Matches 1 - 50 out of 142 1 2 3 >


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US20110293723 SYNTHETIC NANOCARRIER COMBINATION VACCINES  
Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are...
US20120034256 HCV VACCINES AND METHODS FOR USING THE SAME  
Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1 a/1 b NS3 and NS4A. Pharmaceutical...
US20120093863 HCV VACCINES AND METHODS FOR USING THE SAME  
Improved anti-HCV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus HCV genotype 1a, including for example, NS4B, NS5A and...
US20120064169 MULTIPLE ANTIGEN DELIVERY SYSTEM USING HEPATITIS E VIRUS-LIKE PARTICLE  
This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems.
US20110091495 HCV E2 CONSTRUCT COMPOSITIONS AND METHODS  
A construct comprising the ectodomain of the Hepatitis C Virus (HCV) E2 sequence and a mammalian expression system therefor is disclosed. The construct comprises a CMV promoter, prolactin signal...
US20140065100 Compositions and Methods for Cancer Immunotherapy  
The invention relates to immunotherapeutic compounds and to methods for stimulating an immune response in a subject individual at risk for developing cancer, diagnosed with a cancer, in treatment...
US20120003277 NANOEMULSION VACCINES  
The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more...
US20140193459 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
US20130058997 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
US20140105931 HEPATITIS C VIRUS PARTICLES, VACCINES, COMPOSITIONS AND METHODS RELATED THERETO  
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit...
US20130224246 MODIFIED HEPATITIS C VIRUS PROTEINS  
A composition comprising a hepatitis C virus (HCV) Envelope 2 (E2) polypeptide including a receptor binding variant, wherein the polypeptide is modified to comprise: (i) a cysteine mutated or...
US20130004529 VACCINES AND METHODS FOR USING THE SAME  
Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those...
US20150017207 Methods and Compositions for Activation of Innate Immune Responses Through RIG-I Like Receptor Signaling  
Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid...
US20130344106 Methods and Compositions for Improving Immune Response by a Nutraceutical Antioxidant  
The present invention provides a new means of restoring the immune system in aging and immunocompromised individuals using an antioxidant nutraceutical. The nutraceutical stimulates the aging...
US20130202554 COMPOSITIONS AND METHODS THAT ENHANCE AN IMMUNE RESPONSE  
Disclosed herein are isolated nucleic acids, compositions of isolated nucleic acids, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune...
US20130171103 METHODS FOR TREATING VIRAL CONDITIONS  
Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are...
US20130095134 STABILIZED VIRUS LIKE PARTICLES HAVING ENHANCED MUCOSAL IMMUNOGENICITY  
This disclosure relates to compositions and methods for inducing immune response. Specifically, the disclosure relates to a composition comprising a subunit antigen stabilized by a...
US20120251572 HEPATITIS C VIRUS VACCINE COMPOSITION  
A combination of an HCV antigen for inducing an antibody having the activity of inhibiting HCV infection and an optimum adjuvant is discovered, so as to provide an effective HCV vaccine...
US20090060875 HCV Vaccines for Chronic HCV Patients  
The invention discloses the use of polycationic compounds for the preparation and manufacturing of medicaments, pharmaceutical compositions, especially vaccines for the treatment of patients with...
US20120258135 IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS  
The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one...
US20110256098 IMMUNOTHERAPY FOR CHRONIC HEPATITIS C VIRUS INFECTION  
Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic...
US20140056943 IMMUNO-STIMULANT COMBINATION FOR PROPHYLAXIS AND TREATMENT OF HEPATITIS C  
The present invention relates to an immuno-stimulant combination for prophylaxis and treatment of hepatitis C, characterised in that it comprises: a TLR3 agonist, a CD40 agonist and the NS3...
US20120014990 VACCINATION METHODS  
In one aspect, a method of treating cancer in a mammal is provided. The method comprises administering to the mammal an oncolytic vector that expresses a tumour antigen to which the mammal has a...
US20110002961 Interleukin 12 paracrine gene delivery enhanced CTL immunotherapy  
A method of treating a patient with a disease wherein the patient contains diseased cells which cells contain antigens for identification and which cells are capable of presenting at least part of...
US20110293658 USE OF INKT OR TLR AGONISTS FOR PROTECTING AGAINST OR TREATING A DISEASE SUCH AS ACUTE INFECTION OR CANCER  
A method of protecting a mammalian subject against, or treating, a disease, wherein the mammalian subject has elevated numbers and/or activities of MDSC comprising administering to the subject a...
US20140302092 MUTANT REPLICON DERIVED FROM GENOME OF HEPATITIS C VIRUS J6CF STRAIN  
A nucleic acid includes the 5′ untranslated region, a virus protein-coding region including the NS3 protein coding sequence, the NS4A protein coding sequence, the NS4B protein coding sequence, the...
US20100247571 METHODS AND COMPOSITIONS FOR IMMUNIZATION AGAINST VIRUS  
Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral...
US20140023683 IDENTIFICATION OF TRANSMITTED HEPATITIS C VIRUS (HCV) GENOMES BY SINGLE GENOME AMPLIFICATION  
This invention provides methods for identifying HCV genomes and more specifically, methods for identifying nucleotide sequence of viral structural proteins at the time of HCV viral transmission....
US20100040576 Modified Oligonucleotides For The Treatment Of Hepatitis C Infection  
The invention relates to compositions and methods related to the treatment of viral infection. In some embodiments, the invention relates to the treatment of hepatitis C viral infection. In...
US20120171244 MUCOSAL BOOSTING FOLLOWING PARENTERAL PRIMING  
Mucosal immunization using one or more antigens following parenteral administration of the same or different antigens is described.
US20140186292 DEFECTIVE RIBOSOMAL PRODUCTS IN BLEBS (DRIBBLES) AND METHODS OF USE TO STIMULATE AN IMMUNE RESPONSE  
Methods are disclosed for producing defective ribosomal products (DRiPs) in blebs (DRibbles) by contacting cells with a proteasome inhibitor, and in some examples also an autophagy inducer,...
US20070212329 Vaccine Compositions Comprising An Interleukin 18 And Saponin Adjuvant System  
This invention relates to a combination therapy that finds utility in the treatment or prophylaxis of infectious diseases, cancers, autoimmune diseases and related conditions. In particular, the...
US20120251537 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20140161826 NON-SELF T-CELL EPITOPE FUSED TO AN ANTIBODY THAT RECOGNISES A TUMOUR-SPECIFIC CELL-SURFACE RECEPTOR AND USES THEREOF  
A first composition comprising a ligand part being able to specifically bind to a target, the target being on a diseased cell of an organism, and an epitope part having a non-self epitope, or...
US20150258189 HEPATITIS C VIRUS PARTICLES FORMATION PROMOTER, AND METHOD OF PRODUCING HEPATITIS C VIRUS PARTICLES  
A HCV particle formation promoter is capable of promoting formation of HCV particles in culture cells, and a method enhances production of HCV particles. A method evaluates an anti-HCV agent...
US20100310605 ANTI-HCV VACCINE AND PREPARATION METHODS AND USES THEREOF  
An anti-HCV vaccine, which is prepared through recombination of an NS gene in series, including NS3/NS4 and NS4/NS5, with an adenovirus vector. The preparation methods and uses of the anti-HCV...
US20110086006 HCV NS3-NS4 Protease Resistance Mutants  
The present invention is directed to mutants of HCV NS3/4A protease. More particularly, the present invention identifies mutant of HCV NS3/4A protease that are resistant to drug treatment.
US20110014209 RECOMBINANT HCV E2 GLYCOPROTEIN  
The invention provides modified hepatitis C virus (HCV) E2 glycoproteins comprising the HCV-E2 receptor-binding domain (RBD) including the HVR1, HVR2 and igVR variable regions wherein in at least...
US20110177110 COMPOSITIONS COMPRISING CATIONIC MICROPARTICLES AND HCV E1E2 DNA AND METHODS OF USE THEREOF  
Immunogenic HCV E1E2809 DNA compositions and methods of using the same are described. The compositions comprise HCV E1E2809 DNA adsorbed to cationic microparticles, such as...
US20070298093 Synergistic Liposomal Adjuvants  
The present invention relates to liposome, mixtures or liposomes and liposomal compositions comprising at least two different adjuvants and a therapeutic agent, their production and use for the...
US20100150963 Yeast-Based Therapeutic for Chronic Hepatitis C Infection  
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
US20120251571 RNASE L-MEDIATED CLEAVAGE PRODUCTS AND USES THEREOF  
The invention is directed to one or more RNase L mediated cleavage products. In particular aspects, the RNase L mediated cleavage products are RNase L mediated cleavage products of a virus,...
US20100047231 Immuno-Stimulant Combination for Prophylaxis and Treatment of Hepatitis C  
The present invention relates to an immuno-stimulant combination for prophylaxis and treatment of hepatitis C, characterised in that it comprises: a TLR3 agonist, a CD40 agonist and the NS3...
US20090258033 HCV E1E2 vaccine compositions  
HCV E1E2 compositions comprising E1E2 antigens, submicron oil-in-water emulsions and/or immunostimulatory nucleic acid sequences are described. The compositions can be used in methods of...
US20100322972 HCV Vaccines For Chronic HCV Patients  
The use of polycationic compounds for the preparation and manufacturing of medicaments, pharmaceutical compositions, especially vaccines for the treatment of patients with HCV chronic infections...
US20100316669 VACCINE FORMULATION POTENTIATED BY THE COMBINATION OF DNA AND AN ANTIGEN  
Formulation of vaccine antigens, containing as main components: a-) one or several DNA expressing one or several proteins in the immunized individuals and b-) a viral antigen, in appropriate...
US20090311288 IMIDAZOQUINOXALINE COMPOUNDS AS IMMUNOMODULATORS  
The invention proyides novel compositions comprising imidazoquinoxaline compounds of formula (I) and analogs thereof. Also provided are methods of administering the compositions in an effective...
US20100215696 EFFICIENTLY REPLICABLE HEPTITIS C VIRUS MUTANT, A HEPTITIS C VIRUS MUTANT COMPRISING REPORTER GENE, A METHOD OF PREPARING OF HCV VACCINE USING THE SAME AND A METHOD OF SCREENING ANTI HCV COMPOSITION USING THE SAME  
The present invention relates an efficiently replicating a modified hepatitis virus (HCV) mutant, and a modified HCV further comprising reporter gene, a method of preparing HCV vaccine using the...
US20050002967 Product and method for obtaining specific immunisation with one or more antigens  
The invention provides means and methods for vaccinating an animal or a human to obtain therein an immune response against at least one antigen, comprising different vaccine compositions for...
US20100172937 ENVELOPED VIRUS NEUTRALIZING COMPOUNDS  
Methods for reducing infectivity by providing an enveloped virus neutralizing compound (EVNC) are provided. Methods of preparing a vaccine, vaccine formulations, and methods of immunizing a...

Matches 1 - 50 out of 142 1 2 3 >