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US20090017052 |
Methods of determining lethality of pathogens and malignancies involving replikin peak genes
The present invention provides methods of identifying lethal, virulent and rapidly replicating viruses, organisms, and malignancies comprising comparing Replikin concentrations among different... |
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US20130052229 |
COMPOUNDS AND METHODS FOR DIAGNOSIS AND IMMUNOTHERAPY OF TUBERCULOSIS
Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one... |
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US20110293723 |
SYNTHETIC NANOCARRIER COMBINATION VACCINES
Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are... |
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US20110052637 |
PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS VACCINES
The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as vaccines. |
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US20120045476 |
LIVE ATTENUATED MYCOPLASMA STRAINS
The present invention provides live, attenuated Mycoplasma bacteria that exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase,... |
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US20160058860 |
VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant... |
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US20110206715 |
MOLECULAR DIFFERENCES BETWEEN SPECIES OF THE M. TUBERCULOSIS COMPLEX
Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to... |
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US20110117119 |
NOVEL COMPOSITIONS AND METHODS
The present invention is directed to a polypeptide which comprises: (i) an Rv3616c protein sequence; (ii) a variant of an Rv3616c protein sequence; or (iii) an immunogenic fragment of an Rv3616c... |
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US20070292454 |
Therapeutic calcium phosphate particles and methods of manufacture and use
Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release... |
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US20140037700 |
Composition and Method for Enhancing an Immune Response
Disclosed are methods and compositions for treating or preventing microbial infections. |
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US20090004226 |
Fusion proteins of mycobacterium tuberculosis
The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The... |
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US20160074494 |
CANCER THERAPY
The present invention resides in the preparation of a medicament to aid in the treatment of cancer. According to the invention there is a whole cell Mycobacterium for use in the treatment of... |
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US20120244182 |
USE OF TRYPTANTHRIN COMPOUNDS FOR IMMUNE POTENTIATION
The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance... |
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US20130115244 |
Immunogenic Substances Comprising a Polyinosinic Acid - Polycytidilic Acid Based Adjuvant
The present invention provides a polynucleotide adjuvant (PICKCa) composition and methods of use in eliciting an immune response, in particular a mucosal immune response. The polynucleotide... |
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US20120251490 |
Compositions And Methods For Immunotherapy
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become... |
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US20110311478 |
Combinatorial Methods For Treating Cellular Proliferative Disorders And Immune Deficiencies Using Salicinium
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become... |
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US20110311477 |
Infusion Treatment Methods And Compositions Using Salicinium For Treating Cellular Proliferative Disorders And Immune Deficiencies
The present invention provides novel immunotherapeutic compositions and methods useful for treating or preventing microbial infections, weakened immune systems, diseases in which cells have become... |
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US20160151475 |
Bacterial Ribonucleic Acid Cell Wall Compositions and Methods of Making and Using Them
The present invention relates to novel bacterial and mycobacterial compositions containing RNA and cell walls, and methods for making and using these compositions. These compositions have immune... |
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US20110206712 |
TUBERCULOSIS RV2386C PROTEIN, COMPOSITIONS AND USES THEREOF
The present invention is directed to a polypeptide which comprises: (i) an Rv2386c protein sequence; (ii) a variant of an Rv2386c protein sequence; or (iii) an immunogenic fragment of an Rv2386c... |
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US20140287043 |
COMPOSITIONS AND METHODS FOR STABILIZATION OF ACTIVE AGENTS
Provided herein are methods and compositions for stabilization of active agents. The active agents are distributed, mixed or embedded in a silk fibroin matrix, thereby retaining the bioactivity of... |
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US20090263427 |
Vaccines for mycoplasma bovis and methods of use
The invention of novel, effective vaccines against Mycoplasma bovis for use in cattle is described. These vaccines demonstrate no undesirable side effects and protect against M. bovis related... |
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US20070212329 |
Vaccine Compositions Comprising An Interleukin 18 And Saponin Adjuvant System
This invention relates to a combination therapy that finds utility in the treatment or prophylaxis of infectious diseases, cancers, autoimmune diseases and related conditions. In particular, the... |
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US20070141086 |
Use of antibiotics as vaccine adjuvants
The invention describes an adjuvant composition comprising an antimicrobial agent, in particular an azalide, wherein the antimicrobial agent acts as an adjuvant. More particularly, the adjuvant... |
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US20050175630 |
Immunogenic compositions and methods of use thereof
The present invention provides an immunogenic composition comprising lethally irradiated bacteria formulated for mucosal delivery. The present invention further provides methods of preparing a... |
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US20080014281 |
Chitin Micro-Particles As An Adjuvant
A composition and method for the preparation of micro-particles of chitin (a naturally occurring polymer of N-acetyl-D-glucosamine), the characterization of chitin micro-particles as an immune... |
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US20110268764 |
IMMUNE RESPONSE INDUCING PREPARATIONS
The present invention provides a pharmaceutical composition with an adjuvant based on an apathogenic virus, together with an antigen. The adjuvant has a natural or through genetical engineering... |
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US20100047286 |
Recombinant BCG strains with enhanced ability to escape the endosome
Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered... |
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US20070009545 |
Mycoplasma subunit vaccine
The present invention relates i.a. to vaccines for combating Mycoplasma infection, to mycoplasmal L-α-glycerophosphate oxidase for use in such vaccines, to the use of mycoplasmal... |
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US20050202044 |
Immune responses using compositions containing stress proteins
The present invention relates to a vaccine for inducing an immune response to an antigen in a vertebrate (e.g., mammal) comprising an antigen and all or a portion of a stress protein or all or a... |
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US20080145383 |
Method for Solubilizing Peptide Mixtures
Described is a method for making a pharmaceutical preparation comprising the solubilisation of a peptide mixture, characterized in that the peptide mixture is solubilized by an aqueous solution... |
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US20170181988 |
METHODS FOR THE TREATMENT OF BLADDER CANCER
Methods of treating bladder cancer using adapalene are disclosed herein. Adapalene can be administered as part of a comprehensive treatment program, which can also include chemotherapy,... |
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US20110274712 |
ANTIGENIC COMPOSITIONS
The invention relates to antigenic compositions and to methods for immunising animals using same. The antigenic compositions comprises a lipid formulation most usually in solid form, and at least... |
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US20140356397 |
Immunogenic Treatment Of Cancer
The present invention provides an immunomodulator for use in the treatment and/or control of a neoplastic disease in a patient intended to undergo immunogenic cell death therapy simultaneously,... |
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US20110171259 |
Novel Compositions and Adjuvants
The present invention is directed toward adjuvants that effect an innate and/or a specific immune response. The adjuvants contain at least one lipoprotein, such as Lip, Lip fragments or Lip... |
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US20140356395 |
METHODS AND MATERIALS FOR PRODUCING IMMUNE RESPONSES AGAINST POLYPEPTIDES INVOLVED IN ANTIBIOTIC RESISTANCE
This document relates to methods and materials for producing immune responses against polypeptides involved in antibiotic resistance. For example, vaccines against polypeptides involved in... |
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US20110020404 |
DIAGNOSTIC METHOD AND KIT
The invention relates to methods for diagnosis of tuberculosis in an animal, the methods comprising determining the presence or absence of, or an immune response to a group of antigens comprising... |
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US20080171002 |
Products For Receptor Mediated Activation And Maturation Of Monocyte-Derived Dendritic Cells By A Phosphorylated Glucomannane Polysaccharide
Phosphorylated glucomannan polysaccharide compositions are shown to effectively enhance healthy immune function. Dosage forms including pills, sprays, functional foods and cosmetics may achieve... |
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US20080248094 |
VACCINE ADJUVANT PROPERTIES OF LIPSOMES FORMED AT ELEVATED TEMPERATURES FROM THE POLAR CHLOROFORM EXTRACTABLE LIPIDS FROM MYCOBACTERIUM BOVIS
The invention relates to a liposome comprising a chloroform soluble and extractable total polar lipid of Mycobacterium spp, particularly a chloroform soluble extractable total polar lipid of... |
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US20140065096 |
CANCER THERAPY BY EX VIVO ACTIVATED AUTOLOGOUS IMMUNE CELLS
Disclosed are therapeutic methods for ex-vivo activation of immune cells from a cancer patient for the purpose of inducing tumor regression and/or suppressing metastasis and/or tumor recurrence.... |
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US20080311159 |
Methods and Means for Diagnostics, Prevention and Treatment of Mycobacterium Infections and Tuberculosis Disease
The invention identifies a narrow subset of Mycobacterium latency associated antigens and or epitopes that are capable of eliciting an immune response in vivo and in vitro in a mammal. The... |
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US20070298093 |
Synergistic Liposomal Adjuvants
The present invention relates to liposome, mixtures or liposomes and liposomal compositions comprising at least two different adjuvants and a therapeutic agent, their production and use for the... |
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US20070184073 |
TB diagnostic based on antigens from M. tuberculosis
The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides... |
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US20070134273 |
Composition and method for the treatment of carcinoma
The present invention relates to compositions and methods useful for treating a carcinoma or viral infection in mammals, including humans. The methods and compositions typically comprise use of an... |
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US20160175420 |
IMMUNOGENIC COMPOSITIONS AGAINST TUBERCULOSIS
Methods of preparing mutants of Mycobacterium tuberculosis with one or more disrupted genes are presented, where the disrupted genes include ctpV, rv0990c, rv0971c, and/or rv0348. Compositions... |
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US20090123495 |
Immune Response Inducing Preparations
The present invention provides a pharmaceutical composition with an adjuvant based on an apathogenic virus, together with an antigen. The adjuvant has a natural or through genetical engineering... |
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US20110064723 |
Formulation for room temperature stabilization of a live attenuated bacterial vaccine
This invention provides methods and compositions for stabilizing proteins and vaccines in dried formulations. In particular, a cavitation method and compositions of preparing a dried vaccine are... |
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US20060024332 |
Recombinant ESAT-6:CFP-10 fusion protein useful for specific diagnosis of tuberculosis
The fusion protein rESAT-6:CFP-10 is useful for differentiating infection of an animal with Mycobacterium bovis from exposure of the animal to other species of Mycobacteria, especially M. avium... |
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US20150165016 |
POLYSACCHARIDE COMPOSITIONS AND METHODS OF USE
The invention relates, in part, to the use of compositions of poly N-acetylated glucosamine (PNAG) and antibodies specific to PNAG in the prevention and treatment of infections by certain... |
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US20130330375 |
Therapeutic Cancer Vaccine
The present invention relates to vaccine(s) comprising cancer cells expressing antigen(s), excipients, optionally adjuvant wherein the said antigen(s) is expressed on contacting the said cancer... |
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US20110189208 |
TB VACCINE
The invention relates to a vaccine useful in therapy and prevention of mycobacterial infections. |