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US20160279227 ATTENUATED NEGATIVE STRAND VIRUSES WITH ALTERED INTERFERON ANTAGONIST ACTIVITY FOR USE AS VACCINES AND PHARMACEUTICALS  
The present invention relates, in general, to attenuated negative-strand RNA viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated...
US20160076055 LENTIVIRAL VECTORS PSEUDOTYPED WITH A SINDBIS VIRUS ENVELOPE GLYCOPROTEIN  
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle...
US20110064763 LENTIVIRAL VECTORS PSEUDOTYPED WITH A SINDBIS VIRUS ENVELOPE GLYCOPROTEIN  
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle...
US20050266550 TC-83-derived alphavirus vectors, particles and methods  
The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression...
US20120328650 MODIFIED VACCINIA ANKARA VIRUS VARIANT  
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus, wherein the MVA-BN virus, or a derivative thereof, induces at least substantially the same...
US20120244113 IMMUNOGENIC COMPOSITION AND METHODS  
A method of inducing an antigen-specific immune response in a mammalian subject includes the steps of administering to the subject an effective amount of a first composition comprising a DNA...
US20100221276 CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)  
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences,...
US20100215690 CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)  
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences,...
US20090191237 Methods and reagents for vaccination which generate A CD8 T cell immune response  
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes...
US20080311149 DNA-transfection system for the generation of infectious influenza virus  
The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal...
US20080311148 DNA-transfection system for the generation of infectious influenza virus  
The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal...
US20070071770 Recombinant MVA virus, and the use thereof  
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the...
US20070071769 Recombinant MVA virus, and the use thereof  
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the...
US20050249707 Herpes virus vectors for dendritic cells  
An attenuated herpes virus capable of efficiently infecting a dendritic cell without preventing antigen processing occurring within the infected cell. The attenuated herpes virus and dendritic...
US20050214318 Immunogenic composition and method of developing a vaccine based on fusion protein  
The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to HIV fusion protein. The present...
US20050118191 Optimization of gene sequences of chimeric virus-like particles for expression in insect cells  
Chimeric virus-like particles that exhibit conformational antigenic epitopes capable of eliciting neutralizing antibodies are disclosed herein. The chimeric virus-like particles of the invention...
US20050112139 Immunogenic composition and method of developing a vaccine based on factor H binding sites  
An immunogenic composition able to provide an immune response to Human Complement Factor H binding on one or more HIV glycoproteins is disclosed, which is characterized by at least one binding...
US20150238593 MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG AND POL GENES  
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
US20140271677 Newcastle Disease Viruses and Uses Thereof  
Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described...
US20120294890 Recombinant Parainfluenza Virus Expression Systems And Vaccines  
The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue...
US20110250228 Compositions and Methods for Identifying and Targeting Cancer Cells of Alimentary Canal Origin  
Screening and diagnostic reagents, kits and methods for metastatic colorectal cancer or primary and/or metastatic stomach or esophageal cancer are disclosed. Vaccines compositions and methods of...
US20110236416 FOOT AND MOUTH DISEASE VIRUS RECOMBINANT VACCINES AND USES THEREOF  
The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant...
US20110070290 VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT  
Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant...
US20090117034 Microorganisms for imaging and/or treatment of tumors  
Modified viruses encoding transporter proteins and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses also can be used in...
US20090092579 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID  
Disclosed are novel methods for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloidogenic proteins (proteins contributing to...
US20060013826 Recombinant measles viruses expressing epitopes of antigens of RNA viruses - use for the preparation of vaccine compositions  
The invention relates to a recombinant measles virus expressing a heterologous amino acid sequence derived from an antigen of a determined RNA virus, said recombinant measles virus being capable...
US20050008651 Circovirus sequences associated with piglet weight loss disease (PWD)  
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences,...
US20160175428 VACCINE AND DRUG DELIVERY BY INTRANASAL APPLICATION OF VECTOR AND VECTOR EXTRACTS  
Disclosed and claimed is a method of non-invasive immunization in an animal and/or a method of inducing a systemic immune response or systemic therapeutic response to a gene product. The skin of...
US20150265688 Stabilizing Formulations for Recombinant Viruses  
This invention relates to preparations of viruses, e.g. for vaccine or other pharmaceutical or research use, to their stabilization, and to processes of producing such preparations, as well as to...
US20080069837 Composition and method for treating cancer using herpes virus  
The present invention provides a herpes virus in which a non-essential gene for replication is inactivated. More particularly, the present invention provides a herpes virus in which a...
US20050142148 Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus  
The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue...
US20140377306 RECOMBINANT VACCINE VIRUSES EXPRESSING IL-15 AND METHODS OF USING THE SAME  
The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or...
US20130142823 CMV GLYCOPROTEINS AND RECOMBINANT VECTORS  
This invention also relates to recombinant vectors expressing one or more of the human CMV (HCMV) glycoproteins US2, US3, US6 and US11 or corresponding functional rhesus CMV (RhCMV) homologues...
US20120183574 MODIFIED VACCINIA VIRUS ANKARA FOR THE VACCNATION OF NEONATES  
The invention concerns the use of a virus for the preparation of a medicament for the vaccination or treatment of a human, wherein the virus is capable of infecting the cells of the human, but not...
US20110142879 INFECTIOUS CLONES  
Methods of preparing a DNA comprising sequences derived from the genomic RNA (gRNA) of a coronavirus are provided, comprising cloning under the expression of a promoter a coronavirus interfering...
US20070154487 Compositions and methods for modulation of RORgammat functions  
The present invention relates to expression of RORĪ³t in cells and tissues and the effect of expression of this gene on proliferation of specific immune cells and in promotion of immune cell...
US20140335074 METHODS FOR IMPROVING MEDICAL THERAPIES  
Methods are provided herein for enhancing the effectiveness of medical therapies by administering agents that suppress a biological damage response that is inducible by the medical therapy...
US20130045180 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME  
Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines,...
US20110002958 Alphavirus Vectors for Respiratory Pathogen Vaccines  
Described herein are compositions and methods for stimulating an immune response to one or more proteins derived from one or more respiratory pathogens. In particular, the invention relates to...
US20100278773 Chimeric flavivirus vaccines  
A chimeric live, infectious, attenuated virus containing a yellow fever virus, in which the nucleotide sequence for a prM-E protein is either deleted, truncated, or mutated, so that functional...
US20090074810 Modified Adenovirus Hexon Protein and Uses Thereof  
The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein....
US20090035327 Antibody Gene Transfer and Recombinant AAV Therefor  
The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver antibody genes to target...
US20050238656 Recombinant vesiculoviruses and their uses  
The present invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable...
US20100272786 VACCINE  
The invention relates to a replication deficient simian adenoviral vector C7 encoding a protein comprising CS protein from P. falciparum or a fragment thereof, for example as shown in Seq ID No: 1...
US20090175898 Influenza Hemagglutinin And Neuraminidase Variants  
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided.
US20090175897 SYSTEM FOR RAPID PRODUCTION OF HIGH-TITER AND REPLICATION-COMPETENT ADENOVIRUS-FREE RECOMBINANT ADENOVIRUS VECTORS  
The present invention relates generally to the fields of gene therapy, immunology, and vaccine technology. More specifically, the invention relates to a novel system that can rapidly generate high...
US20050118192 Viral preparations, vectors, immunogens, and vaccines  
A genetically disabled mutant virus has a genome which is defective in respect of a selected gene that is essential for the production of infectious new virus particles, and which carries...
US20150044255 INFECTIOUS cDNA CLONE OF NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF  
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the...
US20160058852 IMMUNOTHERAPY OF CANCER THROUGH COMBINATION OF LOCAL AND SYSTEMIC IMMUNE STIMULATION  
Provided herein are compositions and methods for immunotherapy of cancers, said methods combining systemic vaccination with a recombinant expression vector encoding a viral antigen and/or a cancer...
US20080299149 Raccoon Poxvirus Expressing Genes of Feline Antigens  
The present invention relates to new recombinant raccoon poxvirus vectors comprising two or more exogenous nucleic acid molecules, each encoding at least one feline protein, wherein at least two...

Matches 1 - 50 out of 232 1 2 3 4 5 >