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US20130059009 COMPOSITIONS AND METHODS FOR PRODUCING ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS WITH SYNTHETIC NANOCARRIERS  
Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that are produced from combining itDCs with antigen in particulate form, as well as related compositions and methods.
US20130058978 INDUCED TOLEROGENIC DENDRITIC CELLS FOR INDUCING REGULATORY B CELLS  
Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) that generate regulatory B cells, as well as related compositions and methods.
US20130058977 COMPOSITIONS AND METHODS RELATED TO INDUCED TOLEROGENIC DENDRITIC CELLS EXTERNALLY LOADED WITH MHC CLASS I-RESTRICTED EPITOPES  
Disclosed are induced tolerogenic dendritic cells (itDCs) produced by combining itDCs with externally loadable MHC Class I-restricted epitopes, as well as related compositions and methods.
US20130058976 ALLERGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS FOR ALLERGY THERAPY  
Disclosed are allergen-specific induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods.
US20130058975 ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE ANTIBODY RESPONSES  
Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing undesired humoral immune responses, as well as related compositions and methods.
US20130058974 ANTIGEN-SPECIFIC INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE CYTOTOXIC T LYMPHOCYTE RESPONSES  
Disclosed are antigen-specific induced tolerogenic dendritic cells (itDCs) for reducing CD8+ T cell immune responses, as well as related compositions and methods.
US20130058970 INDUCED TOLEROGENIC DENDRITIC CELLS TO REDUCE SYSTEMIC INFLAMMATORY CYTOKINES  
Disclosed are induced tolerogenic dendritic cells (itDCs), as well as related compositions and methods, for reducing systemic inflammatory cytokines.
US20080026011 Immunostimulatory nucleic acid molecules  
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a...
US20070202133 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION  
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
US20160030289 MANUFACTURE OF PEANUT FORMULATIONS FOR ORAL DESENSITIZATION  
The present application relates to a method for managing the development and manufacturing process of a therapeutically effective formulation. Peanut proteins are characterized from peanut flour...
US20120201807 MODULATION OF IMMUNOSTIMULATORY PROPERTIES OF OLIGONUCLEOTIDE-BASED COMPOUNDS BY UTILIZING MODIFIED IMMUNOSTIMULATORY DINUCLEOTIDES  
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and...
US20160206731 Methods, Articles and Kits for Allergic Desensitization via the Oral Mucosa  
Compositions and methods of use for desensitizing a subject to an allergen via regions of the oral mucosa are provided.
US20140134129 RNA Vaccines  
A RNA vaccine containing a RNA molecule encoding an allergen or derivative thereof, in which the allergen is an allergen of Alnus glutinosa, Alternaria alternata, Ambrosia artemisiifolia, Apium...
US20110070267 PACKAGED VIRUS-LIKE PARTICLES FOR USE AS ADJUVANTS: METHOD OF PREPARATION AND USE  
The invention relates to the finding that virus like particles (VLPs) can be loaded and packaged, respectively, with DNA oligonucleotides rich in non-methylated C and G (CpGs). If such CpG-VLPs...
US20080213306 Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines  
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
US20080193437 IMMUNOSTIMULATORY OLIGONUCLEOTIDE MULTIMERS  
The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer...
US20130295139 ADJUVANT COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSES TO POLYNUCLEOTIDE-BASED VACCINES  
The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of...
US20090252762 NOVEL PROTEOSOME-LIPOSACCHARIDE VACCINE ADJUVANT  
An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The...
US20050008579 Deactivants for dust mite allergens  
Der-f and/or Der-p dust mite allergens are deactivated by an amount of L-ascorbic acid. Spray compositions comprise said deactivant in aqueous form or in aerosol form with propellant and optional...
US20170000880 MILK-BASED PROTEIN HYDROLYSATES AND INFANT FORMULAE AND NUTRITIONAL COMPOSITIONS MADE THEREOF  
A composition including protein hydrolysates derived from milk is obtained by the treatment of enzymes derived from microorganisms. A trypsin-like enzyme and a chymotrypsin-like enzyme are used....
US20120301498 CONTROLLED RELEASE OF IMMUNOSUPPRESSANTS FROM SYNTHETIC NANOCARRIERS  
Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen...
US20070065467 Immunostimulatory nucleic acid molecules for activating dendritic cells  
The present invention relates generally to methods and products for activating dendritic cells. In particular, the invention relates to oligonucleotides which have a specific sequence including at...
US20160324955 METHOD OF PREVENTING ALLERGIES  
The present invention relates to compositions and methods for preventing allergy in a subject. Particularly, the present invention relates to epicutaneous prevention of allergies in children. The...
US20140186403 PEPTIDE FOR VACCINE  
The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or...
US20120315264 ZWITTERIONIC IMMUNOMODULATORS FOR THE TEATMENT OF ASTHMA AND ALLERGY  
Methods and products for treating and protecting against asthma and allergic conditions are provided. The methods and products are related to certain naturally occurring and synthetic zwitterionic...
US20160044900 ANIMAL MODELS AND THERAPEUTIC MOLECULES  
The invention discloses methods for the generation of chimaeric human-non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20100291109 TLR AGONIST (FLAGELLIN)/CD40 AGONIST/ANTIGEN PROTEIN AND DNA CONJUGATES AND USE THEREOF FOR INDUCING SYNERGISTIC ENHANCEMENT IN IMMUNITY  
Fusion proteins and DNA conjugates are disclosed which contain a TLR/CD40/agonist and optional antigen combination. The use of these protein and DNA conjugates as immune adjuvants and as vaccines...
US20080044438 Yeast Cell Particles As Oral Delivery Vehicles For Antigens  
Provided herein are yeast cell particles (YCPs) comprising an antigen for use, e.g., as an oral, inhalation, mucosal or parenteral delivery vehicle for the antigen. A YCP may be obtained from a...
US20160243221 COMPOSITIONS AND METHODS FOR TOLERIZING CELLULAR SYSTEMS  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of molecules for tolerizing cellular systems.
US20150182563 CO-PROCESSING METHODS FOR HONEY NASAL RINSE PRODUCTION  
Novel nasal rinse compositions are disclosed. The nasal rinse comprises a dried particulate composed of honey and a carrier. The composition may be a co-processed composition wherein the honey and...
US20140377311 METHOD OF PREVENTING ALLERGIES  
The present invention relates to compositions and methods for preventing allergy in a subject. Particularly, the present invention relates to epicutaneous prevention of allergies in children. The...
US20140271883 CURCUMINOIDS AND METABOLITES THEREOF FOR TREATING ALLERGIC NASAL CONDITIONS  
A pharmaceutical composition for nasal administration comprising: a nanoemulsified curcumin component; a liquid medium for the curcumin component; and a pharmaceutically acceptable excipient. The...
US20110142867 IMMUNOTHERAPEUTIC METHODS AND SYSTEMS  
Methods for desensitising an individual to a selected polypeptide antigen are provided. The methods entail administration of T cell epitope containing peptides from a polypeptide antigen in such a...
US20100247577 TR1 CELLS, MESENCHYMAL STEM CELLS AND USES THEREOF  
The present invention relates to compositions comprising Tr1 cells and mesenchymal stem cells and methods for treating an autoimmune disease, an allergic disease or an inflammatory disease.
US20100092486 MODULATION OF MYELOID DIFFERENTATION PRIMARY RESPONSE GENE 88 (MYD88) EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES  
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of MyD88. The compositions comprise antisense oligonucleotides targeted to nucleic...
US20140207105 Methods for Effectively and Rapidly Desensitizing Allergic Patients  
Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by...
US20060216283 Inhibition of secretion from non-neuronal cells  
A method of treatment of disease by inhibition of cellular secretory processes is provided. The method has particular application in the treatment of diseases dependent upon the exocytotic...
US20120076831 COMPOSITIONS AND METHODS FOR INDUCTION OF ANTIGEN-SPECIFIC TOLERANCE  
The present invention utilizes carrier particles to present antigen peptides and proteins to the immune system in such a way as to induce antigen specific tolerance. The carrier particle is...
US20140127298 MUCOSOMAL ALLERGEN-SPECIFIC IMMUNOTHERAPY WITH INITIAL DOSING AFTER START OF POLLEN SEASON  
The present invention relates to mucosal allergen-specific immunotherapy with a seasonal allergen, wherein the therapy is initiated after start of the pollen season of the seasonal allergen....
US20100111936 Modulation of Toll-Like Receptor 4 Expression by Antisense Oligonucleotides  
Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR4. The compositions comprise antisense oligonucleotides targeted to nucleic...
US20080286311 Protein Allergen Derivatives  
The present invention relates to a method for producing derivatives of wild-type protein allergens with reduced allergenic activity, characterized in by the following steps: providing a wild-type...
US20110243994 STABILIZED PHARMACEUTICAL COMPOSITION, LIQUID PREPARATION OF STABILIZED PHARMACEUTICAL COMPOSITION, FILM-FORM PREPARATION, AND METHOD FOR PRODUCING FILM-FORM PREPARATION  
The present invention provides a stabilized pharmaceutical composition that enables the production of a preparation for desensitization therapy useful as an agent for the prevention or treatment...
US20090155351 Solid Vaccine Formulation  
The invention relates to a solid vaccine formulation adapted for mucosal administration comprising at least one antigen as active substance, wherein the formulation comprises a lyophilisate of a...
US20060024334 Immunotherapeutic methods and systems  
Methods for desensitising an individual to a selected polypeptide antigen are provided. The methods entail administration of T cell epitope containing peptides from a polypeptide antigen in such a...
US20110033416 RNA Vaccines  
The present invention relates to an RNA vaccine comprising an RNA molecule encoding an allergen or derivative thereof and uses thereof.
US20090324650 Method for The Production of Hydrolyzed Allergen  
A method for the production of a purified extract of natural allergens comprising the steps of a) extracting a natural source of allergens comprising allergenic proteins to form an extract,b)...
US20080279785 Novel synthetic agonists of toll-like receptors containing CG dinucleotide modifications  
The invention relates to the therapeutic use of oligonucleotides as immune modulatory agents in immunotherapy applications. More particularly, the invention provides immune modulatory...
US20140010845 SUPPRESSION OF A HYPERSENSITIVITY IMMUNE RESPONSE WITH UNRELATED ANTIGEN DERIVED FROM ALLERGEN SOURCE MATERIAL  
The present invention relates to the treatment of a hypersensitivity immune response, such as allergic rhinitis or asthma, via bystander suppression by use of an antigen unrelated to the allergen...
US20120177701 COMPOSITIONS COMPRISING IMMUNOSTIMULATORY NUCLEIC ACIDS AND RELATED METHODS  
Immunostimulatory compositions include an isolated nucleic acid molecule that includes one or more nucleotide sequences from 5′- or 3′-terminal regions of positive-sense, single-stranded RNA virus...
US20060121064 Method of preventive treatment of allergy by mucosal administration of an allergy vaccine  
The present invention relates to a method of preventive treatment of allergy to an allergen in a subject comprising administering an allergy vaccine containing the allergen as active substance to...

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