSITIONS FOR REPAIR OF CARTILAGE USING AN IN VIVO BIOREACTOR
Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not... |
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US20060029640 |
Medical devices with surface modification for regulating cell growth on or near the surface
High oxidation state metal-containing compounds are formed on or applied to the surfaces of medical devices. These compounds can cause cytostatic, cytotoxic, and anti-proliferative effects to the... |
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US20140248328 |
Methods of treating amniotic membranes using supercritical fluids and compositions and apparatuses prepared therefrom
A method of sterilizing compositions prepared from amniotic membrane tissues may include harvesting placental tissue, separation of amniotic membrane tissue, and treatment of the amniotic membrane... |
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US20120141573 |
Cell Lines That Secrete Anti-Angiogenic Antibody-Scaffolds and Soluble Receptors and Uses Thereof
The invention provides nucleic acid and polypeptide sequences encoding antibody based scaffolds such as full antibodies, antibody Fab fragments, single chain antibodies, soluble VEGF receptor-Fc... |
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US20100098742 |
FABRICATION OF TISSUE LAMINA USING MICROFABRICATED TWO-DIMENSIONAL MOLDS
Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick structures, such as liver tissue is provided. Tissue lamina... |
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US20060051398 |
Method of preventing post-operative surgical adhesion
A method for preventing adhesion using a co-polyester comprising the reaction product of a polycondensation polyester and at least one lactone, wherein the polycondensation polyester comprises the... |
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US20070134293 |
Devices and methods for the delivery of blood clotting materials to bleeding wounds
An apparatus for promoting the clotting of blood comprises a receptacle, at least a portion of which is defined by a mesh having openings therein, and particles of clay retained in the receptacle.... |
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US20070207186 |
Tear and abrasion resistant expanded material and reinforcement
The present invention is a more durable expanded material that enables thinner wall thicknesses and a more flexible reinforcement suitable for stenting. The present invention is especially useful... |
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US20120021039 |
EXPRESSION OF NEUROPEPTIDES IN MAMMALIAN CELLS
The present application relates to expression constructs capable of securing correct processing of neuropeptides upon expression in mammalian cells, and to mammalian cells secreting correctly... |
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US20130108680 |
IMPLANTABLE TIZANIDINE COMPOSITIONS AND METHODS OF TREATMENT THEREOF
A method of treating the symptoms of spasticity comprises implanting a reservoir-based drug delivery composition into a subject to systemically deliver a therapeutically effective amount of... |
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US20050118229 |
Implantable drug delivery device for sustained release of therapeutic agent
An implantable drug-delivery device that utilizes a nanopore diffusion membrane in combination with a microporous hydration membrane for achieving long-term, zero-order release of a therapeutic... |
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US20050273177 |
Prosthetic device having drug delivery properties
A prosthesis includes suitable mechanical properties needed to open and maintain a vessel, duct, tract, or organ in a mammalian body. The prosthesis includes a pharmaceutical coating containing a... |
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US20100124564 |
ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human... |
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US20060029639 |
Biodegradable substrate, prosthetic material for tissue regeneration, and cultured tissue
A biodegradable substrate usable as a prosthetic material (i.e., for tissue regeneration) facilitates the invasion of cells into a substrate and has a thick structure similar to woven fabrics. The... |